PURPOSE: Prolonged fetal hypoxia stimulates erythropoiesis in fetal life and induces increased nucleated erythrocytes(NRBC) counts at the early newborn period. To evaluate the relationship between prolonged fetal hypoxia and neonatal intraventricular hemorrhage (IVH), and the prediction of neonatal IVH by neonatal NRBC. METHODS: We compared the daily courses of the absolute NRBC count in preterm new- boms at 34 weeks' gestation or earlier with(n=17) and without(n=20) IVH for 7 days of life. RESULTS: Absolute NRBC counts at birth were higher in neonates with IVH than in control neonates(2,499/mm3+/-3,748 and 412/mm3+/-272, respectively, P=0.0022). The cut-off value of 1,000/mm3 for absolute NRBC counts at birth showed the best parameter estimate of the predictive model for IVH at early newborn period with 100% of positive predictive value and 74.1% of negative predictive value. CONCLUSION: Prolonged fetal hypoxia inducing fetal erythropoiesis near labor is closely related to IVH at early newborn period. Thabsolute NRBC counts at birth is the very important predictable marker for the condition.
Erythroblasts* ; Erythropoiesis ; Fetal Hypoxia ; Hemorrhage* ; Humans ; Infant, Newborn* ; Parturition ; Pregnancy

This case report demonstrates an unnecessary endodontic treatment of teeth with florid cemento-osseous dysplasia (FCOD) due to a misdiagnosis as periapical pathosis and emphasizes the importance of correct diagnosis to avoid unnecessary treatment. A 30-year-old woman was referred to our institution for apicoectomies of the mandibular left canine and both the lateral incisors. The periapical lesions associated with these teeth had failed to resolve after root canal treatment over a 3-year period. Radiographic examinations revealed multiple lesions on the right canine, the second premolar, and both first molars as well as the anterior region of the mandible. Based on clinical, radiographic and histological evaluations, the patient condition was diagnosed as FCOD. The patient has been monitored for 2 years. To avoid unnecessary invasive treatment, accurate diagnosis is essential before treatment is carried out in managing FCOD.
Apicoectomy ; Bicuspid ; Dental Pulp Cavity ; Diagnostic Errors ; Female ; Fibrous Dysplasia of Bone ; Humans ; Incisor ; Mandible ; Molar ; Osteomyelitis ; Periapical Diseases ; Tooth

No abstract available.
Neurofibroma*

We experienced a case of primary hepatic actinomycosis which was initially diagnosed by means of fine needle aspiration. The patient was a 31-year-old emaciated man with a 2-month history of 10 kg weight loss, right upper quadrant pain and flank pain. The liver was palpable and tender on physical examination. Computerized tomography scan of the liver showed two ill-defined hypodense masses in gallbladder fossa and inferior pole of right lobe. Hepatocellular carcinoma was clinically suspected. A CT-guided fine needle aspiration was performed. Microscopically, smears showed numerous radiating clusters of filamentous bacteria with many neutrophils and monocytes in necrotic background. The symptoms were improved by incision and drainage and massive administration of penicillin.
Actinomycosis ; Adult ; Bacteria ; Biopsy, Fine-Needle ; Breast ; Carcinoma, Hepatocellular ; Diverticulum* ; Drainage ; Fibroadenoma ; Flank Pain ; Gallbladder ; Humans ; Infarction ; Liver ; Monocytes ; Neutrophils ; Penicillins ; Physical Examination ; Vesico-Ureteral Reflux* ; Weight Loss

We investigated the occurrence of color vision loss in 70 organic solvent mixtures exposed workers and in 47 controls. Color Vision was assessed with a color arrangement test designed to identify the defective color sense, the Han Double 15-Hue Test. The results of the test were no significant difference between exposed workers and controls in the proportion of subjects who committed one or two errors. Quantitative analysis, using color confusion index(CCI), showed no signifiant difference between exposed workers and controls. A significant linear correlation was present between age and CCI in both exposed workers(CCi=0.0056age + 0.94; r=0.23; p<0.05) and controls(CCI=0.0066age + 0.86; r=0.33; p<0.05). Qualitative analysis of the patterns on the hue circle showed that the prevalence of acquired dyschromatopsia was 21% in both and no significant difference. Multiple regression analyses showed that age was significantly related to color vision loss. These results did not provide evidence of a relationship between organic solvents exposure and incidence of color vision loss. In field studies for monitor the people at risk of the acquired color vision loss involving low-dose organic solvents exposed workers, both quantitative and qualitative information should be considered.
Color Vision ; Incidence ; Prevalence ; Solvents

An 18-Year-old male hemophiliac with high titer of factorVIII inhibitor, stage V hemophilic arthropathy in right knee joint and a history of hematuria and retroperitoneal hemorrhage was admitted because of acute and massive bleeding of epistaxis, pulmonary hemorrhage and intestinal bleeding. The bleeing was not controolled by massive infusion of factorVIII concentrates but by prothrombin complex concentrates and high dose of factorVIII concentrates. He showned symptoms of sustained fever and diffuse pulmonary infiltration which was diagnosed as pulmonary hemosiderosis by MRI. We suppressed his immune reaction by prednisolne to prevent the formation of factorVIII inhibitor. He has been followed up for 3 years and shown no massive bleeding there-after.
Adolescent ; Epistaxis ; Fever ; Hematuria ; Hemophilia A* ; Hemorrhage ; Hemosiderosis* ; Humans ; Knee Joint ; Magnetic Resonance Imaging ; Male ; Prothrombin

PURPOSE: To assess the results and effectiveness of a small incision technique for ptosis repair. METHODS: Twenty three ptotic eyelids of 17 patients were repaired through a small incision between March 2005 and December 2005. Levator function and pre- and postoperative upper eyelid marginal reflex distances (MRD1) were checked. The small incision was executed on the eyelid crease, with a length of approximately 10.0~12.0 mm. Two 6-0 Ethilon stitches were placed to the tarsus after detecting levator aponeurosis with a Desmarres retractor. RESULTS: Of the 32eyes, 9 eyes had congenital ptosis and 23 eyes had acquired ptosis. The mean follow-up time was 12.1+/-3.4 months, with a levator function of 7.6+/-2.1 mm, preoperative MRD1 of 0.2+/-0.4 mm, and postoperative MRD1 of 2.6+/-0.3 mm. Two eyelids remained mildly undercorrected and required an additional operation. CONCLUSIONS: The small incision technique for ptosis correction is safe and precise, allowing more rapid recovery from surgery. The Desmarres retractor allows the levator to be found easily without complications. In addition, the small incision technique for levator repair is useful for congenital ptosis with good levator function as well as acquired ptosis.
Animals ; Ankle ; Eye ; Eyelids ; Follow-Up Studies ; Humans ; Nylons ; Reflex

No abstract available.
Chancre* ; Eczema* ; Nipples*

PURPOSE: To evaluate the clinical efficacy of a reverse eyelid splitting technique that we performed in cases of trichiasis or distichiasis combined with entropion. METHODS: The study comprised 43 eyes of 31 patients with trichiasis or distichiasis combined with entropion treated from November 2004 to December 2005. After skin incision, the muscular layer and tarsus were reversely dissected to find abnormal follicles. The abnormal hair follicle was cauterized under the muscular layer, and 2~3 rotating sutures were done with Ethilon 6-0 to fix the tarsus and skin. Success was defined as having the meibomian gland located in front of the junction of skin and mucosa, without an abnormal hair protruding into the eye for at least three months. RESULTS: Fifteen patients were male and sixteen patients were female. The mean age was 62.1+/-15.2 years. The patients were followed up for an average of 12.4+/-2.0 months after surgery. Surgery was successful in 74.4% (32 of the 43 eyelids) of the cases, and the recurrence rate was 25.6% (11 of the 43 eyelids). No severe complications occurred, such as infection, hemorrhage, wound dehiscence, or granuloma. However, foreign body sensation (1 eye) and eyelid notch (l eye) did occur. CONCLUSIONS: This reverse eyelid splitting technique produced satisfactory results in both cosmetic and functional aspects. Moreover, it resulted in a low recurrence rate and low complication rate in patients with trichiasis or distichiasis combined with entropion.
Ankle ; Entropion* ; Eyelids ; Female ; Foreign Bodies ; Granuloma ; Hair ; Hair Follicle ; Hemorrhage ; Humans ; Male ; Meibomian Glands ; Mucous Membrane ; Nylons ; Recurrence ; Sensation ; Skin ; Sutures ; Trichiasis* ; Wounds and Injuries

BACKGROUND: FDA recommend that botulinum toxin should be used within 4 hours after reconstruction. Because botulinum toxin is very expensive and also only small amounts of botulinum toxin are needed for one lesion, it should be used for several patients simultaneously to reduce cost. The reports on the decrease of potency according to storage temperature and duration were contradictory among the investigators. OBJECTIVE: The purpose of this study is to compare the change of the potency in various storage temperatures and duration and, to determine the optimal conditions for storage of botulinum toxin without potency reduction. METHODS: The potency of botulinum toxin was measured by the reduction rate of tension of the injected gastrocnemius muscle of Sprague-Dawley rats. The potency of botulinum toxin could be estimated through the comparison of the reduction rate of tension between two muscles; botulinum toxin injected muscle and normal saline injected control muscle, which was denoted as % paralysis. RESULTS: Botulinum toxin induced muscle paralysis in a dose-dependent manner. Muscle was paralysed by 9.8+/-0.6(mean+/-standard error), 10.2+/-2.7, 38.3+/-13.6, and 93.7+/-0.5% at 0(injected normal saline to both sides of gastrocnemius muscles of the same rat), 0.01, 0.1, and 1unit/0.1ml of fresh botulinum toxin injection, respectively. Percent paralyses by 1unit/0.1ml of stored botulinum toxin at 4degreeC and -20degreeC were 98.8+/-0.6% and 98.2+/-0.9% in 4 weeks, respectively. Percent paralyses by 0.1 unit/0.1 ml of stored botulinum toxin at 4degreeC and -20degreeC were 29.6+/-4.8% and 35.5+/-15.1% in 4 weeks, respectively. CONCLUSION: With these findings, the authors proved that if botulinum toxin is stored in refrigerator(4degreeC) or refreezer(-20degreeC) after reconstruction, it can be used without the decrease of its potency.
Botulinum Toxins* ; Humans ; Muscle, Skeletal ; Muscles ; Paralysis ; Rats, Sprague-Dawley ; Research Personnel