Poststroke depression is very common and has been reported in as many as 40~50% of poststroke patients. The fluoxetine is one of the most frequently prescribed drugs for the treatment of poststroke depression. This serotonin selective reuptake inhibitor, known as generally safe and well tolerated drug, has been recently reported to induce mania. We report a case of fluoxetine-induced mania. A 64 year-old male, who has taken 10 mg of fluoxetine daily due to poststroke depression, presented elevated mood, hyperactivity, regressed behavior, excessive planning, sleep deterioration, and talkativeness abruptly. We were suspicious of fluoxetine- induced manic state and discontinued immediately fluoxetine without prescription of mood stabilizer. His symptoms had been ceased over two weeks.
Bipolar Disorder ; Depression ; Fluoxetine ; Humans ; Male ; Prescriptions ; Serotonin

PURPOSE: To analyze the clinical and radiological results of whole lumbosacral fusion, and to identify whether an extension of the fusion level is required. MATERIALS AND METHODS: A retrospective review was carried out on 40 patients who had undergone whole lumbosacral fusion. The adjacent segment changes were evaluated by the radiological findings including intervertebral space narrowing, traction spur, endplate sclerosis and vacuum phenomenon. The clinical results were evaluated using a visual analogue scale (VAS) and Oswestry disability index (ODI). RESULTS: The mean age was 63.8 years and the mean follow-up period was 41.7 months. At the last follow-up, adjacent segment changes were observed in 12 cases of intervertebral space narrowing, 15 cases of traction spur, 20 cases of endplate sclerosis and 8 cases of vacuum phenomenon. In the clinical results, the VAS was improved to 4.0 points from 7.6 points, and the ODI improved to 43.9% from 86.0%. There were no revision cases due to adjacent segment problems. CONCLUSION: Whole lumbosacral fusion in spinal stenosis with degenerative lumbar scoliosis was concomitant with some adjacent segment problems, but presented favorable outcomes. For the prevention of junctional problem, caution should be taken when extending the fusion level to the proximal level in whole lumbosacral fusion.
Follow-Up Studies ; Humans ; Retrospective Studies ; Sclerosis ; Scoliosis ; Spinal Stenosis ; Traction ; Vacuum

Leber's Hereditary Optic Neuropathy(LHON) is a maternally inherited disorders that occurs primarily in young males and is characterized by subacute, sequential, bilateral central visual loss, ultimately, optic atrophy. We report 2 cases of molecularly confirmed LHON which reveal 11778 and 14484 mitochondral DNA mutation, respectively but there is no family history of visual loss. So the diagnosis of LHON deserves to be considered in all crypotogenic cases of acute or subacute optic or chiasmal neuropathy. Late or early age at onset, female gender, and a negative family history should not be dissuasive.
Diagnosis ; DNA ; Female ; Humans ; Male ; Molecular Biology* ; Optic Atrophy ; Optic Nerve Diseases*

Sweet's syndrome is a reactive process characterized by the abrupt onset of tender erythematous plaques and typical histological findings. Currently, the entity recognized as Sweet's syndrome ranges from classic Sweet's disease to a more aggressive neutrophilic process that may be associated with various diseases, malignancy and drug intakes. Also, extracutaneous manifestations of Sweet's syndrome have the potential to involve other organ systems. Pulmonary manifestation of Sweet's syndrome is rare and may be experienced as a cough, dyspnea, pleurisy or pulmonary infiltration upon chest X-ray. We, herein, report a 46-year-old woman with Sweet's syndrome who showed pulmonary infiltration and pleural effusion upon chest X-ray.
Cough ; Dyspnea ; Female ; Humans ; Middle Aged ; Neutrophils ; Pleural Effusion ; Pleurisy ; Sweet Syndrome* ; Thorax

Purpose: To compare perioperative outcomes according to surgical methods among bladder cancer patients who underwent radical cystectomy (RC) with neobladder urinary diversion. Materials and Methods: Between June 2007 and January 2020, 89 bladder cancer patients who received RC with neobladder urinary diversion were enrolled in this study. Patients were stratified into surgical methods – (1) open RC with neobladder (ONB) reconstruction, (2) robotassisted RC (RARC) with extracorporeal neobladder (ECNB) reconstruction, and (3) RARC with intracorporeal neobladder (ICNB) reconstruction. Perioperative outcomes were compared among the 3 groups, with major complications defined according to Clavien-Dindo grades III–V within 90 days. Logistic regression analysis was performed to identify significant factors for postoperative complications. Results: Of 89 patients, 28 (31%) had ONB, 31 (35%) had ECNB, and 30 (34%) had ICNB. The median operative time was 471 minutes, and the ICNB group (424.5 minutes) was significantly less than ONB (444.5 minutes) and ECNB groups (542.9 minutes) (p=0.001). Transfusion rate was also significantly less in the ICNB group (13%) (p=0.001). Complications were recorded in 67 patients (75%) and major complications in 22 of all patients (25%). The major complication rate was significantly less in ICNB (13.4%) than in ONB (25%) and ECNB (35%) (p=0.003). Multivariate analysis showed surgical methods (ICNB) (odds ratio [OR], 0.709; p=0.003) and age (OR, 1.150; p=0.001) were significant factors related to occurrence of major postoperative complications. Conclusions RARC with ICNB reduces postoperative complications compared to ONB and ECNB.

Primary cilium has a signal transduction function that is essential for brain development, and also determines cell polarity and acts as a mediator for important signaling systems, especially the Sonic Hedgehog (SHH) pathway. TBC1D32 is a ciliary protein, implicated in SHH signaling. Biallelic mutations in the TBC1D32 gene causes a kind of ciliopathy, heterogeneous developmental or degenerative disorders that affect multiple organs, including the brain. Here we report a boy who carried compound heterozygous variants in TBC1D32. The patient showed hypotonia, respiratory difficulty, and multiple anomalies at his birth. He was diagnosed with congenital hypopituitarism and treated with T4, hydrocortisone, and growth hormone. Despite the hormonal replacement, the patient needed long-term respiratory support with tracheostomy and nutritional support with a feeding tube. His developmental milestones were severely retarded. Hydrocephalus and strabismus developed and both required surgery, during the outpatient follow-up. Whole-exome sequencing indicated compound heterozygous variants, c.2200C>T (p.Arg734*) and c.156-1G>T, in TBC1D32 gene. This is the first Korean case of TBC1D32-related ciliopathy and we reported detailed and sequential clinical features. This case demonstrated the utility of whole-exome sequencing and provided valuable clinical data on ultra-rare disease.

Primary cilium has a signal transduction function that is essential for brain development, and also determines cell polarity and acts as a mediator for important signaling systems, especially the Sonic Hedgehog (SHH) pathway. TBC1D32 is a ciliary protein, implicated in SHH signaling. Biallelic mutations in the TBC1D32 gene causes a kind of ciliopathy, heterogeneous developmental or degenerative disorders that affect multiple organs, including the brain. Here we report a boy who carried compound heterozygous variants in TBC1D32. The patient showed hypotonia, respiratory difficulty, and multiple anomalies at his birth. He was diagnosed with congenital hypopituitarism and treated with T4, hydrocortisone, and growth hormone. Despite the hormonal replacement, the patient needed long-term respiratory support with tracheostomy and nutritional support with a feeding tube. His developmental milestones were severely retarded. Hydrocephalus and strabismus developed and both required surgery, during the outpatient follow-up. Whole-exome sequencing indicated compound heterozygous variants, c.2200C>T (p.Arg734*) and c.156-1G>T, in TBC1D32 gene. This is the first Korean case of TBC1D32-related ciliopathy and we reported detailed and sequential clinical features. This case demonstrated the utility of whole-exome sequencing and provided valuable clinical data on ultra-rare disease.

PURPOSE: Pyogenic spinal infection encompasses a broad range of clinical entities, treatment and prognosis. We compared the symptoms and treatment efficacy of patients with single and combined spinal infections. MATERIALS AND METHODS: Between June 2001 and November 2006, 30 patients with pyogenic spinal infections were treated in our hospital and outcomes were evaluated through ESR, CRP, and clinical improvement. Groups 1 and 2 represented patients with single lesions and patients with combined lesions, respectively. RESULTS: Group 1 included 7 men and 8 women, and the preoperative mean ESR and CRP were 62.7 mm/hr and 5.7 mg/dl. The most common clinical presentation was back pain. Nine patients in group 1 underwent operation, and two underwent instrumentation. Group 2 included 4 men and 11 women, and the preoperative mean ESR and CRP were 78.5 mm/hr and 16.7 mg/dl. The most common clinical presentations were back pain and fever. Thirteen patients in group 2 underwent operation, and six underwent instrumentation. There were more underlying diseases in group 2. CONCLUSION: There were more underlying diseases and higher preoperative inflammatory-reactive laboratory findings in patients with combined spinal infections. Careful attention must be directed to treatment in order to secure favorable clinical outcomes in patients with combined infections.
Back Pain ; Female ; Fever ; Humans ; Male ; Prognosis ; Treatment Outcome

PURPOSE: To compare the 3 year and over the 7 year results after long-segment posterolateral fusion and to analyze the changes of adjacent segments and the changes according to the segmental lordosis angle of the fusion segments. MATERIALS AND METHODS: A retrospective review was carried out 62 patients of long segment fusion for 7 years follow up and compared that of the 3 year and over the 7 year results. The changes of adjacent segments were evaluated by simple radiography for disc space narrowing, traction spur, endplate sclerosis and vacuum phenomenon.In last follow-up, segmental lordosis angle of fusion level was evaluated by Gelb's criteria and clinical results were analyzed by Katz's classification. RESULTS: In the changes of adjacent segments, disc space narrowing was increased 27.4% to 38.7%, traction spur was 22.6% to 35.5%, endplate sclerosis was 19.4% to 32.2% and vacuum phenomenon was 8.1% to 12.9%. The changes of adjacent segments were observed that from 3.4% to 20.7% in physiologic group and from 33.3% to 90.9% in un-physiologic group. The clinical results showed 83.9% satisfaction and 16.1% un-satisfaction. CONCLUSION: In long-term follow up of long-segment posterolateral fusion, physiologic segmental lordosis angle should be preserved for decrease of changes of adjacent segments in long-segment posterolateral fusion.
Animals ; Classification ; Follow-Up Studies* ; Humans ; Lordosis ; Radiography ; Retrospective Studies ; Sclerosis ; Traction ; Vacuum

Objective: To investigate whether baseline olfactory dysfunction in Parkinson’s disease (PD) patients is associated with baseline and longitudinal motor and cognitive function. Methods: We recruited 228 drug-naïve PD patients who were followed for a mean of 6 years. Patients underwent the Cross-Cultural Smell Identification Test (CCSIT), a neuropsychological test, and N-(3-[18F]fluoropropyl)-2β-carbomethoxy-3β-(4-iodophenyl) nortropane positron emission tomography within 6 months of the baseline evaluation. Olfactory dysfunction was categorized as normosmia (CCSIT score ≥ 9), hyposmia (CCSIT score 5–8), and anosmia (CCSIT score ≤ 4). During the follow-up period, we investigated changes in the levodopa-equivalent dose (LED) and the occurrence of wearing-off, levodopa-induced dyskinesia, and dementia. Results: Among the PD patients, 80.7% were hyposmic at the time of diagnosis, and 26.1% were anosmic. Baseline olfactory dysfunction was not associated with either initial parkinsonian motor symptoms or with the longitudinal LED increment and motor complications. Meanwhile, the anosmic group had lower baseline scores on the Korea version of the Boston Naming Test and Stroop color reading test than the normosmic and hyposmic groups. The anosmic group exhibited a higher rate of conversion to dementia than the normosmic [adjusted hazard ratio (HR) 3.99, 95% confidence interval (CI) 1.08–14.72] and hyposmic (adjusted HR 2.48, 95% CI 1.15–5.32) PD groups, regardless of baseline motor deficits and cognitive status. Conclusion Baseline olfactory dysfunction was not associated with motor deficits and complications, but it was associated with cognitive dysfunction and prognosis, suggesting that severe olfactory impairment may reflect early cortical involvement, probably in the frontotemporal region, and rapid spreading of Lewy body pathology.