OBJECTIVES: Psychoeducation is an important factor in the treatment of chronic mental illness that increases drug compliance, then prevents relapse of illness, and brings the patient a progress of social function and quality of life. The purpose of this study was to elucidate the effect of psychoeducation on relapse of schizophrenic patients. METHODS: Checklist including 33 items was applied to 97 schizophrenic patients that had been treated at Seoul National Mental Hospital. The subject was divided into two groups. The experimental group consisted of 47 cases that were not treated consistently more than 6 months in outpatient department and required at least 3 time hospital treatment. The control group consisted of 50 cases that were treated consistently in outpatient department at least 3 consecutive years. RESULTS: The experimental group had significant differences in terms of deficiency of insight such as denial of disease or relapse, subjective experience of drug side effect, whether or not taking drug and they had higher negative attitude to therapist. Many schizophrenic patients reported that they had not been educated thoroughly about disease, drug, and prognosis. 46.8% in experimental group and 46.0% in control group did not recognized necessity of psychoeducation. CONCLUSION: This study suggested that we need the necessity of psychoeducation in terms of the relationship between the relapse of illness and psychoeducation. However, considering that we did not have an extensive study about psychoeducation and compliance, we need more improved study.
Checklist ; Compliance ; Denial (Psychology) ; Hospitals, Psychiatric ; Humans ; Outpatients ; Prognosis ; Quality of Life ; Recurrence* ; Schizophrenia ; Seoul

No abstract available.
Animals ; Macrophages, Peritoneal* ; Mice* ; Mycobacterium bovis*

One of the complication during or after subclavian vein cannulation is intravascular catheter or wire embolization. Although some studies have reported safety of retaining foreign body embolization, and even death. The intravascular foreign body can be removed surgically or non-surgically. With improvement in instrument technology and technique, percutaneous retrieval of intravascular foreign bodies has become a relatively common procedure. Commonly used methods to remove intravascular foreign bodies are loop snare and basket technique. Sometimes biopy forcep can be used. We have experienced 2 cases of non-surgical removal of intravascular foreign bodies. One of the foreign bodies was 7cm wire fragment in right atrium(RA), the other was a 50cm guide wire. We used the standard loop snare technique for removal of 7cm wire fragment in RA and stone removal basket and 3.0mm ACS PTCA balloon to remove the 50cm short guide wire.
Catheterization ; Catheters ; Foreign Bodies* ; SNARE Proteins ; Subclavian Vein ; Surgical Instruments

No abstract available.
Diabetes Insipidus, Nephrogenic* ; Urinary Tract Infections ; Vesico-Ureteral Reflux*

PURPOSE: The perioperative and long-term outcomes of patients with vesicoureteral reflux (VUR) treated by cross-trigonal ureteroneocystostomy (Cohen's reimplantaion) over the last 18 years were ascertained. MATERIALS AND METHODS: 182 patients (322 renal units), who underwent Cohen's reimplantaion between January 1987 and February 2004, were retrospectively examined. The VUR grades were III in 38, IV in 214 and V in 70 renal units. The patients were followed up with postoperative voiding cystourethrography and intravenous pyelography for a mean 54.3, ranging from 3 to 176 months. RESULTS: The operation was successful in 316 of the 322 renal units (98.1%). The correction rates, according to the reflux grade, were 100, 98.6 and 95.7% for grades III to V, respectively. The correction rates, according to the period, were 98 and 98.4% before and after 1995, respectively. The correction rates, according to age, were 98.1 and 98.2% for below and above 2-years-old, respectively. The mean hospital stay was 8.4 days (6-21). Postoperative complications were observed in 11 patients, including persistent pyuria, persistent ipsilateral reflux, new contralateral reflux, paralytic ileus and acute pyelonephritis. Only 1 of these 11 patient required re-operation, while the remaining 10 were resolved during further follow up. CONCLUSIONS: A Cohen's reimplantation offers very good long-term results in curing VUR. This technique is a safe and effective method for ureteral reimplantation in patient with VUR, as it shows a relatively high success and low complication rates.
Follow-Up Studies ; Humans ; Intestinal Pseudo-Obstruction ; Length of Stay ; Postoperative Complications ; Pyelonephritis ; Pyuria ; Replantation* ; Retrospective Studies ; Ureter ; Urography ; Vesico-Ureteral Reflux*

No abstract available.
Diagnosis* ; Hirschsprung Disease* ; Manometry*

No abstract available.
Cystadenoma, Mucinous* ; Mucins* ; Pancreas*

Although an immune response to bacillus Calmette Guerin (BCG) has often been associated with antitumor activity, the action mechanism(s) of intravesical BCG therapy for prophylaxis and treatment of superficial bladder cancer is not clearly understood. In an attempt to evaluate the roles of tumor necrosis factor (TNF)-alpha and lymphotoxin (LT) in the antitumor activity, TNF-alpha productivities by peripheral blood monocytes, serum levels of TNF-alpha, and LT productivities by peripheral blood lymphocytes were studied in superficial bladder cancer patients after six intravesical administrations of BCG. TNF-alpha productivities by peritoneal macrophages of guinea pigs were also studied after six intravesical administrations of BCG. The maximum TNF-alpha productivities by peripheral blood monocytes of superficial bladder cancer patients were seen after the fourth week of administration of BCG, and the serum TNF-alpha levels were also slightly increased after intravesical BCG administration in the superficial bladder cancer patients. LT productivities by peripheral blood lymphocytes of superficial bladder cancer patients were significantly enhanced and the maximum LT productivity was also seen after the third or fifth BCG administration. TNF-alpha productivities by peritoneal macrophages of guinea pigs were significantly enhanced and the maximum TNF-alpha productivity was seen after the second or third BCG administration. Our data might suggest that six consecutive intravesical BCG administrations could induce the increased productions of TNF-alpha and LT, which might play an important role in the antitumor activity in superficial bladder cancer.Although an immune response to bacillus Calmette Guerin (BCG) has often been associated with antitumor activity, the action mechanism(s) of intravesical BCG therapy for prophylaxis and treatment of superficial bladder cancer is not clearly understood. In an attempt to evaluate the roles of tumor necrosis factor (TNF)-alpha and lymphotoxin (LT) in the antitumor activity, TNF-alpha productivities by peripheral blood monocytes, serum levels of TNF-alpha, and LT productivities by peripheral blood lymphocytes were studied in superficial bladder cancer patients after six intravesical administrations of BCG. TNF-alpha productivities by peritoneal macrophages of guinea pigs were also studied after six intravesical administrations of BCG. The maximum TNF-alpha productivities by peripheral blood monocytes of superficial bladder cancer patients were seen after the fourth week of administration of BCG, and the serum TNF-alpha levels were also slightly increased after intravesical BCG administration in the superficial bladder cancer patients. LT productivities by peripheral blood lymphocytes of superficial bladder cancer patients were significantly enhanced and the maximum LT productivity was also seen after the third or fifth BCG administration. TNF-alpha productivities by peritoneal macrophages of guinea pigs were significantly enhanced and the maximum TNF-alpha productivity was seen after the second or third BCG administration. Our data might suggest that six consecutive intravesical BCG administrations could induce the increased productions of TNF-alpha and LT, which might play an important role in the antitumor activity in superficial bladder cancer.
Administration, Intravesical ; Animal ; Bladder Neoplasms/*metabolism/*therapy ; Female ; Guinea Pigs ; Human ; Mycobacterium bovis/*physiology ; Prospective Studies ; Support, Non-U.S. Gov't ; Tumor Necrosis Factor/*biosynthesis

We performed microscopic sperm aspiration and IVF in 2 cases of distal vas obstruction. 4 cases or epididymal obstruction, 3 cases of congenital vas aplasia. The results were as follows ; 1. The fertilization was successful in 2 cases of distal vas obstruction(100%). 1 case of epididymal obstruction(25%). 1 case of congenital vas. aplasia(33.3%). 2. In 4 cases with Sertoli cell failure. the count and quality of aspirated sperm was lower than in 5 cases with normal hormonal study. The fertilization was successful in 1 case with Sertoli cell failure(25%) and 3 cases with normal hormonal study(60%). In conclusion. microscopic sperm aspiration and IVF proved helpful in treatment of patients with distal vas obstructin, congenital vas aplasia. but the vasoepididymostomy proved more helpful in treatment of patients with epididymal obstruction then microscopic sperm aspiration and IVF until now. When microscopic sperm aspiration and IVF is performed, it seems that in Sertoli cell failure group. there will be lesser fertilization success cases than in normal hormonal study group.
Azoospermia* ; Fertilization ; Fertilization in Vitro* ; Humans ; Sperm Retrieval* ; Spermatozoa*

PURPOSE: The purpose of this study is to investigate the correlations of various kinetic parameters derived from the time intensity curve in a xenograft mouse model injected with a prostate cancer model (PC-3 and LNCaP) using an ultrasound contrast agent with histopathologic parameters. MATERIALS AND METHODS: Twenty nude mice were injected with human prostate cancer cells (15 PC-3 and five LNCaP) on their hind limbs. A bolus of 500 microL (1 x 10(8) microbubbles) of second-generation US contrast agent (SonoVue) was injected into the retroorbital vein. The region of interest was drawn over the entire tumor. The time intensity curve was acquired and then fitted to a gamma variate function. The maximal intensity (A), time to peak (Tp), maximal wash-in rate (washin), washout rate (washout), area under the curve up to 50 sec (AUC50), area under the ascending slope (AUC(in)), and area under the descending slope (AUC(out)) were derived from the parameters of the gamma variate fit. Immunohistochemical staining for VEGF and CD31 was performed. Tumor volume, the area percentage of VEGF stained in a field, and the count of CD31 (microvessel density, MVD) positive vessels showed correlation with the parameters from the time intensity curve. RESULTS: No significant differences were observed between the kinetic and histopathological parameters from each group. MVD showed positive correlation with A (r=0.625, p=0.003), washin (r=0.462, p=0.040), AUC50 (r=0.604, p=0.005), and AUC(out) (r=0.587, p=0.007). Positive correlations were also observed between tumor volume and AUC50 (r=0.481, p=0.032), washin (r=0.662, p=0.001), and AUC(out) (r=0.547, p=0.012). Washout showed negative correlations with MVD (r=-0.454, p=0.044) and tumor volume (r=-0.464, p=0.039). The area percentage of VEGF did not show any correlation with calculated data from the curve. CONCLUSION: MVD showed correlations with several of the kinetic parameters. CE-US has the potential for prediction of tumor vascularity in a prostate cancer animal model.
Animals ; Extremities ; Humans ; Mice ; Mice, Nude ; Models, Animal ; Prostate ; Prostatic Neoplasms ; Transplantation, Heterologous ; Tumor Burden ; Vascular Endothelial Growth Factor A ; Veins