There are substantial evidence suggesting that DNA content of tumors may provide the prognostic information with independent significances. With the advent of computer and video technology, image analysis becomes a practical method of measuring DNA that also makes it possible to classify cells. Among the patients who were operated and diagnosed as bone tumor at Department of Orthopedic Surgery, Korea University Hospital, from March 1992 to March 1995, we evaluated 19 cases by image cytometry and studied them. Among 19 case, 4 cases were fibrous dysplasia, 2 cases chondroma, 3 cases osteosarcoma, 2 cases chondrosarcoma, and 8 cases were metastatic bone tumors. Total benign tumors were 6 cases and malignant tumors were 13 cases. All benign tumors were diploid and all malignant tumors but one metastatic tumor were aneuploid. As a result, DNA quantitation by image analysis is effective in the differential diagnosis of malignancy in bone tumor. It seems that DNA quantitation will be used on the evaluation of tumor staging and prognosis by further clinical study.
Aneuploidy ; Chondroma ; Chondrosarcoma ; Clinical Study ; Diagnosis, Differential ; Diploidy ; DNA ; Humans ; Image Cytometry ; Korea ; Methods ; Neoplasm Staging ; Orthopedics ; Osteosarcoma ; Prognosis

BACKGROUND AND OBJECTIVES: The frontal recess is the drainage pathway for the frontal sinus and its boundaries are formed by adjacent structures: they include agger nasi (anterior wall), medial orbital wall (lateral wall), ethmoid bulla/agger nasi (lateral wall), ground lamella (posterior wall), and anterior ethmoid air cells (posterosuperior). It is known that the drainage of the frontal recess is influenced by anatomic variants (agger nasi cell, frontal cells, supraorbital cell, intersinus septal cell, and attachment type of uncinate process). Because of its complex anatomy, the frontal sinus has been a difficult area in which to obtain consistently good long-term surgical results. SUBJECTIVES AND METHOD: To show the prevalence of anatomic variants and the relationship between the variants and frontal sinusitis, we analyzed the coronal and axial computed tomography of 225 patients, and 450 side sinuses (from 2001-6-1 to 2002-12-31). RESULTS: Frontal cells are observed in 176 cases (40.1%), agger nasi cell in 380 cases (84.8%), supraorbital cell in 17 cases (3.8%), and intersinus septal cell in 19 cases (11%). In the attachment type of the uncinate process, the lamellar type was seen in 272 cases (60.2%), the skull base type in 171 cases (26%), and the middle turbinate type in 62 cases (13.8%). The frontal sinusitis were seen in 8 cases (88.9%) among the type IV frontal cell group (9 cases) and in 149 cases (39.1%) among the agger nasi group. CONCLUSION: Relatively higher prevalence of anatomic variants was seen. The type IV frontal cells and agger nasi cells were significantly related to the frontal sinusitis.
Drainage ; Frontal Sinus* ; Frontal Sinusitis* ; Humans ; Orbit ; Prevalence ; Sinusitis ; Skull Base ; Turbinates

Thyroid papillary cancer is the most common type of thyroid cancer and the incidence rate is 70-80% of entire thyroid cancer. 10-year survival rate is more than 90%. It is mostly irregular marginated- hard mass but, may have cystic property. The most common clinical symptom is silent neck mass, but rapid growth or local invasion may develope the symptoms such as pain, hoarseness, dysphagia, hemoptysis and dyspena. With the 10% of invasion rate, it spreads to adjacent muscle, recurrent laryngeal nerve, pharynx, larynx, trachea, esophagus and spinal cord. We report a case of acute airway obstruction due to intracystic hemorrhage of thyroid papillary cancer which invades the retropharynx.
Airway Obstruction* ; Deglutition Disorders ; Esophagus ; Hematoma ; Hemoptysis ; Hemorrhage* ; Hoarseness ; Incidence ; Larynx ; Neck ; Pharynx ; Recurrent Laryngeal Nerve ; Spinal Cord ; Survival Rate ; Thyroid Gland* ; Thyroid Neoplasms ; Trachea

Sinusitis is a common problem that is routinely diagnosed and treated by most primary care physicians. Although most cases usually respond to appropriate therapy, some occasionally progress to the development of intracranial complications, including meningitis, osteomyelitis, epidural and subdural empyema, intracranial mucocele or polyps, and frank brain abscess. It is important to develop a rational approach to the diagnosis and treatment of these conditions. Intracranial complications are pathologically caused by direct extension of the disease through the bony defect or hematogenous spread. Radiologic evaluation must include computerized tomography for accurate diagnosis and surgical planning. Therapy includes surgical drainage and high doses of intravenous antibiotics. Recently we have experienced one subdural abscess secondary to acute sinusitis.
Abscess ; Anti-Bacterial Agents ; Brain Abscess ; Diagnosis ; Drainage ; Empyema, Subdural ; Humans ; Meningitis ; Mucocele ; Osteomyelitis ; Physicians, Primary Care ; Polyps ; Sinusitis

Sinogenic intracranial complications are rare but serious conditions. Sometimes, the diagnosis is delayed because the initial symptoms of sphenoid sinuses intracranial complications are not remarkable especially when they are of sphenoid sinus origin. Deep location of the sphenoid sinuses places them adjacent to the dura mater, major intracranial vessels, and some cranial nerves. Therefore, delayed diagnosis of the sphenoid sinusitis and its complications can make disastrous results. We experienced a 55 year old female patient who developed fulminant meningitis, vasculitis, and a stroke due to vasculitis as a complication of sphenoid sinusitis. We review the case and related articles.
Cranial Nerves ; Delayed Diagnosis ; Diagnosis ; Dura Mater ; Female ; Humans ; Meningitis ; Middle Aged ; Sphenoid Sinus* ; Sphenoid Sinusitis* ; Stroke* ; Vasculitis*

OBJECTIVES: To investigate the nature of emotional responsiveness in normal adults, we exam the emotional responses to emotional pictures in an evaluative space defined by arousal and valence. METHODS: Subjects were instructed to rate the arousal and valence that they experienced from the presentation of one of two sets of 60 emotional pictures. These two picture sets were comprised of 107 pictures: 101 selected from International Affective Pictures System and six pictures from our own collection. According to "evaluative space model", the authors set an evaluative space defined by the arousal scores as independent variable and the valence scores as dependent variable. In this evaluative space, one-hundred-and-seven pairs of coordinates representing respective emotional pictures were plotted. With regression analyses, the steepness of the regression lines on the plots with positive emotional responsiveness (n=51) and those with negative emotional responsiveness (n=56) were compared. RESULTS: In the evaluative space, the regression line of negative emotional responsiveness was significantly different from that of positive responsiveness. The slope of negative responsiviveness was significantly steeper than that of positive responsiveness. At a low arousal level, the absolute valence of a positive stimuli was larger than that of a negative picture. CONCLUSION: This finding indicates that the function of the negative affective responsiveness might be different from that of the positive responsitiveness. IAPS also seems applicable to Korean subjects.
Adult ; Arousal ; Humans

Pleomorphic adenoma is most frequently seen in the major salivary glands. Pleomorphic adenoma in minor salivary gland is relatively rare and can be found in palate, lip, buccal mucosa, tongue, oropharynx, nasal cavity, paranasal sinus, parapharynx as well as in the nasopharynx. Pleomorphic adenoma of nasopharynx is very rare, and only a few cases were reported both in neonates (congenital type) and adults (acquired type). We report the adult case of nasopharyngeal pleomorphic adenoma (Eustachian tube origin) with a review of literature.
Adenoma, Pleomorphic* ; Adult ; Eustachian Tube ; Humans ; Infant, Newborn ; Lip ; Mouth Mucosa ; Nasal Cavity ; Nasopharynx* ; Oropharynx ; Palate ; Salivary Glands ; Salivary Glands, Minor ; Tongue

Laryngeal amyloidosis is a rare disease that was first documented in 1875. The incidence of the larynx limited amyloidosis is less than 1% of all benign lesions of larynx. It may occur as primary or secondary to other diseases. Generalized secondary amyloidosis is very rare among them. It is a condition characterized by the extracellular deposition of homogenous, eosinophilic, proteinous material in the form of fibrils. The aim of treatment is to maintatin or improve voice quality and to maintain laryngeal airway. We report a case of laryngeal amyloidosis of AL (amyloid light chain) type that was treated with KTP laser (potassium titany phosphate laser).
Incidence

Psoriasiform lesion is rare in secondary syphilis. We report a case of psoriasiform syphilid in a 36-year-old man, who showed condyloma lata on the perianal area and multiple erythematous scaly plaques on the face, glans penis, scrotum, and both palms and soles. He had sexual contact with prostitute about 3 months ago. The differential diagnosis included papulosquamous diseases, especially psoriasis but a psoriasiform syphilid was confirmed through skin biopsies and serologic tests. The patient was treated with benzathine penicillin G 2.4 million units intramuscularly weekly for 3 weeks. After the treatment with benzathine penicillin G, the skin lesions disappeared completely.
Adult ; Biopsy ; Diagnosis, Differential ; Humans ; Male ; Penicillin G Benzathine ; Penis ; Psoriasis ; Scrotum ; Serologic Tests ; Sex Workers ; Skin ; Syphilis ; Syphilis, Cutaneous*

BACKGROUND: Early detection of metabolic syndrome (MS) is important to prevent complications. Yet, there is no internationally agreed definition for MS. This study was performed to compare the diagnostic criteria of MS using various definitions and agreements, and to find better definition for screening high risk group of coronary heart disease. METHODS: The participants were 426 men above forty years old who had visited to have health screening in a general hospital in Daegu from March to December in 2007. The diagnostic criteria of MS and Kappa statistic were calculated according to the following five diagnostic definitions; modified World Health Organization (WHO), National Cholesterol Education Program Third Adult Treatment Panel (NCEP-ATP III), International Diabetes Federation (IDF), American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI) and NCEP-ATP III modified waist circumference > or = 90 cm (modified NCEP-ATP III). The sensitivity and specificity of each definition of MS were calculated with respect to high risk group by Framingham risk score (FRS). RESULTS: The diagnostic criteria of MS were 6.6% by IDF, 7.7% by WHO, 10.6% by NCEP-ATP III, 18.1% by modified NCEP-ATP III and 22.3% by AHA/NHLBI. The kappa satistic ranged from 0.30 to 0.87. The sensitivity of each definition with respect to FRS was 8.3% in IDF, 13.4% in WHO, 15.3% in NCEP-ATP III, 27.4% in modified NCEP-ATP III and 32.5% in AHA/NHLBI. CONCLUSION: There was great difference in the diagnostic criteria of MS according to diagnostic definitions. The author suggests that AHA/NHLBI or modified NCEP-ATP III definition may be better for screening high risk group of coronary heart disease than others.
Adult ; Cholesterol ; Coronary Disease ; Heart ; Hospitals, General ; Humans ; Lung ; Male ; Mass Screening ; Sensitivity and Specificity ; Waist Circumference ; World Health Organization