No abstract available.
Propranolol*

BACKGROUND: The visceral fat accumulation, an important factor to increase the insulin resistance is known to be associated with coronary artery disease. We investigated the relation between visceral fat accumulation and the coronary artery disease. METHODS: The coronary artery disease (CAD) group included 14 patients (9 men and 5 women) with angina pectoris. All patients had typical chest pain, diagnosed as coronary artery disease with coronary angiogram or treadmill test. The patients with hypertension, hyperlipidemia, non-insulin dependent diabetes mellitus (NIDDM), impaired glucose tolerance (IGT) and taking any medication known to affect the insulin sensitivity were excluded. The control group included 24 healthy volunteers (11 men and 13 women) who were not taking any medication. We measured the visceral fat area, abdominal subcutaneous fat area, thigh muscle area and the thigh fat area with computed tomography (CT) in both groups. We measured the plasma lipid profile, plasma insulin and glucose level during the oral glucose tolerance test in both groups. RESULTS: There were no differences in the age, sex ratio, body mass index (BMI) and the waist to hip ratio (WHR) between both groups. The total cholesterol and LDL cholesterol were significantly higher in CAD group (p<0.001). The HDL cholesterol was significantly lower in CAD group (p<0.05). The fasting insulin, fasting glucose, area under curve (AUC) of the insulin and glucose, and the insulin to glucose (IG) ratio were significant higher in CAD group (p<0.001). There were significant differences between CAD group and the control group in the visceral fat area (94.2+/-19.1 cm2 vs. 76.5+/-34.3 cm2, p<0.05), thigh fat area (60.2+/-24.8 cm2 vs. 92.6+/-41.0 cm2, p<0.01) and the visceral fat to thigh fat area ratio (VSFTF ratio : 1.74+/-0.61 vs. 1.07+/-0.80, p<0.01). The visceral fat area was independently associated with fasting insulin (r=0.661, p<0.01), fasting glucose (r=0.490, p<0.05), the AUC of glucose (r=0.605, p<0.01), HDL cholesterol (r= -0.528, p<0.01) and triglyceride (r=0.483, p<0.05) in control group. After adjustment for visceral fat area, there were still significant differences in the fasting insulin, fasting glucose, AUC of insulin, AUC of glucose and the IG ratio between both groups. CONCLUSION: We observed significant increase in the visceral fat area and VSFTF ratio and decrease in thigh fat area in CAD group compared with age, BMI, WHR matched control group. The insulin resistance was observed in the CAD group. The visceral fat area and VSFTF ratio was associated with cardiovascular risk factors such as low HDL cholesterol and the insulin resistance in control group.
Angina Pectoris ; Area Under Curve ; Body Mass Index ; Chest Pain ; Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Coronary Artery Disease* ; Coronary Vessels* ; Diabetes Mellitus ; Exercise Test ; Fasting ; Glucose ; Glucose Tolerance Test ; Healthy Volunteers ; Humans ; Hyperlipidemias ; Hypertension ; Insulin ; Insulin Resistance ; Intra-Abdominal Fat* ; Male ; Plasma ; Risk Factors ; Sex Ratio ; Subcutaneous Fat, Abdominal ; Thigh ; Triglycerides ; Waist-Hip Ratio

BACKGROUND: The visceral fat accumulation, an important factor to increase the insulin resistance is known to be associated with coronary artery disease. We investigated the relation between visceral fat accumulation and the coronary artery disease. METHODS: The coronary artery disease (CAD) group included 14 patients (9 men and 5 women) with angina pectoris. All patients had typical chest pain, diagnosed as coronary artery disease with coronary angiogram or treadmill test. The patients with hypertension, hyperlipidemia, non-insulin dependent diabetes mellitus (NIDDM), impaired glucose tolerance (IGT) and taking any medication known to affect the insulin sensitivity were excluded. The control group included 24 healthy volunteers (11 men and 13 women) who were not taking any medication. We measured the visceral fat area, abdominal subcutaneous fat area, thigh muscle area and the thigh fat area with computed tomography (CT) in both groups. We measured the plasma lipid profile, plasma insulin and glucose level during the oral glucose tolerance test in both groups. RESULTS: There were no differences in the age, sex ratio, body mass index (BMI) and the waist to hip ratio (WHR) between both groups. The total cholesterol and LDL cholesterol were significantly higher in CAD group (p<0.001). The HDL cholesterol was significantly lower in CAD group (p<0.05). The fasting insulin, fasting glucose, area under curve (AUC) of the insulin and glucose, and the insulin to glucose (IG) ratio were significant higher in CAD group (p<0.001). There were significant differences between CAD group and the control group in the visceral fat area (94.2+/-19.1 cm2 vs. 76.5+/-34.3 cm2, p<0.05), thigh fat area (60.2+/-24.8 cm2 vs. 92.6+/-41.0 cm2, p<0.01) and the visceral fat to thigh fat area ratio (VSFTF ratio : 1.74+/-0.61 vs. 1.07+/-0.80, p<0.01). The visceral fat area was independently associated with fasting insulin (r=0.661, p<0.01), fasting glucose (r=0.490, p<0.05), the AUC of glucose (r=0.605, p<0.01), HDL cholesterol (r= -0.528, p<0.01) and triglyceride (r=0.483, p<0.05) in control group. After adjustment for visceral fat area, there were still significant differences in the fasting insulin, fasting glucose, AUC of insulin, AUC of glucose and the IG ratio between both groups. CONCLUSION: We observed significant increase in the visceral fat area and VSFTF ratio and decrease in thigh fat area in CAD group compared with age, BMI, WHR matched control group. The insulin resistance was observed in the CAD group. The visceral fat area and VSFTF ratio was associated with cardiovascular risk factors such as low HDL cholesterol and the insulin resistance in control group.
Angina Pectoris ; Area Under Curve ; Body Mass Index ; Chest Pain ; Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Coronary Artery Disease* ; Coronary Vessels* ; Diabetes Mellitus ; Exercise Test ; Fasting ; Glucose ; Glucose Tolerance Test ; Healthy Volunteers ; Humans ; Hyperlipidemias ; Hypertension ; Insulin ; Insulin Resistance ; Intra-Abdominal Fat* ; Male ; Plasma ; Risk Factors ; Sex Ratio ; Subcutaneous Fat, Abdominal ; Thigh ; Triglycerides ; Waist-Hip Ratio

No abstract available.

BACKGROUND: The insulin resistance is common in the patients with essential hypertension, even in the absence of non-insulin-dependent diabetes mellitus(NIDDM) or hyperlipidemia. It is well known that the offspring of patients with NIDDM have shown less insulin sensitivity compared with that of normal parents. But it is not yet known whether the insulin resistance is common in the offspring of patients with essential hypertension in Korea, who have no hypertension, NIDDM and hyperlipidemia. The aims of this study were to find out whether the insulin resistance exist in the middle aged normal offspring of the patients with essential hypertension and whether the insulin resistance is dependent on the metabolic abnormalities such as the body mass index(BMI), obesity and hyperlipidemia. METHODS: The serum lipid profiles and oral glucose tolerance test were performed. The anthropometrical measurement was done. The abdominal CT scan at umbilicus level and thigh CT was performed in the 11 offspring of parents with essential hypertension(group I;male : 7, female : 4)and 24 offspring of parents without essential hypertension, NIDDM, ischemic heart disease and hyperlipidemia(group II; male : 9, female : 15). RESULTS: The average age of group I was 44.1+/-6.9 years, and that of the group II was 47.5+/-9.5 years. There were no significant differences in the blood pressure, weight, BMI, waist to hip ratio, waist to thigh ratio. And there were no significant differences in the serum cholesterol, triglyceride, HDL-cholesterol, serum Na, and plasma renin activities between both groups. Fasting plasma insulin and 2 hour insulin after 75gm glucose ingestion were significantly higher in group I than in group II(8.5+/-3.0mU/mL versus 5.0+/-1.8mU/mL, 61.6+/-31.7mU/mL versus 33.3+/-16.8mU/mL, p<0.05). The insulin sensitivity index was significantly lower in group I than in group II(355.1+/-92.6 versus 451.8+/-88.1, p<0.05). The visceral fat area was wider in group I than in group II(102.0+/-30.7cm2 versus 64.5+/-28.5cm2, p<0.05). The multiple regression analysis with the fasting plasma insulin and insulin sensitivity index as the dependent variables and family history of essential hypertension, visceral fat area and BMI as the predictor variables revealed that only the family history was associated with the fasting plasma insulin and insulin sensitivity index. CONCLUSIONS: The offspring of the parents with essential hypertension showed the insulin resistance with increased visceral fat area in comparison with the offspring of the parents without essential hypertension.
Blood Pressure ; Cholesterol ; Diabetes Mellitus, Type 2 ; Eating ; Fasting ; Female ; Glucose ; Glucose Tolerance Test ; Humans ; Hyperlipidemias ; Hypertension ; Insulin Resistance* ; Insulin* ; Intra-Abdominal Fat ; Korea* ; Male ; Middle Aged* ; Myocardial Ischemia ; Obesity ; Parents* ; Plasma ; Renin ; Thigh ; Tomography, X-Ray Computed ; Triglycerides ; Umbilicus ; Waist-Hip Ratio

Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that clinically manifests both upper and lower motor neuron signs. However, it is unknown where and how the motor neuron degeneration begins, and conflicting hypotheses have been suggested. Recent advanced radiological techniques enable us to look into ALS neuropathology in vivo. Herein, we report a case with upper motor neuron-predominant ALS in whom the results of brain magnetic resonance imaging (MRI) and myelin water fraction MRI suggest axonal degeneration.
Amyotrophic Lateral Sclerosis* ; Axons ; Brain ; Magnetic Resonance Imaging* ; Motor Neurons ; Myelin Sheath* ; Neuropathology ; Pathology ; Water*

OBJECTIVE: It has been well known that alcohol can modulate several ligand-gated ion channel and voltage-gated ion channels. But the roles of alcohol in the autonomic neurons still remain unclear. In this study, thus we characterized the neuronal acetylcholine receptor (nnAChRs) and investigated the modulation of nnAChRs by ethanol (EtOH). METHODS: We used whole-cells which were acutely dissociated male rat major pelvic ganglion (MPG) neurons, and used gramicidin perforated patch clamp techniques. RESULTS: MPG neurons can be classified on the basis of the response of the soma membrane to depolarizing current pulses ; either tonic or phasic neurons. Sympathetic neurons expressing T-type Ca(2+) channels showed tonic firing pattern, while parasympathetic neurons lacking T-type Ca(2+) channels phasic firing to depolarizing current pulses. When hyperpolarizing currents were injected, sympathetic neurons produced post-anodal rebound spikes, while parasympathetic neurons were silent. Under current clamp mode, Acetylcholine (ACh) evoked significant membrane depolarization and produced subsequently marked membrane hyperporization. Under whole-cell mode, application of ACh-induced inward currents held at holding potentials below 0 mV and reversal potential was close to 0 mV, an equilibrium potential of nonselective cation channel. The ACh-activated current was blocked by methyllycaconitine (MLA ; 10 micrometer), hexamethonium (100 micrometer) and alpha-bungarotoxin (alpha-BuTx ; 100 nM), nAChRs antagonists. EtOH (40 mM) potentiated ACh-induced depolarization and hyperpolarization. EtOH also increased both alpha-BuTx-sensitive and -insensitive ACh-activated currents. Futhermore, EtOH potentiated 5-HT-activated current but had a little effect on GABA-activated current. CONCLUSION: These results suggest that EtOH modulates nnAChRs and 5-HT receptors in MPG neurons.
Acetylcholine ; Animals ; Bungarotoxins ; Carisoprodol ; Ethanol ; Fires ; Ganglia, Autonomic ; Ganglion Cysts ; Gramicidin ; Hexamethonium ; Humans ; Ion Channels ; Male ; Membranes ; Neurons ; Patch-Clamp Techniques ; Rats ; Receptors, Nicotinic* ; Receptors, Serotonin

To determine the effects of excessive drinking and alcohol dependency on mortality and chronic health problems in a rural community in South Korea, this study represents a nested case-control study. In 1998, we conducted the Alcohol Dependence Survey (ADS), a population survey of a village in Korea. To measure the effects of alcohol on chronic health conditions and mortality over time, in 2004, we identified 290 adults from the ADS sample (N=1,058) for follow-up. Of those selected, 145 were adults who had alcohol problems, either alcohol dependence as assessed in the ADS by the Severity of Alcohol Dependence Questionnaire (N=59), or excessive drinking without dependency (N=86). Further 145 nondrinkers were identified, matching those with alcohol problems in age and sex. We revisited the village in 2004 and completed personal interviews with them. In multivariate logistic regressions, the rates of mortality and morbidity of chronic health conditions were three times greater for alcohol dependents compared with the rate for nondrinkers. Importantly, however, excessive drinking without dependency was not associated with the rates of either mortality or morbidity. Future investigations would benefit by attending more specifically to measures for alcohol dependence as well as measures for alcohol consumption.
Adult ; Aged ; Aged, 80 and over ; Alcohol-Related Disorders/epidemiology ; Alcoholism/complications/*mortality ; Chronic Disease ; Female ; Humans ; Korea/epidemiology ; Logistic Models ; Male ; Middle Aged ; Rural Population ; Sex Factors ; Smoking/epidemiology

OBJECTIVES: Children with post-injury attention deficit disorder (ADD) exhibit deficiencies in academic functioning, social skills, and self-control, that are comparable to developmental attention-deficit hyperactivity disorder (ADHD). The similarities and differences of the two conditions have to be studied because some children with traumatic brain injury have shown premorbid ADD and seem to be less responsive to psychostimulants. METHODS: Characteristics of cognition and attention of post-injury ADD (n=12) and developmental ADHD (n=12) boys were investigated by administering KEDI-WISC and Visual and Auditory TOVA. RESULTS: No differences in KEDI-WISC subtests were found between two diagnostic groups. Post-injury ADD boys show lower commission error (lower impulsivity) in visual and auditory TOVA, and lower variability of reaction time (higher information-processing consistency) in auditory TOVA than developmental ADHD boys (p<0.05, p<0.01). CONCLUSION: Post-injury ADD and developmental ADHD are different in their attention components suggestively, which warrants further study for differential diagnosis and proper treatment.
Attention Deficit Disorder with Hyperactivity ; Brain Injuries ; Child* ; Cognition ; Diagnosis, Differential ; Humans ; Reaction Time

PURPOSE: Medical and business are one of the most popular majors among students, and both fields require intensive training to reach certain level of expertise. During the development of professionalism, goal can become a crucial role in psychological impetus. The purpose of this study is to compare goal contents, goal characteristics, and effect of goal characteristics on student's major satisfaction between medical and business. METHODS: A total of 193 undergraduate students (97 medical students, 96 business students) answered survey questions including goal contents, goal characteristics (goal autonomy, goal attainability, social value of goal) and satisfaction on their majors. Qualitative analysis of goal contents and quantitative analysis of goal characteristics, and their effects on student major satisfaction were performed. RESULTS: Goal content analysis showed percentage of social concern goal was higher in medical students (25.8%) than business students (6.3%), whereas percentage of wealth goal was higher business students (24.0%) than medical students (3.1%). Among goal characteristics, goal attainability and social value of goal were higher in medical students than business students. In both groups, social value of goal was significantly predict major satisfaction. CONCLUSION: Goal contents and goal characteristics are different between medical and business students. Curriculum and educational interventions that concerning students' goal and developing programs to enhance students' social value of goal is necessary.
Adolescent ; Adult ; *Career Choice ; Commerce ; Curriculum ; *Education, Medical, Undergraduate ; Female ; *Goals ; Humans ; Income ; Male ; *Motivation ; *Personal Satisfaction ; Social Responsibility ; Social Values ; Students ; *Students, Medical ; Surveys and Questionnaires ; Young Adult