Primary malignancy of the thymus gland in myasthenia gravis remains rare, especially metastasis of the malignancy to a distant organ. We have presented a case of myasthenia gravis with invasive thymoma and its meatastasis to the diaphragm. The literature concerned with this aspect is reviewed.
Diaphragm ; Humans ; Myasthenia Gravis ; Neoplasm Metastasis* ; Thymoma* ; Thymus Gland

Erythropoietic protoporphyria, sometimes also called erythrohepitic protoporphyria or simple protoporphyria, is a heritable detect of heme synthesis in which the last enzyme of the heme synthetic pathway, ferrochelatase(or heme synthetase), is functioning subopt,imally. A 23-year-old male has experi nced erythema and edema on the fae and hands during or immediately after sun exposure, since 3 years of age. The skin lesions have been accompanied by severe itching, a buring sensation and pain. Severe episodes were followed hy head iche and vomiting. We have seen a case of erythropoietic protoporphyria presenting clinically and histo athologically, wit.h a skin lesion on the sun exposured area, and free erthrocyte protoporphyrin serologically.
Edema ; Erythema ; Hand ; Head ; Heme ; Humans ; Male ; Protoporphyria, Erythropoietic* ; Pruritus ; Sensation ; Skin ; Solar System ; Vomiting ; Young Adult

PURPOSE: The purpose of this study was to identify the effects of service orientation on the organizational commitment and management performance of public health center workers. METHODS: A cross-sectional survey design was used. A convenience sample of 280 workers was recruited from six public health centers in J province, South Korea. Data were collected by self-report questionnaires, including general characteristics, service orientation, organizational commitment, and management performance. Data were analyzed with descriptive statistics, Pearson correlation coefficients, independent t-test, one-way ANOVA, and hierarchical regression using the SPSS 22.0 program. RESULTS: The service orientations explained 34.1%of the variance in organizational commitment and explained 31.4% of the variance in management performance. The service orientation was a significant predictor of organizational commitment and management performance. CONCLUSION: The results of this study suggest that better strategies for service orientations will be helpful to enhance organizational commitment and management performance in the public health center.
Cross-Sectional Studies ; Korea ; Public Health*

No abstract available.
Asthma* ; Child* ; Eosinophils* ; Humans

No abstract available.
Child* ; Humans ; Hypercalciuria*

BACKGROUND: High glucose upregulates MCP-1 expression in rat glomerular mesangial cells and in human peritoneal mesothelial cells. However, the role of high glucose-induced MCP-1 on the development and progression of diabetic renal injury and peritoneal injury during peritoneal dialysis(PD) using high glucose PD solutions are not clear. Since MCP-1 was shown to upregulate transforming growth factor-beta1(TGF-beta1) and collagen expression in lung fibroblasts, the present study investigated the effects of MCP-1 on fibronectin secretion by mouse mesangial cells(MMC), human peritoneal mesothelial cells (HPMC), and human peritoneal fibroblasts(HPFB). METHODS: Synchronized cells were stimulated by different concentrations of MCP-1(0.1-100 ng/mL) or TGF-beta1(0.1-10 ng/mL) for 48 hours. Fibronectin protein secreted into the media was analyzed by Western blot analysis. RESULTS: MCP-1 up to 100 ng/mL did not affect fibronectin secretion by MMC. TGF-beta1 10 ng/mL, however, increased fibronectin secretion by MMC 2.8 fold that of control. MCP-1 up to 100 ng/mL did not affect fibronectin secretion by HPMC. But, TGF-beta1 0.1 ng/mL increased fibronectin secretion by HPMC 1.8 fold compared to control. On the other hand, MCP-1 increased fibronectin secretion by HPFB in a dose-dependent manner. MCP-1 at 1-10 ng/mL significantly increased fibronectin when compared to M199 control. 100 ng/mL MCP-1 further increased fibronectin secretion by HPFB compared to 0.1-10 ng/mL MCP-1. CONCLUSION: These results suggest a possible role for MCP-1 in the development and progression of peritoneal fibrosis and support the view that in addition to recruiting inflammatory cells MCP-1 may play a role in tissue fibrosis in other organs.
Animals ; Blotting, Western ; Chemokine CCL2* ; Collagen ; Fibroblasts* ; Fibronectins* ; Fibrosis ; Glucose ; Hand ; Humans* ; Lung ; Mesangial Cells ; Mice ; Monocytes* ; Peritoneal Fibrosis ; Rats ; Transforming Growth Factor beta1

Purpose: To report a case of optic neuritis caused by anti-aquaporin 4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibody double-seropositive neuromyelitis optica spectrum disorder (NMOSD).Case summary: An 86-year-old female presented with a 10-day history of blurred vision in her right eye. The initial best-corrected visual acuity in the right eye was limited to hand motion, while the left eye had a visual acuity of 0.9; a relative afferent pupillary defect was observed in the right eye. Fundus examination showed normal optic disc appearance, and optical coherence tomography (OCT) indicated normal retinal nerve fiber layer thickness. Magnetic resonance imaging revealed enhancement and swelling of the right optic nerve, and signs of myelitis. The patient tested positive for anti-AQP4 and anti-MOG antibodies, leading to a diagnosis of NMOSD, and high-dose intravenous steroids and immunoglobulins were administered. Two months after the initial visit, fundus examination and OCT revealed optic disc atrophy in the right eye, with no improvement in visual acuity. After additional immunosuppressive treatment for 2 months, the anti-MOG antibody test returned negative. The patient continued on oral steroids and immunosuppressive agents for 12 months, during which no improvement in visual acuity was observed, with no recurrence of optic neuritis. The left eye remained unaffected throughout the 2-year follow-up period. Conclusions Cases of double-seropositive NMOSD are rare, with unclear treatment protocols and prognosis. In this case, despite treatment with steroids and immunosuppressants, the patient's optic nerve atrophy did not improve, with no recurrence of optic neuritis during the 2-year follow-up period.

Purpose: To report a case of optic neuritis caused by anti-aquaporin 4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibody double-seropositive neuromyelitis optica spectrum disorder (NMOSD).Case summary: An 86-year-old female presented with a 10-day history of blurred vision in her right eye. The initial best-corrected visual acuity in the right eye was limited to hand motion, while the left eye had a visual acuity of 0.9; a relative afferent pupillary defect was observed in the right eye. Fundus examination showed normal optic disc appearance, and optical coherence tomography (OCT) indicated normal retinal nerve fiber layer thickness. Magnetic resonance imaging revealed enhancement and swelling of the right optic nerve, and signs of myelitis. The patient tested positive for anti-AQP4 and anti-MOG antibodies, leading to a diagnosis of NMOSD, and high-dose intravenous steroids and immunoglobulins were administered. Two months after the initial visit, fundus examination and OCT revealed optic disc atrophy in the right eye, with no improvement in visual acuity. After additional immunosuppressive treatment for 2 months, the anti-MOG antibody test returned negative. The patient continued on oral steroids and immunosuppressive agents for 12 months, during which no improvement in visual acuity was observed, with no recurrence of optic neuritis. The left eye remained unaffected throughout the 2-year follow-up period. Conclusions Cases of double-seropositive NMOSD are rare, with unclear treatment protocols and prognosis. In this case, despite treatment with steroids and immunosuppressants, the patient's optic nerve atrophy did not improve, with no recurrence of optic neuritis during the 2-year follow-up period.

Purpose: To report a case of optic neuritis caused by anti-aquaporin 4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibody double-seropositive neuromyelitis optica spectrum disorder (NMOSD).Case summary: An 86-year-old female presented with a 10-day history of blurred vision in her right eye. The initial best-corrected visual acuity in the right eye was limited to hand motion, while the left eye had a visual acuity of 0.9; a relative afferent pupillary defect was observed in the right eye. Fundus examination showed normal optic disc appearance, and optical coherence tomography (OCT) indicated normal retinal nerve fiber layer thickness. Magnetic resonance imaging revealed enhancement and swelling of the right optic nerve, and signs of myelitis. The patient tested positive for anti-AQP4 and anti-MOG antibodies, leading to a diagnosis of NMOSD, and high-dose intravenous steroids and immunoglobulins were administered. Two months after the initial visit, fundus examination and OCT revealed optic disc atrophy in the right eye, with no improvement in visual acuity. After additional immunosuppressive treatment for 2 months, the anti-MOG antibody test returned negative. The patient continued on oral steroids and immunosuppressive agents for 12 months, during which no improvement in visual acuity was observed, with no recurrence of optic neuritis. The left eye remained unaffected throughout the 2-year follow-up period. Conclusions Cases of double-seropositive NMOSD are rare, with unclear treatment protocols and prognosis. In this case, despite treatment with steroids and immunosuppressants, the patient's optic nerve atrophy did not improve, with no recurrence of optic neuritis during the 2-year follow-up period.

Purpose: To report a case of optic neuritis caused by anti-aquaporin 4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibody double-seropositive neuromyelitis optica spectrum disorder (NMOSD).Case summary: An 86-year-old female presented with a 10-day history of blurred vision in her right eye. The initial best-corrected visual acuity in the right eye was limited to hand motion, while the left eye had a visual acuity of 0.9; a relative afferent pupillary defect was observed in the right eye. Fundus examination showed normal optic disc appearance, and optical coherence tomography (OCT) indicated normal retinal nerve fiber layer thickness. Magnetic resonance imaging revealed enhancement and swelling of the right optic nerve, and signs of myelitis. The patient tested positive for anti-AQP4 and anti-MOG antibodies, leading to a diagnosis of NMOSD, and high-dose intravenous steroids and immunoglobulins were administered. Two months after the initial visit, fundus examination and OCT revealed optic disc atrophy in the right eye, with no improvement in visual acuity. After additional immunosuppressive treatment for 2 months, the anti-MOG antibody test returned negative. The patient continued on oral steroids and immunosuppressive agents for 12 months, during which no improvement in visual acuity was observed, with no recurrence of optic neuritis. The left eye remained unaffected throughout the 2-year follow-up period. Conclusions Cases of double-seropositive NMOSD are rare, with unclear treatment protocols and prognosis. In this case, despite treatment with steroids and immunosuppressants, the patient's optic nerve atrophy did not improve, with no recurrence of optic neuritis during the 2-year follow-up period.