Lobular carcinoma of the male breast is very rare, because of the absence of lobules in the normal male breast. Herein, a case of lobular carcinoma of the male breast with cellular features of signet ring cells is described. A 57-year-old man presented with a left breast mass. Histologic examination showed classic invasive lobular carcinoma with in situ component. Most infiltrating tumor cells had a prominent signet ring cell appearance. The patient was phenotypically male and had fathered children. There was no history of predisposing factors to breast lesion, such as hormone use or gynecomastia.
Breast* ; Carcinoma, Lobular* ; Causality ; Child ; Fathers ; Gynecomastia ; Humans ; Male* ; Middle Aged

Lobular carcinoma of the male breast is very rare, because of the absence of lobules in the normal male breast. Herein, a case of lobular carcinoma of the male breast with cellular features of signet ring cells is described. A 57-year-old man presented with a left breast mass. Histologic examination showed classic invasive lobular carcinoma with in situ component. Most infiltrating tumor cells had a prominent signet ring cell appearance. The patient was phenotypically male and had fathered children. There was no history of predisposing factors to breast lesion, such as hormone use or gynecomastia.
Breast* ; Carcinoma, Lobular* ; Causality ; Child ; Fathers ; Gynecomastia ; Humans ; Male* ; Middle Aged

Purpose: This study aimed to investigate the prevalence of peripheral neuropathy (PNP) and its related serum metabolites in de novo patients with Parkinson’s disease (PD). PNP is a type of frequent comorbidity in PD. Although the administration of levodopa has been described as a presumptive risk factor in its development, few studies have explored its effect on unmedicated PD patients. Materials and Methods: This study included 105 drug-naïve de novo PD patients. A standardized nerve conduction study (NCS) technique was used to evaluate motor or sensory neuropathy. We analyzed serologic tests including metabolic markers of vitamin B12, homocysteine (Hcy), and uric acid (UA). Results: We found abnormal nerve conduction velocity findings in 24 out of 105 total patients. Among them, 20 patients showed a type of combined motor-sensory, while three were a type of pure sensory and one was a pure motor. Nine patients had carpal tunnel syndrome. PD with PNP group demonstrated higher serum levels of Hcy and UA compared to PD without PNP group. Conclusion Our data demonstrated a potential role of Hcy and UA on PNP in de novo patients with PD. These results suggest the contribution of the inherent metabolic pathway in deterioration of the peripheral nervous system in PD.

The periodic sharp wave complexes are the most characteristic EEG abnormalities in sCJD. We report the serial EEG findings in a patient with probable sCJD. The initial EEG showed diffuse theta and delta slowings only. However, it changed to the typical periodic sharp wave complexes according to the worsening clinical state. These changes occurred during a short-term interval. The serial EEGs within the short-term interval will be helpful for the earlier diagnosis of sCJD.
Diagnosis ; Electroencephalography* ; Humans

No abstract available.
Adult ; Humans ; Meningitis* ; Salmonella*

Coloring Agents ; Cytomegalovirus ; Endothelial Cells ; Humans ; Intranuclear Inclusion Bodies ; Male ; Methenamine ; Mouth ; Oral Manifestations ; Stomatitis ; Tongue ; Ulcer

BACKGROUND: Sleep disturbances in Parkinson's disease (PD) are common and symptoms can be broadly categorized into insomnia, motor, urinary and neuropsychiatry. However, there are no formal instruments available for quantifying sleep problems in Parkinson's disease. METHODS: We studied 15 items of sleep related symptoms on the Parkinson's disease sleep scale (PDSS) for 50 patients with PD and 50 age healthy matched subjects. Test-retest reliability was assessed in a subgroup of the subjects. RESULTS: The PD patients group had impaired scores compared with age healthy matched group in PDSS scores. Within the PD group, it was different between the mild and moderate group in PDSS scores. It showed a discriminatory power in all individual items of scale, except item 14 (sleep refreshment). In test retest reliable score, it showed good reliability. CONCLUSIONS: We suggest that PDSS is a simple instrument for evaluating sleep disturbances in PD and it could be used to help targeted treatment strategies for nocturnal problems in PD.
Humans ; Korea* ; Neuropsychiatry ; Parkinson Disease* ; Research Design ; Sleep Initiation and Maintenance Disorders

Hemichorea or hemiballism has been correlated clinico-anatomically with lesions of the contralateral side, most commonly of the subthalamic nucleus. Hemichorea due to an ipsilateral lesion is extremely rare. We report a case of a 74-year-old man who developed a left sided hemichorea due to a left thalamic infarction. The literature on the rare occurrence of ipsilateral hemichorea/hemiballism is discussed and possible pathomechanisms are reviewed.
Aged ; Dyskinesias ; Humans ; Infarction* ; Subthalamic Nucleus

OBJECTIVE: To explore the central aortic pressure in patients with Parkinson's disease (PD). METHODS: We investigated central arterial stiffness by measurement of the augmentation index (AIx) in PD patients. Patients were eligible for the study if they were de novo PD and 45 years of age or older. The patients’ demographics, vascular risk factors, and neurologic examinations were collected at baseline. The AIx was measured by applanation tonometry. RESULTS: A total of 147 subjects (77 in control and 70 in PD groups) were enrolled in the study. While there was no significant difference in peripheral systolic blood pressure (SBP), diastolic blood pressure (DBP), or mean arterial pressure between groups, peripheral pulse pressure (PP) was significantly lower in the PD group than in the control group (p = 0.012). Regarding central pressure, aortic DBP was significantly higher and PP was significantly lower in the PD group (p = 0.001, < 0.0001). Although there was no significant difference in the AIx between the groups, a trend toward a lower AIx was observed in the PD group (31.2% vs. 28.1%, p = 0.074). CONCLUSION: This study showed that peripheral and central PP was significantly lower in the PD group than in the control group. Our study suggests that PD patients may have a low risk of a cardiovascular event by reason of a lower PP.
Arterial Pressure ; Blood Pressure ; Demography ; Hemodynamics* ; Humans ; Manometry ; Neurologic Examination ; Parkinson Disease* ; Risk Factors ; Vascular Stiffness

We describe two patients with speech-induced oromandibular dystonia. One patient showed mainly jaw dystonia, while the other patient had lingual dystonia. A brain MRI revealed acute cerebral infarctions in the midbrain near the substantia nigra in the patient with jaw dystonia, while the patient with the lingual dystonia showed no structural lesions. Symptoms in both patients were partly improved with sensory tricks, such as chewing gum or holding a candy in their mouths. Their symptoms were completely recovered with anticholinergic therapy.
Brain ; Candy ; Cerebral Infarction ; Chewing Gum ; Dystonia* ; Humans ; Jaw ; Magnetic Resonance Imaging ; Mesencephalon ; Mouth ; Substantia Nigra