In order to evaluate the effectiveness of Vibramycin (Doxycycline) to acne vulgaris, a double-blind study was performed in forty three patients of ance vulgaris. The patients were classified as to the severity of the disease before the treatment according to Wand, et al. and the degree of the effectiveness was evaluated weekly by Clinical improvement. The results obtained were as follows: Among 14 patients who received a 100mg capsule orally per day for four weeks, 12 cases (85.7%) showed excellent improvement, whereas in the placebo group only 4 out of 12 patients (33.3%) showed good responses. Statistical analysis of the data revealed that there was a significant difference (P<0.05) in effectiveness between the Vibramycin group (100mg) and the placebo group, and that at the end of the first week of the treatment there was no significant improvement, but at the end of the third week there was a highly significant improvement, p_value between the first-week response and the third-week response among the patients in administering 100mg of Vibramycin being less than 0.01. It was noted that 24 out of 43 patients(55.8%) had a distint familial history of the disease, suggesting that there might be a predisposing factor involved in the manifestation of acne vulgris. It is concluded from this study that Vibramycin, when administered in dose of 100mg per day for more than three weeks, is effective in improving the acne vulgaris.
Acne Vulgaris* ; Causality ; Double-Blind Method ; Doxycycline* ; Humans

This is a case report of juvenile xanthogranulomas which developed at cutaneous lesions are rare and characterized by asymptomatic multiple cutaneous lesions and extracutaneous lesions. Juvenile xanthogranulomas are benign, usually asymptomatic, self healing yellowish papules and nodules composed of histiocytic cells that predominantly occur in infancy and childhood. Papules or nodules occur in the skin, eyes, and viscera. Juvenile xanthogranuloma is characterized histologically by a dense, sheetlike, well-demarcated histiocytic infiltration within the papillary and reticular dermis, with occasional extension into subcutaneous tissue, fascia, and peripheral muscle. We report a case of juvenile xanthogranuloma developed in a 3-months- old male infant which showed mulitiple cutaneous lesions and viscera involved the lung, heart, liver, pancreas, and testicle.
Dermis ; Fascia ; Heart ; Humans ; Infant ; Liver ; Lung ; Male ; Pancreas ; Skin ; Subcutaneous Tissue ; Testis ; Viscera ; Xanthogranuloma, Juvenile*

INTRODCTION: Microsurgical replantation of amputated digit have become common procedure in recent years. However replantation of fingertip amputation, Zone I by Yamano classification, is still difficult because digital arteries branch into small arteries and also digital veins are hard to separate from the immobile soft tissue. So, fingertip amputation was covered by volar V-Y flap, composite graft, cross finger flap and groin flap. But patients who have been treated by these methods experience shortening of digit, nail deformity, excessive tenderness and persistent pain. Replantation could solve most of these problems. MATERIAL & METHODS: In our department, from March 2004 to August 2007, 36 digits in 32 patients with complete amputation at distal to nail base were replanted using a microsurgical technique. RESULTS: The overall survival rate of the replanted finger was 75%. Venous anastomosis was possible in 8 cases and impossible in 28 cases. In latter cases external bleeding technique was applied with medical leech. CONCLUSION: After replantation, a few patient complained decreased sensibility, nail deformity and cold intolerance. But most of patients were satisfied with the functional and cosmetic appearance of the viable replanted digits. We believe the replantation should be the first choice in fingertip amputation
Amputation ; Arteries ; Classification ; Congenital Abnormalities ; Fingers* ; Groin ; Hemorrhage ; Humans ; Replantation* ; Survival Rate ; Transplants ; Veins