Objective To investigate the clinical characteristics and classification of diabetic patients with unprovoked ketoacidosis.Methods According to body mass index(BMI),56 patients were divided into 3 groups: low body weight group(LBW,BMI25 kg/m2,n=20).Clinical characteristics,including age,gender,the course of the disease,positive rate of glutamic acid decarboxylase antibody(GAD-Ab) and the function of islet beta-cell,were compared between these three group.Results There were no significant differences in some clinical features(glycemia,and ketosis status) at beginning of disease between 3 groups.The level of serum TG and Insulin was higher in OBW group than that in other groups.Only 3 patients were found GAD-Ab positive in LBW group.Conclusion The clinical and immunological characteristics of OBW and LBW patients were quite different,some of the obese patients should be classified into type2 diabetes,and some into idiopathic type1 diabetes.

Research on effects of environmental endocrine disrupting chemicals (EDCs) is an important field in environmental science.The research progress on mechanism of EDCs in environment was present in this paper.Not only the action mechanism of EDCs mediated via receptor was expatiated,but also the interference influencing the synthesis and metabolism of endogenous hormone and the effects of EDCs on neural and immune system were discussed in this paper.This paper will conduce to the further studies on the mechanism of EDCs and the development of screening method for new EDCs.