The clinicopathological study was performed on 80 patients with urinary bladder tumor between 1973 and 1983. The histopathological survey was carried out using preserved tumor specimen slide on the retrospective fashion, that included the growth pattern and vessel invasion. The results were as follows : 1. The tumor histology were papillary and nonpapillary in 70 %, and 30 %, respectively in growth pattern and 74 transitional cell carcinoma(TCC), 3 squamous cell carcinoma(SCC), 2 adenocarcinoma (AC) and 1 mucoepithermoid carcinoma in cell type. 2. The Fade of TCC, Go, G1. G2 and G3 were 1.4%, 36.5%, 39.2% and 22.9% respectively, and the stage of those, in which superficial tumors(pTis-pT1) and invasive tumors( pT2-pT4) were 57.0% and 30.8% respectively. The histopathological mode of local spread was to have strands, nests and individual cells in about one sixth, lymphatic invasion in about one third and venous invasion in about one fifth. 3. The intramural hispathological mode of local spread (INF alpha,beta, and alpha), lymphatic invasion ( lyo, 1 and 2) and venous invasion were highly significant with respect to the hispathological grade and stage, and also within mutual relationship on the other hand.
Adenocarcinoma ; Hand ; Humans ; Retrospective Studies ; Urinary Bladder Neoplasms ; Urinary Bladder*

Restoration of functional and anatomic changes of kidney in UPJ stricture is one of most important subjects in urology. A clinical observation was made on the 28 cases (29 kidneys) of pyeloplasties for UPJ stricture from Jan. 1976 to Dec. 1981. Of them 20 cases (21 kidneys) were followed up for more than 6 months postoperatively. The following results were obtained; 1. The patients in this series were 22 males and 6 females, and 11 children and 17 adults. The left side was 3 times more frequently affected than the right. They symptoms on admission were mostly flank pain, palpable mass, and etc. 2. Preoperative status of UPJ was; UPJ stricture alone in 20, UPJ stricture with aberrant vessel in 4, UPJ stricture with stone in 3, and UPJ stricture with vesicoureteral reflux in 1 case. 3. Preoperative grade of hydronephrosis was closely related to each other in the functional and anatomic aspects of kidney. In general, children showed relatively more advanced hydronephrosis than adults and the degree of improvement of hydronephrosis postoperatively was similar to each other. 4. Anderson Hynes' method of pyeloplasty in most cases (20 kidneys) and simple pyeloureterostomy in 9 kidneys were performed, and results between both operations showed no difference. But Anderson Hynes' method was more effective in marked hydronephrosis such as giant hydronephrosis and simple pyeloureterostomy in mild hydronephrosis. 5. In cases in which UTI was present preoperatively, postoperative UTI tended more to persist than in those not complicated with preoperative UTI, and in both sides postoperative UTI mostly persisted for 2 months and disappeared within 6 months. 6. The period of nephrostomy and ureteral stent was not directly related to postoperative results, but nephrostomy without ureteral stent relatively showed good results. 7. Postoperative complication was UTI in 2, re-do pyeloplasty in 1 and secondary nephrectomy in 1 case. 8. Improvement Of hydronephrosis continued for about a year after operation. It is recommended that more careful attention should be paid for the first year and be continued to watch for consecutive 2 years.
Adult ; Child ; Constriction, Pathologic* ; Female ; Flank Pain ; Humans ; Hydronephrosis ; Kidney ; Male ; Nephrectomy ; Postoperative Complications ; Prognosis* ; Stents ; Ureter ; Urology ; Vesico-Ureteral Reflux

This paper deals with clinical study of 23 cases of non-visualizing kidney on intravenous pyelography in children during 11 years from Jan. 1965 to Dec. 1975. The studying period was divided into the earlier term('68~'71) and the later term('72~'75) because since 1972 we have had special considerations in pediatric urology. The following results were obtained from the study. 1. More than half of the cases with non-visualizing kidney were seen in the age under 5 years. There were no remarkable difference between both sexes and terms of studying. 2. The chief complaints were flank mass, hematuria, incontinence and urinary frequency etc. in order of frequency without regarding to terms of studying. 3. In boys, the duration of symptoms was generally shorter than in girls. 4. As causative diseases, obstructive uropathy occupies more than half of the cases and more frequent in the earlier term of study than in later term. There was seen no difference between sexes. 5. In treatment of causative diseases, as possible conservative operations of the kidney were done.
Child* ; Female ; Hematuria ; Humans ; Kidney* ; Urography ; Urology

A and B blood type isoantigens were investigated in 17 cases surrounding bladder cancer by means of the specific red cell adherence test (SRCA). The tissue specimen were classified into positive, intermediate and negative groups according to SR CA reaction of the primary tumors. The histologically normal epithelium was SRCA-positive in 86.2 % of the specimens in the positive group and 70.0% in the negative, group; for hyperplastic epithelium it was 76.4 % and 50.0% and for the dysplastic epithelium it was 60.0% and 53.3 % respectively. The results may indicate that dedifferentiation expressed as the loss of blood group isoantigens has occurred in the histologically benign epithelium of the tumor-bearing bladders and that its occurrences is frequent in the bladder, associated with SRCA-negative tumors.
Epithelium* ; Isoantigens* ; Urinary Bladder ; Urinary Bladder Neoplasms

Urachal carcinoma is an uncommon neoplasm associated with a poor prognosis. We have encountered two another cases of urachal adenocarcinoma recently 5 years after our first report. The common sign of urachal cancer was painless hematuria. We diagnosed the specific site of origin preoperatively by means of computerized tomography. One patient was performed partial cystectomy and another was total cystectomy with double barrel ureterocutaneostomy. A brief review of the literature of urachal adenocarcinoma was also made.
Adenocarcinoma* ; Cystectomy ; Hematuria ; Humans ; Prognosis

A case of torsion of the right cryptorchid testis was herein reported. The patient was 6-year-old boy who was rolled on a staircase and traumatized his right inguinal area. There after painful and tender swelling developed on the area, and it spent 4 days prior to visit our department The involved cryptorchid testis showed dark reddish discoloration and external rotation of 360 degrees and was removed because of no re-establishment of blood supply in spite of detorsion for 30 minutes.
Child ; Humans ; Male ; Testis*

Case 1 was a 55-year-old housewife with the 1-year history of mild recurrent gross hematuria and recent history of massive hematuria following radiation treatment for uterine cancer 7 years ago. Various conservative treatments showed no effect but complete hemostasis was obtained immediately after instillation of 100 ml of 4% formalin solution for 30 minutes under sedation. And to date, there has been no recurrence of hematuria or significant complications for 5 months after the treatment. Case 2 was a 45-year-old housewife with the 3-month history of symptomless gross hematuria following irradiation for a gynecologic malignancy 8 years ago. Complete hemostasis was obtained one day after instillation of 100 ml of 4% formalin solution for 30 minutes under sedation. and to date, there has been no recurrence of hematuria or any complications for 2 months after the treatment. Postradiation vesical bleeding is a very difficult condition to control and may result in total cystectomy and urinary diversion. The treatment by intravesical instillation of formalin solution for the intractable vesical bleeding is simple to perform, shows excellent effect and no significant complications, and is a highly recommendable mode of treatment for massive, uncontrollable vesical bleeding before total cystectomy and urinary diversion.
Administration, Intravesical* ; Cystectomy ; Formaldehyde* ; Hematuria ; Hemorrhage* ; Hemostasis ; Humans ; Middle Aged ; Recurrence ; Urinary Diversion ; Uterine Neoplasms

The aim of this study was to assess the degree of association between individual stress and the amount of smoking among male senior students of a medical college. The questionnaire survey was conducted twice for collecting the data on stress level in terms of BEPSl score, smoking amounts, alcohol intake, and residence type in 1992 and 1993. Among the 223 responders, 39.9% were smokers. In the smokers, the association between stress level and smoking amount was significant after controlling for alcohol intake and residence type (P < 0.l). Especially in the group of living without family, the association was more significant (p=0.06). Therefore, it is recommendable that the stress management program is called upon for the student smokers to reduce smoking amount.
Humans ; Male ; Surveys and Questionnaires ; Smoke* ; Smoking*

A clinical study was made on the 28 cases underwent prostatectomy during the 5 year-period from 1964 to 1968. The results are summarized as follows: 1. The patient underwent prostatectomy revealed increasing tendency in incidence, residual urine in average and being usually in the age range between 60 and 70 years. 2. The degree of prostatic enlargement was mostly grade 11 on rectal palpation and the removed prostate was 49. 3gm. in average weight. 3. Blood loss attributable to the operative manipulation was 1143 cc. in average. The patients underwent prostatectomy were discharged on the average 21.3 days postoperatively in which postoperative indwelling catheter was left in place for 15.3 days in average. 4. Postoperatively the convalescence was uneventful and the residual urine was disappeared or decreased markedly. 5. In the patients underwent prostatectomy via retropubic approach operative blood loss was mild and postoperative duration of indwelling catheterization was short as compared to that via the suprapubic approach. 6. No serious complication other than epididymitis developed in a few patients was observed postoperatively. 7. Suprapubic prostatectomy was found to be suitable for the patient with marked prostatic enlargement while the retropubic one yielded less tissue damage and somewhat rapid postoperative convalescence as compared to the former.
Catheters, Indwelling ; Convalescence ; Digital Rectal Examination ; Epididymitis ; Humans ; Incidence ; Male ; Prostate ; Prostatectomy*

Dendritic cell (DC)s are protessional antigen presenting cells and they have been used for antitumor immunotherapy or cell vaccines. However therapy using DC is restricted because the number of DC available from tissue is very low. Flt3 ligand (FL) has been known as a hematopoietic growth factor that increases proliferation of hematopoietic stem cells and progenitor cells, and recently it showed inducibility of dendritic cell (DC)s and signiticant antitumor effects in vivo. Thus FL will be frequently used for DC induction and antitumor immunotherapy in future. Here we constructed FL plasmid and studied its in vivo effect. FL plasmids were made by cloning of partial FL cDNA into pcDNA3 plasmid, and gene expression and protein producibility of FL plasmid were confirmed in Renca cells transfected with FL plasmid. Mice were injected with FL plasmid (100ug/mouse) three times and 20 days later mouse spleens were harvested for staining and RT-PCR. There were lots of blastogenic cells in the spleen of mice treated with FL plasmid. FL plasmid also induced DEC205, IL-12 and GM-CSF gene expression in mouse splenocyte. All these data suggest FL plasmid may be used for induction of DC and antitumor therapy as DNA adjuvant.
Mice ; Animals