1.Calcification and Aneurysms of Coronary Artery without Atherosclerosis in Young Adult.
Ji Shin LEE ; Young Jik LEE ; Jong Tae PARK
Korean Journal of Legal Medicine 1997;21(1):105-112
Coronary artery calcification(CAC) is found frequently in the atheromatous plaques CAC is known to have increased frequency above 40 years. CAC without evidence of atherosclerosis in young adults is quite rare, however, CAC combined with aneurysms in young adults have been infrequently reported in patients with a past history of a Kawasaki disease in child. We report an autopsy case showing CAC and aneurysm in the absence of macroscopically identified atherosclerotic lesions in a healthy 23-year-old man. The autopsy examination revealed aneurysmal dilatation of the right coronary artery which was connected with calcified lesion. A calcified lesion of the left anterior descending coronary artery was aslo noted. Microscopically, aneurysmal wall was non-specific except for hyalinized wall and foci of calcification. A striking histologic finding of calcified mass was ring calcification along the wall of the coronary artery. Antecedent Kawasaki disease in the past was suggestive as other reports.
Aneurysm*
;
Atherosclerosis*
;
Autopsy
;
Child
;
Coronary Vessels*
;
Dilatation
;
Humans
;
Hyalin
;
Mucocutaneous Lymph Node Syndrome
;
Plaque, Atherosclerotic
;
Strikes, Employee
;
Young Adult*
2.A Study for Hemodynamic Mechanism of Myocardial Infarction following Aortic Dissection.
Young Jik LEE ; Ji Shin LEE ; Jong Tae PARK
Korean Journal of Legal Medicine 1997;21(1):97-104
Aortic dissection may be considered the result of a discrepancy between the strength of the aortic wall and the intramural pressure. And factors that predispose to aortic dissection may include systemic hypertension, cystic medial necrosis, Marfan's syndrome, atherosclerosis, disease of aortic valve, pregnancy, giant cell arteritis, hyperthyrosis, disease of aortic valve, pregnancy, giant cell arteritis, hyperthyroidism, and blunt chest trauma. A few of aortic dissection may extend retrograde toward the aortic valve and involve the coronary arteries. Coronary artery occlusions due to mural dissection are an uncommon but well documented cause of myocardial infarction. Although rare, extramural hematoma compressing the coronary artery is another cause of myocardial infarction. At autopsy of 43 years old male who had no critical external wound, pericardial sac was distended and contained 400ml of dark red and clotted blood. Examination of the aorta revealed only minute atherosclerosis, intact aortic valve, and patent coronary ostia. 0.5cm sized aortic rupture was noted at the 3.5cm distal to the aortic valve. DeBakey type II aortic dissection was found to involve the ascending aorta and brachiocephalic trunk. Three intimal tears were 1.5cm, 8cm. 11.5cm distal to the aortic valve and two false lumens which had intact area between them extended 3.5cm distal to the third intimal tear and proximally in a retrograde fashion to the aortic root. Microscopically, sections of aorta showed relatively intact arrangement of smooth muscle and elastic fibers, except mild vascular ectasia and scattered several foci of the small sized aggregation of foamy histiocytes, and there was no evidence of cystic medial degeneration in aorta. Sections of both coronary arteries did not show mural dissection or atherosclerosis. Sections of right atrium and sinus node showed inflammatory reaction, extensive replacement of myocardium by active fibrous tissue consistent with infarction. There was no histologic evidence of myocardial infarction in the walls of other chambers or septum of the heart. We believe that extramural compression of the artery to sinus m\node by the dissecting hematoma was the cause of myocardial infarction involving the right atrium and the sinus node.
Adult
;
Aorta
;
Aortic Rupture
;
Aortic Valve
;
Arteries
;
Atherosclerosis
;
Autopsy
;
Brachiocephalic Trunk
;
Coronary Vessels
;
Dilatation, Pathologic
;
Elastic Tissue
;
Giant Cell Arteritis
;
Heart
;
Heart Atria
;
Hematoma
;
Hemodynamics*
;
Histiocytes
;
Humans
;
Hypertension
;
Hyperthyroidism
;
Infarction
;
Male
;
Marfan Syndrome
;
Muscle, Smooth
;
Myocardial Infarction*
;
Myocardium
;
Necrosis
;
Pregnancy
;
Sinoatrial Node
;
Thorax
;
Wounds and Injuries
3.Fibroadenoma with Formation of Epidermal Cyst: A case report.
Jong Jae JUNG ; Ji Shin LEE ; Seung HYUN
Korean Journal of Pathology 2000;34(7):537-539
Epidermal cyst in the fibroadenoma of the breast is very rare. A 29-year-old woman presented with a lump in the upper outer quadrant of the right breast. Clinically it was a fibroadenoma and the excisional specimen showed an encapsulated, firm lobulated lesion with a cystic area on cut surface. The cystic area showed squamous metaplasia of the ductal epithelium and keratinous cyst formation in the fibroadenoma. We report this unusual case with review of literatures.
Adult
;
Breast
;
Epidermal Cyst*
;
Epithelium
;
Female
;
Fibroadenoma*
;
Humans
;
Metaplasia
4.AN EXPERIMENTAL STUDY OF AURICULAR CARTILAGE FRAMEWORK FORMATION BY PERICHONDRAL GRAFT AND FLAP.
Jong Hoon LEE ; Kyeong Sook CHO ; Ji Young SONG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(2):284-292
Reconstruction of the auricle is one of the most fastidious fields in plastic and reconstructive facial surgery, because the ear is made up of complex cartilage framework arid its thin skin envelope. Insertion of carved rib cartilage is the most popular method for framework fabrication. But it has some disadvantages such as donor site morbidity, lesser flexibility of rib cartilage, difficulty in carving structure and distortion of cartilage after calving. Furthermore surgeon's talent and sufficient practice are necessary for a satisfactory result. So we introduced the concept of perichondral graft to improve the framework fabrication. In 1972 Skoog and associates reported that free perichondral grafts could be used to produce new cartilage. And several other reports supported the chondrogenesis of free perichondral graft. We molded the human ear using silicone rubbed impression material. And the eat mold was wrapped up in perichodrium of rabbit ear and placed in a subcutaneous pocket in formes of graft and flap. Six and eight weeks later, rabbits were sacrified and the newly formed cartilage framework was harvested. Grossly it showed the same appearance as the human eat and elastic property of normal cartilage. In histologic examination, it showed mature structure of normal cartilage; large lacunae containing spherical chondrocytes surrounded by well defined capsule.
Aptitude
;
Cartilage
;
Chondrocytes
;
Chondrogenesis
;
Ear
;
Ear Cartilage*
;
Fungi
;
Humans
;
Plastics
;
Pliability
;
Rabbits
;
Ribs
;
Silicones
;
Skin
;
Tissue Donors
;
Transplants*
5.A Case of Terra Firma-forme Dermatosis Treated with CO₂ Laser.
Ji Won YUN ; Kyung Ho LEE ; Chul Jong PARK
Korean Journal of Dermatology 2017;55(8):547-549
No abstract available.
Skin Diseases*
6.A Study on the Expression of p53 Oncogene Products, PCNA Index and DNA Ploidy in Renal Cell Carcinoma.
Jong Jae JUNG ; Ji Shin LEE ; Chan CHOI
Korean Journal of Pathology 1997;31(7):672-682
Mutant p53 is associated with the advanced stages of some human tumor but there is a wide variation in the reported incidence of p53 mutation in renal cell carcinoma and its prognostic significances. We designed this study to assess the expression of p53 in renal cell carcinomas and to compare with the established prognostic factors. Immunoreactivity for p53 protein and proliferating cell nuclear antigen (PCNA) were assessed in 44 cases of primary renal cell carcinoma, and flow cytometric analysis of DNA ploidy was perfon-ned in 37 of those cases. p53 protein was over-expressed in 16/44 (36.4%) renal cell carcinomas and 5 rumors had more than 10 immunoreactive tumor cells. The expression of p53 protein was positively related to nuclear grade (p=0.007) and PCNA index (p=0.002), but was independent of stage and DNA ploidy. In univariate survival analysis, stage (p<0.001), nuclear grade (p=0.017), DNA ploidy (p=0.045) and PCNA index (p<0.001) were significantly associated with patient survival. However, considering the stage, all of the last three factors had no prognostic influence. Cases showing strong positivity of p53 expression had worse prognosis than those with no or weak p53 expression, especially in early lesions (stage I,II) (p<0.001).
Carcinoma, Renal Cell*
;
DNA*
;
Humans
;
Incidence
;
Oncogene Proteins*
;
Oncogenes*
;
Ploidies*
;
Prognosis
;
Proliferating Cell Nuclear Antigen*
7.Pseudosarcomatous Metaplastic Carcinoma of the Breast with Extensive Cystic Change: A case report.
Ji Shin LEE ; Jong Jae JUNG ; Dong Sug KIM
Korean Journal of Pathology 2000;34(4):314-317
Metaplastic carcinomas (carcinomas with metaplasia) of the breast are difficult to accurately diagnose and classify because of their rarity and varied histologic patterns. Cystic change can be encountered in mammary carcinoma, especially in carcinoma with squamous metaplasia, but are rare in pseudosarcomatous metaplastic carcinoma. We recently experienced a case of pseduosarcomatous metaplastic carcinoma in a 69-year-old female who had an extensive cystic change in radiologic and histopathologic findings. The precise cell type that gives rise to metaplastic carcinomas remains uncertain. Immunohistochemical findings raised the possibility of the myoepithelial nature of the tumor.
Aged
;
Breast*
;
Female
;
Humans
;
Immunohistochemistry
;
Metaplasia
8.Tumor Angiogenesis in Renal Cell Carcinoma.
Ji Shin LEE ; Jong Jae JUNG ; Chang Soo PARK
Korean Journal of Pathology 1999;33(11):1055-1060
Angiogenesis is essential for the growth of solid tumors. Microvessel counts, which represent a measure of tumor angiogenesis, have been correlated with the overall survival of patients with a variety of malignancies. However, the significance of angiogenesis in renal cell carcinoma remains controversial. To determine whether angiogenesis correlates with prognosis of patients with renal cell carcinoma, we counted the microvessels within the primary tumors and compared their numbers with patients' prognosis. Tumor specimens from 42 patients were investigated. Microvessels were stained with anti-CD34 and anti-factor VIII-related antigen monoclonal antibodies. Significant correlation between microvessel counts for two antibodies was observed (r=0.875, p<0.01), although microvessel counts for CD34 were approximately two times higher. Microvessel counts were higher in clear cell than in non-clear cell carcinoma (p<0.05). These results suggest that immunostaining with anti-CD34 antibody may provide a more sensitive and accurate measure of tumor angiogenesis. There was no correlation between microvessel counts and nuclear grade, or TNM stage. In univariate analyses, nuclear grade and TNM stage were significantly associated with patient survival (p<0.01). But further studies on tumor angiogenesis of renal cell carcinoma are needed before it can be adopted as a prognostic marker.
Antibodies
;
Antibodies, Monoclonal
;
Carcinoma, Renal Cell*
;
Humans
;
Microvessels
;
Prognosis
;
von Willebrand Factor
9.Tumor Angiogenesis in Renal Cell Carcinoma.
Ji Shin LEE ; Jong Jae JUNG ; Chang Soo PARK
Korean Journal of Pathology 1999;33(11):1055-1060
Angiogenesis is essential for the growth of solid tumors. Microvessel counts, which represent a measure of tumor angiogenesis, have been correlated with the overall survival of patients with a variety of malignancies. However, the significance of angiogenesis in renal cell carcinoma remains controversial. To determine whether angiogenesis correlates with prognosis of patients with renal cell carcinoma, we counted the microvessels within the primary tumors and compared their numbers with patients' prognosis. Tumor specimens from 42 patients were investigated. Microvessels were stained with anti-CD34 and anti-factor VIII-related antigen monoclonal antibodies. Significant correlation between microvessel counts for two antibodies was observed (r=0.875, p<0.01), although microvessel counts for CD34 were approximately two times higher. Microvessel counts were higher in clear cell than in non-clear cell carcinoma (p<0.05). These results suggest that immunostaining with anti-CD34 antibody may provide a more sensitive and accurate measure of tumor angiogenesis. There was no correlation between microvessel counts and nuclear grade, or TNM stage. In univariate analyses, nuclear grade and TNM stage were significantly associated with patient survival (p<0.01). But further studies on tumor angiogenesis of renal cell carcinoma are needed before it can be adopted as a prognostic marker.
Antibodies
;
Antibodies, Monoclonal
;
Carcinoma, Renal Cell*
;
Humans
;
Microvessels
;
Prognosis
;
von Willebrand Factor
10.A Case of Human Immunodeficiency Virus Infection in Recurrent Herpes Zoster.
Ji Won KIM ; Jong Ho LEE ; Sook Kyung LEE ; Won Woo LEE
Korean Journal of Dermatology 1999;37(4):553-555
Herpes zoster is characterized by several groups of vesicles on an erythematous base situated unilaterally within the distribution of a single spinal or cranial sensory ganglion. Recurrent herpes zoster is rare and may be associated with severe immunocompromised state. Human immunodeficiency virus(HIV) infection is associated with an increased incidence of zoster, which tends to be severe, presumably due to HIV-induced depression of cellular immunity. We report a case of a 46-year-old female who was presented with recurrent herpes zoster and concurrent HIV infection.
Depression
;
Female
;
Ganglia, Sensory
;
Herpes Zoster*
;
HIV Infections
;
HIV*
;
Humans*
;
Immunity, Cellular
;
Incidence
;
Middle Aged