1.Usefulness of Triple Marker Testing for Prenatal Diagnosis.
Jong Rak CHOI ; Kyung A LEE ; Kyung Soon SONG
Korean Journal of Clinical Pathology 1997;17(4):575-580
BACKGROUND: Our purpose was to assess the utility of prenatal triple-marker (alpha- fetoprotein (AFP), beta-human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) testing for chromosomal abnormalities in women with Down syndrome screen-positive results. METHODS: Total 1,082 women between 15 and 21 weeks' gestation received second trimester Down syndrome risk evaluation by triple marker testing. AFP, beta-hCG and uE3 were measured by Coat-A-Count(R) IRMA (Diagnostic Products Corporation, LA, USA), The risk for Down syndrome was calculated using a commercially available software program (AFP Expert; Benetech Medical System, Toronto, Canada) by use of a Down syndrome risk cutoff value(1:270 at midtrimester). Karyotypes were reviewed for 32 (54.2%) of these patients who received prenatal chromosome analysis. RESULTS: Fifty nine (5.5%) patients of the 1,082 women screened were identified as positive. Two chromosome abnormalities (47,XYY and 46,XX, int (9) ) were found in the 32 patients who underwent prenatal chromosome analysis (6.3%). Any cases on the abnormal serum tests torn out not to be associated with trisomy 21. CONCLUSIONS: Although triple marker screen appears to be an effective method detecting chromosome abnormalities there is a high false positive rate. Therefore, new screening test that reduce false positive rate is need to be introduced.
Chorionic Gonadotropin
;
Chromosome Aberrations
;
Down Syndrome
;
Estriol
;
Female
;
Fetal Proteins
;
Humans
;
Karyotype
;
Mass Screening
;
Pregnancy
;
Pregnancy Trimester, Second
;
Prenatal Diagnosis*
2.Mercury contents in scalp hair of dentists and in their dental office.
Kyung Hee SONG ; Doo Hie KIM ; Jong Young LEE
Korean Journal of Occupational and Environmental Medicine 1991;3(1):21-31
No abstract available.
Dental Offices*
;
Dentists*
;
Hair*
;
Humans
;
Scalp*
5.Molecular Cloning and Nucleotide Sequence of the Gene Encoding Fusion(F) Protein of the Thermostable Newcastle Disease Virus Isolated from a Diseased Pheasant.
Kyung Soo CHANG ; Kui Hyun KIM ; Moo Hyung JUN ; Hee Jong SONG ; Jong Hyeon PARK
Journal of the Korean Society of Virology 1998;28(3):233-244
The gene encoding F protein of CBP-1 strain, a heat-stable Newcastle disease virus (NDV) isolated from the diseased pheasants in Korea, was characterized by reverse transcription-polymerase chain reaction (RT-PCR), nucleotide and amino acid sequences. Virus RNA was prepared from the chorioallatoic fluid infected with NDV CBP-1 virus and cDNA was amplified by RT-PCR, cloned and sequenced to analyze. The PCR was sensitive as to detect the virus titer above 25 hemagglutination unit. 1.7kb (1,707bp) size of the cDNA was amplified and cloned into BamHI site of pVL1393 Baculo transfer vector. The nucleotide sequences for F protein were determined by dye terminator cyclic sequencing using four pairs of primers, and 553 amino acid sequences were predicted. In comparison of the nucleotide sequence of F gene of CBP-1 with those of other NDV strains, the homology revealed 88.8%, 98.5% and 98.7% with Kyojungwon (KJW), Texas GB and Beaudette C strains, respectively. As the deduced 553 amino acid sequences of F protein of CBP-1 were compared with those of other NDV strains, the homology appeared 89.9%, 98.7% and 98.9% with KJW, Texas GB and Beaudette C strains, respectively. The putative protease cleavage site (112-116) was R-R-Q-K-R, indicating that CBP-1 strain is velogenic type. The amino acid sequences include 6 sites of N-asparagine-linked glycosylation and 13 cysteine residues. These data indicate that the genotype of CBP-1 strain is more closely associated with the strains of Texas GB and Beaudette C than KJW strain.
Amino Acid Sequence
;
Animals
;
Base Sequence*
;
Clone Cells
;
Cloning, Molecular*
;
Cysteine
;
DNA, Complementary
;
Genotype
;
Glycosylation
;
Hemagglutination
;
Korea
;
Newcastle disease virus*
;
Newcastle Disease*
;
Polymerase Chain Reaction
;
RNA
;
Texas
;
Viral Load
6.Meibomian Gland Adenocarcinoma of the Orbit.
Jong Sul KIM ; Joon Kyung SONG
Journal of the Korean Ophthalmological Society 1986;27(4):651-656
Meibomian gland adenocarcinoma is a rare neoplasm which may be overlooked until it spreads into the orbit. We have experienced a case of meibomian gland adenocarcinoma which spread into the orbit, and performed orbital exenteration. Two months later, the patient had a recurrence at the superolateral margin of the orbit that surgically excised. The radiation therapy with total dose of 5000 rads over a period of one month was performed and the tumor mass was regressed. There was no evidence of recurrence at 12 months after radiation therapy.
Adenocarcinoma*
;
Humans
;
Meibomian Glands*
;
Orbit*
;
Recurrence
7.Mediastinal parasitic cyst by paragonimiasis.
Ki Ho SONG ; Man Jong BAEK ; Kyung SUN ; Kwang Taik KIM ; In Sung LEE ; Hyoung Mook KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(1):67-69
No abstract available.
Paragonimiasis*
8.Piezoelectric lithotripsy of gallstones: an in vitro study of sonographic characteristics and fragmentation.
Jong Kyung MOON ; Yoon Jin OH ; Young Goo KIM ; In Sup SONG ; Kun Sang KIM
Journal of the Korean Radiological Society 1991;27(5):592-596
No abstract available.
Gallstones*
;
Lithotripsy*
;
Ultrasonography*
9.Hallervorden-Spatz Disease: 2 Cases of Siblings.
Woo Sun KIM ; In One KIM ; Kyung Mo YEON ; Jong Gi SONG
Journal of the Korean Radiological Society 1994;30(4):779-781
We report two patients with Hallervorden-Spatz disease, who were diagnosed by same MR findings of marked low signal intensity in the globus and substantia nigra. They presented with ataxic and spastic gait, intention tremor, delayed mental development, and dysarthria. They were 7 year-old male and 8 yea r-old female siblings, who were healthy until 3 years of age when they suffered from progressive symptoms. T2-weighted images showed marked low signal intensity in the globus pallidus and substantia nigra indicating an increased irondeposition, and it might suggest Hallervorden-Spatz disease.
Child
;
Dysarthria
;
Female
;
Gait Disorders, Neurologic
;
Globus Pallidus
;
Humans
;
Male
;
Pantothenate Kinase-Associated Neurodegeneration*
;
Siblings*
;
Substantia Nigra
;
Tremor
10.A Case of Transient Symptomatic Zinc Deficiency - in A cows milk - Fed , preterm Infant -.
Jong Kyung SONG ; Su Jin KIM ; Ji Hae KANG ; Ghee Young JUNG
Journal of the Korean Society of Neonatology 1998;5(1):100-103
Acrodermatitis enteropathica(AE) which starts in early infancy after weaning is a rare hereditary chronic disorder of zinc absorption. AE is characterized by alopecia, diarrhea and skin lesions localized to periorificial areas and acrally on the extremities. However, recent reports presented Transient Symptomatic Zinc Deficiency(TSZD) in preterm infants. TSZD is clinically similar to AE and skin lesions rapidly heals after zinc supplementation. When the treatment was withheld, no recurrence was seen. We experienced a TSZD case in a cow's milk fed, preterm infant, so We report it with a brief review of literature.
Absorption
;
Acrodermatitis
;
Alopecia
;
Diarrhea
;
Extremities
;
Humans
;
Infant*
;
Infant, Newborn
;
Infant, Premature*
;
Milk*
;
Recurrence
;
Skin
;
Weaning
;
Zinc*