No abstract available.
Animals ; Doxorubicin* ; Mononuclear Phagocyte System* ; Rats* ; Vincristine*

No abstract available.
Diskectomy*

Since the discovery of Helicobacter pylori in 1983 by Warren and Marshall, it has been recognized as one of the most significant risk factors for gastric cancer and has been associated with various gastrointestinal disorders such as peptic ulcer disease. In Korea, the triple therapy of proton pump inhibitor, clarithromycin, and amoxicillin has been recommended as a primary regimen since 1998. However, the eradication rate of conventional first line therapy of H. pylori infection has been decreasing progressively, primarily due to increased resistance to antibiotics. A recent meta-analysis showed that the overall eradication rates were 74.6% by intention-to-treat analysis and 82.0% by per-protocol analysis. Therefore, the need for alternative first line eradication regimens has been rising. Sequential therapy, concomitant therapy, and various combinations of new antibiotics such as quinolone and rifabutin have been introduced as new options, but they have yet to be proven as standard first line therapy. Further nation-wide surveillance regarding the antibiotic resistance rates and well-designed prospective randomized controlled multicenter trials on the empirical first line therapy are necessary to establish the appropriate treatment for H. pylori in Korea.
Amoxicillin ; Anti-Bacterial Agents ; Clarithromycin ; Drug Resistance ; Drug Resistance, Microbial ; Helicobacter pylori* ; Helicobacter* ; Korea* ; Multicenter Studies as Topic ; Peptic Ulcer ; Prospective Studies ; Proton Pumps ; Rifabutin ; Risk Factors ; Stomach Neoplasms

No abstract availble.
Adult ; Carcinoma, Squamous Cell/*diagnosis/pathology/surgery ; Esophageal Neoplasms/*diagnosis/pathology/surgery ; Esophagectomy ; Esophagus/*pathology/ultrasonography ; Humans ; Male ; Mucous Membrane/pathology

No abstract available.
Humans ; Lymphocytes* ; Siblings* ; Sister Chromatid Exchange* ; Thyroid Gland* ; Thyroid Neoplasms*

No abstract available.
Humans ; Listeria* ; Meningitis, Listeria*

The aim of the present study was to evaluate the ability of Tl-201 abdominal SPECT to differentiate between chronic focal pancreatitis and pancreatic malignancy. Seventeen patients (12 men, 5 women; mean age, 56 years; 9 pancreatic cancer, 8 chronic pancreatitis) with pancreatic mass were prospectively investigated with Tl-201 abdominal SPECT. In all patients, CT and/or US could not clarify the nature of the pancreatic mass. Focal hot uptake was present in 8 of 9 patients with pancreatic cancer, while it was present in 2 of 8 patients with chronic pancreatitis. Therefore, the sensitivity and specificity of the present study were 89% and 75%, respectively. A significant difference of Tl-201 uptakes was noted between benign and malignant masses (p& 0.05). Therefore, we concluded that Tl-201 abdominal SPECT was a useful test in differentiation of malignant from benign pancreatic mass, especially when the differentiation could not be made by other imaging modalities
Abdomen/*radionuclide imaging ; Chronic Disease ; Diagnosis, Differential ; Evaluation Studies ; Female ; Follow-Up Studies ; Human ; Male ; Middle Age ; Pancreatic Neoplasms/*radionuclide imaging ; Pancreatitis/*radionuclide imaging ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity ; Support, Non-U.S. Gov't ; Thallium Radioisotopes/*diagnostic use ; Tomography, Emission-Computed, Single-Photon/methods

PURPOSE: During the last 10 years, a multitude of different ileal neobladders have been reported. The ureterointestinal anastomotic site stricture has been shown to be one of the most common late complications. To avoid the stricture, a new orthotopic ileal neobladder was constructed, with two chimneys and two afferent ileal limbs beside the reservoir. MATERIALS AND METHODS: Twenty-six men, with invasive bladder cancer, underwent a radical cystectomy, with the creation of a two chimney ileal neobladder. The mean follow-up was 18 months. The complications were assessed and divided into those related or unrelated to the urinary tract. The continence was evaluated using patient questionnaires. RESULTS: There was no case of an ureteroileal anastomotic site stricture. Five cases of vesicoureteral reflux were noted in the 52 ureteral units. Good, or satisfactory, day- and nighttime urinary continence was reported at the 6 month follow-up by 92.3 and 69.2% of patients, respectively. CONCLUSIONS: The ileal neobladder with two chimneys would be an appropriate technique for the reduction of the ureteroileal anastomotic stricture rate and to overcome some of limitations of the ureteral length.
Constriction, Pathologic ; Cystectomy ; Extremities ; Follow-Up Studies ; Humans ; Male ; Surveys and Questionnaires ; Ureter ; Urinary Bladder Neoplasms ; Urinary Diversion ; Urinary Tract ; Vesico-Ureteral Reflux

BACKGROUND/AIMS: Delayed bleeding after gastric endoscopic submucosal dissection (ESD) commonly occurs within 3 days, but it may also occur after 1 week following ESD, especially in antiplatelet agent users. We evaluated the risk of delayed bleeding in post-ESD ulcers using the Forrest classification. METHODS: Registry data on the Forrest classification of post-ESD ulcers (n=371) at 1 week or 2 weeks after ESD were retrospectively evaluated. The Forrest classification was categorized into two groups: increased risk (Forrest Ia to IIc) or low risk (Forrest III). The odds ratios (ORs) were calculated using logistic regression analysis. RESULTS: Among 371 post-ESD ulcers, one ulcer (0.3%) was classified as Forrest Ib, two (0.5%) as Forrest IIa, 17 (4.6%) as Forrest IIb, 172 (46.4%) as Forrest IIc, and 179 (48.2%) as Forrest III. The proportion of increased-risk ulcers was 72.2% (140/194) at 1 week after ESD, which decreased to 29.4% (52/177) at 2 weeks after ESD (p<0.001). In the multivariate analysis, a post-ESD ulcer at 1 week after ESD (OR, 7.54), younger age (OR, 2.17), and upper/middle ulcer location (OR, 2.05) were associated with increased-risk ulcers. CONCLUSIONS: One week after ESD, ulcers still have an increased risk of bleeding when assessed using the Forrest classification. This risk should be considered when resuming antiplatelet therapy.
Classification* ; Hemorrhage* ; Logistic Models ; Multivariate Analysis ; Odds Ratio ; Platelet Aggregation Inhibitors* ; Retrospective Studies ; Stomach Neoplasms ; Ulcer

Botulinum toxin A injection has been recently used in the treatment of spasmodic disorders and the focal dystonia for relieving its abnormal conditions. This treatment, however, is not popular in Korean because of difficulty in getting the drug. Se have injected Botulinum toxin A in 7 various patients;spasmodic torticollis:2, hemifacial spasm:3, blepharospasm:1, ankle spasticity:1. 3 patients improved greatly and 2 patients showed moderate, but 1 patient showed only mild improvement. No significant side effects showed except the transient ptosis in the blepharospasm and the mild focal muscle weakness in the hemifacial spasm.
Ankle ; Blepharospasm ; Botulinum Toxins* ; Dystonic Disorders* ; Hemifacial Spasm ; Humans ; Muscle Weakness