No abstract available.

No abstract available.
Aneurysm, False ; Child ; Humans ; Iliac Artery

The authors studied the early morphologic changes of peripheral nerve, which is known as relatively radioresistant tissue to the X-ray irradiation, but recently clamied by several clinician through development of neuropathies after radiotherapy of the malignacy. Rabbits were received 1,000 or 2,000 cGy of X-ray on the knee joint areas. Sciatic nerves were extracted out 30 minutes, 1, 2, 4, 24 hours, and 3 and 7 days after irradiation. The morphologic changes were observed by light and electron microscopes. The results were summarized as follows: Light microscopically, only mild edema is noted. Electron microscopically, irregular separation and folding of myelin sheath with spherical body formation are noted. Above features were more prominent at later stages and aggregated nests of fragmented myelin were scattered 16 hours after irradiation. Schwann cell necrosis is noted after 24 hours. But above degenerative changes were scarcely present 7 days after irradiation. There is no remarkable axonal changes. The interstitial tissue revealed swelling and irregularity of surface of endothelial cells, and edema. On the basis of the results, it may be concluded that the peripheral nerve is injured by irradiation in early stages, and the main target of irradiation injury is thought to be myelin sheath and Schwann cells, which would be reversible and could be recovered promptly.
Rabbits ; Animals

The authors studied depression, using Zung's Self-Rating Depression Scale (SDS) in the subjects of 3,499 male and 1,335 female college freshmen of Yeungnam University. The authors collected the reports of SDS during the periods from January to February, 1986, and applied ANOVA and t-test on depression scores in order to compare them between various psychosocial factors, and sexes. The results are as follows: There was significant difference in the mean averages of total depression scores between male and female students: male students scored 35.68+7.46, female students scored 38.93+7.26 (P<0.01). The depression scores relating to the items of indecisiveness, psychomotor retardation, decreased libido, and diurnal variation were relatively higher in both groups. One hundred and sixty-one male students (4.6%) showed seriously high degree depression scores of 50 or higher, while one-hundred and seventeen female students (8.8%) showed the same scores. Female students attending in liberal arts showed higher level of depression scores (P<0.01). There was a strong tendency toward higher depression scores in the students who were dissatisfies with their home atmosphere, college, department and familiarity of parents and those who had pessimistic views of self in the past, present or future in both groups (P<0.001).
Atmosphere ; Depression* ; Female ; Humans ; Libido ; Male ; Parents ; Psychology ; Recognition (Psychology)

A case of malignant melanoma is described. The patient, 67 years old male, had thumb tip sized two tumor masses with linear arcuate spread on left upper back near spine of 3 months duration, and metastatic lesion on right axillary lymphnode. Lesions were removed surgically and split skin graft was done.
Aged ; Humans ; Male ; Melanoma* ; Skin ; Spine ; Thumb ; Transplants

No abstract available.
Takayasu Arteritis*

Trichophyton verrucosum is a worldwide zoophilic dermatophye. The human infection was first reported in t.he South western part of Korea in 1986 and Fas been increasing in Taegu area. Thirty-one strains of T. verrucosum isolated from the patients in Taegu area were investigated for their mycological features. Gross observation on Sabot rauds dextrose agar, microscopic examination by scotch tape method and slide culture or Sabourauds dextrose agar and potato dextrose agar, and hair perforation test were perforn ed at 37C. The averages of the largest dimensions of the colonies were .9mm at 2 weeks and 59mm at 4 weeks. The morphologic features of the colonies were clasified into three types. Eighteen of 31 strains showed flatwhitish, disc-like colonies with suvmerging hyphae, 11 strains had large radiating follows on the center of the colonies, and 2 strains showed colonies having diffuse fine folds on their surfaces with well-defined borders. On microscopic exaniination, many chlamydospores, antlerlive hyphae, oval and clavate microconidia, and rat tail or string bean shaped macroconidia were observed. It seemed that observation on potato dextrose agar during 10 to 14 days af er inoculation was suitable method for microscopic examination of T. verrucosum. All 31 strains showed positive reaction on hair perforation test.
Agar ; Animals ; Daegu* ; Glucose ; Hair ; Humans ; Hyphae ; Korea ; Rats ; Solanum tuberosum ; Tail ; Trichophyton*

No abstract available.
Cyclotrons*

In order to evaluate antitumor rnechanisms of interleukin (IL)-12/IL-2 that has been shown significant tumor suppressive activity on established primary and metastatic Renca tumor, we studied chemokine gene expression induced by direct action of IL- 12/IL-2 or cytokine cascade. IL-12/IL-2 induced gene expression of interferon gamma (IFN-r) and granulocyte monocyte-colony stimulating factor (GM-CSF) in splenocytes, and it induced gene expression of monokine induced by IFN-r (Mig), interferon inducible protein 10 (IP- 10), SDF-1, macrophage inflammatory protein (MIP)-1a, MIP-1B, MIP-2, monocyte chemotactic protein (MCP)-1, and Rantes in tumor mass. However IL-12/IL-2 could not induce these chemokines in tumor mass of GKO mice and Renca cell in vitro. IL- 12 also did not increased chemokine gene expression in Renca cell in vitro, but IFN-r induced gene expression of Mig, IP-10, MCP-1 in Renca cell in vitro. In the chemotaxis assay, culture supernatant of Renca cell stimulated with IFN-r increased splenocyte migration in vitro. All these data suggest IL-12/IL-2 can induce IFN-r-chemokine cascade in tumor mass, and Mig, IP-10, MCP-1 produced from tumor cell may play an important role for initial immune cell migration into tumor mass.
Animals ; Cell Movement ; Chemokine CCL5 ; Chemokine CXCL10 ; Chemokines ; Chemotaxis ; Gene Expression* ; Granulocytes ; Interferons ; Interleukins ; Macrophages ; Mice ; Monocytes

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is one of the mitochondrial encephalomyopathy, A rare disease caused by a disturbance of the mitochondrial chain of respiration. MELAS is confirmed by typical light and electron microscopic findings : "ragged red fibers" by modified Gomori trichrome stain on light microscope and numerous abormal mitochondria on electron microscope. We experienced a boy with the characteristic clinical and pathologic findings of MELAS. Our patient demonstrated bilateral basal ganglia calcifications and infarction at right parieto-occipital and thalamic areas on CT and MR We found that MRI was more sensitive and represented the infarcted lesions better than CT. Detection of cerebral insults of MELAS by MRI is important in making decision on patient treatment and also in predicion of the patient prognosis.
Acidosis, Lactic ; Basal Ganglia ; Brain Diseases ; Child* ; Humans ; Infarction ; Magnetic Resonance Imaging ; Male ; MELAS Syndrome* ; Mitochondria ; Mitochondrial Encephalomyopathies ; Muscular Diseases ; Rare Diseases ; Respiration