We report a case of focal dermal hypoplasia associated with ichthyosis in an 18-year-old Korean female. The patient showed a yellowish atrophic patch on the left side of her abdomen, abnormal skin pigmentation, nail dystrophy and ichthyosis since birth.We could also find skeletal and dental deformities. The biopsy specimen obtained from the yellowish atrophic patch showed marked attenuation of collagen fibers and ectopic fatty tissue nearly reaching up to the upper dermis.
Abdomen ; Adipose Tissue ; Adolescent ; Biopsy ; Collagen ; Congenital Abnormalities ; Dermis ; Female ; Focal Dermal Hypoplasia* ; Humans ; Ichthyosis* ; Skin Pigmentation

We report a case of focal dermal hypoplasia associated with ichthyosis in an 18-year-old Korean female. The patient showed a yellowish atrophic patch on the left side of her abdomen, abnormal skin pigmentation, nail dystrophy and ichthyosis since birth.We could also find skeletal and dental deformities. The biopsy specimen obtained from the yellowish atrophic patch showed marked attenuation of collagen fibers and ectopic fatty tissue nearly reaching up to the upper dermis.
Abdomen ; Adipose Tissue ; Adolescent ; Biopsy ; Collagen ; Congenital Abnormalities ; Dermis ; Female ; Focal Dermal Hypoplasia* ; Humans ; Ichthyosis* ; Skin Pigmentation

The clinicolaboratory findings, cardiac catheterization, and outcome of operation were analyzed in 78 patients with tetralogy of Fallot, which were diagnosed by echocardiography, cardiac catheterization, and a cardiac angiography and confirmed by operation at Dong San Hospital, Keimyung University, during a 4(1/2)-year period from January 1984 to June 1988. The following results were obtained : 1) Out of the 78 cases, 45 were male and 64 were female. 2) The electrocardiogram showed right axis deviation in 71 cases(91%) and right ventricular hypertrophy in 66 cases(84.6%). 3) Chest X-ray revealed that, the cardiothoracic ratio was normal or decreased in 68 cases(87.3%), and cardiac apex elevation was noticed in 57 cases(73%). 4) Pulmonary stenosis were chiefly valvular and infundibular type(53.8%). 5) The associated heart diseases with TOF were patent foramen ovale(64.1%), right sided aortic arch(19.2%), and secundum ASD(10.3%), in that order. 6) There was an intimate correlation between secondary polycythemia and thrombocytopenia. 7) Among the 78 Cases, 73 cases had total correction, 1 case had shunt operation, and 4cases had total correction after shunt operation. The highest mortality rate occurred in the cases of total correction after shunt operation(25%). The cases with a main pulmonary artery size of 1/3 to 2/3 against, the aorta had a higher mortality than the other group, and no cases expired in the group with a ratio of more than 2/3. The overall surgical mortality was 8.9%.
Angiography ; Aorta ; Axis, Cervical Vertebra ; Cardiac Catheterization ; Cardiac Catheters ; Echocardiography ; Electrocardiography ; Female ; Heart Diseases ; Humans ; Hypertrophy, Right Ventricular ; Male ; Mortality ; Polycythemia ; Pulmonary Artery ; Pulmonary Valve Stenosis ; Tetralogy of Fallot* ; Thorax ; Thrombocytopenia

The authors experience 3 cases of angiographically occult vascular malformation(AVOM) of the brain during the last 3 months in 1990. All cases were diagnosis of either operative or pathological finding and were associated with intracerebral hemorrhage. The authors recommend that surgery should be considered even to those angiographically negative intracerebral hemorrhage cases, once clinical features are highly suggestive of AOVM. Surgery can be an effective and define therapy for these entities, which are prone to cause recurrent hemorrhage and persistent neural deficits.
Brain* ; Cerebral Hemorrhage ; Diagnosis ; Hemorrhage ; Magnetic Resonance Imaging ; Vascular Malformations*

No abstract available.
Animals ; Cell Adhesion* ; Female ; Leiomyoma* ; Mice ; Myometrium* ; Neural Cell Adhesion Molecules*

Ultrasonograms of proven liver abscesses in 44 patients were analysed. In ulltrasonography prior to otherdiagnostic approach, 38 patients(86.4%) were accurately diagnosed as liver abscess with correlation of clinicalsymptoms. The outline of abscess is smoothly defined. oval and round in 19 patients, irregularly and ill-definedin 25 patients. Only in 5 patients echogenic capsules are demonstrated. The internal echogenecity is variable;they are predominantly echo-free in 14, predominantly low-echo in 25 and predominantly echogenic, similar to solidtumor in 2 patients . 36 patients who were treated by medication only and combined needle aspiration had follow-up ultrasonography within 3 weeks since initial treatment. 33 patients were ultrasonically and clinically improved.Only one patients died of sepsis after needle aspiration and 2 patients were discharged without any sign ofimprovement.
Abscess ; Capsules ; Follow-Up Studies ; Humans ; Liver Abscess ; Liver ; Needles ; Sepsis ; Ultrasonography

Pityriasis rotunda is an uncommon dermatosis characterized by asymptomatic, multiple, widely distributed, strikingly circular hypopigmented or hyperpigmented, scaly patches on the trunk and extremities. Histopathologic findings are consistent with ichthyosis vulgaris. It has been associated with a variety of underlying systemic diseases. We report a case of pityriasis rotunda aggravated during pregnancy.
Extremities ; Ichthyosis Vulgaris ; Pityriasis* ; Pregnancy* ; Skin Diseases

Hobnail hemangioma is a benign vascular tumor that typically presents as a small, single lesion on the skin of the trunk or limb. It occurs mainly in young or middle-aged adults (mean age: 30 years) but rarely in childhood. Histologically, hobnail hemangioma is characterized by a biphasic growth pattern, with dilated vascular spaces lined by hobnail endothelial cells in the superficial dermis, and collagen dissection narrow vascular channels in the deeper dermal parts, as well as inflammatory aggregates, fibrosis, and hemosiderin deposits. We report a case of hobnail hemangioma in a 10-year-old girl who had a violaceous papule surrounded by an ecchymotic halo on the left thigh. She underwent treatment with surgical excision with primary closure. To the best of our knowledge, our case is the first reported case of childhood hobnail hemangioma in Korean dermatological literatures.
Adult ; Child ; Collagen ; Dermis ; Endothelial Cells ; Extremities ; Female ; Fibrosis ; Hemangioma* ; Hemosiderin ; Humans ; Skin ; Thigh

Sweet's syndrome, first described in 1964 by Sweet, is characterized by fever, neutrophilic leukocytosis, sudden onset of asymmetric, erythematous, often painful skin lesions, and dense dermal infiltrates of mature neutrophils without signs of vasculitis. The disease responds rapidly to systemic therapy with corticosteroids but recurs in about 25% of the cases. Alternative treatments include potassium iodide, colchine, dapsone, clofazimine, cyclosporin. We report a case of classic sweet's syndrome which was successfully treated with potassium iodide without adverse reactions. 33 year-old male patient became afebrile and symptom free within 24h after starting potassium iodide 900mg/day. The cutaneous eruptions subsided completely in 5 days. He received the drug only for 12days, but there has been no recurrence after 6 months under observation.
Adrenal Cortex Hormones ; Adult ; Clofazimine ; Cyclosporine ; Dapsone ; Fever ; Humans ; Leukocytosis ; Male ; Neutrophils ; Panniculitis* ; Potassium Iodide* ; Potassium* ; Recurrence ; Skin ; Sweet Syndrome* ; Vasculitis

BACKGROUND: Malignant melanoma is the cancer derived from melanocyte and its prevalence and mortality has increased constantly. Recently, newly developed monoclonal antibodies such as antibodies to MART-1, tyrosinase, TRP-1, MITF and NKI-beteb are frequently used in the diagnosis of melanoma. OBJECTIVE: We evaluated these antibodies to see if there are differences of positivity and expression pattern of immunohistochemical labelings between melanocytic nevi and malignant melanomas. METHODS: We have examined 6 antibodies (antibody to S-100, tyrosinase, TRP-1, MART-1, MITF and HMB-45) in their expressions in 8 malignant melanomas and 24 benign melanocytic nevi. RESULTS: No remarkable difference in positivity of staining between benign melanocytic nevi and malignant melanomas was observed. The staining pattern for S-100 protein is homogenous in all melanocytic nevi and malignant melanomas. HMB-45 showed staining confined to the junctional and superficial dermal components in both diseases. Tyrosinase and TRP-1 showed staining confined to the junctional and superficial dermal cells in most benign melanocytic nevi and variable in malignant melanomas. Although more variable patterns were found in the malignant melanomas, MART-1 demonstrated homogenous staining of all cells in the benign lesions. The staining pattern of MITF in melanocytic nevi was principally in junctional and superficial dermal components, whereas it was homogenous in malignant melanomas. CONCLUSIONS: It should be stated that none of the melanocytic differentiation antibodies has any diagnostic value in differentiating between melanoma and nevus cells, but new monoclonal antibodies taken together could contribute to the detection of malignant melanoma due to their high specificity and complementary natures.
Antibodies* ; Antibodies, Monoclonal ; Diagnosis ; Immunohistochemistry ; Melanocytes ; Melanoma* ; Monophenol Monooxygenase ; Mortality ; Nevus ; Nevus, Pigmented* ; Prevalence ; S100 Proteins ; Sensitivity and Specificity