The transition from preinvasive to invasive disease is a crucial juncture in the development of cervical cancer. The clinical experience that microvasive lesions carry a better prognosis justifies a sepetate diagnostic category. Besides clinical and cliagmostic problerns, the rnicroinvasive cervical cancer presents morphological peculiarities. To investigate the clinieal and pethological aspects of micrenvasive eervical carcinornn, a retrospective study was made on 40 cases, histologically reconfirrned surgical specimens, which had been treated during the period from March, 198I3 to March, 1992 at, Departrnent of Obstetrics and Gynecology, Pusan Paik Hospital, Inje University. The results obtained were as follows ; 1. Mean age of 40 patents was 44.6 year old, all were rnultipatous. Nineteen cases helonged to I s, and 21 cases to I a2. 2. Main presenting symptoms were leukorr hea and/or genital bleeding and the majority of patients showed cervical erosion on groas finding, 3. The corresponding rate of Pap, smear to histologic diagnosis was approximately 67.5%, However, corresponding rate within one histologie grade was about 85%. 4, Aecording to the eolpuacapie examination, less than half of the examined cases revealed suspected abnormal findings suggeeting invasive lesion. 5. As to the reports of punch biopsy, 64.8% of cases showed microinvasive and/or inuasive lesian. With additional diagnostic conization of cervix, the preoperative diagnosis were correct in 82.5%. 6. Histopathological reevaluatin ef surgiral specimens revealed positive correlation between depth of stromal invasion and width of leaior, confluent growth pattern, numher of invasive foci, and invasion of capillary-like spaee, respectively.
Biopsy ; Busan ; Cervix Uteri* ; Conization ; Diagnosis ; Female ; Gynecology ; Hemorrhage ; Humans ; Obstetrics ; Prognosis ; Retrospective Studies ; Uterine Cervical Neoplasms

Epidermolysis bullosa simplex (EBS) is a group of autosomal dominantly inherited genetic disorders characterized by blistering due to mechanical- stress-induced degeneration of basal epiderrnal cells. Recently, it was discovered that EBS is induced by keratin 5 and 14 gene mutations. Weber Cockayne (W-C) EBS is the mildest type, with blistering concentrates primarily on palar and plantar regions, and basal cell cytolysis by keratin filament perturbations is present. Herein we report a case of W-C EBS with its ultrastructural findings. Electron microscopy showed cytolysis and separation of the basal epidermal cells, mainly at the subnuclear cytoplasm. The cyto- plasm of basal cells showed edema, loosening and intact rnitochondria. Besides the cytoplasmic changes, the nucleus also showed lytic degeneration. Characteristically, dense condensation of tonofilarnent was observed, which suggests that W-C EBS is. also a disorder of keratin.
Blister ; Cytoplasm ; Edema ; Epidermolysis Bullosa Simplex* ; Epidermolysis Bullosa* ; Keratin-5 ; Microscopy, Electron

No abstract available.
Neck*

No abstract available.
Torticollis*

No abstract available.
Child* ; Hepatitis B Surface Antigens* ; Hepatitis B Vaccines* ; Hepatitis B* ; Hepatitis B, Chronic* ; Hepatitis* ; Hepatitis, Chronic* ; Humans ; Infant* ; T-Lymphocyte Subsets*

No abstract available.
Incidence* ; Nurseries* ; Parenteral Nutrition, Total* ; Pharmacy* ; Sepsis*

Granulocytic sarcoma is a rare localized tumor composed of granulocytic precusor cells. Granu-locytic sarcoma occurs in a variety of clinical conditions and it is often misdiagnosed histologically. Differential diagnosis frorh lymphoma or nonhematopoietic malignancies such as undifferentiated carcinoma or sarcoma is difficult in the routing histologic examination. An evaluation of clinical and histopathologic features was done on 4 cases of granulocytic sarcoma which were diagnosed at Pusan Paik Hospital from 1988 to 1992. During the period, 282 cases of myelogenous leukemia were diagnosed. Immunohistochemical reaction for lysozyme, myelopero-xidase, leukocyte common antigen, epthelial membrane antigen and cytokeratin was assessed comparing to lymphoma and undifferentiated carcinoma. The histologic features of the granulocytic sarcoma revealed thin nuclear membrane, fine chromatin pattern and one or two small nucleoli. It also often involved the vascular wall and infiltrated the native structures without destruction. Immunohistochemical stain revealed that all(4 cases) of granulocytic sarcoma showed diffuse and strong positivity for myeloperoxidase, and partial but strong positivity for lysozyme. One case of granulocytic sarcoma was negative and 3 cases revealed focal positive reaction for LCA, and all 4 cases was negative for cytokeratin and EMA. In summary, careful observation under light microscopy with immunohistochemical stain for myeloperoxidase, lysozyme, and LCA is helpful in the differential diagnosis of granulocytic sarcoma from malignant lymphoma and cytokeratin and EMA is useful for differential diagnosis from undifferentiated carcinoma.
Diagnosis, Differential

No abstract available.
Balloon Valvuloplasty* ; Child* ; Constriction, Pathologic* ; Humans

No abstract available.
Hepatolenticular Degeneration*

No abstract available.
Barium* ; Child* ; Diatrizoate Meglumine* ; Humans ; Intussusception*