1.A Case of Cellular Schwannoma of the Retroperitoneum.
Jong Bum LEE ; Jin KIM ; Young Gyun OH ; Chang Hwan LEE ; Sung Kyong SON ; Sang Lyun NAM ; Kwang Sun SUH
Korean Journal of Gynecologic Oncology and Colposcopy 1999;10(2):194-199
Cellular schwannoma is a variant of schwannoma, and is diagnosed as malignant tumor in over one fourth of cases because of its cellularity, mitotic activity and the occasional presence of bone destruction. This tumor is a tumor with low malignant potential and usually occurs in peripheral nervous system, mainly in the posterior mediastinum and retroperitoneal space. But pelvic retroperitoneal cellular schwannoma is very rare. Recently, we experienced a case of pelvic retroperitoneal cellular schwannoma in a 42-year-old woman; in reporting the case a brief review of the literature is included.
Adult
;
Female
;
Humans
;
Mediastinum
;
Neurilemmoma*
;
Peripheral Nervous System
;
Retroperitoneal Space
2.Clinical Characteristics of Peritoneal Fluid Eosinophilia in Patients on CAPD.
Young Il JO ; Sug Kyun SHIN ; Jong Oh SON
Korean Journal of Nephrology 2003;22(2):219-227
BACKGROUND: The clinical characteristics and significance of peritoneal fluid eosinophilia (PFE) in patients on continuous ambulatory peritoneal dialysis (CAPD) in Korea were uncertain. The present study was performed to clarify the clinical characteristics of PFE in our CAPD patients. METHODS: Between January 2000 and December 2001, we analyzed retrospectively the clinical data of 112 patients on CAPD at two renal centers. RESULTS: The mean period of the observation was 12.6+/-6.7 months, and the total number of peritoneal effluent sampling was 1, 024 (10.5/patient-year). PFE was found in 4.4% of patients. The incidence of PFE was 4.25 per 100 patients/year. Sixty percent of patients with PFE experienced within 2 weeks of initiation of dialysis. The duration of PFE episode varied from 1 to 4 days with the mean value of 2.8 days. All PFE episodes except one patient with abdominal pain treated by oral prednisolone had no symptoms and was spontaneously resolved. The only distinction between the patients with PFE and those without was concomitant peripheral blood eosinophilia (80.0% vs. 15.8%, p=0.0027). Other factors such as age, sex, primary renal disease, bacterial peritonitis, previous use of heparin or antibiotics, blood in peritoneal fluid, and allergic history were not significantly different between the two groups. CONCLUSION: The majority of PFE episode in CAPD patients developed within 2 weeks of initiation of dialysis and spontaneously resolved without treatment. Peripheral blood eosinophilia was a good predictor of PFE.
Abdominal Pain
;
Anti-Bacterial Agents
;
Ascitic Fluid*
;
Dialysis
;
Eosinophilia*
;
Heparin
;
Humans
;
Incidence
;
Korea
;
Peritoneal Dialysis
;
Peritoneal Dialysis, Continuous Ambulatory*
;
Peritonitis
;
Prednisolone
;
Retrospective Studies
3.Age, hypertension, and genetic polymorphisms and their relative associations with white matter hyperintensities in Korean patients with Alzheimer’s disease
Heejeong Jeong ; Seungnam Son ; Soo-Kyoung Kim ; Ki-Jong Park ; Nack-Cheon Choi ; Oh-Young Kwon ; Byeonghoon Lim ; Heeyoung Kang
Neurology Asia 2015;20(1):35-41
Objectives: White matter hyperintensities are known to influence dementia in Alzheimer’s disease.
Genetic components are suggested as putative risk factors for vascular pathology and cognitive
decline. This study aimed to determine whether there is an association between candidate genetic
polymorphisms and the severity of white matter hyperintensities in patients with Alzheimer’s disease.
Methods: Seventy-five patients diagnosed with Alzheimer’s disease underwent genetic tests for specific
alleles of apolipoprotein E, angiotensin-converting enzyme, and methylenetetrahydrofolate reductase.
All patients underwent brain magnetic resonance imaging scans and neuropsychological tests. The
severity of white matter hyperintensities was semiquantified using the CREDOS rating scale, and
patients were divided into three groups according to their rating. Results:The severity of white matter
hyperintensities was related to age and hypertension. However, none of the gene polymorphisms we
tested was found to be associated with the severity of white matter hyperintensities.
Conclusion:The genetic polymorphisms found in apolipoprotein E, angiotensin-converting enzyme
and methylenetetrahydrofolate reductase did not contribute to white matter hyperintensities in
Alzheimer’s disease.Only age and hypertension factors were found to be contributory to white matter
hyperintensities.
Alzheimer Disease
;
Dementia
4.The Effect of Long-Term Care Ratings and Benefit Utilization Characteristics on Healthcare Use
Kang Ju SON ; Seung-Jin OH ; Jong-Min YOON
Health Policy and Management 2023;33(3):295-310
Background:
The long-term care (LTC) group has higher rates of chronic disease and disability registration compared to the general older people population. There is a need to provide integrated medical services and care for LTC group. Consequently, this study aimed to identify medical usage patterns based on the ratings of LTC and the characteristics of benefits usage in the LTC group.
Methods:
This study employed the National Health Insurance Service Database to analyze the effects of demographic and LTC-related characteristics on medical usage from 2015 to 2019 using a repeated measures analysis. A longitudinal logit model was applied to binary data, while a linear mixed model was utilized for continuous data.
Results:
In the case of LTC ratings, a positive correlation was observed with overall medical usage. In terms of LTC benefit usage characteristics, a higher overall level of medical usage was found in the group using home care benefits. Detailed analysis by medical institution classification revealed a maintained correlation between care ratings and the volume of medical usage. However, medical usage by classification varied based on the characteristics of LTC benefit usage.
Conclusion
This study identified a complex interaction between LTC characteristics and medical usage. Predicting the requisite medical services based on the LTC rating presented a challenge. Consequently, it becomes essential for the LTC group to continuously monitor medical and care needs, even after admission into the LTC system. To facilitate this, it is crucial to devise an LTC rating system that accurately reflects medical needs and to broaden the implementation of integrated medical-care policies.
5.The Difference of Lower Urinary Tract Symptoms Between Sympathetic Hyperactive and Hypoactive Men.
Dong Geun OH ; Dae Sung CHO ; In Suk YUN ; Kuk Bin LEE ; Jong Bo CHOI ; Jung Hwan LEE
International Neurourology Journal 2013;17(1):30-33
PURPOSE: Heart rate variability (HRV) is a tool used to measure autonomic nervous function; however, there is no evidence that it can be used to define sympathetic hyperactivity in men with lower urinary tract symptoms (LUTS). We suspected that LUTS would differ between sympathetic hyperactive and hypoactive patients. Therefore, we measured HRV and divided the LUTS patients into two groups, a sympathetic hyperactive group and a sympathetic hypoactive group according to the low frequency/high frequency (LF/HF) ratio and made clinical comparisons between the groups. METHODS: A total of 43 patients with symptomatic LUTS (International Prostate Symptom Score [IPSS] over 8) and 49 healthy volunteers were enrolled. No subjects had diseases that could affect the autonomic nervous system, such as diabetes or hypertension. Electrocardiographic signals were obtained from subjects in the resting state and HRV indexes were calculated with spectral analyses. We divided the LUTS patients into two groups by an LF/HF ratio of 1.9, which was the median value in the healthy volunteers, and compared the differences in clinical characteristics, IPSS, prostate-specific antigen (PSA), and transrectal ultrasound (TRUS) results. The parameters were compared by independent sample t-test by use of SPSS ver. 19. RESULTS: There were no significant differences in age, serum PSA, or volume of the prostate between the 2 LUTS groups. However, analyzing IPSS questionnaires between two groups showed that there were significant differences in mean of Q2 score (frequency) and storage symptom score ([Q2+Q4+Q7]/3) (P<0.05). CONCLUSIONS: We suggest that an imbalance of autonomic nervous system activity may be a factor that evokes varieties of symptoms in men with LUTS. LUTS patients with hypoactive sympathetic tone may suffer from frequency and storage symptoms.
Autonomic Nervous System
;
Electrocardiography
;
Heart Rate
;
Humans
;
Hypertension
;
Lower Urinary Tract Symptoms
;
Male
;
Prostate
;
Prostate-Specific Antigen
;
Prostatic Hyperplasia
6.Clinical study on lymphocyte immunization in recurrent abortion.
Jong Pyo LEE ; Hwan Wook CHUNG ; Jae Bum YOON ; Jung Hye HWANG ; Il Pyo SON ; In Soo KANG ; Jong Young JUN ; Ki Suck OH ; Soo Kyung CHOI
Korean Journal of Obstetrics and Gynecology 1993;36(11):3718-3726
No abstract available.
Abortion, Habitual*
;
Female
;
Immunization*
;
Lymphocytes*
;
Pregnancy
7.Bronchospasm Caused by N-Acetylcysteine Intratracheal Instillation in a Patient with Bronchial Asthma: A Case Report.
Duck Kyoung KIM ; Jong Chan SON ; Hong Yong JIN ; Du Gab CHA ; Hyung Rae OH
Korean Journal of Anesthesiology 2004;46(2):241-244
We report of a successfully treated case of fatal bronchospasm, which developed after N-acetylcysteine bolus intratracheal instillation in a 49-year-old female patient with bronchial asthma undergoing laparoscopic cholecystectomy. N-acetylcysteine has been widely used as a potent mucolytic agent since 1963, with few reported adverse reactions. Its mucolytic action is due to the breakage of disulfide bonds in mucus mucoproteins. Most adverse reactions to N-acetylcysteine are usually mild and respond to the termination of the medication and symptomatic treatment with antihistamine. However, several cases of fatal bronchospasm have been reported in asthmatic patients after inhaled or intravenous N-acetylcysteine. N-acetylcysteine induced bronchospasm could be avoided in most asthmatic patients if its concentration is not allowed to exceed 10%, and concomitant beta2-selective bronchodilators are utilized. Nevertheless, asthma is still a potent risk factor and requires special precautions, including careful risk-versus-benefit assessment, close observation and the immediate availability of resuscitation equipment and staff in the event of life-threatening bronchospasm.
Acetylcysteine*
;
Asthma*
;
Bronchial Spasm*
;
Bronchodilator Agents
;
Cholecystectomy, Laparoscopic
;
Female
;
Humans
;
Middle Aged
;
Mucoproteins
;
Mucus
;
Resuscitation
;
Risk Factors
8.Glucocorticoid Mechanism of Inhibition of the Inflammatory Cells in Lumbar Intervertebral Disc Cells Stimulated by TNF-alpha Production of Nuclear Factor-kappaB.
In Soo OH ; Sang Eun PARK ; Jong Min SON ; Jun Young CHUNG ; Young Yul KIM
Journal of Korean Orthopaedic Research Society 2010;13(2):80-87
PURPOSE: To analyze the action mechanism of NF-kappaB, IkappaB-alpha and effect of the Dexamethasone (DEXA) in mediating this inflammation, after stimulating cultured herniated intervertebral disc cells with TNF-alpha. MATERIALS AND METHODS: After cultured human intervertebral disc cells passaged three times, they were divided into four groups: A control group (A), DEXA treatment group (B), TNF-alpha treated group (C), TNF-alpha and DEXA were treated at the same time (D). IL-6 and IL-1beta gene expression were measured with semi-quantitative RT-PCR. Western blot analysis was performed to measure protein expression of IkappaB-alpha in the above groups for 10 minutes, 1 hour, 2 hours. In addition, in order to explain the mechanism of NF-kappaB nuclear binding for each group, the nuclear amount of NF-kappaB binding in the nucleus is measured by EMSA. RESULTS: In RT-PCR, expression of IL-6 and IL-1beta was greatest in group C, followed by group D, group A. IkappaB-alpha expression of the group treated with DEXA was not detected in Western blot results within 10 minutes. However, if stimulated by TNF-alpha, the DEXA was not inhibited of IkappaB-alpha concentration. After 1 hour and 2 hours, IkappaB-alpha levels were expressed by cells autonomously (autoregulatory induction). EMSA results expression levels in nuclear protein was maintained in accordance with protein expression. CONCLUSIONS: Our study shows that DEXA inhibits the production of mediators such as inflammatory IL-6 and IL-1beta, however, may not inhibit the transcription of NF-kappaB stimulated by TNF-alpha.
Blotting, Western
;
Dexamethasone
;
Gene Expression
;
Humans
;
I-kappa B Proteins
;
Inflammation
;
Interleukin-6
;
Intervertebral Disc
;
Negotiating
;
NF-kappa B
;
Nuclear Proteins
;
Tumor Necrosis Factor-alpha
9.MR Imaging of Meniscal Tears' Correlation with History of Trauma.
Jung Yoon LEE ; Sung Keun SOHN ; Kyung Taek KIM ; Seoung Oh YANG ; Jong Cheul CHOI ; Sun Seob CHOI ; Seok Hyun SON ; Yung Il LEE ; Duck Hwan CHUNG
Journal of the Korean Radiological Society 1994;30(1):175-179
PURPOSE: The medial meniscus is injured much more than the lateral meniscus. Because the medial meniscus is much larger in diameter, is thinner in its periphery and narrower in body than the lateral meniscus, and does not attach to either cruciate ligament. We evaluated correlations with sites of tear and history of trauma. METHODS AND MATERIALS: We reviewed retrospectively in 43 patients with meniscal tears on MRI(51 cases) and correlated them with history of trauma. RESULTS: The most common site of injury was the posterior horn of the medial meniscus(32/51), but high incidence of lateral meniscal tear compared with previous reports was seen. In the cases which had history of trauma, the posterior horn of medial meniscus was most commonly injured(26/34) and 5 meniscal tears were combined with meniscal tear in the other site. The tear in the anterior horn of the medial meniscus was seen only in a patient which had history of trauma and combined with meniscal tear in the other site. But in the meniscal tears without definite history of trauma, the incidence of meniscal tear was different from the meniscal tear with history of trauma. The incidence of lateral meniscal tear(11/17) was highter than medial meniscal tear and the posterior horn of lateral meniscus was commonly injured. CONCLUSION: We concluded that the medial meniscus was commonly injured, especially posterior horn, but in the cases which had no definite history of trauma, the lateral meniscus was commonly ipjured. An awareness of prevalent site of meniscal injuries may be helpful in the diagnostic interpretation of MR imaging of knee.
Animals
;
Horns
;
Humans
;
Incidence
;
Knee
;
Ligaments
;
Magnetic Resonance Imaging*
;
Menisci, Tibial
;
Retrospective Studies
10.A Case of Simultaneous Disseminated Cerebral Infarction after Open Cardiac Massage.
Seungnam SON ; Oh Young KWON ; Seonhye KIM ; Ki Jong PARK ; Nack Cheon CHOI ; Byeong Hoon LIM
Journal of the Korean Neurological Association 2005;23(5):709-711
No abstract available.
Cerebral Infarction*
;
Heart Massage*
;
Intracranial Embolism