This study was performed to investigate clinical and histopathologic features of steroid acne, which was induced by systemic administration and topical application of corticosteroids. Thirty five cases of steroid acne visited to Department of Dermatology, Hangang Sacred Heart Hospital from September, 1g79 to June, 1984 were analyzed, and the results obtained can be summarized as follows: 1. The peak age of the subjects was third decade(42.9%) with an average age of 30. 1 years, and male to female ratio was l.9: 1,2. The skin lesions had unique clinical features that showed many, uniform sized, erythematous papules and pust;ules. 3 The predilection sites of steroid acne induced by systemic steroid therapy were anterior chest(93.1%), back(44,8%), neck(31.0%), shoulder(31.0%) and face (20.7%) 4 Among thirty five cases of steroid acne, twenty cases were induced by parenteral adrninistration of dexamethasone disodium phosphate(group A), nine cases by oral administration of prednisolone(group B), and six cases by topical application of three kinds of steroid creams(group C). 5. The mean induction time after starting steroid in group A(ll. 3 days) was shorter than those in group B and C(18.9 days and l4.8 days respective)y). The mean total dosage of used steroid in group A was 191. 3mg of dexamethasone disodium phosphate and that in group B was 515. 7mg of prednisolone. On histopathologic findings of twenty two skin biopsy specimens of the three groups, perivascular inflammatory reaction was the most common finding followed by intra-and peri-follicular inflammatory reaction, dermal vascular dilatation, necrosis of follicular epithelium, comedo, intraand periollicular abscess and rupture of follicle.
Abscess ; Acne Vulgaris* ; Administration, Oral ; Adrenal Cortex Hormones ; Biopsy ; Dermatology ; Dexamethasone ; Dilatation ; Epithelium ; Female ; Heart ; Humans ; Male ; Necrosis ; Prednisolone ; Rupture ; Skin

No abstract available.
Child* ; Humans ; Urinary Tract Infections* ; Urinary Tract*

Many investigators were interested in the pathogenesis and the relationship between microscopical features and clinical behavior of hydatidiform mole. Trophoblastic cells in the trophoblastic disease were intensively examined histologically, ultrastructurally, immunohistochemically, and with hormone assay method, etc. But ultrastructural study on the stroma of hydatidiform mole was scarcely reported. In this paper, hydatidiform mole was examined at light and electron microscopic levels, with emphasis on the stroma. The results were as follows: 1) Hydropic degeneration of H-mole is more severe in the center of stroma and is not related with the degree of trophoblastic proliferation. Hofbauer cell and vascular structure are extremely rarely observed in the periphery of stroma which has relatively preserved cellular components. 2) Basement membrane is sometimes separated from trophoblastic layer. Degenerated cells in the stroma contain vacuoles, autophagosomes, and lipid droplets. Collagen is abundant in the loose interstitium. Hofbauer cells have no lysosome or phagosome. Vascular lumen is patient and endothelial cells are degenerated. From the above results, H-mole may be produced due to abnormal changes of trophoblasts and stromal changes may be a secondary process, so called autolysis. Hofbauer cells are not engaged in the stromal degeneration and may be different from usual tissue macrophages.

A case of znelanotic whitlow is presented which resembles clinically as chronic paronichia. Patient was 71 years old man and he has had a single brownish pigmented spot on left mid. finger since 3 years ago which was progressively grow and skin biopsy could be established the pathological diagnosis of superficial malignant melanoma.
Aged ; Biopsy ; Diagnosis ; Fingers ; Humans ; Melanoma ; Skin

The association rate of antibody with antigen has been reported to be greatly increased by lowering ionic strength. Low-ionic strength salt solution(LISS) method has been used for the detection of various alloantibodies. To investigate the sensitivity of LISS in indirect antiglobulin test, a comparison study of LISS with saline and albumin methods was conducted. A total of 32 patients' samples requested for indirect antiglobulin test were evaluated. Out of 32 patients with clinical immune hemolytic anemia, 11(34.3%) were positive in 37 degrees C saline antiglobulin test, 18(56.2%) in albumin antiglobulin test, 23(71.8%) in LISS antiglobulin test respectively. These results were statistically analyzed using non parametric Page's test for ordered alternatives. LISS method is more sensitive than 37 degrees C saline method or albumin method significantly (p<0.01).
Anemia, Hemolytic ; Coombs Test* ; Humans ; Isoantibodies ; Osmolar Concentration

No abstract available.
Neurons*

No abstract available.
Animals ; Antigen-Antibody Complex* ; Bacteria* ; Mice*

We carried out a prospective study with three aims:(1) to observe the renal computed tomography (CT) patterns in APN; (2) to compare the radiological imaging techniques used for the diagnosis of APN(renal CT and DMSA scintigraphy); (3) to correlate the clinical manifestations with CT findings in APN. Between 1 April 1997 and 31 March 1998, all adults who were admitted to our internal medicine ward with APN were included in this study. They presented with symptoms and signs of upper UTI, accompanied by pyuria and bacteriuria. All patients with renal abscess, or uropathy on the ultrasound (US) examination, were excluded from the study. 23 cases of APN were evaluated. There were 22 females and 1 male. The mean age of 23 cases was 45+/-19 years old(from 20 to 79 years old). Two cases we re diabetics. On the basis of postcontrast- enhanced CT findings, 23 cases were grouped into (1) Group I(6 cases), no abnormal lesions; (2) Group II(13 cases), wedge-shaped lesions (focal or diffuse); (3) Group III(2 cases), focal mass-like lesions; and (4) Group IV(2 cases), diffuse mass-like lesions. The incidences of CT and DMSA scintigraphy abnormalities were 74%(17/23) and 68%(13/19), respectively. A significant correlation was demonstrated between the clinical parameters(including duration of flank pain and fever, ESR, serum creatinine, and degree of pyuria) and the pattern of renal parenchymal findings detected on CT(P<0.05). In conclusion, we classify APN into four subgroups according to CT findings, and suggest that renal CT is useful in the diagnosis and assessment of severity of APN.
Abscess ; Adult ; Bacteriuria ; Creatinine ; Diagnosis ; Female ; Fever ; Flank Pain ; Humans ; Incidence ; Internal Medicine ; Male ; Prospective Studies ; Pyelonephritis* ; Pyuria ; Radionuclide Imaging ; Succimer ; Ultrasonography

BACKGROUND: Hypermagnesemia may be implicated to have both harmful and beneficial effects in dialysis patients. It may contribute to osteomalacic renal osteodystrophy and suppression of parathyroid hormone. The purposes of this study were to analyze the serum magnesium concentration in hemodialysis patients, and to clarify the relationship between serum magnesium and intact parathyroid hormone concentration (iPTH) independently of other clinical parameters. METHODS: Eighty-one patients (38 males and 43 females) with end-stage renal failure undergoing maintenance hemodialysis in Dankook University Hospital were included in this study. The mean age was 53+/-12 years and the duration of dialysis was 36+/-35 months. The underlying kidney disease was diabetic nephropathy in 24 patients (30%). The patients used a dialysate magnesium concentration of 1.5 mEq/L. The serum magnesium, iPTH and other clinical parameters were evaluated and analyzed. RESULTS: The mean serum magnesium concentration was 2.78+/-0.45 mEq/L (range 1.50-3.95 mEq/ L). Hypermagnesemia (defined as serum Mg >2.1 mEq/L) was found in 72 patients (89%). The mean iPTH was 128+/-224 pg/mL (range 3-1, 344 pg/mL). The iPTH was significantly low, and the serum aluminum concentration was significantly high in patients (n=28) with more severe hypermagnesemia (defined as serum Mg >3.0 mEq/L). The serum magnesium, aluminum and calcium concentration have significant negative correlations with iPTH respectively (r=-0.27, -0.31, -0.28, p<0.05) in patients (n=55) with relative hypoparathyroidism (defined as iPTH <120 pg/mL). CONCLUSION: Hypermagnesemia was common in hemodialysis patients. High serum aluminum concentration should be considered in patients with moderate to severe hypermagnesemia. Furthermore, hypermagnesemia as well as high serum aluminum and calcium concentration may have a suppressive effect on PTH in patients with relative hypoparathyroidism or adynamic bone disease.
Aluminum ; Bone Diseases ; Calcium ; Diabetic Nephropathies ; Dialysis ; Humans ; Hypoparathyroidism ; Kidney Diseases ; Kidney Failure, Chronic ; Magnesium* ; Male ; Parathyroid Hormone ; Renal Dialysis* ; Renal Osteodystrophy

We report herein a case of smooth muscle hamartoma associated with Beckers nevus in a 5-year-old female. The child presented with a slight.ly brownish. 2 x 3 cm sized, pigmentecl patch with follicular accentuation on the right forearm, witch had been observecl since age of 2. Histopathologic findings showed the epidermal changes most consistent with Becker's nevus and the presence of irregularly arranged hyperplastic smooth muscle hundless in the dermis.
Child ; Child, Preschool ; Dermis ; Female ; Forearm ; Hamartoma* ; Humans ; Muscle, Smooth* ; Nevus*