The objectives of this study were to evaluate the effect of methylphenidate on attention deficit hyperactivity disorder (ADHD) and the comorbidity of the disorder, using child attention problem checklist to .56 (male : 38, female : 18) patients from. March 992 to February 1993. The results were as follows: Among 56 subjects, ADHD alone were 20 (335.71%) subjects, and with one additional diagnosis were 31 (55.35%) subjects and with two additional diagnosis were 5 (8.93%) subjects. There was significant improvement on symptoms in the scores rated by teachers in 7th and 28th day after mentylphenidate administration compared to baseline score (P<0.05) and 28th day score showed significant improvement compared to. 7th day score (P<0.05) and 28th day score showed significant improvement compared to 7th day score (P<0.05). There was significant improvment on symptoms in the scores rated by parents in 28th day after methylphenidate administration improvement compared with 7th day score. In single administration of methylphenidate in Sunday morning score compared to afternoon score (P<0.05). In the administration of significant improvement on symptoms compared with the Sunday morning rating score of parents (P<0.05) and the 28th day comparison was also showed significant improvement on symptoms in the scores rated by teachers compared with the scores rated by parents on symptoms (P<0.05). Among group comparison, all groups showed significant improvements (P<0.05) except conduct disorder & oppositional defiant group.
Attention Deficit Disorder with Hyperactivity* ; Checklist ; Child ; Comorbidity* ; Conduct Disorder ; Diagnosis ; Female ; Humans ; Methylphenidate* ; Parents

No abstract available.
Autistic Disorder*

To evaluate the simplicity and efficacy of the 7-symptom screen test for somatization disorder, the authors tried 7-symptom screen test to find out the easiness in diagnosing the somatization disorder and to evaluate the simplicity and efficacy of it from Mar 1991 to Feb 1992. The objects were 135 female outpatients who visited Department of Psychiatry, College of Medicine, Yeungnam University. The results were as follows; The discriminant index was over 3.0 for all 7 symptoms and two item accuracy was 89% (sensitivity 99%, specificity 77%), three item accuracy was 87% (sensitivity 83%, specificity 90%). In discriminant analysis, the cut off score for the criteria of somatization disorder was 87% when three or more symptoms were checked for 7-symptoms. This result means that 7-symptom screen test is the simple and accurate method for screening and diagnosing the somatization disorder.
Diagnosis ; Female ; Humans ; Mass Screening ; Methods ; Outpatients ; Sensitivity and Specificity ; Somatoform Disorders

No abstract available.

No abstract available.
Animals ; Haloperidol* ; Mice*

No abstract available.
Collagen Type IV* ; Mucocutaneous Lymph Node Syndrome* ; Ventricular Function, Left*

To evaluate the relationship between eating behavior and neurotic trait in middle school students, the authors applied eating scale, Middlesex Hospital Puestionaire and Zung's self-reting depression scale to 419 middle school students(male : 187, female : 232) in Taegu city in 1993. There was no significant relationship between weight devided groups. Female middle school students showed significant high scores(p<0.05) in all scales compared to male middle school students. The correlation between eating scale and the other two scales showed significant correlationship(p<0.05) Among psychosocial factors, the items related to dissatisfaction to present and future self image(each p<0.05, p<0.05), dissatisfaction to present environmental status(p<0.05) and dissatisfaction to future attitude showed significant high score in both sex. The item related to dissatisfaction to present interpersonal relationship (p<0.05) showed significant high score in male middle school students. The items related to eat consumption rate of 61-90% (p<0.05), unsatisfied to relationship with family(p<0.05), unsatisfied to childhood family atmosphere(p<0.05), unsatisfied to past self image(p<0.05) and unsatisfied to present relationship between parent(p<0.05) showed significant high score.
Adolescent* ; Daegu ; Depression ; Eating* ; Feeding Behavior* ; Female ; Humans ; Male ; Psychology ; Weights and Measures

The authors studied ED50 of bethanechol on the contractilities of the smooth muscles isolated from various organs of rat under the presence of atropine (a classical competitive blocker of cholinergic muscarinic receptor) or minaprine (a newly developed antidepressant drug) to investigate the peripheral anticholinergic effect of minaprine. The results were as follow: 1) There was no significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine 10⁻⁸M and 10⁻⁷M in the smooth muscles isolated from the duodenum. 2) There was no significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine 10⁻⁸M and 10⁻⁷M in the smooth muscles isolated from the ascending colon. 3) There was significant difference between ED50 of bethanechol in the control group and that under the presence of minaprine 10⁻⁸M and 10⁻⁷M in the smooth muscles isolated from the urinary bladder (P<0.01) 4) There was significant difference between ED50 of the atropine 10⁻⁸ and minaprine (10⁻⁸M) in the smooth muscles isolated from the urinary bladder (P<0.05).
Animals ; Atropine ; Bethanechol ; Colon, Ascending ; Duodenum ; Muscle, Smooth ; Rats ; Urinary Bladder

Clinical analysis of 170 patients with childhood leukemia was made, who were admitted to the department of Pediatrics, Pusan Paik Hospital, Inje University, College of Medicine during 10 years from 1981 to 1990. The results were as follows: 1) The annual number of the patients with childhood leukemia was in the range of 6~25 cases. And the annual rate of the number of the patients in the department of the Pediatrics was 0.37~1.60% with the average of 1.06%. 2) Of the 170 patients, 72 cases(42.3%) were in the range of 0~5 years of age, which was the largest age group. In male, of the 97 patients, the largest age group was the age group of 0~5 years, which included 45 cases (46.4%), while in female, the largest was that of 6~10 years, which included 29 cases of 73 patients (39.8%). 3) Of the 170 patients, sex ratio was 1.33:1 with male dominance in all age groups except 1:1.6 with female dominance in the age group of 6~10 years. 4) Of the 170 patients, 113 cases were ALL (66.5%), 50 cases AML (29.4%), and 7 cases CML (4.1%). 5) In ALL, 51 cases of the 113 patients (45.1%), were in the age group of 0~5 years, 35 cases (31%) in the age group of 6~10 years, and 27 cases (23.9%) in the age group of 11~15 years. In AML, 19 cases of the 50 patients (38.0%) were in the age group of 0~5 years, 17 cases (34%) in the age group of 6~10 years, and 14 cases (28%) in the age group of 11~15 years. 6) In ALL, the sex ratio of male: female was 1.21:1, 1,50:1 in AML, and 2.5:1 in CML. 7) According to the FAB classification in ALL, of the 113 patients, 72 cases (63,7%) were in L1 type, 34 cases (30.0%) in L2 type, and only 3 cases in L3 type. In AML, of the 50 patients, 19 cases (38%) were in M2 type, 16 cases (32%) in M1 type, and 6 cases (12%) in M4 type, in order. 8) In CML, of the 7 patients, 4 cases were juvenile type, who were all under 10 years old, while 3 cases were adult type, who were all male above 11 years old. 9) Of the 170 patients, clinical symptoms on admission were pallor in 112 cases (65.9%), fever in 84 cases (49.4%), hemorrhage in 78 cases (45.9%), weakness in 40 cases (25.3%), bone pain in 32 cases (18.8%) in order. 10) Of the 170 patients, physical findings on admission were hepatomegaly in 113 cases (66.5%), lymphnode swelling in 84 cases (49.4%), splenomegaly in 78 cases (45,9%)in order. 11) Of the 170 patients, the hemoglobin level on admission were 4~7gm/dl in 95 cases (55.9%), 8~10gm/dl in 42 cases (24.7%), and 0~3gm/dl in 22 cases (12.9%) in order. 12) Of the 170 patients, the WBC count on admission were 10,000~50,000/mm3 in 58 cases (34.1%), below, 5,000/mm3 in 49 cases (28.8%), and 5,5000~100,000/mm3 in 24 cases (14.1%) in order. 13) Of the 170 patients, the platelet count on admission were below 50,000/mm3 in 93 cases (54,7%), above 100,000/mm3 in 48 cases (28.2%), 20,000~50,000/mm3 in 43 (25,3%), 43 cases (25,3%), and 50,000~100,000/mm3 in 29 cases (17.1%) in order.
Adult ; Busan ; Child ; Classification ; Female ; Fever ; Hemorrhage ; Hepatomegaly ; Humans ; Leukemia* ; Male ; Pallor ; Pediatrics ; Platelet Count ; Sex Ratio ; Splenomegaly

Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system, and skin. Neurofibromatosis is characterized by cafe au lait macules, neurofi- bromas, Lisch nodules, optic gliomas, bony dysplasia, intertriginous freckling, and autosomal inheritance. Juvenile xanthogranuloma(JXG) is a benign, self-healing disorder of infants, children, and occa- sionally adults, characterized by yellowish papulonodular lesions located in the skin and other organs and consisting of an infiltrate of histiocytes with a progressively greater degree of lipidation in the absence of metabolic disorders. In 1954 Normland reported the first case of a JXG in a child with numerous cafe au lait macules. Royer, in 1958, reported the triple association of JXG, neurofibromatosis, and leukemia. It is estimated that children with neurofibromatosis and JXG have a higher risk for leukemia than do patients with neurofibromatosis who do not have JXG. In patients with both JXG and neurofibromatosis, long-term follow-up is required because of the additional association with leukemia. We report a case of JXG associated with neurofibromatosis.
Adult ; Child ; Follow-Up Studies ; Histiocytes ; Humans ; Infant ; Leukemia ; Nervous System ; Neurofibromatoses* ; Neurofibromatosis 1 ; Optic Nerve Glioma ; Skin ; Wills ; Xanthogranuloma, Juvenile*