Lobular carcinoma of the male breast is very rare, because of the absence of lobules in the normal male breast. Herein, a case of lobular carcinoma of the male breast with cellular features of signet ring cells is described. A 57-year-old man presented with a left breast mass. Histologic examination showed classic invasive lobular carcinoma with in situ component. Most infiltrating tumor cells had a prominent signet ring cell appearance. The patient was phenotypically male and had fathered children. There was no history of predisposing factors to breast lesion, such as hormone use or gynecomastia.
Breast* ; Carcinoma, Lobular* ; Causality ; Child ; Fathers ; Gynecomastia ; Humans ; Male* ; Middle Aged

Lobular carcinoma of the male breast is very rare, because of the absence of lobules in the normal male breast. Herein, a case of lobular carcinoma of the male breast with cellular features of signet ring cells is described. A 57-year-old man presented with a left breast mass. Histologic examination showed classic invasive lobular carcinoma with in situ component. Most infiltrating tumor cells had a prominent signet ring cell appearance. The patient was phenotypically male and had fathered children. There was no history of predisposing factors to breast lesion, such as hormone use or gynecomastia.
Breast* ; Carcinoma, Lobular* ; Causality ; Child ; Fathers ; Gynecomastia ; Humans ; Male* ; Middle Aged

Purpose: This study aimed to investigate the prevalence of peripheral neuropathy (PNP) and its related serum metabolites in de novo patients with Parkinson’s disease (PD). PNP is a type of frequent comorbidity in PD. Although the administration of levodopa has been described as a presumptive risk factor in its development, few studies have explored its effect on unmedicated PD patients. Materials and Methods: This study included 105 drug-naïve de novo PD patients. A standardized nerve conduction study (NCS) technique was used to evaluate motor or sensory neuropathy. We analyzed serologic tests including metabolic markers of vitamin B12, homocysteine (Hcy), and uric acid (UA). Results: We found abnormal nerve conduction velocity findings in 24 out of 105 total patients. Among them, 20 patients showed a type of combined motor-sensory, while three were a type of pure sensory and one was a pure motor. Nine patients had carpal tunnel syndrome. PD with PNP group demonstrated higher serum levels of Hcy and UA compared to PD without PNP group. Conclusion Our data demonstrated a potential role of Hcy and UA on PNP in de novo patients with PD. These results suggest the contribution of the inherent metabolic pathway in deterioration of the peripheral nervous system in PD.

The periodic sharp wave complexes are the most characteristic EEG abnormalities in sCJD. We report the serial EEG findings in a patient with probable sCJD. The initial EEG showed diffuse theta and delta slowings only. However, it changed to the typical periodic sharp wave complexes according to the worsening clinical state. These changes occurred during a short-term interval. The serial EEGs within the short-term interval will be helpful for the earlier diagnosis of sCJD.
Diagnosis ; Electroencephalography* ; Humans

No abstract available.
Adult ; Humans ; Meningitis* ; Salmonella*

Coloring Agents ; Cytomegalovirus ; Endothelial Cells ; Humans ; Intranuclear Inclusion Bodies ; Male ; Methenamine ; Mouth ; Oral Manifestations ; Stomatitis ; Tongue ; Ulcer

We describe two patients with speech-induced oromandibular dystonia. One patient showed mainly jaw dystonia, while the other patient had lingual dystonia. A brain MRI revealed acute cerebral infarctions in the midbrain near the substantia nigra in the patient with jaw dystonia, while the patient with the lingual dystonia showed no structural lesions. Symptoms in both patients were partly improved with sensory tricks, such as chewing gum or holding a candy in their mouths. Their symptoms were completely recovered with anticholinergic therapy.
Brain ; Candy ; Cerebral Infarction ; Chewing Gum ; Dystonia* ; Humans ; Jaw ; Magnetic Resonance Imaging ; Mesencephalon ; Mouth ; Substantia Nigra

Hemichorea or hemiballism has been correlated clinico-anatomically with lesions of the contralateral side, most commonly of the subthalamic nucleus. Hemichorea due to an ipsilateral lesion is extremely rare. We report a case of a 74-year-old man who developed a left sided hemichorea due to a left thalamic infarction. The literature on the rare occurrence of ipsilateral hemichorea/hemiballism is discussed and possible pathomechanisms are reviewed.
Aged ; Dyskinesias ; Humans ; Infarction* ; Subthalamic Nucleus

BACKGROUND: To define the pathophysiology of paroxysmal kinesigenic dyskinesia(PKD), we analyzed detailed clin-ical features. METHODS: We studied characteristics of the attack, family history, response to the treatment and clinical courses of 30 patients with PKD. RESULTS: Twenty-six of the 30 patients were men and four were women. Thirteen patients had a family history of PKD. There were no patients who had symptomatic PKD. In three-fourths of our patients, the attacks ameliorated within 10 seconds and two-thirds experienced one to ten attacks per day. They showed dystonia much more frequently than chorea. In all patients,sudden movements of the legs while standing precipitated the attacks. The attack occurred very rarely during driving or swimming. Sudden movements of the arm did not precipi-tate the attacks. CONCLUSIONS: We suggest that neuronal system maintaining standing posture and strong afferent inputs delivering sudden high velocity movements of the legs to the spinal cord are involved in the genesis of PKD.
Arm ; Chorea ; Dyskinesias* ; Dystonia ; Female ; Humans ; Leg ; Male ; Neurons ; Posture ; Spinal Cord ; Swimming

Hemiparkinson-hemiatrophy (HP-HA) syndrome is a rare form of secondary parkinsonism. We present a case of a 19-year-old, left-handed man with subcortical heterotopia. He had hemiatrophy and hemiparkinsonian symptoms on his right side. We described the clinical, neuroradiological and neurophysiologic findings including transcranial magnetic stimulation study. These findings were compatible with HP-HA syndrome and his symptoms were markedly improved with levodopa treatment.
Humans ; Levodopa ; Parkinson Disease, Secondary ; Transcranial Magnetic Stimulation ; Young Adult