1.Successful Treatment with Empirical Erlotinib in a Patient with Respiratory Failure Caused by Extensive Lung Adenocarcinoma.
Suk Hyeon JEONG ; Sang Won UM ; Hyun LEE ; Kyeongman JEON ; Kyung Jong LEE ; Gee Young SUH ; Man Pyo CHUNG ; Hojoong KIM ; O Jung KWON ; Yoon La CHOI
Korean Journal of Critical Care Medicine 2016;31(1):44-48
We herein describe a 70-year-old woman who presented with respiratory failure due to extensive lung adenocarcinoma. Despite advanced disease, care in the intensive care unit with ventilator support was performed because she was a newly diagnosed patient and was considered to have the potential to recover after cancer treatment. Because prompt control of the cancer was needed to treat the respiratory failure, empirical treatment with an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor was initiated before confirmation of EGFR-mutant adenocarcinoma, and the patient was successfully treated. Later, EGFR-mutant adenocarcinoma was confirmed.
Adenocarcinoma*
;
Aged
;
Female
;
Humans
;
Intensive Care Units
;
Lung*
;
Protein-Tyrosine Kinases
;
Receptor, Epidermal Growth Factor
;
Respiration, Artificial
;
Respiratory Insufficiency*
;
Ventilators, Mechanical
;
Erlotinib Hydrochloride
2.Microleakage of resilon: Effects of several self-etching primer.
Jong Hyeon O ; Se Hee PARK ; Hye Jin SHIN ; Kyung Mo CHO ; Jin Woo KIM
Journal of Korean Academy of Conservative Dentistry 2008;33(2):133-140
The purpose of this study was to compare the apical microleakage in root canal filled with Resilon by several self-etching primers and methacrylate-based root canal sealer. Seventy single-rooted human teeth were used in this study. The canals were instrumented by a crown-down manner with Gate-Glidden drills and .04 Taper Profile to ISO #40. The teeth were randomly divided into four experimental groups of 15 teeth each according to root canal filling material and self-etching primers and two control groups (positive and negative) of 5 teeth each as follows: group 1 - gutta percha and AH26(R) sealer; group 2 - Resilon, RealSeal(TM) primer and RealSeal(TM) sealer; group 3 - Resilon, Clearfil SE Bond(R) primer and RealSeal(TM) sealer group 4 - Resilon, AdheSe(R) primer and RealSeal(TM) sealer. Apical leakage was measured by a maximum length of linear dye penetration of roots sectioned longitudinally by diamond disk. Statistical analysis was performed using the One-way ANOVA followed by Scheffe's test. There were no statistical differences in the mean apical dye penetration among the groups 2, 3 and 4 of self-etching primers. And group 1, 2 and 3 had also no statistical difference in apical dye penetration. But, there was statistical difference between group 1 and 4 (p < 0.05). The group 1 showed the least dye penetration. According to the results of this study, Resilon with self-etching primer was not sealed root canal better than gutta precha with AH26(R) at sealing root canals. And there was no significant difference in apical leakage among the three self-etching primers.
Dental Pulp Cavity
;
Diamond
;
Gutta-Percha
;
Humans
;
Mandrillus
;
Tooth
3.Cases of Transarterial embolization in Arteriovenous Malformation of Uterus.
Jong Won LEE ; Hyeon Chul KIM ; Sung Woon CHANG ; Suk Ho KANG ; Young Ran O ; Hyun Ha SEOK ; Jin Hui KANG ; Min Jung BAEK
Korean Journal of Obstetrics and Gynecology 2005;48(10):2468-2473
Uterine arteriovenous malformations are very rare but potentially life-threatening lesions. These lesions may be congenital or acquired, but especially in patients with a history of infection, curettage, abortion, pelvic surgery or cancer. Ultimate treatment depends on the patients desire for fertility. Embolization therapy is effective method in reproductive age patients of. We have experienced two clinical cases of arteriovenous malformation of uterus, which is presented with a brief review of literature.
Arteriovenous Malformations*
;
Curettage
;
Fertility
;
Humans
;
Uterus*
4.Successful Treatment with Empirical Erlotinib in a Patient with Respiratory Failure Caused by Extensive Lung Adenocarcinoma
Suk Hyeon JEONG ; Sang Won UM ; Hyun LEE ; Kyeongman JEON ; Kyung Jong LEE ; Gee Young SUH ; Man Pyo CHUNG ; Hojoong KIM ; O Jung KWON ; Yoon La CHOI
The Korean Journal of Critical Care Medicine 2016;31(1):44-48
We herein describe a 70-year-old woman who presented with respiratory failure due to extensive lung adenocarcinoma. Despite advanced disease, care in the intensive care unit with ventilator support was performed because she was a newly diagnosed patient and was considered to have the potential to recover after cancer treatment. Because prompt control of the cancer was needed to treat the respiratory failure, empirical treatment with an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor was initiated before confirmation of EGFR-mutant adenocarcinoma, and the patient was successfully treated. Later, EGFR-mutant adenocarcinoma was confirmed.
Adenocarcinoma
;
Aged
;
Female
;
Humans
;
Intensive Care Units
;
Lung
;
Protein-Tyrosine Kinases
;
Receptor, Epidermal Growth Factor
;
Respiration, Artificial
;
Respiratory Insufficiency
;
Ventilators, Mechanical
;
Erlotinib Hydrochloride
5.The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study
Hyeji KWON ; Song Hwa CHAE ; Hyo Jin JUNG ; Hyeon Min SHIN ; O-Hyun BAN ; Jungwoo YANG ; Jung Ha KIM ; Ji Eun JEONG ; Hae Myung JEON ; Yong Won KANG ; Chan Kum PARK ; Daeyoun DAVID WON ; Jong Kyun LEE
Annals of Surgical Treatment and Research 2021;101(5):281-290
Purpose:
Microbiota manipulation through selected probiotics may be a promising tool to prevent cancer development as well as onset, to improve clinical efficacy for cancer treatments. The purpose of this study was to evaluate change in microbiota composition after-probiotics supplementation and assessed the efficacy of probiotics in improving quality of life (QOL) in postoperative cancer patients.
Methods:
Stool samples were collected from 30 cancer patients from February to October 2020 before (group I) and after (group II) 8 weeks of probiotics supplementation. We performed 16S ribosomal RNA gene sequencing to evaluate differences in gut microbiota between groups by comparing gut microbiota diversity, overall composition, and taxonomic signature abundance. The health-related QOL was evaluated through the EORTC Quality of life Questionnaire Core 30 questionnaire.
Results:
Statistically significant differences were noted in group II; increase of Shannon and Simpson index (P = 0.004 and P = 0.001), decrease of Bacteroidetes and Fusobacteria at the phylum level (P = 0.032 and P = 0.014, retrospectively), increased of beneficial bacteria such as Weissella (0.096% vs. 0.361%, P < 0.004), Lactococcus (0.023% vs. 0.16%, P < 0.001), and Catenibacterium (0.0% vs. 0.005%, P < 0.042) at the genus level. There was a significant improvement in sleep disturbance (P = 0.039) in group II.
Conclusion
Gut microbiota in cancer patients can be manipulated by specific probiotic strains, result in an altered microbiota. Microbiota modulation by probiotics can be considered as part of a supplement that helps to increase gut microbiota diversity and improve QOL in cancer patients after surgery.