PURPOSE: As well as patient survival, the restoration of postoperative function such as ambulation is important in limb salvage operations for treatment of malignant bone tumors involving the proximal femur. The authors analyzed clinical outcomes of limb salvage operations using tumor prostheses for metastatic or primary malignant bone tumors in the proximal femur. MATERIALS AND METHODS: From February 2005 to January 2014, 20 cases (19 patients) with malignant bone tumor involving the proximal femur with pain or complicated pathologic fracture were treated with segmental resection and limb salvage operations with tumor prostheses. Mean age was 63.1 years (range 35-86). Fourteen patients were male and six ones were female. The mean follow-up period was 20 months (1-94 months). There were 15 cases of metastatic bone tumor, 4 cases of osteosarcoma, and 1 case of multiple myeloma. The primary tumors of the metastatic bone tumors included 4 lung cancers, 3 hepatocellular carcinomas, and 3 renal cell carcinomas. Other primary tumors were breast cancer, thyroid cancer, colon cancer, prostate cancer, and malignant spindle cell tumor, each in 1 case. Modular tumor prostheses were used in all cases; (Kotz's(R) Modular Tumor prosthesis (Howmedica, Rutherford, New Jersey) in 3 cases, MUTARS(R) proximal femur system (Implantcast, Munster, Germany) in 17 cases). Perioperative pain was assessed with Visual Analogue Scales (VAS). Postoperative functional outcome was assessed with Musculoskeletal Tumor Society (MSTS) grading system. RESULTS: Out of 20 cases (19 patients), 11 cases (10 patients) survived at the last follow-up. Average postoperative survival of the 9 deceased patients was 10.1 months (1-38 months). VAS score improved from pre-operative average of 8.40 (5-10) to 1.35 (0-3) after operation. Average postoperative MSTS function score was 19.65 (65.50%, 7-28). The associated complications were 2 local recurrences, 3 hematomas, 3 infections, 2 scrotal swellings, and 1 dislocation. There was no case of periprosthetic fracture or loosening. CONCLUSION: Limb salvage operation with tumor prosthesis is an appropriate treatment for early pain reduction and functional restoration in malignant bone tumors in the proximal femur with pain an/or complicated pathologic fractures.
Breast Neoplasms ; Carcinoma, Hepatocellular ; Carcinoma, Renal Cell ; Colonic Neoplasms ; Dislocations ; Female ; Femur* ; Follow-Up Studies ; Fractures, Spontaneous ; Hematoma ; Humans ; Limb Salvage* ; Lung Neoplasms ; Male ; Multiple Myeloma ; Osteosarcoma ; Periprosthetic Fractures ; Prostatic Neoplasms ; Prostheses and Implants* ; Recurrence ; Thyroid Neoplasms ; Walking ; Weights and Measures

Fetal bilateral renal agenesis is a lethal congenital anomaly. An early and reliable prenatal diagnosis is extremely important as it may offer options for pregnancy termination as early as possible. The criteria for the ultrasonographic diagnosis of bilateral renal agenesis are severe oligohydramnios, nonvisualization of the bladder, and the empty renal fossa. However, severe oligohydramnios makes it difficult to diagnose the disease because of poor sonographic resolution. We present two cases of bilateral renal agenesis, one is diagnosed by ultrasonography after amnioinfusion at 24 weeks gestation, the other is diagnosed postnatally after term delivery.
Diagnosis ; Female ; Oligohydramnios ; Pregnancy ; Prenatal Diagnosis ; Ultrasonography ; Urinary Bladder

Absorption ; Adult ; Animals ; Bicuspid ; Blood Platelets ; Bone Density ; Bone Development ; Centrifugation ; Dogs ; Humans ; Intercellular Signaling Peptides and Proteins ; Osteogenesis ; Peri-Implantitis ; Platelet-Rich Plasma ; Transforming Growth Factor beta ; Transplants

Recently, much attention has been paid to the gut mucosal oxygenation in shock resuscitation, because many studies has been reported that the ultimate etiologies of death due to shock are mainly due to multiple organ failure caused by translocation of endotoxins and microorganisms from the ischemic gut mucosa. As there has been persistent controvesies over the relative merits of various kinds of resuscitation fluids in regard to the tissue oxygenation during management of shock, we studied the effects of various kinds of resuscitation fluids on the gut mucosal oxygenation with cats which were in hemorrhagic shcok 24 anesthetized cats were subjected to ge to decrease the mean arterial blood pressure to 40~45 mmHg and this pressure was maintained for 120 minutes (oligemic period). After this period, normal saline, hydroxyethyl starch and hypertonic saline/dextran mixture were administered respectively to raise systolic blood pressure up to 85 mmHg over 30 minutes and this level was maintained for another 120 minutes (post-oligemic period). Mesenteric venous oxygen tension, mesenteric venous-arterial lactate difference, carbon dioxide tension difference and arterial-venous pH difference were measured far evaluating the effects of three groups of resucitation fluids in regard to the gut mucosal oxygenation. There were no statistical significances among three groups by measuring the venous oxygen tension, venous-arterial carbon dioxide difference, arterial-venous pH difference. But venousarterial lactate difference in normal saline resuscitation group was significantly elevated from 5.0 +/-l.l mg/dl immediately after fluid resuscitation to 8.4+/-1.8 mg/dl 1 hour after fluid resuscitation (p<0.05). The difference in normal saline group was significantly high compared to the hydroxyethyl starch group which was 4.4+/-0.5 mg/dl and also compared to the hypertonic saline/dextran mixture group which was 4.1+/-0.9 mg/dl (p<0.05). Hydroxyethly starch and hypertonic saline/dextran mixture are more effective than normal saline in regard to the gut mucosal oxygenation in shock resuscitation, based on changes in venous-arterial lactate difference in each group. Further clinical studies may be needad.
Animals ; Arterial Pressure ; Blood Pressure ; Carbon Dioxide ; Cats* ; Endotoxins ; Hydrogen-Ion Concentration ; Lactic Acid ; Mucous Membrane* ; Multiple Organ Failure ; Oxygen* ; Resuscitation* ; Shock ; Shock, Hemorrhagic ; Starch

PURPOSE: Nowadays, the population of foreign women who are married to Korean men is increasing. This study was undertaken to get clinical data for perinatal care of marriage immigrant women and their babies. METHODS: Retrospective analysis of medical records was conducted on marriage immigrant women and their babies who were admitted at Dongsan Medical Center, Keimyung University over a 5-year period (Jan. 2005-Dec. 2009). Additionally, birth year-, gestational age-, number (s) of fetus-, and gender-matched native parturient women and their babies were selected by random sampling with twice the number as the control group. RESULTS: Total 5,158 babies were born during the study period (male: 52.7%, female: 47.3%). The number of babies born from native mothers was 5,046 (97.8%). Babies born from immigrant women and other foreign mothers were 66 (1.3%) and 48 (0.9%), respectively. The most common nationality of immigrant women was Vietnam (n=43, 65.2%), and the others were China (n=13, 19.7%) and Philippines (n=6, 9.1%). Immigrant women (24.1+/-4.6 yr) were younger than native parturients (32.7+/-4.0 yr), and spouses were older in immigrant group (42.3+/-7.1 yr) than the control (35.1+/-4.5 yr) (P<0.001). The body weight of the immigrant women (59.2+/-10.5 kg) were lighter than the control (69.1+/-9.1 kg) around delivery (P<0.001). In maternal morbidity, the incidence of hepatitis B surface (HBs) antigenemia was higher in immigrant women (13.8%) than the control (3.8%) (P<0.05). Intrauterine growth retardation was more frequently developed in immigrant women, whereas hypertension and diabetes were more frequent in the control, but not significant. In babies born from immigrant women, birth weight (2,680+/-630 g) and head circumference (32.4+/-2.3 cm) were less than that (2,870+/-590 g and 33.2+/-2.1 cm) of native mothers' babies (P<0.05). Birth height was similar in two groups (47.3+/-3.3 cm vs. 47.8+/-3.3 cm). There were no differences between two groups in terms of presence of perinatal diseases in babies. CONCLUSIONS: Marriage immigrant women have a higher incidence of HBs antigenemia and their spouses tend to be elders. Babies born from immigrant women may show significant differences in physical measures including birth weight and head circumference in comparison with native mothers' babies. Therefore follow-up evaluation of growth and development during infancy is necessary.
Birth Weight ; Body Weight ; China ; Emigrants and Immigrants ; Ethnic Groups ; Female ; Fetal Growth Retardation ; Growth and Development ; Head ; Hepatitis B ; Humans ; Hypertension ; Incidence ; Infant, Newborn ; Marriage ; Medical Records ; Mothers ; Multiple Endocrine Neoplasia Type 1 ; Parturition ; Perinatal Care ; Philippines ; Retrospective Studies ; Spouses ; Vietnam

No abstract available.
Cystic Adenomatoid Malformation of Lung, Congenital* ; Lung*

No abstract available.

The present study investigated the urinary tract toxicity of melamine alone or in combination with cyanuric acid in rats. Male rats were orally administered melamine alone (800 mg/kg) or melamine plus cyanuric acid (50 mg/kg each) for 3 consecutive days. Although melamine treatment did not show any significant difference in body weight, kidney or urinary bladder weight, serum blood urea nitrogen (BUN) or creatinine levels, it caused a decrease in urinary pH and mild histopathological alterations in the kidney and urinary bladder. In contrast, co-administration of melamine and cyanuric acid induced a decrease in body weight, an increase in kidneys and urinary bladder weights, and an elevation in serum BUN and creatinine levels, which were not observed in animals treated with melamine alone. Histopathological examination showed that the incidence and severity of histopathological lesions in the kidney and urinary bladder were much higher than those in the melamine group. Urinalysis revealed an increase in urine occult blood, leukocytes and protein and a decrease in urinary pH. These results indicate that concomitant administration of cyanuric acid synergistically potentiated the urinary tract toxicity induced by melamine in rats. In this study, we first demonstrated the synergistic toxic effects of melamine in combination with cyanuric acid on urinary bladder and urinalysis in rats.
Animals ; Blood Urea Nitrogen ; Body Weight ; Calculi ; Creatinine ; Humans ; Hydrogen-Ion Concentration ; Incidence ; Kidney ; Leukocytes ; Male ; Occult Blood ; Rats* ; Triazines ; Urinalysis ; Urinary Bladder ; Urinary Tract* ; Urine ; Weights and Measures

No abstract available.
Adenoids* ; Carcinoma, Adenoid Cystic* ; Lacrimal Apparatus*

BACKGROUND: Demodicosis is a parasitic skin disease caused by Demodex mites, and the determination of mite density per square centimeter is important to diagnose demodicosis. Standardized skin surface biopsy (SSSB) and direct microscopic examination (DME) are commonly used to determine Demodex mites density (Dd). However, no study has previously compared these two methods with respect to clinical types and distribution patterns of demodicosis. OBJECTIVE: The aim of this study was to compare the value of SSSB and DME findings in reference to the clinical types and distribution patterns of demodicosis. METHODS: The medical records of 35 patients diagnosed with demodicosis between December 2011 and June 2015 were retrospectively reviewed. Demodicosis was classified according to four clinical types (pityriasis folliculorum, rosacea type, acne type, and perioral type) and three distribution patterns (diffuse pattern, U-zone pattern, and T-zone pattern). Two samples, one for SSSB and one for DME, were obtained from a lesion of each patient. RESULTS: In all patients, mean Dd and the proportion with a high Dd (>5D/cm²) by DME (14.5±3.3, 80.0%, respectively) were higher than by SSSB (5.5±1.3, 37.1%, respectively; p<0.01, p=0.02, respectively). In terms of clinical types, for rosacea type, mean Dd and proportion with a high Dd by DME (12.4±3.5, 84.6%, respectively) were significantly greater than those determined by SSSB (3.6±1.2, 23.1%; p=0.04, p=0.04, respectively). In terms of distribution pattern, for the diffuse pattern, mean Dd and the proportion with a high Dd by DME (17.5±3.7, 100%, respectively) were significantly higher than those determined by SSSB (6.0±2.7, 26.7%; p<0.01, p<0.01, respectively). CONCLUSION: The results of our study revealed that DME is a more sensitive method for detecting Demodex than SSSB, especially in patients with diffuse pattern and suspected rosacea type. Further research is needed to confirm this finding.
Acne Vulgaris ; Biopsy* ; Humans ; Medical Records ; Methods ; Mites* ; Retrospective Studies ; Rosacea ; Skin Diseases, Parasitic ; Skin*