For selected subsets of colon cancer (T4 lesions or those with cancers in areas of the colon where anatomic factors preclude surgery with adequate resection margins), local failure rates are similar with those of rectal cancers. The role of adjuvant external beam radiation therapy in this subset of patients has been evaluated in both retrospective and prospective studies. Postoperative radiation with or without 5-FU improved local control and disease-free survival when compared with historical controls in many single-institution studies such as MGH series, however, there is no phase-III prospective randomized study to elucidate the role of postoperative radiation therapy. One must treat each patient on the basis of through evaluation of stage, operative findings, and results of pathologic and imaging studies.
Colon* ; Colonic Neoplasms* ; Disease-Free Survival ; Fluorouracil ; Humans ; Prospective Studies ; Radiotherapy* ; Rectal Neoplasms ; Retrospective Studies

OBJECTIVE: To compsre the efficiency, success rate, and abortion time of applications of intravaginal misoprostol versus prostaglandin E2 vaginal tablet for mid-trimester pregnancy termination Subjects and methods: Eighty four patients between 17-29 weeks of gestation with medical, obstetric, or genetic reasons far termination were randomized to receive either 50 ug tablets of misoprostol placed in the posterior vaginal fornix or prostaglandin E2 3mg in tables placed into the endocervix. RESULTS: Among eighty four patients recruited, fourty five patients received misoprostol and thirty nine patients received prostaglandin E2 vaginal tablets. The average interval hom start of induction to vaginal delivery was 13.35 +/- 3.34 hours in misoprostol poup and 19.14 +/- 10.64 hours in the prostaglandin E2 group. The success rate of complete termination within 12 and 24 hours in misopr-ostol group were 57.7%, 93.3%, respectively, while in prostaglandin E2 group were 20.5%, 82.1% repectively. Oxytocin augumentation was 6.7% in misoprostol group and 17.9% in the prostaglardin E2 group. No serious complication occumd. CONCLUSION: Intracervicovaginal misoprostol appears to be acceptably safe and effective agents for second trimester pregnancy termination. The abortion time is less in misoprostol group than those in the prostaglandin E2 group. Misoprostol has the advantage of being expensive, easily stored and readily available. We used 50 ug tablets of misoprostol every four hours. But, we suspect that the regimen of 100ug misopostol inserted intracervico-vaginally every eight hours will beis the proper and optimal method for pregnancy termination.
Dinoprostone* ; Female ; Humans ; Misoprostol* ; Oxytocin ; Pregnancy Trimester, Second ; Pregnancy* ; Tablets ; Vaginal Creams, Foams, and Jellies*

No abstract available.

In mammal, lots of follicles start simultaneously their growth but only a few oocytes are ovulated in every sexual cycles. Most of matured and grown oocytes are destined to degenerate by atresia. However, the molecular and physiological mechanisms are not elucidated yet. The present study was designed to establish an induction method of follicular atresia with ketamine or pentobarbitone and evaluate the effect of these anesthetics on oocyte maturation and granulosa cell apoptosis of the mouse ovarian follicle. The percentages of degenerated oocyte and apoptotic granulosa cell in ketamine treated groups were significantly higher than that in controls (58.9% vs 33.5%, p<0.01, degeneration; 44.9% vs 26.6%, p<0.01, apotosis). Futhermore, it was revealed that the concentrations of progesterone in both groups were markedly higher than that in control. In conclusion, it is considered that ketamine induce an atresia as pentobarbitone, and may be useful for inducing follicular atresia.
Anesthetics ; Animals ; Apoptosis ; Female ; Follicular Atresia ; Granulosa Cells* ; Ketamine* ; Mammals ; Mice* ; Oocytes* ; Ovarian Follicle ; Ovary* ; Pentobarbital* ; Progesterone

No abstract available.
Fever* ; Microwaves*

No abstract available.
Erythrocytes* ; Humans ; Kidney Failure, Chronic*

No abstract available.
DNA* ; Uterine Cervical Neoplasms*

No abstract available.
Bone Density* ; Child* ; Glucocorticoids* ; Humans ; Nephrotic Syndrome*

No abstract available.
Child ; Humans ; Mandibular Condyle

No abstract available.
Cerebrospinal Fluid Rhinorrhea* ; Cerebrospinal Fluid*