Manifest latent nystagmus (MLN) combined with esotropia may be confused with the nystagmus blockage syndrome (NBS), so the NBS may be overdiagnosed. The NBS is similar to MLN in the characteristics of the nystagmus and the clinical features, thus two diseases must be differentiated. In order to differentiate the MLN with esotropia from the NBS, accurate calibration of slow phase of nystagmus is essential with the aid of electro-oculography (EOG). With EOG recording, authors report a case of MLN associated with esotropia which may be misdiagnosed as the NBS.
Calibration ; Electrooculography ; Esotropia

PURPOSE: Bone marrow contains many kinds of primitive cells and endothelial progenitor cells that secrete several growth factors. We hypothesized that angiogenesis could be induced by autogenous whole bone marrow stem cell implantation in an animal ischemic limb. METHOD: A chronic ischemic hind limb model was created by encircling the femoral artery with an ameroid constrictor (2 mm inner diameter) in a dog model. About 20 ml of autogenous whole bone marrow stem cells were aspirated from the femur and then injected into ischemic limb muscles. Contralateral limbs injected with 20 ml of normal saline as controls. To assess angiogenic effects, an angiogram and a histologic evaluation were performed at 8 weeks after bone marrow stem cell implantation. RESULT: Imaging analysis of angiograms showed that newly developed capillaries were significantly more plentiful in treated limbs. Mean capillary density in the treated limb group was significantly greater than that in the control group (151+/-11.7 vs 81.5+/-7.2 cap/mm2, respectively, P<0.05), and the proportion of larger diameter (Fig. 6) newly developed capillaries was significantly higher in treated limbs than in control limbs. CONCLUSION: These findings indicated that autogenous whole bone marrow stem cell implantation increases the efficiency of angiogenesis.
Animals* ; Bone Marrow* ; Capillaries ; Dogs ; Extremities ; Femoral Artery ; Femur ; Intercellular Signaling Peptides and Proteins ; Models, Animal* ; Muscles ; Stem Cells*