Fiftyeight patients with cardiac neurosis were studied to evaluate the effects of Carteolol 10mg/day. Systolic blood pressure was declined to 122.7+/-17.2mmHg from 137.1+/-23.2mmHg, diastolic blood pressure was declined to 79.6+/-11.1mmHg from 88.2+/-17.5mmHg. Pulse rate was decreased from 83.0+/-10.2 to 73.9+/-6.8per minute. The most frequent subjective symptom was palpitation (74.1%) and effectiveness of therapy for subjective symptom was 91.4%, for usefulness was 93.1%. There was no significant serious side reaction observed. We concluded that Carteolol therapy for the patients with cardiac neurosis could be useful and safe with a small dosage.
Blood Pressure ; Carteolol* ; Heart Rate ; Humans ; Neurocirculatory Asthenia*

No abstract available.
Femur Neck*

Compensatory hypertrophy of muscle fibers has been known to occur when burden on a skeletal muscle is increased. However, there have not been reports concerning the response of extraocular muscles following a monocular resection and recession of horizontal muscles, which procedure is a common form of strabismus surgery. A large lateral rectus resection and medial rectus recession was performed in each right eye of 28 rats. After the horizontal muscle surgery, both medial and lateral rectus muscles were obtained from both eyes of each rat with an interval of 2 weeks from the initial operation until 8th week after operation. A mid-portion of an extirpated muscles were frozen and prepared for ATPase staining. With a differential preincubation in two buffered solutions, pH 4.6 and pH 10.3 and ATPase staining, muscle fibers were classified into 3 kinds-global singly innervated fiber(GSIF, alkali-stable), global multi-innervated fiber(GMIF, alkali-labile), and orbital surface layer fiber(OSLF). These muscle fibers were measured using micrometer to find out their diameters and compared with the diameter of extraocular muscle fibers of unoperated rats. All kinds of muscle fibers of a resected lateral rectus showed an increase in their diameteris(p<0.05, Wilcoxon rank sum test) but there was no hypertrophy in the recessed medial rectus the yolk muscle of the resected lateral rectus, medial rectus of the fellow eye also showed hypertrophy of GMIF and OSLF. The lateral rectus of the unoperated fellow eye did not reveal muscle fiber hypertrophy. The postoperative hypertrophy of muscle fibers were observed only at the 2nd and 4th postoperative week specimens. the hypertrophied muscles subsequently returned to the baseline fiber diameter.
Adenosine Triphosphatases ; Animals ; Hydrogen-Ion Concentration ; Hypertrophy* ; Muscle, Skeletal ; Muscles ; Orbit ; Rats* ; Strabismus

No abstract available.
Mandibular Reconstruction*

The gene encoding F protein of CBP-1 strain, a heat-stable Newcastle disease virus (NDV) isolated from the diseased pheasants in Korea, was characterized by reverse transcription-polymerase chain reaction (RT-PCR), nucleotide and amino acid sequences. Virus RNA was prepared from the chorioallatoic fluid infected with NDV CBP-1 virus and cDNA was amplified by RT-PCR, cloned and sequenced to analyze. The PCR was sensitive as to detect the virus titer above 25 hemagglutination unit. 1.7kb (1,707bp) size of the cDNA was amplified and cloned into BamHI site of pVL1393 Baculo transfer vector. The nucleotide sequences for F protein were determined by dye terminator cyclic sequencing using four pairs of primers, and 553 amino acid sequences were predicted. In comparison of the nucleotide sequence of F gene of CBP-1 with those of other NDV strains, the homology revealed 88.8%, 98.5% and 98.7% with Kyojungwon (KJW), Texas GB and Beaudette C strains, respectively. As the deduced 553 amino acid sequences of F protein of CBP-1 were compared with those of other NDV strains, the homology appeared 89.9%, 98.7% and 98.9% with KJW, Texas GB and Beaudette C strains, respectively. The putative protease cleavage site (112-116) was R-R-Q-K-R, indicating that CBP-1 strain is velogenic type. The amino acid sequences include 6 sites of N-asparagine-linked glycosylation and 13 cysteine residues. These data indicate that the genotype of CBP-1 strain is more closely associated with the strains of Texas GB and Beaudette C than KJW strain.
Amino Acid Sequence ; Animals ; Base Sequence* ; Clone Cells ; Cloning, Molecular* ; Cysteine ; DNA, Complementary ; Genotype ; Glycosylation ; Hemagglutination ; Korea ; Newcastle disease virus* ; Newcastle Disease* ; Polymerase Chain Reaction ; RNA ; Texas ; Viral Load

No abstract available.
Foreign Bodies*

No abstract available.
Congenital Hypothyroidism* ; Thyroid Dysgenesis*

No abstract available.
Mandibular Reconstruction* ; Ribs* ; Transplants*

The author studied hiigh Risk Factor during a period of 1 year from July 1975 to June 1976 Among 1129 of newborns who were admitted to our nursery, 494 cases of the newborn were associated with hiigh risk factor? Following results were obtained : 1) The newborn associated with ?high risk factor?were 494 cases and about 44%,2) There was similar distribution in both sexes, 258 male to 236 female 3) The distribution of the newborn according to the risk factors was as follows: a. Meconium stained amniotic fluid(140 cases) b. Toxemia(121 cases) c. Cesarean section(120 cases) d. Birth weight under 2,500gm. Or over 4,000gm.(115 cases) e. Prematurity (92 cases) f. Multiple pregnancy(53 cases), in given order of frequency. 4) Among a total of 15 expired cases, 11 were premature-born. 5) Non-risk factor group were taken antepartum care in high percentage(77.3%), but high risk factor group in very low percentage(37.2%)
Birth Weight ; Female ; Humans ; Infant, Newborn* ; Male ; Meconium ; Nurseries ; Risk Factors*

PCR implication using the primers for gag, pol and rev genes in BLV (bovine leukemia virus) proviral DNA and syncytium assay were carried out for the Korean native goats experimentally infected with bovine leukemia virus to investigate pathogenesis of BLV in the goats, and to establish a model animal for BLV infection. The oligonucleotide primers used in PCR revealed very high specificity, The minimal amount of FLK-BLV cellular chromosomal DNA to detect the integrated BLV proviral DNA was 10 ng. The peripheral blood lymphocytes from the goat infected with BLV were examined at regular intervals by PCR amplification and syncytium assay. Pol or gag genes were detected in none of three infected goats at the 1st week post-infection (p.i.). At the 4th week p.i., one of three goats showed the amplified gag gene. Thereafter detection rates for the genes were increased, indicating that the BLV proviral genes were integrated in all of the lymphocytes from three goats, at the 16th weeks p.i., when it was evident in syncytium assay that the lymphocytes from all of three goats were infested with infective BLV. Investigating the tissues from the necropsied goats at the 8th month p.i., the amplified BLV proviral genes and infective BLV were detected in all of the peripheral lymphocytes from three infected-goats. Among various tissues examined, the amplified BLV proviral genes were observed in spleen and superficial cervical, mandibular and retropharyngeal lymph nodes, and the infective BLV, in superficial cervical and mandibular lymph nodes. It was assumed that the Korean native goat was quite susceptible to BLV infection, indicating that the goat could be a good model animal for BLV.
Animals ; Cattle ; Deltaretrovirus Infections ; DNA Primers ; DNA* ; Enzootic Bovine Leukosis* ; Genes, gag ; Genes, rev ; Giant Cells ; Goats* ; Leukemia ; Leukemia Virus, Bovine* ; Lymph Nodes ; Lymphocytes ; Polymerase Chain Reaction* ; Sensitivity and Specificity ; Spleen