Riboflavine tetrabutyrate is a fat soluble riboflavine derivative. It was synthesized by esterification of riboflavine with fatty acid chloride or by esterification of riboflavine with fatty acid anbydride. The advantage of riboflavine tetrabutyrate is prolongation of its biologic half life and as a result enhancing effectivity of riboflavine, This riboflavine tetrabutyrate has been used for treatment of various dermatoses of which Pathogenesis are believed to be related with abnorma1 Iipid rnetabolism. Receatty, there were many case reports showing markedly improved clinical synptoms ofpsoriatic patients who had been administered oral riboflavine tetrabutyrate for more than one month in Japan. In this clinical trial, we have also experienced effectiveness in 4 of 7 psoriatic pztients who was given oral riboflavine t trabutyrate for more than 3 months.
Esterification ; Half-Life ; Humans ; Japan ; Psoriasis* ; Riboflavin* ; Skin Diseases

A clinical survey on the syphilitic cases of the military personnel was carried out during the period of 18 months from July, l976 to December, 1977 by means of ready-made STD chart and questianaire. This survey included 180 cases of syphilitic patients who had been diagnosed and treated in the Dept. of Dermatology of ROK Army Hospital. The results can be summarized as follows: I . Total 180 cases af syphilis were classified as 147 cases (81.7%) of secondary syphilis, 22 cases (12. 2%) of primary syphilis and 11 cases (6. l%) of latent syphilis. The cases of secondary syphilis were camposed of 96 cases (65. 3%) of alopecia syphilitica, 88 cases (60.0%) of condyloma latum, 12 cases (8. 2%) of macular syphilid and 1 case (0. 7%) of mucous patch, each. 3. Among 147 cases of secondary syphilis, 42 cases (28.6%) had a positive history of typical chancre at the genital region. III. 68. 3% of patients had first sexual experience between the age of 18 and 20 and the average age was 19.1 years. 71.7% of total patients of syphilis were between the age of 21 and 23 and the average age was 22.8 years. IV. Fourteen cases(63.6%) of primary syphilis had the chancre on the coronal sulcus, 4 cases(18.2%) on the prepuce, 3 cases(13.6%) on the penile shaft and 1 case(4.5%) on the glans penis. V. To review the number of the lesion of 88 cases of condyloma latum, 45 cases(51.1%) had one to three lesions and the average number of the lesion was 3.7 Predilection sites of condyloma latum were perianal region(90.9%), penile shaft(11.4%), scrotum(6.8%) and corona and coronal sulcus(4.5%). VI. Out of 180 cases, 76 cases(42.2%) had a past history of other STD, and 26 cases(14.4%) had other coincidently combined STD which were composed of condyloma acuminatum(8.9%) urethritis(3.3%), chancroid(1.6%) and pediculosis pubis(0.6%). VII. The most common partners of the first sexual experience was lover(50.0%) and followed by barmaid(25.6%) and prostitute(8.9%). Barmaid(56.7%) was the most frequently suspected source of present infection and other sources were prostitute(18.9%) and lover(.9.4%).
Alopecia ; Chancre ; Dermatology ; Hospitals, Military ; Humans ; Lice Infestations ; Male ; Military Personnel ; Penis ; Syphilis* ; Syphilis, Cutaneous ; Syphilis, Latent

We report herein a case of smooth muscle hamartoma associated with Beckers nevus in a 5-year-old female. The child presented with a slight.ly brownish. 2 x 3 cm sized, pigmentecl patch with follicular accentuation on the right forearm, witch had been observecl since age of 2. Histopathologic findings showed the epidermal changes most consistent with Becker's nevus and the presence of irregularly arranged hyperplastic smooth muscle hundless in the dermis.
Child ; Child, Preschool ; Dermis ; Female ; Forearm ; Hamartoma* ; Humans ; Muscle, Smooth* ; Nevus*

Painful fat hemiation is characterized. by the soft, skin colored painful papules on the heels that appears only when weight is bome and disappears when weight. is taken off the heels. The papules were thought to be caused by hemiation of adipose tissue through connective tissue defect. To our knowledge, such a case or similar one has not been reported previously in Korea. The patient was 30 year-old housewife, who have had soft, skin colored painful papules on the medial aspect of the both heels when weight was placed on the foot. Routine laboratory findings were within normal limit. Skin biopsy revealed nodules of lobulated adipose tissue on the mid-dermis far above the original subcutaneous tissue and large venous channels with thick muscular walls. Hypertrophied peripheral nerve trunks were scattered adjacent to the above vascular structure. Diagnosis was confirmed by clinical and histopathological features. Literatun was briefly reviewed.
Adipose Tissue ; Adult ; Biopsy ; Connective Tissue ; Diagnosis ; Foot ; Heel ; Humans ; Korea ; Peripheral Nerves ; Skin ; Subcutaneous Tissue

Recently tnere have been many reports about scabies aggravated during treatment with topical fluorinated st roid. We describe bere two cases of scabies showing unusual clinical features associated. with topical steroid a.nd morphology of different s.zges of 5arcoptes scabiei coliected from the patient. In first case who was 20 year-old riiale patient treated with topical betamethasone cream and antihistaminics per os for 2 months, we collected 62 mites from 130 burrows: 45 adult females, 5 adult males, 6 deutonymphs, 4 protonymphs and 2 larvae. In second case who was 29 year old male patient treated with topical steroid (Esperson), for one month, we rollected 9 adult female itch mites and two (male & female) Dermatophagoides pteronyssnus from 48 burrows.
Adult ; Betamethasone ; Female ; Humans ; Larva ; Male ; Mites ; Pyroglyphidae ; Scabies* ; Young Adult

Recurrent zoster myelitis is quite rare. We present a previously healthy 27-year-old woman who developed recurrent attacks of myelopathy shortly after the characteristic skin rashes of herpes zoster. Magnetic resonance imaging studies demonstrated each lesion in the spinal cord at the same segments as the skin lesions. She had two attacks at opposite sites at the same spinal cord level and complete recovery after being treated with intravenous acyclovir. We suspect that direct invasion of varicella zoster virus was the cause of recurrent myelopathy in our patient.
Adult ; Case Report ; Female ; Herpes Zoster/complications* ; Human ; Magnetic Resonance Imaging ; Myelitis/virology* ; Myelitis/diagnosis ; Recurrence

No abstract available.
Neoplasm Metastasis* ; Vena Cava, Inferior*

Two patients with cutaneous leishmaniasis were treated with itraconazole. One patient was a 24-year-old man who had several erythematous papulonodules on the extremities for 1 month, which revealed cutaneous leishmaniasis, histopathologically. He was treated with itraconazole (200 mg/day) for 2 months. After treatment he showed clinical healing and the biopsy specimens no longer showed leishmania organisms. The other patient was a 27-year-old female who had several erythematous papulonodules on the face and neck for 3 months. The skin lesions revealed leishmania organisms in the tissue sections and culture media. She was also treated with itraconazole (200 mg/day) for 2 months. After treatment she also showed satisfying clinical healing and the biopsy specimens revealed no leishmania organisms. No specific side effects were encountered in both patients during the treatment. From these results, itraconazole is considered to be one of the promising anti-leishmanial drugs.
Adult ; Biopsy ; Culture Media ; Extremities ; Female ; Humans ; Itraconazole* ; Leishmania ; Leishmaniasis, Cutaneous* ; Neck ; Skin ; Young Adult

BACKGROUND: We evaluated the efficacy and safety of positive pressure ventilation (PPV) with a ProSeal laryngeal mask airway (PLMA), as compared with an endotracheal tube (ETT) and with a classic laryngeal mask airway (LMA) during laparoscopic cholecystectomy. METHODS: One hundred, ASA 1, 2 adults scheduled for elective laparoscopic cholecystectomy were randomly assigned to ETT, LMA or PLMA. Anesthesia was induced with fentanyl 2 microgram/kg, lidocaine 0.5 mg/kg and propofol 2 mg/kg and maintained with a continous infusion of propofol 6-12 mg/kg/h in 67% N2O, atracurium and fentanyl. ETT, LMA or PLMA was placed with atracurium 0.5 mg/kg. Respiratory and hemodynamic parameters were measured before and after intraabdominal CO2 insufflation. The surgeon assessed the degree of gastric distension change using a laparoscope. RESULTS: Oxygen saturation, end tidal CO2, inspiratory pressure, expiratory tidal volume and compliance of the respiratory system were similar in the three groups. Blood pressure and heart rate were lower in the PLMA and LMA groups than in the ETT group 5 min after induction (P < 0.05). Audible gas leakage occurred more so in the LMA group (48.5%) than in the PLMA group (8.8%). Because of inadequate ventilation, endotracheal intubation was changed in one case in the LMA group. The degrees of gastric distension change were similar in the three groups. The PLMA and LMA resulted in less coughing after removal than ETT (P < 0.05). A postoperative sore throat and dysphagia were similar in the three groups, but dysphonia was more frequent in the ETT group. CONCLUSION: During laparoscopic cholecystectomy, PPV with PLMA provide more effective pulmonary ventilation than LMA and fewer side effects than ETT.
Adult ; Anesthesia ; Atracurium ; Blood Pressure ; Cholecystectomy, Laparoscopic* ; Compliance ; Cough ; Deglutition Disorders ; Dysphonia ; Fentanyl ; Heart Rate ; Hemodynamics ; Humans ; Insufflation ; Intubation, Intratracheal ; Laparoscopes ; Laryngeal Masks* ; Lidocaine ; Oxygen ; Pharyngitis ; Positive-Pressure Respiration* ; Propofol ; Pulmonary Ventilation ; Respiratory System ; Tidal Volume ; Ventilation

We report a case of accidental intrathecal administration of Nucomyt(R)(acetylcysteine), a mucolytic agent used for intratracheal instillation. A 21-year-old healthy female with a complete syndactyly at the 4th and 5th toes was scheduled for a web release under spinal anesthesia. Immediately after accidental intrathecal administration of Nucomyt(R)2.4 ml instead of bupivacaine for spinal anesthesia, tonic extension developed at first in the lower extremities and then the upper extremities, too. Thiopental sodium 200 mg was injected intravenously twice. Endotracheal general anesthesia with N2O- enflurane-vecuronium was maintained for the operation for about two hours. For about 1 hour after emergence of general anesthesia, tonic extension intermittently developed in the lower extremities and was controlled with midazolam. Mild elevated blood pressure, tachycardia, tachypnea, high fever (up to 38.5degrees C) and respiratory acidosis occurred. Thirty minutes later, she became mentally clear with a normal neurologic examination. No delayed sequelae were detectable at a follow-up visit 1 month and 1 year after surgery.
Acetylcysteine* ; Acidosis, Respiratory ; Anesthesia, General ; Anesthesia, Spinal ; Blood Pressure ; Bupivacaine ; Female ; Fever ; Follow-Up Studies ; Humans ; Lower Extremity ; Midazolam ; Neurologic Examination ; Syndactyly ; Tachycardia ; Tachypnea ; Thiopental ; Toes ; Upper Extremity ; Young Adult