No abstract available.
Takayasu Arteritis*

Anthrax in man is usually cutaneous, resulting from contact with materials derived from infected livestock. Internal organs are infrequently involved,. This report concerns a case of primary anthrax of intestine. The first case of primary anthrax of intestine is to our knowledge in Korea. The patient was a 14-year-old male who has complained of nausea, vomiting and acute abdominal pain. History was otherwise noncontributory except for ingestion raw meat of the dead cattle, one day before the onset of the disease. The cattle presumably died due to Bacillus anthracis in a village Bae-Ban Dong in the city of Kyung ju, Kyung Pook. Among 15 sufferers, 2 cases died 3 days later. Bacillus anthracis isolated from the raw beef, blood samples of two patients and throat culture of one patient. At laparotomy, the peritoneal cavity was full of serosanginous fluid. Right hemicolectomy including partial resection of ileum was done. The bowel was segmentally dilated, hemorrhagic and necrotic, especially at terminal ileum. The mucosa was edematous and largely ulcerated covered with greenish yellow exudate. The intense vascular congestion with hemorrhage and numerous colonization of bacteria were present through the entire wall. The organisms were large, gram-positive and PAS-negative bacilli in long chain. Bacterial emboli were scattered in lymphatics. The other feature was band like lymphoid cell infiltration in ulcer base and submucosal layer. Payer's patches were prominent and the germinal centers were necrotic. Interfollicular spaces exhibited aggregates of numerous atypical lymphoid cells. The cells were five times larger than resting lymphocytes and had several prominent nucleoli and abundant amphophilic cytoplasm. On immunohistochemical staining, most of atypical cells were positive for T-cell marker and Ki-I Ag. The mesenteric lymph nodes were enlarged, showing reactive feature, and the atypical cells were also demonstrated. The patient recovered completely.
Male ; Humans

We report a case of type IV hyperlipoproteinemia associated with xanthoma tuberosum and diabets mellitus in a 48 year old female patient. She had several yellowish-brown papules on the knees and palms. The blood glucose level was elevated and serum lipid and lipoprotein analysis revealed patterns of type IV hyperlipoproteinemia. Histopathologic findings of yellowish-brown papules on the knee showed the aggregation of foam cells in the dermis. She has been treated with diet control and hypolipidemic drug(lovastatin and procetofen) and is under our continuing supervision.
Blood Glucose ; Dermis ; Diabetes Mellitus* ; Diet ; Female ; Foam Cells ; Humans ; Hyperlipoproteinemia Type IV* ; Knee ; Lipoproteins ; Middle Aged ; Organization and Administration ; Xanthomatosis*

We report a case of subungual solitary glomus tumor in a 28-year-old female, who has suffered from pain and tenderness of the left 4th finger tip for about 5 years. Simple surgical excision was performed for removal of the tumor mass and for the relief of the subjective symptoms. No recurrence has been observed for 5 months following excision of the tumor.
Adult ; Female ; Fingers ; Glomus Tumor* ; Humans ; Recurrence

Colonic angiodysplasia is important because of the likelihood of lower gastrointestinal tract bleeding, either massively or chronically. A 66-year-old male patient visited our hospital because of hematochezia and lower abdominal discomfort. He underwent colonoscopy, which revealed 0.5 cm sized, cherry red colored, branching, ozzing vessel with fern-like margin on cecum. Although he received endoscopic injection therapy with hypertonic saline and oral estrogen-progesterone therapy, subsequent ileocecal resection was performed due to recurrent bleeding. Histology of the resected specimen showed irregularly dilated, distorted, thin-walled vessels in submucosa.
Aged ; Angiodysplasia* ; Cecum ; Colon* ; Colonoscopy ; Gastrointestinal Hemorrhage ; Hemorrhage* ; Humans ; Lower Gastrointestinal Tract ; Male ; Prunus

It is Known that ocular tuberculosis occurs as a consequence of active infection from hematogenous spread or a hypersensitivity reaction to circtlating tuberculoproteins. The common findings of ocular tuberculosis are uveitis and choroidal tuberculoma. Paralleling the decrease of pulmonary tuberculosis and improvemem of differential diagnostic metnods, there has been a dramatic decline in the number of diagnosed cases of ocular tuberculosis. In a 65-year-old female a choroidal tumor was diagn03ed at our hospital a year ago Thereafter, she has been medicated with antituberculotic agents for brain tuberculosis in the other hospital. Recently she returned to our clinic cOffiJlaining of aggravated ocular symptom. The right vision was no light perception Enucleation of her right eye was perfomed under the impression of malignant tumor of choroid with secondary glaucoma. Pathologic findings of enucleated eyeball revealed the nature of tuberculoma; so, we report it with a review of literature.
Aged ; Brain ; Choroid* ; Female ; Glaucoma ; Humans ; Hypersensitivity ; Tuberculoma* ; Tuberculosis ; Tuberculosis, Ocular ; Tuberculosis, Pulmonary ; Uveitis

It is Known that ocular tuberculosis occurs as a consequence of active infection from hematogenous spread or a hypersensitivity reaction to circtlating tuberculoproteins. The common findings of ocular tuberculosis are uveitis and choroidal tuberculoma. Paralleling the decrease of pulmonary tuberculosis and improvemem of differential diagnostic metnods, there has been a dramatic decline in the number of diagnosed cases of ocular tuberculosis. In a 65-year-old female a choroidal tumor was diagn03ed at our hospital a year ago Thereafter, she has been medicated with antituberculotic agents for brain tuberculosis in the other hospital. Recently she returned to our clinic cOffiJlaining of aggravated ocular symptom. The right vision was no light perception Enucleation of her right eye was perfomed under the impression of malignant tumor of choroid with secondary glaucoma. Pathologic findings of enucleated eyeball revealed the nature of tuberculoma; so, we report it with a review of literature.
Aged ; Brain ; Choroid* ; Female ; Glaucoma ; Humans ; Hypersensitivity ; Tuberculoma* ; Tuberculosis ; Tuberculosis, Ocular ; Tuberculosis, Pulmonary ; Uveitis

Mutations in the tumor suppressor p53 gene are the most frequently observed genetic lesions in human cancers. It seems that wild type p53 does significant role on growth and differentiation of normal cells, Mutations and allelic loss of the p53 gene are thought to be a cause of tumor development and to be correlated with the prognostic factors in various human cancers such as breast, ovary and lung cancer. Mutant p53 proteins have a prolonged half-life and can be detected by immunohistochemistry. In case of GTD(gestational trophoblastic disease), although the mutation of p53 gene mutation was revealed to be very rare, the overexpression of p53 in immunohistochemical staining has been reported in wide range of discrepancy and its role or prognostic significance in GTD is uncertain. This study is performed to define the status of p53 overexpression in GTD and to evaluate the correlations between p53 overexpression and prognostic factors of GTD. THE RESULTS WERE AS FOLLOWS: 1. p53 overexpression was detected in none of normal placental tissue, in 58.3%(14/24) of hydatidiform mole, in 15%(6/8) of invasive mole, in 75%(3/4) of choriocarcinoma, and in 100%(1/1) of placental site trophoblastic tumor, and showed significant difference between normal placenta and GTD. We could not find any difference of the p53 overexpression between benign group(H-mole) of GTD and malignant one(invasive mole, choriocarcinoma, and placental site trophoblastic tumor) 2. In H-mole, low-risk group showed significantly higher prevalence of p53 overexpression than high-risk group did. In malignant group, there is no difference in the prevalence of p53 overexpression between early(FIGO stage I) and late(II- IV)stage-diseases, but the prevalence of p53 overexpression of low-risk group is slightly higher than that of high-risk group although we failed to find statistical significance. In conclusion, the high prevalence of p53 overexpression in GTD suggests that p53 may have a certain role in the pathogenesis of GTD or at least represent generalized DNA damage or genetic instability of GTD. And the higher prevalence of p53 overexpression in low-risk group suggests that accumulation of wild-type p53 may be related with favorable prognosis in GTD.
Breast ; Choriocarcinoma ; DNA Damage ; Female ; Genes, p53 ; Gestational Trophoblastic Disease* ; Half-Life ; Humans* ; Hydatidiform Mole ; Hydatidiform Mole, Invasive ; Immunohistochemistry ; Loss of Heterozygosity ; Lung Neoplasms ; Ovary ; Placenta* ; Pregnancy ; Prevalence ; Prognosis ; Trophoblastic Tumor, Placental Site ; Trophoblasts

Pneumatic retinopexy(PR) is an alternative procedure to treat an uncomplicated rhegmatogenous retinal detachment with the retinal tear(s) within the superior 8 clock hours of the retina. To determine the efficacy of the PR, the authors treated 45 consecutive retinal detachment not exceeding proliferative vitreoretinopathy grade C2 with PR(PR group) and compared the results with those of 63 similar cases treated with scleral buckling procedure(SB group). Initially, 87% of PR group and 91% of SB group were reattached. However, overall cure rates with single operation decreased to 789,6 and 83%, respectively. With subsequent procedures, retinas were finally reattached in 98% and 94%, respectively. In eyes with preoperative macular detachment, vision was similarly improved 2 lines or more in 73% of PR group and in 77% of SB group after surgery. The incidence of the new breaks was higher in PR group than in SB group(9% vs 5%). Other postoperative complications including reopening of original tear, proliferative vitreoretinopathy, and delayed resorption of subretinal fluid were also noted with similar frequency in both group. These data suggest that PR would be a good alternative procedure in the selected cases of retinal detachments and initial failure with this procedure does not adversely affect the final retinal attachment.
Incidence ; Postoperative Complications ; Retina ; Retinal Detachment* ; Retinaldehyde* ; Scleral Buckling* ; Subretinal Fluid ; Vitreoretinopathy, Proliferative

Idiopathic macular holes are believed to arise from traction of the posterior vitreous membrane. Traditionally, macular holes have been considered as untreatable condition, but recently vitreous surgeries are being attempted to manage them. Pars plana vitrectomy in conjunction with separation of the posteror vitreous membrane and intraocular achieve visual improvement and anatomic reattachment in eyes with full thickness macular hole. A total of 9 eyes which included 2 eyes with stage 2 macular hole and 7 eyes with stage 4 macular hole underwent vitrectomy. The macular holes were successfully occluded in all 9 eyes and visual improvement of two lines or more was achieved in 6(67%) in which symptom duration was 3 months or less and/or hole size was 1/3DD or smaller. These results suggested that the full thickness macular holes would be surgically treatable lesions and better visual results can be expected in cases with shorter duration and smaller size.
Membranes ; Retinal Perforations* ; Traction ; Vitrectomy