BACKGROUND: The integrins comprise a family of transmembrane glycoproteins which mediate cell-cell and cell-matr ix intera ctions, and the bcl-2 oncogene is involved in tumorigenesis by blocking apoptosis. Typical acquired melanocytic nevi appear to follow a life cycle characterized by active growth, maturation, and progressive involution. In contrast, congenital rnelanocytic nevi have a different course and prcgnosis with potential for development of melanoma, and metastatic spread is very common in malignant melanoma. Objective . We investigated the expression of integrins (a2,a3,a) and bcl-2 in congenital and acquired rnelanocytic nevi, and malignant, melanomas by immunohistochemical technique. Methods . Formalin-fixed and paraffin-embedded tissues from 7 compound nevi, 7 intradermal nevi, 5 congenital melanocytic nevi, and 5 malignant melanomas were immunolabeled with monoclonal antibodies directed against a2, a3,and a integrin, and bcl-2 protein. RESULTS: All acquired and congenital melanocytic nevi showed a uniform staining for a2, a3, a and bcl-2. In 3 compound nevi which the nevus cells lie mainly within the upper dermis, the nevus cells in the papillary dermis showed weak to negative a expression. Within neurotized are as of intradermal nevus, bcl-2 and a expression became weaker and totally absent. All 5 malig- nant melanomas exhibited strong a2, a3, a, and bcl-2 expression. However, the tumor cells in the lower advancing border failed to express a integrin in 3 of 5 malignant, melanomas. In most malignant melanomas, there was variable intensity of staining for bcl-2 in different areas of the tumor. Conclusion . These findings suggest that the integrins and bcl-2 may be involved in active growth, maturation, and progressive involution of the melanocytic nevi, and seem to be related to metastasis and tumorigenesis of the malignant melanoma.
Antibodies, Monoclonal ; Apoptosis ; Carcinogenesis ; Dermis ; Glycoproteins ; Humans ; Integrins* ; Life Cycle Stages ; Melanoma* ; Neoplasm Metastasis ; Nevus ; Nevus, Intradermal ; Nevus, Pigmented* ; Oncogenes

In 1970, Boutine introduced a alumina ceramic for cemented total hip replacement . A ceramic articulation thought to be superior to metal on polyethylene due to its extremely low coefficient of friction and its potential for resistance to wear. Mechanical failure of ceramic femoral head is rare. We report a case of fracture of ceramic femoral head, which occured after implantation of uncemented total hip replacement.
Aluminum Oxide ; Arthroplasty, Replacement, Hip* ; Ceramics* ; Friction ; Head* ; Polyethylene

The authors, in this paper, addressed a variety of problems and difficulties which Korean psychiatrists should cope with. The surprising development of neurosciences, splitting of neuropsychiatry into neurology and psychiatry, easygoing attitude of psychiatrists, changes in the delivery system of health care and ill-balanced education of psychiary were listed as causes of or contributors to them. Social bias to psychiatry and regulations from outside are also considered as contributors. Psychiatric education, including medical school, residency training, continuing medical education and psychiatric textbooks, need to be changed in order to enlarge the boundary of psychiatry. Reestablishment of identity of psychiatry and psychiatrist is unavoidable, considering far-reaching new knowledge of neuroscience and gradually invisible borderzone between neurology and psychiatry. The other ways worth while to consider are : the expansion of psychiatrists' activities, development of medical behavioral science to a clinical specialty, creation of new psychiatric subspecialties, and additional training of psychiatric residencies in the primary medical care.
Behavioral Sciences ; Bias (Epidemiology) ; Delivery of Health Care ; Education ; Education, Medical, Continuing ; Internship and Residency ; Neurology ; Neuropsychiatry ; Neurosciences* ; Psychiatry ; Schools, Medical ; Social Control, Formal

p53 gene mutation is commonly accepted to be associated with loss of negative cell cycle control and progression of tumors. The proliferative activity of tumor cells is considered to be a valuable indicator of tumor aggressiveness. This study is intended to compare p53 protein expression with cell proliferation rates in the ovarian epithelial tumors according to the various clinicopathological parameters. Immunohistochemistry using monoclonal p53 antibody (DO-1) and PCNA antibody (PC10) was applied to 56 cases of ovarian epithelial tumors including 17 cases of borderline tumor. The results were as follows. Both immunohistochemical staining of PCNA and p53 protein showed positive reactions confined to the nuclei of tumor cells. There were significant differences of p53 protein expression rates between borderline malignancies (11.8%) and cystadenocarcinomas (56.4%) of ovary. The expression rate of p53 protein was not significantly different according to the differentiation and the stage, but the cases of strong positive reaction to p53 protein were more frequently noted in the poorly differentiated and advanced staged tumors. The PCNA indices of p53 strong positive cases were higher than those of p53 weak positive cases. In summary, p53 protein and PCNA expression may be used as an adjuvant in differentiating borderline lesions from carcinomas of ovary and predicting their biological behaviors.
Cell Cycle Checkpoints ; Cell Proliferation ; Cystadenocarcinoma ; Female ; Genes, p53 ; Immunohistochemistry ; Ovary ; Proliferating Cell Nuclear Antigen*

No abstract available.

No abstract available.
Leiomyoma* ; Vulva*

No abstract available.
Actinomycosis*

To evaluate the relationships among the c-erbB-2 oncogene expression, DNA ploidy and other prognostic factors, an immunohistochemical study of the c-erbB-2 oncogene product and flow cytometric analysis of DNA ploidy were performed in paraffin sections of 42 cases of ovarian carcinomas. The results were as follows: 1) The positive reaction for c-erbB-2 oncogene product was observed mainly along the cytoplasmic membrane, and occasionally within the cytoplasm of the tumor cells. 2) Overall the positivity of c-erbB-2 oncogene expression was 45.2% of the ovarian carcinomas. By the histological types, the positivity was 35.7% in serous carcinoma, 80.0% in mucinous carcinoma, and 45.2% in endometrioid carcinoma; by the degree of differentiation, 57.1% in well differentiated carcinoma, 40.0% in moderately differentiated, and 27.3% in poorly differentiated; by the nuclear grading, 58.3% in grade I, 52.6% in grade II, and 18.2 % in grade III; and by the clinical staging, 57.1% in stage I, 42.8% in stage II, and 35.0% in stage III. The expression of the c-erbB-2 oncogene in the ovarian carcinomas was higher in the tumors of good differentiation, of the lower nuclear grade and of the lower clinical stage. 3) The incidence of DNA aneuploidy in the cases positive for the c-erbB-2 oncogene expression(47.3%) was higher than that in the negative cases(31.4%). From the above results, therefore, it is suggested that the c-erbB-2 oncogene may be involved in the early stage of ovarian carcinogenesis. Also suggested is that ovarian carcinomas positive for the c-erbB-2 oncogene in the early stages may have higher probability of having a DNA aneuploid cell line during the progress of the tumors.
Adenocarcinoma, Mucinous ; Aneuploidy ; Carcinogenesis ; Carcinoma, Endometrioid ; Cell Membrane ; Cytoplasm ; DNA* ; Incidence ; Oncogene Proteins ; Oncogenes ; Paraffin ; Ploidies*

No abstract available.

We herein present a case of simultaneous occurrence of apocrine adenocarcinoma, syringocystadenoma papilliferum, syringoma, and eccrine hydrocystoma arising in an organoid nevus (nevus sebaceus of Jadassohn) which had been present on the right occipitoparietal scalp of a 60-year-old man since birth.
Adenocarcinoma* ; Humans ; Middle Aged ; Nevus* ; Organoids* ; Parturition ; Scalp ; Skin* ; Syringoma