Suture threads have been the mainstay material for bonding biologic tissues in the medical field, and are still used as the basic method for wound closure; on the other hand, various types of medical glue have also been continuously developed as an alternative approach. Cyanoacrylate, fibrin glue, protein glue, polyethylene glycol polymer hydrogel glue, and mussel protein are currently marketed as clinical products; among these, cyanoacrylate and fibrin glue are the most widely used bonding materials. Cyanoacrylate hardens rapidly with a high bonding strength, but is vulnerable to external stress and has tissue toxicity; fibrin glue may be easily applied on wide tissue surfaces and has an excellent hemostatic effect, but has a weak bonding strength and may provide a spreading source for infectious disease through its blood components. A perfect bonding material without such disadvantages is yet to be developed, and it is important to use each product judiciously with regard to its merits and drawbacks. Many types of medical glue are being developed and marketed in more medically advanced countries, and their usage in the medical field is constantly increasing. Global markets for such medical bonding products are undergoing rapid expansion; therefore, active research and development in the relevant fields is imperative.
Adhesives* ; Bivalvia ; Communicable Diseases ; Cyanoacrylates ; Fibrin Tissue Adhesive ; Hand ; Hydrogel ; Polyethylene Glycols ; Polymers ; Sutures ; Tissue Adhesives ; Wounds and Injuries

Adipose tissue is an ideal tissue to use as an autologous substitute with which to approach tissue deficiency. Clinically, the use of fat grafts and adipose-derived stem cells has dramatically increased worldwide for reconstructive and aesthetic purposes. Human adipose tissue contains a population of pluripotent stem cells capable of differentiating along multiple mesenchymal cell lineages. Adipose tissue is an abundant, expendable, and easily obtained tissue that may prove to be an ideal source of autologous stem cells for regenerating tissues. The recent identification and characterization of multilineage cells from human adipose tissue has been met with a great deal of excitement by the field of tissue engineering. The authors' laboratory has characterized a population of cells obtained from human adipose tissue that have the capacity to differentiate into osteoblasts, chondrocytes, adipocytes, and neuron-like cells in vitro. This article summarizes the basic study of the adipose tissue as a multipotential stem cell source of tissue engineering techniques that are currently being developed to solve common aesthetic problems.
Adipocytes ; Adipose Tissue ; Cell Lineage ; Cell Transplantation ; Chondrocytes ; Humans ; Osteoblasts ; Pluripotent Stem Cells ; Stem Cells ; Tissue Engineering ; Transplants

No abstract available.

No abstract available.
Wounds and Injuries*

Based on the histopathologic findings of the lacrimal gland tumor, the lesion is classified as either epithelial or nonepithelial tumor. 22% of lacrimal gland lesions were primary epithelial neoplasm. 4%of epithelial tumor of lacrimal glands were primary malignant tumor. Squamous cell carcinoma arising from pleomorphic adenoma of lacrimal gland is a very rare(0.4%). Inspite of surgical intervention, postoperative radiation and chemotherapy, the mortality and recurrence rate of the carcinoma ex pleomorphic adenoma of lacrimal gland is very high. We report a case of squamous cell carcinoma ex pleomorphic adenoma of lacrimal gland, which was completely removed via lateral orbitotomy with bicoronal incision and had no major complication or recurrence.
Adenoma* ; Adenoma, Pleomorphic ; Carcinoma, Squamous Cell ; Drug Therapy ; Lacrimal Apparatus* ; Mortality ; Neoplasms, Glandular and Epithelial ; Recurrence

BACKGROUND: The prenatal ultrasound detection of cleft lip with or without cleft palate (CL/P) and its continuous management in the prenatal, perinatal, and postnatal periods using a multidisciplinary team approach can be beneficial for parents and their infants. In this report, we share our experiences with the prenatal detection of CL/P and the multidisciplinary management of this malformation in our institution's Congenital Disease Center. METHODS: The multidisciplinary team of the Congenital Disease Center for mothers of children with CL/P is composed of obstetricians, plastic and reconstructive surgeons, pediatricians, and psychiatrists. A total of 11 fetuses were diagnosed with CL/P from March 2009 to December 2013, and their mothers were referred to the Congenital Disease Center of our hospital. When CL/P is suspected in the prenatal ultrasound screening examination, the pregnant woman is referred to our center for further evaluation. RESULTS: The abortion rate was 28% (3/11). The concordance rate of the sonographic and final diagnoses was 100%. Ten women (91%) reported that they were satisfied with the multidisciplinary management in our center. CONCLUSIONS: Although a child with a birth defect is unlikely to be received well, the women whose fetuses were diagnosed with CL/P on prenatal ultrasound screening and who underwent multidisciplinary team management were more likely to decide to continue their pregnancy.
Abortion, Induced ; Child ; Cleft Lip* ; Cleft Palate ; Congenital Abnormalities ; Craniofacial Abnormalities ; Diagnosis ; Female ; Fetus ; Humans ; Infant ; Interdisciplinary Communication ; Mass Screening ; Mothers ; Palate* ; Parents ; Plastics ; Pregnancy ; Pregnant Women ; Prenatal Care* ; Psychiatry ; Ultrasonography

PURPOSE: Pemphigus vulgaris, a rare autoimmune blistering disease of the skin and mucous membranes remains a challenging disease to treat. Management is focused on immunotherapy against autoimmune antibodies that target keratinocyte cell adhesion molecules, and antibiotics preventing secondary infections. There is no established dressing protocol and skin is usually manipulated the least amount possible in order to minimize irritation. The authors suggest that early initiation of aggressive bathing and debridement of skin lesions, with nutritional support, is essential in accelerating resolution. METHODS: A 40 year-old male previously diagnosed with pemphigus vulgaris was admitted due to exacerbation of mucocutaneous lesions involving the epidermis and mucosa of the whole body. Steroids, immunosuppressants, intravenous immunoglobulin and antibiotics were administrated, but infection and de-epithelialization progressed, while his general condition deteriorated with a weight loss of over 20 kilograms. The plastic surgery department intervened with daily bathing, debridement of unhealthy debris and non-traumatizing coverage of growing epithelium. Total parenteral nutrition and mobilization with rehabilitation therapy was initiated as early as possible. RESULTS: After bathing, healthy epithelium gradually covered the patient's entire body, while his general condition improved with a corresponding weight gain of 14 kgs. CONCLUSION: Treatment of pemphigus vulgaris focuses on immunotherapy and infection control. However, an equal amount of attention should be laid on early intervention with daily dressings including bathing and irrigation, nutritional support, and exercise as this accelerates resolution of existing infections, promotes healthy epithelialization and leads to faster recovery.
Anti-Bacterial Agents ; Antibodies ; Bandages ; Baths ; Blister ; Cell Adhesion Molecules ; Coinfection ; Debridement ; Early Intervention (Education) ; Epidermis ; Epithelium ; Humans ; Immunoglobulins ; Immunosuppressive Agents ; Immunotherapy ; Infection Control ; Keratinocytes ; Male ; Mucous Membrane ; Nutritional Support ; Parenteral Nutrition, Total ; Pemphigus ; Skin ; Steroids ; Surgery, Plastic ; Weight Gain ; Weight Loss

No abstract available.
Mucocele* ; Paranasal Sinuses*

No abstract available.
Mucocele* ; Paranasal Sinuses*

No abstract available.
Fournier Gangrene* ; Myocutaneous Flap*