1.A clinical study of parotid gland tumor.
Tea Ha PARK ; Wook KIM ; Jong Man WON
Journal of the Korean Surgical Society 1992;42(1):15-20
No abstract available.
Parotid Gland*
2.Status of Serum Hepatitis C Virus Antibodies in Hansen's Disease.
Jong Pill KIM ; Yun Sil KIM ; Tea Byoung PARK ; Young Hoon KO
Korean Leprosy Bulletin 2001;34(2):81-89
According to the reports, the prevalence of anti-HCV is about 1%. In past, the results of the prevalence of HBs Ag & HBs Ab in the patients of Hansen's disease were reported. But we don't know about that of anti-HCV. So we study about the prevalence of serum anti-HCV of 60 patients & PALS of Hansen's disease. And we test about Alk. Phosp., ALT, AST, Gtlc HBs Ag & HBs Ab. 1. The prevalence of anti-HCV is 8.33%. It is higher than past reports(about 1-2%). 2. The prevalence of HBs Ag is 3.4% & that of HBs Ab is 36.3%. 3. Because of the high prevalence of anti-HCV in the patients of Hansen's disease & PALS, we think that more studies are need about it.
Hepacivirus*
;
Hepatitis C Antibodies*
;
Hepatitis C*
;
Hepatitis*
;
Humans
;
Leprosy
;
Prevalence
3.A Cli ieal Observation of Infectious Hepatitis in Children.
Teak Sae LEE ; Jong Youl KIM ; Tea Myung KIM ; Young Hea PARK
Journal of the Korean Pediatric Society 1978;21(5):376-388
We performed a clinical observation on the 208 cases of infectious hepatitis who were cared at the pediatric department of Fatima Hospital from July, 1, 1970, to June, 30, 1977, and obtained the following results. 1. The ratio of infectious hepatitis to the total number of in-patients was 3.25 in average. 2. There was no significant difference in seasonal incidence except spring when the incidence was lower than the other seasons. 3. The age-group of 3~8 years old occupied 69% of the total cases and sex incidence revealed mali predominence with the ratio about 2:1. 4. The frequently observed clinical manifestations included ; Anorexia(71%)Nausea/Vomiting(65%), Tiredness(53%), Dark urine(59%), Abdominal pain(54%), Fever(45%), Jaundice(75%), Hepatomegaly(71%), Tenderness on upper adbomen(40%), and Palpable spleen(12.3%). 5. In the most of the cases the hematologic findings were with-in normal limit. 6. Bilirubinuria was observed in about 65% of the tested cases during the first 2 weeks of the illness and urinary urobilinogen was decreased during the second week of the illness. 7. In the majority of the cases the serum bilirubin reached peak during the second week of the illness and ranged 2~15mg%. And by the end of the 4th week illness, they returned to less than 2mg% in the 85%of the tested cases. 8. SGOT and SGPT reached peak during the first week of the illness and by the end of 4th week, they returned to less than 100 unit in the most the tested cases. And the values of SGOTwere higher than SGOT throughout the course of the illness. 9. The electrophoresis of the serum protein revealed as follow ; 1-globulin decreased slightly and -globulin in creased. 10. We experienced 30 cases (14.4%) of anicteric hepatitis. 11. ABHg was positive in 2(3.8%) of the 52 tested cases. 12. 10 of the 208 cases complicated hepatic coma and 10 of them expired and 3 of them dischared without clinical improvement.
Alanine Transaminase
;
Aspartate Aminotransferases
;
Bilirubin
;
Child*
;
Electrophoresis
;
Hepatic Encephalopathy
;
Hepatitis
;
Hepatitis A*
;
Humans
;
Incidence
;
Mali
;
Seasons
;
Urobilinogen
4.Association between Cardiac Troponin Level and Coronary Flow Reserve in Patients without Coronary Artery Disease: Insight from a Thermodilution Technique Using an Intracoronary Pressure Wire.
Kyungil PARK ; Minkwan KIM ; Young Rak CHO ; Jong Sung PARK ; Tea Ho PARK ; Moo Hyun KIM ; Young Dae KIM
Korean Circulation Journal 2014;44(3):141-147
BACKGROUND AND OBJECTIVES: Cardiac troponins are associated with increased mortality, even among patients with no coronary artery disease. Elevated cardiac troponin levels are frequently observed in patients without significant coronary lesions, although the mechanism underlying this finding is unclear. The aim of our study was to evaluate the association between the levels of cardiac troponin and coronary flow reserve (CFR). SUBJECTS AND METHODS: We evaluated serum cardiac troponin-I in 19 patients (9 female; age 61.9+/-10.9 year-old). All patients had an ejection fraction >40% and angiographically normal coronary arteries. Simultaneous measurements of fractional flow reserve (FFR), the index of microcirculatory resistance (IMR), and CFR measurements using an intracoronary temperature- and pressure-sensing guidewire under basal conditions and during maximal hyperemia were performed in three vessels: the left anterior descending artery (LAD), left circumflex artery (LCX) and right coronary artery (RCA). RESULTS: All patients were followed for a median of 13 months. FFR, IMR, and CFR measurements were performed successfully in all subjects. Mean CFRs of LAD, LCX, and RCA were 1.98+/-1.20, 2.75+/-2.11, and 4.44+/-2.51, respectively. Mean IMRs of LAD, LCX and RCA were 33.28+/-18.78, 29.11+/-26.70, and 30.55+/-23.65, respectively. There was a poor correlation between CFR and troponin-I values in each vessel. In selecting the lowest value of CFR in each patient as the corresponding value, the lowest CFR was not associated with troponin-I levels (r=-0.219, p=0.367). CONCLUSION: In patients without significant coronary lesions, the correlation between CFR and troponin-I level was not significant using a thermodilution technique. Further study of a larger population with longer-term follow-up may be needed to more fully understand microvascular dysfunction.
Arteries
;
Coronary Artery Disease*
;
Coronary Vessels
;
Female
;
Follow-Up Studies
;
Humans
;
Hyperemia
;
Microvessels
;
Mortality
;
Thermodilution*
;
Troponin I
;
Troponin*
;
Vascular Resistance
5.The Management of Spontaneous Intracerebral Hemorrhage: Medical Versus Surgical Therapy for Spontaneous Intracerebral Hemorrhage.
Tea Ho KIM ; Shin JUNG ; Je Hyuk LEE ; Jong Keun PARK ; Jea Hyoo KIM ; Soo Han KIM ; Sam Suk KANG
Journal of Korean Neurosurgical Society 1996;25(2):373-380
The results of treatment for 248 patients with spontaneous intracerebral hemorrhage are described. Spontaneous intracerebral hemorrhages are classified into primary(215 patients) and secondary(33 patients) hemorrhages. Most of the secondary hemorrhages were located in the subcortical area(64%). In the Non-treated group, eighty patients died immediately after diagnosis. In the treated group, the overall mortality was 5% in primary hemorrhages and 15% in secondary hemorrhages, and the percentages of hypertensive intracerebral hemorrhage patients returning to full-time work or independent life without disability or with minimal disability were 30% in putaminal hemorrhages, 86% in caudate hemorrhages, 44% in thalamic hemorrhages, 61% in subcortical hemorrhages, 78% in cerebellar hemorrhages and 40% in brainstem hemorrhages respectively. This study showed that surgical treatment did not give better result over conservative treatment in the management of hypertensive supratentorial and brainstem hemorrhage. However hypertensive caudate and cerebellar hemorrhage were associated with favorable outcomes regardless of the mode of therapy chosen. In severe hemorrhages, surgery may improve the length of survival, but the quality of life remains poor. The authors have shown again that aspiration surgery for hypertensive cerebellar hemorrhage is a valuable alternative to craniotomy.
Brain Stem
;
Cerebral Hemorrhage*
;
Craniotomy
;
Diagnosis
;
Hemorrhage
;
Humans
;
Intracranial Hemorrhage, Hypertensive
;
Mortality
;
Quality of Life
6.Subarachnoid Hemorrhage of Unknown Etiology: Long-term Follow-up.
Jeong Man LEE ; Gook Ki KIM ; Jong Tea PARK ; Young Jin LIM ; Tae Sung KIM ; Bong Arm RHEE ; Won LEEM
Journal of Korean Neurosurgical Society 1998;27(12):1687-1692
Twenty eight patients with negative but technically satisfactory four-vessel angiography-admitted to our department from 1985 to 1995 were followed for long term evaluation. The aim of this retrospective study of patients with SAH of unknown etiology was to evaluate the clinical features, long-term prognosis in mortality rate and risk of rebleeding, and the daily functional capacity. Twenty eight out of 1035(2.7%) spontaneous subarachnoid hemorrhage patients were found to have subarachnoid hemorrhage(SAH) of unknown etiology. Twenty eight patients were confirmed as SAH, by computed tomography or lumbar puncture. CT scan was undertaken in all cases(in 28 cases within 5 days of hemorrhage). SAH of unknown etiology classified as Hunt and Hess grade I was 60.7% of cases, but there were no patients with Grade V. Arterial hypertension was present on admission in 35.7% of cases. We only performed the angiogram once in 16 of 28 patients, but there were no rebleedings caused by aneurysm. The period of follow-up ranged from 2 to 11 years, with the mean of 4.3 years. Only one of 28 patients(3.6%) experienced late rebleeding, and again had normal cerebral panangiography. Two patients(7.1%) showed a moderate disability in activities of daily living, one patient(3.6%) was mild disabled, and two(7.1%) had died of pneumonia. Based on the ADL grade, Grade I was 28.6% at the time of discharge however, during follow-up, increased up to 81.5%.
Activities of Daily Living
;
Aneurysm
;
Follow-Up Studies*
;
Humans
;
Hypertension
;
Mortality
;
Pneumonia
;
Prognosis
;
Retrospective Studies
;
Spinal Puncture
;
Subarachnoid Hemorrhage*
;
Tomography, X-Ray Computed
7.Implications of Mechanical Endovascular Thrombectomy for Acute Basilar and Posterior Cerebral Artery Occlusion.
Hyun Nyung LEE ; Bum Tea KIM ; Soo Bin IM ; Sun Chul HWANG ; Je Hoon JEONG ; Moon Young CHUNG ; Jong Hyun PARK ; Dong Seong SHIN
Journal of Cerebrovascular and Endovascular Neurosurgery 2018;20(3):168-175
OBJECTIVE: Protocols for posterior circulation ischemic stroke have not been established by randomized clinical trials. Mechanical endovascular thrombectomy (MET) devices are evolving, and many of these devices already developed or in development are suitable for posterior circulation MET. MATERIALS AND METHODS: We investigated the medical records of patients who underwent MET for posterior circulation ischemic stroke from January 2012 to August 2016. Fifteen patients were included. MET was performed in patients with or without injected intravenous tissue plasminogen activator. MET was considered in patients with a National Institute of Health Stroke Scale score of 4 or more, older than 18 years, with definite occlusion of the basilar artery or posterior cerebral artery (PCA), and who arrived at the hospital within 24 hours from onset. RESULTS: The direct catheter aspiration technique was used in five cases, and the stent retrieval technique was used in seven cases. The stent retrieval technique with the direct aspiration technique was used in three cases. Recanalization failed in two cases. Basilar occlusion without PCA involvement is the only effective factor of successful recanalization (p = 0.03). Successful recanalization (p = 0.005) and the presence of a posterior communicating artery (p = 0.005) affected the good outcome at discharge. CONCLUSION: An early diagnosis and active MET may improve the patient outcome. MET may help recanalization and good flow restoration and the potential for a good outcome.
Arteries
;
Basilar Artery
;
Catheters
;
Early Diagnosis
;
Humans
;
Medical Records
;
Passive Cutaneous Anaphylaxis
;
Posterior Cerebral Artery*
;
Stents
;
Stroke
;
Thrombectomy*
;
Tissue Plasminogen Activator
8.Effectiveness of the Trauma Team-Staffed Helicopter Emergency Medical Service
Tea youn KIM ; Sang Ah LEE ; Eun Cheol PARK ; Yo HUH ; Kyoungwon JUNG ; Junsik KWON ; Jonghwan MOON ; Jiyoung KIM ; Juryang KIM ; Kyungjin HWANG ; Seong Keun YUN ; John Cook Jong LEE
Health Policy and Management 2018;28(4):411-422
BACKGROUND: Whether there is a difference in outcomes for trauma patients transferring to the helicopter emergency medical service (HEMS) according to their previous team composition is controversial. The purpose of this study is to evaluate the effectiveness of trauma team-staffed-HEMS (TTS-HEMS) when transferring to a trauma center. METHODS: A retrospective comparison was conducted on patients transported to a trauma center over a 6-year period by the TTS-HEMS and paramedic-staffed-HEMS (119-HEMS). Inclusion criteria were blunt trauma with age ≥15 years. Patient outcomes were compared with the Trauma and Injury Severity Score (TRISS) (30-day mortality) and the Cox proportional hazard ratio of mortality (in hospital). RESULTS: There were 321 patients of TTS-HEMS and 92 patients of 119-HEMS. The TTS-HEMS group had a higher Injury Severity Score and longer transport time but a significantly shorter time to emergency surgery. The prehospital data showed that the trauma team performed more aggressive interventions during transport. An additional 7.6 lives were saved per 100 TTS-HEMS deployments. However, the TRISS results in the 119-HEMS group were not significant. In addition, after adjusting for confounders, the hazard ratio of mortality in the 119-HEMS group was 2.83 times higher than that in the TTS-HEMS group. CONCLUSION: HEMS was likely to improve the survival rate of injured patients when physicians were involved in TTS-HEMS. Survival benefits in the TTS-HEMS group appeared to be related to the fact that the trauma team performed both more aggressive prehospital resuscitation and clinical decision making during transportation.
Aircraft
;
Clinical Decision-Making
;
Emergencies
;
Emergency Medical Services
;
Humans
;
Injury Severity Score
;
Mortality
;
Resuscitation
;
Retrospective Studies
;
Survival Rate
;
Transportation
;
Trauma Centers
9.Acute toxicity and cytotoxicity evaluation of Dendrobium moniliforme aqueous extract in vivo and in vitro.
Mu Jin LEE ; Ho Kyung JUNG ; Min Suk KIM ; Ji Hun JANG ; Mi Ok SIM ; Tea Mook KIM ; Ho PARK ; Byung Kwan AHN ; Hyun Woo CHO ; Jung Hee CHO ; Won Seok JUNG ; Jong Choon KIM
Laboratory Animal Research 2016;32(3):144-150
Dendrobium moniliforme (L.) Sw., an herb of the Orchidaceae family, has long been used in traditional medicine to strengthen bones, nourish the stomach, and promote the production of bodily fluid. Recently, polysaccharides isolated from Dendrobium have been used in functional foods and nutraceutical products. A traditional method to process Dendrobium is to soak fresh stems in an ethanol solution, which is the most important factor to ensure high yields of aqueous-extractable polysaccharides. The present study was carried out to investigate the potential acute toxicity of D. moniliforme aqueous extract (DMAE), by a single oral dose in Sprague-Dawley rats. The test article was orally administered once by gavage to male and female rats at doses of 0, 2,500, and 5,000 mg/kg body weight (n=5 male and female rats for each dose). Throughout the study period, no treatment-related deaths were observed and no adverse effects were noted in clinical signs, body weight, food consumption, serum biochemistry, organ weight, or gross findings at any dose tested. The results show that a single oral administration of DMAE did not induce any toxic effects at a dose below 5,000 mg/kg in rats, and the minimal lethal dose was considered to be over 5,000 mg/kg body weight for both sexes. With respect to cytotoxicity, the cell viability of human embryonic kidney (HEK293) cells was less than 50% when the cells were treated with 10 mg/mL aqueous extract for 24 h.
Administration, Oral
;
Animals
;
Biochemistry
;
Body Weight
;
Cell Survival
;
Dendrobium*
;
Dietary Supplements
;
Ethanol
;
Female
;
Functional Food
;
Humans
;
In Vitro Techniques*
;
Kidney
;
Male
;
Medicine, Traditional
;
Methods
;
Orchidaceae
;
Organ Size
;
Polysaccharides
;
Rats
;
Rats, Sprague-Dawley
;
Stomach