The clinicolaboratory findings, cardiac catheterization, and outcome of operation were analyzed in 78 patients with tetralogy of Fallot, which were diagnosed by echocardiography, cardiac catheterization, and a cardiac angiography and confirmed by operation at Dong San Hospital, Keimyung University, during a 4(1/2)-year period from January 1984 to June 1988. The following results were obtained : 1) Out of the 78 cases, 45 were male and 64 were female. 2) The electrocardiogram showed right axis deviation in 71 cases(91%) and right ventricular hypertrophy in 66 cases(84.6%). 3) Chest X-ray revealed that, the cardiothoracic ratio was normal or decreased in 68 cases(87.3%), and cardiac apex elevation was noticed in 57 cases(73%). 4) Pulmonary stenosis were chiefly valvular and infundibular type(53.8%). 5) The associated heart diseases with TOF were patent foramen ovale(64.1%), right sided aortic arch(19.2%), and secundum ASD(10.3%), in that order. 6) There was an intimate correlation between secondary polycythemia and thrombocytopenia. 7) Among the 78 Cases, 73 cases had total correction, 1 case had shunt operation, and 4cases had total correction after shunt operation. The highest mortality rate occurred in the cases of total correction after shunt operation(25%). The cases with a main pulmonary artery size of 1/3 to 2/3 against, the aorta had a higher mortality than the other group, and no cases expired in the group with a ratio of more than 2/3. The overall surgical mortality was 8.9%.
Angiography ; Aorta ; Axis, Cervical Vertebra ; Cardiac Catheterization ; Cardiac Catheters ; Echocardiography ; Electrocardiography ; Female ; Heart Diseases ; Humans ; Hypertrophy, Right Ventricular ; Male ; Mortality ; Polycythemia ; Pulmonary Artery ; Pulmonary Valve Stenosis ; Tetralogy of Fallot* ; Thorax ; Thrombocytopenia

We report a case of focal dermal hypoplasia associated with ichthyosis in an 18-year-old Korean female. The patient showed a yellowish atrophic patch on the left side of her abdomen, abnormal skin pigmentation, nail dystrophy and ichthyosis since birth.We could also find skeletal and dental deformities. The biopsy specimen obtained from the yellowish atrophic patch showed marked attenuation of collagen fibers and ectopic fatty tissue nearly reaching up to the upper dermis.
Abdomen ; Adipose Tissue ; Adolescent ; Biopsy ; Collagen ; Congenital Abnormalities ; Dermis ; Female ; Focal Dermal Hypoplasia* ; Humans ; Ichthyosis* ; Skin Pigmentation

We report a case of focal dermal hypoplasia associated with ichthyosis in an 18-year-old Korean female. The patient showed a yellowish atrophic patch on the left side of her abdomen, abnormal skin pigmentation, nail dystrophy and ichthyosis since birth.We could also find skeletal and dental deformities. The biopsy specimen obtained from the yellowish atrophic patch showed marked attenuation of collagen fibers and ectopic fatty tissue nearly reaching up to the upper dermis.
Abdomen ; Adipose Tissue ; Adolescent ; Biopsy ; Collagen ; Congenital Abnormalities ; Dermis ; Female ; Focal Dermal Hypoplasia* ; Humans ; Ichthyosis* ; Skin Pigmentation

The authors experience 3 cases of angiographically occult vascular malformation(AVOM) of the brain during the last 3 months in 1990. All cases were diagnosis of either operative or pathological finding and were associated with intracerebral hemorrhage. The authors recommend that surgery should be considered even to those angiographically negative intracerebral hemorrhage cases, once clinical features are highly suggestive of AOVM. Surgery can be an effective and define therapy for these entities, which are prone to cause recurrent hemorrhage and persistent neural deficits.
Brain* ; Cerebral Hemorrhage ; Diagnosis ; Hemorrhage ; Magnetic Resonance Imaging ; Vascular Malformations*

No abstract available.
Animals ; Cell Adhesion* ; Female ; Leiomyoma* ; Mice ; Myometrium* ; Neural Cell Adhesion Molecules*

Ultrasonograms of proven liver abscesses in 44 patients were analysed. In ulltrasonography prior to otherdiagnostic approach, 38 patients(86.4%) were accurately diagnosed as liver abscess with correlation of clinicalsymptoms. The outline of abscess is smoothly defined. oval and round in 19 patients, irregularly and ill-definedin 25 patients. Only in 5 patients echogenic capsules are demonstrated. The internal echogenecity is variable;they are predominantly echo-free in 14, predominantly low-echo in 25 and predominantly echogenic, similar to solidtumor in 2 patients . 36 patients who were treated by medication only and combined needle aspiration had follow-up ultrasonography within 3 weeks since initial treatment. 33 patients were ultrasonically and clinically improved.Only one patients died of sepsis after needle aspiration and 2 patients were discharged without any sign ofimprovement.
Abscess ; Capsules ; Follow-Up Studies ; Humans ; Liver Abscess ; Liver ; Needles ; Sepsis ; Ultrasonography

BACKGROUND: The anatomical relation between a malignant tumor and its vascular and lymphatic bed is an important influencing metastasis. Hox D3 is required for these expressions of integrin alpha v beta3 and urokinase plasminogen activator (uPA), which contribute to endothelial cell adhesion, invasion, and migration during angiogenesis. Recent studies in different tumor types have shown that vascular endothelial growth factor-C (VEGF-C), which displays a high specificity for lymphatic endothelium, is involved in tumor-induced lymphagiogenesis and lymphatic metastatic spread. OBJECTIVE: This study was designed to measure the expression of HOX D3 and VEGF-C in different skin cancers. METHODS: The expression of HOX D3 and VEGF-C was examined by immunohistochemical staining of 40 skin cancer tissue samples, including 8 keratoacanthomas, 8 extramammary paget's disease, 8 basal cell carcinomas, 8 squamous cell carcinomas and 8 malignant melanomas. RESULTS: Immunohistochemical analysis of 40 skin cancer tissue samples revealed a high expression of HOX D3 and VEGF-C in the more aggressive and invasive skin tumors, including squamous cell carcinomas and malignant melanomas. On the other hand, low expression was seen in the less-invasive skin tumors, including keratoacanthomas, extramammary paget's disease and basal cell carcinomas. Also the degree of expression of HOX D3 and VEGF-C showed a statistically-significant correlation with each skin tumor (p<0.05). CONCLUSION: These findings provide evidence that the upregulation of HOX D3 and VEGF-C might be involved in the promotion of angiogenesis and lymphagiogenesis in skin tumors and play an important role in metastasis.
Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Endothelial Cells ; Endothelium, Lymphatic ; Hand ; Integrin alphaV ; Keratoacanthoma ; Lymphangiogenesis ; Melanoma ; Neoplasm Metastasis ; Paget Disease, Extramammary ; Plasminogen Activators ; Sensitivity and Specificity ; Skin Neoplasms ; Skin* ; Up-Regulation ; Urokinase-Type Plasminogen Activator ; Vascular Endothelial Growth Factor C*

Eccrine poroma is a benign neoplasm, whicn is thought to originate from the eccrine sweat gland. Previous studies suggest that these are primarily lesions of the hairless acral surface. We report a clinicopathological case of a 30-year-old man who presented with a 2.0 by 1.2 cm sized, unusual scalp lesion, which proved to be an eccrine poroma. There has been no local recurrence in the 4 months since complete excision.
Adult ; Humans ; Poroma* ; Recurrence ; Scalp* ; Sweat Glands

Generalized granuloma annulare (GGA) is an uncommon type of granuloma annulare. It is frequently characterized by chronicity and unresponsiveness to a number of therapeutic modalities. A variety of systemic treatment modalities for GGA have been tried, including PUVA, dapsone, hydroxychloroquine, systemic corticosteroids, niacinamide, vitamin E and chlorambucil. However, their efficacy was not very encouraging. We present a case of GGA which showed a satisfactory response to isotretinoin. To conclude, isotretinoin may be considered as treatment for GGA in patients with unacceptable cosmetic disfigurements or symptoms.
Adrenal Cortex Hormones ; Chlorambucil ; Dapsone ; Granuloma Annulare* ; Granuloma* ; Humans ; Hydroxychloroquine ; Isotretinoin* ; Niacinamide ; Vitamin E ; Vitamins

Recently a distinct subtype of lymphoma was reported, the natural killer(NK)/T-cell lymphoma, which can involve the skin in a primary or secondary event. NK/T-cell lymphoma is characterized by the expression of the NK-cell antigen CD56. CD56+ lymphoma are further subdivided into nasal and non-nasal NK/T-cell lymphoma. We report a case of primary nasal NK/T-cell lymphoma with secondary cutaneous involvement.
Lymphoma* ; Skin