No abstract available.

No abstract available.
Diaphragm* ; Ultrasonography*

In the course of immunoscreening of Clonorchis sinensis cDNA library, a cDNA CsRP12 containing a tandem repeat was isolated. The cDNA CsRP12 encodes two putative peptides of open reading frames (ORFs) 1 and 2 (CsRP12-1 and -2). The repetitive region is composed of 15 repeats of 10 amino acids. Of the two putative peptides, CsRP12-1 was proline-rich and found to have homologues in several organisms. Recombinant proteins of the putative peptides were bacterially produced and purified by an affinity chromatography. Recombinant CsRP12-1 protein was recognized by sera of clonorchiasis patients and experimental rabbits, but recombinant CsRP12-2 was not. One of the putative peptide, CsRP12-1, is designated CsPRA, proline-rich antigen of C. sinensis. Both the C-termini of CsRP12-1 and -2 were bacterially produced and analysed to show no antigenicity. Recombinant CsPRA protein showed high sensitivity and specificity. In experimental rabbits, IgG antibodies to CsPRA was produced between 4 and 8 weeks after the infection and decreased thereafter over one year. These results indicate that CsPRA is equivalent to a natural protein and a useful antigenic protein for serodiagnosis of human clonorchiasis.
Amino Acid Sequence ; Animals ; Antigens, Helminth/*genetics/isolation & purification ; Base Sequence ; *Cloning, Molecular ; Clonorchis sinensis/genetics/*immunology ; DNA, Helminth ; Gene Library ; Human ; Molecular Sequence Data ; Rabbits ; Recombinant Proteins ; *Repetitive Sequences, Nucleic Acid ; Support, Non-U.S. Gov't

No abstract available.
Animals ; Macrophages, Peritoneal* ; Mice* ; Mycobacterium bovis*

A case of Porokeratosis (Mibelli) involved to the nail plate in 25 years old male was described, This is rare and the first case of Porokeratosis (mibelli) variety reported in Korea. The clinical and histopathological study revealed characteristic features of this disease. Author reviewed reports of the literature.
Adult ; Humans ; Korea ; Male ; Porokeratosis

A statistical study of soldiers who visited the outpatient ciepartment of the Capital Armed Forces General Fiospital from 1987 to 1989 was performed. The results were as follows : 1. The total number of outpatients was 9969 with peak clinic visits in June(11.2%) and the lowest number of clinic visits in February(6.4% ). 2. The most frequent age was 22 years(20.7% ). Soldiers between 19 and 24 years old comprised 68.1% of total patients. 3. By rank 69.3% of the outpatients were private', 16.0% sergeant and 14,4% officers. 4. The most common dermatoses were dermatophytosis, contact dermatitis, scabies, acne, seborrheic dermatosis, urticaria, alopecia, condyloma acuminatum, verruca, folliculitis, psoriasis, insect bite reactions, pityriasis rosea, herpes zoster and corns. 5. Frequent diseases, which occured during summer season, included dermatophytosis, contact dermatitis and inser,t bites. The incidence of scabies, pityriasis prsea was increased during winter and that of psoriasis was increased during spring.
Acne Vulgaris ; Alopecia ; Ambulatory Care ; Arm ; Callosities ; Dermatitis, Contact ; Folliculitis ; Herpes Zoster ; Humans ; Incidence ; Insect Bites and Stings ; Military Personnel* ; Outpatients ; Pityriasis ; Pityriasis Rosea ; Psoriasis ; Scabies ; Seasons ; Skin Diseases* ; Statistics as Topic* ; Tinea ; Urticaria ; Warts ; Young Adult ; Zea mays

No abstract available.

The first ray, including the hallux and first metatarsal, has historically been the most common location of congenital and functionally acquired deformities of the lower extremity. It has been the subject of extensive historical review and study as an untold number of authors and surgeons have directed their talents toward the comprehension and correction of the condition. But, few reports have been made on that subject in Korean population. So, we made a clinical and radilogical study of the hallux valgus angle (HVA), intermetatarsal angle (IMA) and hallux valgus in 200 Korean population. The results obtained were as follows: 1. The mean value of HVA was 14.8°±4.6° in male and 17.6°±5.4°in female. The mean value of HVA of the hallux valgus patient was 33° 2. The mesn value of IMA was 8.6°±1.9°in male and 10.2°±2.2°in female. The mean value of IMA of the hallux valgus patient was 14° 3. The incidence of hallux valgus was 11% in male, 37% in female and female was 77% of all hallux vslgus patient. 4. The family history of hallux valgus was found in 63% and 94% of patients has bilateral involvement. 5. The most common chief complaint was pain over the medial side of the first MP joint or base of the other metatarsal bone. Symptoms were not correlated with angle value. 6. In the first MP joint of hallux valgus by Piggott, the deviated joint was most common (52%). 7. In the three basic MP joint types by Haas, the round metatarsal head was most common. 8. DASA was ranged from 0°to 7°in normal persons and from 2°to 16°in hallux valgus patients. 9. PASA was ranged from 1°to 9°in normsl persons and from 3°to 35°in hallux valgus patient. 10. The tibial sesamoid displacement more than grade 4 by Haas rating system was found 63% of hallux valgus patients.
Aptitude ; Asian Continental Ancestry Group ; Comprehension ; Congenital Abnormalities ; Female ; Hallux Valgus ; Hallux ; Head ; Humans ; Incidence ; Joints ; Lower Extremity ; Male ; Metatarsal Bones ; Surgeons

BACKGROUND: Ambulatory blood pressure monitoring is widely available in clinical practice. To evaluate the pattern of normal 24 hour variation of blood pressure and the problems in analysis of data which was obtained with use of automatic blood pressure recorder, 24 hour ambulatory blood pressure was measured. METHODS: Ambulatory blood pressure was recorded for 24 hours with automatic blood pressure monitor in 22 normotensive young adolescents. RESULTS: 1) Average 24-hour BP was 109mmHg in systolic(115+/-30 for male, 102+/-30 for female), 66mmHg in diastolic(69+/-18 for male, 63+/-19 for female) and pulse rate was 72 beats per minute(70+/-23 for male, 75+/-26 for female). 2) Data obtained from ambulatory blood pressure monitor should be analyzed after deletion of unacceptable data with use of conventional criteria. Blood pressure increase which is not accompanied by increase in pulse rate increase can be used as another criteria to rule out unacceptable blood pressure data. 3) Blood pressure was low from mid-night to 6 A.M. and began to rise slowly till mid-day and then maintained steadily through the remainder of the day. And 24 hour variation of blood pressure was more adequately assessed after application of Fourier analysis. CONCLUSIONS: These results suggest that certain deletion criteria was inevitable during analysis of the data which were obtained from ambulatory blood pressure recorder and Fourier analysis can be used as valuable smoothing technique to assess the 24-hour blood pressure profiles.
Adolescent* ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory* ; Blood Pressure Monitors ; Fourier Analysis ; Heart Rate ; Humans ; Male

BACKGROUND: At the neuromuscular junction, pefloxacin (P) may exacerbate myasthenia gravis and reduce the tau of MEPC. So here we investigated the effect of P on the neuromuscular blocking action of rocuronium (R). METHODS: Hemidiaphragm-phrenic nerve preparations were obtained from male Sprague-Dawley rats (150-250 g). Preparations were bathed in Kreb's solution (in (mM): NaCl 118, KCl 5, CaCl2 2.5, NaHCO3 30, KH2PO4 1, MgCl2 1 and glucose 11), maintained at 32oC and then aerated with a mixture of 95% O2 and 5% CO2. Isometric forces generated in response to 0.1 Hz, and, 50 Hz for 19 seconds with supramaximal electrical stimulation(0.2 msec, rectangular) to the phrenic nerve, were measured with a force transducer. Single twitch tension (ST) and peak tetanic tension (PTT) were calculated as % reduction versus the control, and tetanic fade (TF), as a % increase. Each preparation was exposed to one of 4 P concentrations of Krebs' solution (0, 0.25, 0.5, 1.0 mM), and enough R solution was added to the tissue bath to achieve the desired R concentration. The effects of P and R were allowed to stabilize before measuring tension parameters. EC5, EC25, EC50, EC75, and EC95 of R for ST, PTT and TF were calculated using a probit model. The interactions between the two drugs were drawn with Berenbaum's additive isobole at 25% isobole, 50% isobole, and 75% isobole. Differences between EC50's of R according to P concentrations were tested by one way ANOVA with Tamhane for post hoc; P <0.05 was regarded as significant. RESULTS: The cumulative concentration-effect curves shifted to the right in ST, and to the left in TF as the concentration of P was increased. The interactions between these two drugs varied from additive to antagonistic according to the magnitude of relaxation effect, drug concentration, and the frequency of stimulation. CONCLUSIONS: P augmented the TF of R. Our results suggest that simultaneous 0.1 Hz and 50 Hz stimulations allow the neuromuscular blocking action of a drug to be correctly evaluated.
Animals ; Baths ; Drug Interactions ; Glucose ; Humans ; Magnesium Chloride ; Male ; Myasthenia Gravis ; Neuromuscular Blockade* ; Neuromuscular Junction ; Pefloxacin* ; Phrenic Nerve ; Rats* ; Rats, Sprague-Dawley ; Refractory Period, Electrophysiological ; Relaxation ; Transducers