Faced with patients who underwent TURP and who were given antibiotics until catheter-removal, usually complain of urinary frequency or burning on ruination and showing sterile urine (less than l00 bacteria per ml., in clean-caught midstream about 24 hours after catheter-removal), we often hesitate to make a decision whether they should be given antibiotics or not. So we divided 27 such patients into three groups : group l ; 7 patients, no additional antibiotics after catheter-removal, group 2; 12 patients, antibiotics for one week after catheter-removal and we performed weekly urine culture for clarifying the necessity of additional antibiotic therapy and its appropriate duration, if necessary. The following results and conclusions were obtained. I. Group l showed bacteriuria in 86%(6 of 7 patients). 2.Group 2 and 3 showed bacteriuria 5%(1 of 20 patients). 3. These data suggested that additional antibiotic therapy rather than stopping antibiotic therapy might be justified(P : less than 0.001). 4. Group 2 showed no bacteriuria and group 3 showed bacteriuria in one patient which disappeared promptly. Namely, there was no practical difference in the incidence of bacteriuria between the two groups. 5. 9 cases of fungiuria were found, all of which developed in patients given antibiotics perioperatively for more than 2 weeks. 6. Considering the above items and cost-effectiveness, a week`s additional antibiotic therapy is probably an appropriate answer to treating the above-mentioned patients. 7. Main causative organism in post-TURP bacteriuria was Pseudomonas spp(4of 7 cases).
Anti-Bacterial Agents* ; Bacteria ; Bacteriuria ; Burns ; Humans ; Incidence ; Pseudomonas ; Transurethral Resection of Prostate* ; Urinary Catheters

No abstract available.
Neoplasm Metastasis* ; Perfusion*

No abstract available.

To study factors related to release of atrial natriuretic polypeptide(ANP) in human subjects, instracardiac pressure and plasma ANP concentration in peripheral and central circulation were measured in patients with various heart disease (18 valvular heart disease, 4 congenital heart disease, 2 cardiomyopathy). 1) The concentration in peripheral venous plasma were increased in 14 patients with New York Heart Associaion (NYHA) functional class III-IV (87+/-38 pg/ml) as compared with that in 10 patients with NYHA functional class I-II (39+/-21 pg/ml, P<0.005)and 15 normal subjects (51+/-21 pg/ml, P<0.01). 2)The concentration of plasma ANP in inferior vena cava, right ventricle, pulonary artery, left ventricle and aorta were markedly increased in patient with NYHA functional class III-IV, elevated mean right atrial pressure (MRAP> or =8 mmHg) elevated mean pulmonary capllary wedge pressure (MPCWP> or =15 mmHg) and/or elevated pulminary artery systolic pressure (PASP> or =35 mmHg), as compared with those in patients with NYHA functional class I-II and/or lower intracardiac pressure (MRAP<8 mmHg, MPCWP<15 mmHg, and/or PASP<35 mmHg). 3) A step up in ANP concentration between inferior vena cava and right atrium was seen in patients with elevated MRAP (81+/-28pg/ml, 137+/-60pg/ml, P<0.05), MPCWP (74+/-37pg/ml,112+/-62pg/ml, P<0.05) and/or PASP (75+/-29 pg/ml,119+/-64 pg/ml, P<0.05). But there were no differences among intracardiac ANP concentrations from right atrium though aorta. 4) Plasma concentrations in right atrium, pulmonary artery, left ventricle and aorta correlated with MRAP (r=0.82, 0.63, 0.56, p<0.005 and r=0.52, P<0.01, respectively), MPCWP (r=0.86, 0.75, 0.73 and 0.72 respectively, P<0.005 in all) and PASP (r=0.73, 0.57, 0.68 and 0.59 respectively P<0.005 in all). 5) Left atrial diameter correlated with plasma ANP concentration in peripheral plasma (r=0.55, P<0.01), inferior vena cava (r=0.51, P<0.025), right atrium (r=0.45, P<0.05), right ventricle (r=0.55, P<0.01), pulmonary artery (r=0.52, P<0.01), left ventricle (r=0.55, P<0.01) and aorta (r=0.56, P<0.005). These results suggest that the heart secrets atrial natriuretic polypeptide into right atrium in response to increased mean right atrial pressure, mean pulmonary capillary wedge pressure, pulmonary artery systolic pressure and/or left atrial distention.
Aorta ; Arteries ; Atrial Natriuretic Factor ; Atrial Pressure ; Blood Pressure ; Heart ; Heart Atria ; Heart Defects, Congenital ; Heart Diseases* ; Heart Valve Diseases ; Heart Ventricles ; Humans ; Plasma* ; Pulmonary Artery ; Pulmonary Wedge Pressure ; Vena Cava, Inferior

This research was conducted to evaluate the effect of improvement in work environment and of segregation in a fluorescent lamp manufacturing factory. Among the total of 80 workers, 8 workers whose mercury concentration in urine reached a hazardous level (200-299 microgram/l) were moved to mercury free workplace. The follow-up examination for their mercury concentration in urine was done three times; on May 3, 1988, September 1, 1988 and April 3, 1989. The results were as follows: 1. Mercury concentration in the air was reduced from 0.140 to 0.107 mg/m3 in 4 months, and to 0.087 mg/m3 in one year after environmental improvement in workplace. However the level still exceeded the Threshold Limit Value. 2. The geometric mean of urinary mercury concentration among 80 workers was 173.0 microgram/l (5.1~458.6 microgram/l). The distribution of workers according to urinary mercury concentration showed that 9 workers (11.2%) were above the mercury poisoning level (300 microgram/l), 24 workers (30.0%) were 200-299 microgram/l, 35 workers (43.8%) were 50-199 microgram/l, and 12 workers (15.0%) were below 50 microgram/l. 3. Among the 24 workers whose urinary mercury concentration was 200-299 microgram/l, 8 were able to be followed up. Their mean urinary mercury concentration before segregation was 244.9 microgram/l, but decreased to 151.4 microgram/l in four months, 128.8 microgram/l in six months, and 46.8 microgram/l in one year after segregation.
Follow-Up Studies ; Mercury Poisoning

Tuberculoma means a tumor-like mass resulting from enlargement of a caseous tubercle which microscopically shows infiltration of epithelioid cells, Langhans giant cells and lymphocytes. In a 57-year-old woman suffering from left renal tuberculosis, we incidentally found a large retroperitoneal tuberculoma (site: retrohepatic, above right adrenal gland, below diaphragm and outside Gerota`s fascia, size: 13X11x9cm). Generally, Mycobacteria tuberculosis invade the lung via airway, and subsequently, they can be disseminated to any organ or tissue. They are apt to establish disease in the organ or tissue of high oxygen tension level. We report a case of retroperitoneal tuberculoma with wonder that it could develop in the retroperitoneum of poor blood supply.
Adrenal Glands ; Diaphragm ; Epithelioid Cells ; Fascia ; Female ; Giant Cells, Langhans ; Humans ; Lung ; Lymphocytes ; Middle Aged ; Oxygen ; Tuberculoma* ; Tuberculosis ; Tuberculosis, Renal

Determination of urinary marker proteins was carried out trying to evaluate renal tubular damage as a part of renal injury caused by ESWL via EDAP LT-01+lithotiptor. All of twenty patients undergoing ESWL, suffered from unilateral, nonobstructive, infection-free, and previously untreated renal stone (s). Two urinary marker proteins, N-acetyl-beta-gluoosaminidase (NAG) and beta 2-micmglobulin (beta2-M) were monitored in all the patients 1 day before, 1 and 3 day (s) after ESWL using total 100 storage of 3 sessions which is average therapeutical dose. Urinary level or NAG (normal value; 0.29-7.23 U/L) was 1.66+/-1.31 1 day before, 1.97+/-1.57, 2.66+/-2.90 U/L 1 and 3 day (s) after ESWL respectively. beta2-M level (normal value <300 ug/L) was 142+/-137 1 day before. 133+/-100, 151+/-186 ug/L 1 and 3 day(s) alter ESWL, respectively. Consequently it was concluded that ESWL using average therapeutical dose (100 storage) via EDAP LT-01+ litholriptor can hardly develop renal tubular damage.
Humans

The use of artificial nerve conduit containing viable Schwann cells is one of the most promising strategies to repair the peripheral nerve injury. To fabricate an effective nerve conduit whose microstructure and internal environment are more favorable in the nerve regeneration than existing ones, a new three-dimensional Schwann cell culture technique using Matrigel(R) and dorsal root ganglion (DRG) was developed. Nerve conduit of three-dimensionally arranged Schwann cells was fabricated using direct seeding of freshly harvested DRG into a Matrigel(R) filled silicone tube (I.D. 1.98 mm, 14 mm length) and in vitro rafting culture for 2 weeks. The nerve regeneration efficacy of three-dimensionally cultured Schwann cell conduit (3D conduit group, n=6) was assessed using SD rat sciatic nerve defect of 10 mm, and compared with that of silicone conduit filled with Matrigel(R) and Schwann cells prepared from the conventional plain culture method (2D conduit group, n=6). After 12 weeks, sciatic function was evaluated with sciatic function index (SFI) and gait analysis, and histomorphology of nerve conduit and the innervated tissues of sciatic nerve were examined using image analyzer and electromicroscopic methods. The SFI and ankle stance angle (ASA) in the functional evaluation were -60.1+/-13.9, 37.9 degrees +/-5.4 degrees in 3D conduit group (n=5) and -87.0 +/-12.9, 32.2 degrees +/-4.8 degrees in 2D conduit group (n=4), respectively. And the myelinated axon was 44.91%+/-0.13% in 3D conduit group and 13.05%+/-1.95% in 2D conduit group to the sham group. In the TEM study, 3D conduit group showed more abundant myelinated nerve fibers with well organized and thickened extracellular collagen than 2D conduit group, and gastrocnemius muscle and biceps femoris tendon in 3D conduit group were less atrophied and showed decreased fibrosis with less fatty infiltration than 2D conduit group. In conclusion, new three-dimensional Schwann cell culture technique was established, and nerve conduit fabricated using this technique showed much improved nerve regeneration capacity than the silicone tube filled with Matrigel(R) and Schwann cells prepared from the conventional plain culture method.
Animals ; Ankle ; Axons ; Cell Culture Techniques ; Collagen ; Diagnosis-Related Groups ; Fibrosis ; Gait ; Ganglia, Spinal ; Muscle, Skeletal ; Myelin Sheath ; Nerve Fibers, Myelinated ; Nerve Regeneration ; Peripheral Nerve Injuries ; Peripheral Nerves* ; Rats ; Regeneration* ; Schwann Cells ; Sciatic Nerve ; Silicones ; Tendons

CT is the most accurate and reliable method for the diagnosis of intracerebral and intraventricularhemorrhage. The precise anatomic extent of the hematoma, associated cerebral edema, ventricular deformity anddisplacement, and hydrocephalus are all readily assessed. Aside from head trauma, the principal cause ofintracerbral hematoma is hypertensive vascular disease. Although hematomas from various causes may present similarCT appearances frequetnly the correct etiology may be suggested by considereation of patient's age, clinicalhistory, and the location of the hematoma. The analytical study was performed in 180 cases of intracerebralhamorrhages by CT from Oct. 1981 to Jan. 1983. The results were as follows; 1. The most prevalent age group was6th decade(37.2%) Male was prevalent to female at the ration of 1.6 to 1. 2. The most common symptom and sign wasmental distrubance (48.7%), motor weakness(23%), headache(10.6%), nausea and vomiting (9.8%). 3. The causes ofhemorrhage were hypertension (53.9%), head trauma (30.6%), aneurysm(6.1%) and A-V malformation (7.2%). 4. Thefrequent locations of hemorrhage were basal ganglia and thalamus(40.4%), lobes(35%), ventricles(21.8%). 5. Thedistribution of hemorrhage was intracerebral hemorrhage(65.6%), intracerebral and intraventricularhemorrhage(30.3%), intraventricular hemorrhage(4.4%).
Basal Ganglia ; Brain Edema ; Cerebral Hemorrhage ; Congenital Abnormalities ; Craniocerebral Trauma ; Diagnosis ; Female ; Hematoma ; Hemorrhage ; Humans ; Hydrocephalus ; Hypertension ; Male ; Methods ; Nausea ; Vascular Diseases ; Vomiting

Styela clava, called non-native tunicate or sea squirt, is habitat which include bays and harbors in Korea and several sites in the sea faced world. We fabricate cellulose membrane nerve conduit (CMNC) from this native sea squirt skin, and evaluate the capacity of promoting peripheral nerve regeneration in the rat sciatic nerve defect model. After processing the pure cellulose membrane from the sea squirt skin as we already published before, CMNC was designed as a non-tubular sheet with 14 mm length and 4 mm width. Total eleven male Spraque-Dawley rats (12 weeks, weighing 250 to 300g) were divided into sham group (n=2), silicone tube grafted control group (n=3) and experimental group (n=6). Each CMNC grafted nerve was evaluated after 4, 8 and 12 weeks in the experimental group, and after 12 weeks, sciatic function was evaluated with sciatic function index (SFI) and gait analysis, and histomorphology of nerve conduit and the innervated tissues of sciatic nerve were all examined using image analyzer and electromicroscopic methods in the all groups. The regenerated axon and nerve sheath were found only in the inner surface of the CMNC after 4 weeks and became more thicker after 8 and 12 weeks. In the TEM study, CMNC grafted group showed more abundant organized myelinated nerve fibers with thickened extracellular matrix than silicone conduit grafted group after 12 weeks. The sciatic function index (SFI) and ankle stance angle (ASA) in the functional evaluation were -47.2+/-3.9, 35.5.+/-4.9.in CMNC grafted group (n=2) and -80.4+/-7.4, 29.2.+/-5.3.in silicone conduit grafted group (n=3), respectively. And the myelinated axon was 41.59% in CMNC group and 9.51% in silicone conduit group to the sham group. The development of a bioactive CMNC to replace autogenous nerve grafts offers a potential and available approach to improved peripheral nerve regeneration. As we already published before, small peptide fragment derived from the basement membrane matrix proteins of squirt skin, which is a kind of anchoring protein composed of glycocalyx, induced the effective axonal regeneration with rapid growth of Schwann cells beneath the inner surface of CMNC. So the possibilities of clinical application as a peripheral nerve regeneration will be able to be suggested.
Animals ; Ankle ; Axons ; Basement Membrane ; Bays ; Cellulose* ; Ecosystem ; Extracellular Matrix ; Gait ; Glycocalyx ; Humans ; Korea ; Male ; Membranes* ; Myelin Sheath ; Nerve Fibers, Myelinated ; Peripheral Nerves* ; Rats ; Regeneration* ; Schwann Cells ; Sciatic Nerve ; Silicones ; Skin ; Transplants ; Urochordata