No abstract available.
Drosophila* ; Phosphotransferases*

No Abstract Available.
Phosphotransferases* ; Receptors, Cell Surface* ; Tyrosine*

No abstract available.
Diabetic Nephropathies*

In pili torti, the affected Eair shaft is flattened and twisted through 180 degrees on its own axis. The involved hairs are dry, thin, brittle, and break off easily. Congenital pili torti may occur as an isolated phenomenon or may occur in association with other abnormalities. Acquired pili torti is usually associated with some sort of scarring process in the scalp itself. We present a case of congnital pili torti without any other abnormalities in a 14 year-old female. The pedigree of her fariiily was consistent with the inheritance of congenital pili torti as an autosomal dominant trait.
Adolescent ; Axis, Cervical Vertebra ; Cicatrix ; Female ; Hair ; Humans ; Pedigree ; Scalp ; Wills

258 feet of patients with flatfoot were evaluated in this paper. The incidence of flatfoot is about 0.6% of the general population. The longitudinal arch was depressed in all of our cases of flatfoot, and there have been many patients suffering from pain after some kinds of heavy work. But there were no definite correlations found between the depression of the longitudinal arch and clinical symptom. The sag in the naviculo cuneiform joint is the most common X-ray finding in this series (93%), followed by the talo-navicular sagging (27%), Degenerative arthritis of the inter-tarsal joints was frequently found after the adolescent period. The talo-navicular joint was involved in arthritic changes in 60% of the cases, the subtalar joint 46% and the naviculo-cuneiform joint 42%. The prevalence of these changes was not increasing with the increasing age, so it is poatulated that the degenerative changes begin early in adolescent period. Accessory tarsal bones were more frequently seen in patients with flatfoot than in normal population. and the neck of the talus was usually deviated inferomedially. Now that the arthriric changes are very prevalent in the triple joints, there are many cases of flatfoot that should undergo the triple arth odesis inevitably if his conservative treatment was failed.
Adolescent ; Depression ; Flatfoot ; Foot ; Humans ; Incidence ; Joints ; Neck ; Osteoarthritis ; Prevalence ; Subtalar Joint ; Talus ; Tarsal Bones

Open brochus with diffuse narrowing, stretching, and leafless tree appearance of the bronchi is the well know bronchographic criterior of bronchiloalveolar carcinoma. Though similar findings are expected in CT, authors couldfind no report concerninng the open bronchus sign of bronchioloalveolar carcinoma demonstrated by CT., Authorspresents CT of bronchioloalveolar carcinoma showing lobar or segmental distribution and patent bronchus within thetumor mass.
Adenocarcinoma, Bronchiolo-Alveolar ; Bronchi ; Trees

Lung cancer is the most common malignant tumor worldwide and its incidence continues to rise each year. Recent development of molecular biologic method has led to advances in determining the etiologic factors of lung cancer and the establishment of cell lines has provided a lot of information on the through chemosensitivity, radiation biology studies, cytogenetics, and molecular biologic studies, which permits improved treatment for lung cancer. We established a small cell lung cancer cell line, designated JePa-1, obtained from malignant pericardial effusion of small cell lung cancer patient and characterized its morphologic and molecular biologic features. the JePa-1 cell line grew relatively slowly (doubling time 45hrs) as very loosely adherent floating aggregates growing in small clumps with distinct cell outlines and intertwined cords. Also JePa-1 cell line secreted antidiuretic hormones. Electronmicroscopic examination revealed that JePa-1 cell line and xenografts contained electron dense core granules, characteristic of being of neuroendocrine origin. To investigate the tumorigenic capacity, the JePa-1 cell line was injected into SCID and nude mice. Tumors taken from xenografts were observed in 3 out of 4 of the SCID mice and 2 out of 4 of the nude mice. The histologic characteristics of the xenografts were similar to those of the cell line and the original cytologic finding of the pericardial fluid, suggesting small cell carcinoma. The results of immunohistochemical markers showed reactivity for Rb protein, c-myc, TGF-alpha, TGF-beta , EGFR, keratin, NSE, chromogranin, and EMA. The DNA ploidy and the index of the JePa-1 cells was tetraploid and 2.13, respectively. The positive rate for the Rb, c-myc and K-ras proteins of the JePa-1 cell line were 98.9%, 99.3%, and 99.7% respectively as determined by flow cytometry. Cytogenetic analysis using the G-banding technique showed 65 chromosomes with various numerical and structural abnormalities. On examination of the expression of TGF-alpha, TGF-beta , and EGFR by PCR, only the EGFR was positive Through the establishment of JePa-1 cell line, we report in this paper the characterization of a small cell lung cancer such as morphologic and immunocytochemical features, growth characteristics in culture, hormone production, expression of oncoprotein and several growth factors, tumorigenicity, chromosomal abnormalities, and DNA ploidy and index. The JePa-1 cell line will be valuable in vitro studies for the etiology, treatment and the prognostic factors in small cell lung cancer.
Animals ; Carcinoma, Small Cell ; Cell Line ; Chromosome Aberrations ; Cytogenetic Analysis ; Cytogenetics ; DNA ; Flow Cytometry ; Heterografts ; Humans ; Immunohistochemistry ; Incidence ; Intercellular Signaling Peptides and Proteins ; Lung Neoplasms ; Mice ; Mice, Nude ; Mice, SCID ; Pericardial Effusion ; Ploidies ; Polymerase Chain Reaction ; Radiobiology ; Retinoblastoma Protein ; Small Cell Lung Carcinoma* ; Tetraploidy ; Transforming Growth Factor alpha ; Transforming Growth Factor beta ; Vasopressins

As the result of a significant improvement in the economic situation and development of scientific techniques in Korea during the last 20 years, the life expectancy of Korea people has lengthened considerably and as a result the number of old aged people has markedly increased. Such an increase of the number of aged people brought about many problems. Authors would like to take a medical look at the “Problem of old aged people” presently facing us in Korea. Currently the number of people over 65 has increased rapidly and is 1,620,000, 4% of total population. But it is still much lower than 8.9% in Japan, 10.7% in U.S.A., and 14.9% in the United Kingdom. Over 25% of these aged people were found to have at least more than one disease which requires medical care. Diseases occur in the circulatory system, 30.9%, respiratory system, 17.1%, digestive system 8.6%, metal disorders, 8.4%, malignant neoplasms, 7.0%. About 51% of the aged over 65 are under medical security benefit, mostly with partial coverage plan. Their clinic visit rate was very low (2.0% in 1981), which might be due to financial reasons. Since diseases affecting the aged progress chronically, early detection and long term care are utter most important. However there is almost no special facility, long term care center or geriatric specialist. For proper management of medical problems in the growing population of the Korea elderly expansion of medical security coverage, greater number of specialized facilities, education of geriatric special manpower and efficient operating system should be established.
Aged ; Ambulatory Care ; Digestive System ; Education ; Great Britain ; Humans ; Japan ; Korea ; Life Expectancy ; Long-Term Care ; Respiratory System ; Specialization

No abstract available.

BACKGROUND: The integrins comprise a family of transmembrane glycoproteins which mediate cell-cell and cell-matr ix intera ctions, and the bcl-2 oncogene is involved in tumorigenesis by blocking apoptosis. Typical acquired melanocytic nevi appear to follow a life cycle characterized by active growth, maturation, and progressive involution. In contrast, congenital rnelanocytic nevi have a different course and prcgnosis with potential for development of melanoma, and metastatic spread is very common in malignant melanoma. Objective . We investigated the expression of integrins (a2,a3,a) and bcl-2 in congenital and acquired rnelanocytic nevi, and malignant, melanomas by immunohistochemical technique. Methods . Formalin-fixed and paraffin-embedded tissues from 7 compound nevi, 7 intradermal nevi, 5 congenital melanocytic nevi, and 5 malignant melanomas were immunolabeled with monoclonal antibodies directed against a2, a3,and a integrin, and bcl-2 protein. RESULTS: All acquired and congenital melanocytic nevi showed a uniform staining for a2, a3, a and bcl-2. In 3 compound nevi which the nevus cells lie mainly within the upper dermis, the nevus cells in the papillary dermis showed weak to negative a expression. Within neurotized are as of intradermal nevus, bcl-2 and a expression became weaker and totally absent. All 5 malig- nant melanomas exhibited strong a2, a3, a, and bcl-2 expression. However, the tumor cells in the lower advancing border failed to express a integrin in 3 of 5 malignant, melanomas. In most malignant melanomas, there was variable intensity of staining for bcl-2 in different areas of the tumor. Conclusion . These findings suggest that the integrins and bcl-2 may be involved in active growth, maturation, and progressive involution of the melanocytic nevi, and seem to be related to metastasis and tumorigenesis of the malignant melanoma.
Antibodies, Monoclonal ; Apoptosis ; Carcinogenesis ; Dermis ; Glycoproteins ; Humans ; Integrins* ; Life Cycle Stages ; Melanoma* ; Neoplasm Metastasis ; Nevus ; Nevus, Intradermal ; Nevus, Pigmented* ; Oncogenes