Two cases of pseudoxanthoma elasticum associated with angioid streaks in both eyes were presented and the literatures were reviewed. The affected sisters were 15 and 18 years female among the five siblings. They had pin head sized yellowish maculopapular eruptions on the sides of the neck and axillae, and also visual distubance of the both eyes. They seemed to be autosomal recessive inberitance in their family background. There were no other complications.
Angioid Streaks ; Axilla ; Female ; Head ; Humans ; Neck ; Pseudoxanthoma Elasticum* ; Siblings

A wide variety of malignancies, including carcinoma of the lung, breast, prostate thyroid and kidney, frequently metastasize to bone. Patient suffering pathological fracture secondary to these metastases are frequently referred to the orthopaedic surgeon for care and management. In such cases, operative intervention with rigid fixation and early ambulation offer much in terms of over-all patient management. One case of breast careinoma metastatic to right proximal femur, neck and femoral head of segmental resection and restoration by special segmental femoral prosthesis with Giliberty Bipolar Endoprosthesis was presented. This technique provides an effective means of restoring the structural integrity of proximal femur and of preserving physiologic function of the joint.
Breast Neoplasms ; Breast ; Early Ambulation ; Femur ; Fractures, Spontaneous ; Head ; Humans ; Joints ; Kidney ; Lung ; Neck ; Neoplasm Metastasis ; Prostate ; Prostheses and Implants ; Thyroid Gland

For many years, developmental and physiological differences have been known to exist between anatomic segments of the colorectum. Because of different outcomes, prognoses, and clinical responses to chemotherapy, the distinction between right colon cancer (RCC) and left colon cancer (LCC) has gained attention. Furthermore, variations in the molecular features and gut microbiota between right and LCCs have recently been a hot research topic. CpG island methylator phenotype-high, microsatellite instability-high colorectal cancers are more likely to occur on the right side whereas tumors with chromosomal instability have been detected in approximately 75% of LCC patients and 30% of RCC patients. The mutation rates of oncogenes and tumor suppressor genes also differ between RCC and LCC patients. Biofilm is more abundant in RCC patients than LLC patients, as are Prevotella, Selenomonas, and Peptostreptococcus. Conversely, Fusobacterium, Escherichia/Shigella, and Leptotrichia are more abundant in LCC patients compared to RCC patients. Distinctive characteristics are apparent in terms of molecular features and gut microbiota between right and LCC. However, how or to what extent these differences influence diverging oncologic outcomes remains unclear. Further clinical and translational studies are needed to elucidate the causative relationship between primary tumor location and prognosis.
Biofilms ; Chromosomal Instability ; Colon* ; Colonic Neoplasms* ; Colorectal Neoplasms ; CpG Islands ; Drug Therapy ; Fusobacterium ; Gastrointestinal Microbiome* ; Genes, Tumor Suppressor ; Humans ; Leptotrichia ; Microsatellite Repeats ; Mutation Rate ; Oncogenes ; Peptostreptococcus ; Prevotella ; Prognosis ; Selenomonas ; Treatment Outcome

No abstract available.
Liver Transplantation* ; Liver*

No abstract available.
Hodgkin Disease* ; Radiotherapy*

No abstract available.
Animal ; Calcium-Binding Proteins/metabolism ; Feedback/physiology ; Ligases/metabolism ; Mice ; Patch-Clamp Techniques ; Salivary Ducts/physiology* ; Salivary Ducts/cytology ; Sodium/metabolism ; Sodium Channels/metabolism* ; Submandibular Gland/physiology* ; Submandibular Gland/cytology

For orthodontic tooth movement, optimal orthodontic force should be maintained without periodontal breakdown and alveolar bone should be remodeled physiologically. Therefore, To obtain proper occlusion through tooth movement within alveolar bone, we should know the biomechanics of teeth and supporting tissues. The present study was performed to observe histologic changes of periodontal tissue immediately after application of orthodontic force and during the retention period in growing young adult dogs. In this study, experimental group contained between mandibular left canie and 1st molar and control group contained contralateral teeth of same animal. The .018"x.22" stainless steel closed coil spring(Dentaurum Co.) was ligated on the experimental teeth at initial 200gm-force from mandibular canine to 1st molar. The animals(4 to 6 months aged young adult dogs) were sacrificed on 0, 14, 28 days after the finish of appliance activation, and then tissue samples were divided into hematoxylin-eosin(HE) staining section, ground section, alkaline phosphatase(ALP) staining section, and tartrate-resistant acid phosphatase(TRAP) staining section. Thereafter, the preparations were examined under light microsopy. The following results were obtained: 1. Immediately after the finish of appliance activation, the periodontal space was increased in tension side, but decreased in pressure side compared to that of control. The hyalinized zone was also observed in the periodontium. 2. After the 14-day retention, periodontal space was decreased in tension side and slightly increased in pressure side compared to that of immediately after the finish of appliance activation. The hyalinized zone was repaired and a few osteoblasts showing slightly new bone formation were seen. Osteoblasts were scarcely observed along the alveolar bone. 3. After the 28-day retention, the periodontal fibers are normally repaired. A lot of TRAP(+) osteoclasts and increased alveolar bone resorption were observed in pressure side, and AP(+) osteoblast and increased new bone formation were observed in tension side.
Animals ; Bone Resorption ; Dogs* ; Humans ; Hyalin ; Molar ; Osteoblasts ; Osteoclasts ; Osteogenesis ; Periodontium ; Stainless Steel ; Tooth Movement* ; Tooth* ; Young Adult*

Purpose: This study aimed to explore how autonomy support mediates the association between exercise knowledge and exercise self-efficacy in patients with severe mental illness. Methods: A total of 181 individuals were selected through convenience sampling. They completed self-administered surveys measuring exercise knowledge, autonomy support, and exercise self-efficacy. The data analysis was conducted using descriptive statistics, t-tests, one-way analysis of variance, Pearson’s correlation coefficients, and multiple linear regression. To determine the statistical significance of the mediating effect, a bootstrapping test was also conducted. Results: This research revealed that autonomy support significantly predicted exercise self-efficacy and partially mediated the association between exercise knowledge and exercise self-efficacy (lower limit confidence interval [LLCI]: 2.34; upper limit confidence interval [ULCI]: 5.97). The model incorporating exercise knowledge and autonomy support explained 42.0% of the variance in exercise self-efficacy. Conclusion Collaborative endeavors involving mental health practitioners and exercise experts demonstrate notable efficacy in enhancing exercise self-efficacy of individuals with mental illness.

In the United Kingdom, 4-year graduate-only medical education programmes (Graduate Entry Programme, GEP) started in 2000, and are running in 16 medical schools with over 800 students annually. This study presents the grounds for introduction of the GEP, and explores its benefits in increasing the medical workforce and widening participation in medical education. An increase in medical student numbers was proposed to cope with the pressing shortage of British doctors and the growing demand for doctors, and the GEP was introduced as a flexible and cost-effective way to meet this demand. It has contributed to increasing the diversity of students in medical schools and widening access to students from more varied social and educational backgrounds. In the United Kingdom, the GEP was established as a supplementary means of providing medical education, and it is unlikely to totally replace traditional 5- or 6-year programmes.
Education, Medical ; Great Britain ; Humans ; Phosphatidylethanolamines ; Running ; School Admission Criteria ; Schools, Medical ; Students, Medical

PURPOSE: An investigation has been carried out on the factors which affect the response reading of thermoluminescent dosimeters (TLD-100) loaded with thin material in high energy photon. The aim of the study was to assess the energy response of TLD-100 to the therapeutic ranges of photon beam. MATERIALS AND METHODS: In this technique, TLD-100 (abbreviated as TLD) chips and three different thin material (Tin, Gold, and Tissue equivalent plastic plate) which mounted on the TLD chip were used in the clinical photon beam. The thickness of each metal plates was 0.1 mm and TE plastic plate was 1 mm thick. These compared with the photon energy dependence of the sensitivities of TLD (normal chip), TLD loaded with Tin or Gold plate, for the photon energy range 6 MV to 15 MV, which was of interest in radiotherapy. RESULTS: The enhancement of surface dose in the TLD with metal plate was clearly detected. The TLD chips with a Gold plate was found to larger response by a factor of 1.83 in 10 MV photon beam with respect to normal chip. The sensitivity of TLD loaded with Tin was less than that for normal TLD and TLD loaded with Gold. The relative sensitivity of TLD loaded with metal has little energy dependence. CONCLUSION: The good stability and linearity with respect to monitor units of TLD loaded with metal were demonstrated by relative measurements in high energy photon (6~15 MV) beams. The TLD laminated with metals embedded system in solid water phantom is a suitable detector for relative dose measurements in a small beam size and surface dose.
Metals ; Plastics ; Radiotherapy ; Tin ; Water