OBJECTIVE: The study aims to determine the factors associated with central line-associated bloodstream infection (CLABSI) among children admitted in a tertiary government hospital. MATERIALS AND METHODS: This was a retrospective case-control study which utilized records review of pediatric patients admitted from January 2018 to December 2022. Random sampling was employed to include confirmed cases of patients with CLABSI and controls who did not develop CLABSI. Patients were matched in terms of unit of admission. Data were collected through chart review and odds ratio was used to determine the factors associated with CLABSI using univariate and multivariate regression analysis. RESULTS: A total of 92 cases and 184 controls were included in the study. Results of multivariate regression analysis revealed that the age group of 6 to 12 years old (OR=18.91, 95% CI 2.32 to 153.9) had the highest odds of acquiring CLABSI. Blood transfusion as indication for central line insertion increased the risk of CLABSI (OR=5.24, 95% CI 1.67 to 16.48). Those more likely to acquire CLABSI were patients with duration of CVC use of more than 14 days (OR=25.68, 95% CI 2.77 to 238.4), those who received total parenteral nutrition (OR=13.44, 95% CI 2.67 to 67.56) and chemotherapeutic or immunosuppressive drugs (OR=3.07, 95% CI 1.2 to 7.85). CONCLUSION This study revealed that age, blood transfusion as indication for central line use, receipt of total parenteral nutrition, receipt of chemotherapeutic and immunosuppressive drugs, and duration of CVC utilization of more than 14 days were found to increase the risk of CLABSI. Careful consideration of these factors in patients with CVCs should be observed to prevent the occurrence of CLABSI.
Children ; Child