1.Comparison of Standardized Peristomal Skin Care and Crusting Technique in Prevention of Peristomal Skin Problems in Ostomy Patients.
Seungmi PARK ; Yun Jin LEE ; Doo Nam OH ; Jiyun KIM
Journal of Korean Academy of Nursing 2011;41(6):814-820
PURPOSE: This study was performed to compare the effects of standardized peristomal skin care (SPSC) and crusting technique (CT) on the peristomal skin of ostomates. SPSC was developed by a consensus among the expert group based on a comprehensive review of the relevant literature and hospital protocols. METHODS: A randomized controlled pilot trial with 2 parallel arms was used. A total of 81 ostomates, who were recruited from a tertiary hospital, completed the baseline, 1-month, 2-month, and 3-month follow-up (SPSC group, n=45; CT group, n=36). SPSC consisted of water cleansing and direct application of ostomy appliances. CT involved crusting hydrocolloid powder and patting with water sponge or protective barrier liquid film. The outcomes of the study were assessed by skin problems, such as discoloration, erosion and tissue overgrowth; the domains of the evaluation tool used in examining the peristomal skin. A generalized estimating equation model was used to examine the effects according to time and group. RESULTS: In both SPSC and CT groups, the likelihood of occurrence of discoloration (OR, 1.99; 95% CI, 1.61-2.46), erosion (OR, 1.87; 95% CI, 1.55-2.25) and tissue enlargement (OR, 1.94; 95% CI, 1.36-2.77) increased with time. There was no significant difference in discoloration between the groups, whereas the probability of erosion (OR, 0.38; 95% CI, 0.16-0.89) and tissue overgrowth (OR, 0.09; 95% CI, 0.02-0.55) was lower in the SPSC group than in CT group. CONCLUSION: SPSC was sufficient in preventing peristomal skin problems of ostomates compared to the CT.
Adult
;
Aged
;
Aged, 80 and over
;
Colorectal Neoplasms/surgery
;
Female
;
Follow-Up Studies
;
Humans
;
Inflammatory Bowel Diseases/surgery
;
Male
;
Middle Aged
;
Odds Ratio
;
Ostomy/*nursing
;
Skin Care/instrumentation/*methods/standards
;
Wounds and Injuries/etiology/prevention & control
2.Autoantibody Positivity and Clinical Characteristics of Diabetes Mellitus in Childhood.
Jiyun PARK ; Jongseok OH ; Jeesuk YU
Journal of Korean Society of Pediatric Endocrinology 2011;16(2):119-127
PURPOSE: Most childhood diabetes mellitus (DM) is usually thought of as type 1 DM (T1DM), but the incidence of type 2 DM (T2DM) in childhood is increasing. Sometimes, it might not be easy to determine which type of DM a patient has and to choose the best treatment. The purpose of this study is to evaluate the usefulness of autoantibody test and clinical characteristics for the specific diagnosis of DM in childhood. METHODS: In this study, we retrospectively reviewed the medical records of 42 patients who were diagnosed with DM and followed at the department of pediatrics, Dankook University Hospital from January 2002 to October 2010. RESULTS: The patients were grouped as T1DM, T2DM, or T1.5DM (unclassified) according to the clinical and laboratory findings. T1DM had an earlier onset age compared to T2DM. Diabetic ketoacidosis (DKA) was the presenting symptom in 57% of T1DM, but there was no DKA in T2DM. Initial serum insulin and C-peptide levels were lower in T1DM than T2DM. Thirty nine percent and 70% of the patients had a family history of DM, respectively. The average body mass index (BMI) in T2DM was higher than that in T1DM. At least one of autoantibodies was positive in 80% of T1DM. But no antoantibody was detected in T2DM. During follow up, higher levels of HbA1c and more frequent microalbuminuria were detected in the female adolescents. CONCLUSION: We can confirm that the autoantibody test is very valuable in diagnosing specific types of DM. And adolescent period was thought as a very vulnerable period to manage the diabetes requiring more intensive emotional support including family cooperation.
Adolescent
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Age of Onset
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Autoantibodies
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Body Mass Index
;
C-Peptide
;
Child
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Diabetes Mellitus
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Diabetic Ketoacidosis
;
Female
;
Follow-Up Studies
;
Humans
;
Incidence
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Insulin
;
Medical Records
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Pediatrics
;
Retrospective Studies
3.Effects of a Health Education Program based on Social Cognitive Theory on the Health Promotion of University Students with Metabolic Syndrome.
Hee Gerl KIM ; Jinhwa LEE ; Jiyun KIM ; Hyunju PARK ; Hyun Sook OH ; Won Jae LEE ; Eun Aae KIM ; Hye Kyung JUNG
Journal of Korean Academy of Community Health Nursing 2013;24(4):451-460
PURPOSE: The purpose of this study is to evaluate effects of a health education program based on social cognitive theory on university students with risk factors for metabolic syndrome. METHODS: A nonequivalent control group pretest-posttest design was used. Participants were 88 students who had at least 2 risk factors for Metabolic Syndrome (47 students for the experimental and 41 for the control group). The health education program consisted of thirteen sessions. Knowledge regarding smoking and alcohol drinking, self-efficacy and self-esteem were evaluated. t-test, chi2-test, Fisher's exact test, and paired t-test were conducted to analyze the data. SPSS/WIN 19.0 Statistics program was used. RESULTS: There was a statistically significant increase in self-efficacy in the experimental group compared to the control group. No significant changes in knowledge and self-esteem were found. CONCLUSION: The results suggest that the health education program for university students was partially effective. Further work is required to develop more effective health education programs.
Alcohol Drinking
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Health Education*
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Health Promotion*
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Humans
;
Metabolic Syndrome X
;
Risk Factors
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Smoke
;
Smoking
4.Electronic Cigarette or Vaping Product Use-Associated Lung Injury: A Case Report
Jiyun LIM ; Bo Da NAM ; Jung Hwa HWANG ; Yang-Ki KIM ; Eunsun OH ; Eun Ji LEE
Journal of the Korean Radiological Society 2021;82(6):1581-1588
Electronic cigarette (e-cigarette) or vaping product use-associated lung injury (EVALI) has emerged as a social issue as e-cigarette use is rapidly increasing worldwide and is related to many deaths in the United States. To our knowledge, this is the first case report of EVALI in South Korea of a 24-year-old man with acute respiratory symptoms and a history of e-cigarette use. Chest CT revealed diffuse bilateral ground-glass opacities with subpleural sparing, airspace consolidation, and centrilobular micronodules as typical patterns of EVALI with organizing pneumonia and diffuse alveolar damage. Infection was excluded with meticulous laboratory examinations, and the patients’ illnesses were not attributed to other causes. EVALI was diagnosed by meeting the diagnostic criteria with consistent clinico-radiologic findings through a multidisciplinary approach. Radiologists should have good knowledge of EVALI radiologic findings and play a cardinal role in the proper diagnosis and management of EVALI.
5.Sensory Stimulation-dependent Npas4 Expression in the Olfactory Bulb during Early Postnatal Development
Oh-Hoon KWON ; Jiyun CHOE ; Dokyeong KIM ; Sunghwan KIM ; Cheil MOON
Experimental Neurobiology 2024;33(2):77-98
The development of the olfactory system is influenced by sensory inputs, and it maintains neuronal generation and plasticity throughout the lifespan. The olfactory bulb contains a higher proportion of interneurons than other brain regions, particularly during the early postnatal period of neurogenesis. Although the relationship between sensory stimulation and olfactory bulb development during the postnatal period has been well studied, the molecular mechanisms have yet to be identified. In this study, we used western blotting and immunohistochemistry to analyze the expression of the transcription factor Npas4, a neuron-specific immediate-early gene that acts as a developmental regulator in many brain regions.We found that Npas4 is highly expressed in olfactory bulb interneurons during the early postnatal stages and gradually decreases toward the late postnatal stages. Npas4 expression was observed in all olfactory bulb layers, including the rostral migratory stream, where newborn neurons are generated and migrate to the olfactory bulb. Under sensory deprivation, the olfactory bulb size and the number of olfactory bulb interneurons were reduced. Furthermore, Npas4 expression and the expression of putative Npas4 downstream molecules were decreased. Collectively, these findings indicate that Npas4 expression induced by sensory input plays a role in the formation of neural circuits with excitatory mitral/tufted cells by regulating the survival of olfactory bulb interneurons during the early stages of postnatal development.
6.No association between the IL28B SNP and response to peginterferon plus ribavirin combination treatment in Korean chronic hepatitis C patients.
Nae Yun HEO ; Young Suk LIM ; Woochang LEE ; Minkyung OH ; Jiyun AN ; Danbi LEE ; Ju Hyun SHIM ; Kang Mo KIM ; Han Chu LEE ; Yung Sang LEE ; Dong Jin SUH
Clinical and Molecular Hepatology 2014;20(2):177-184
BACKGROUND/AIMS: There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients. METHODS: This was a retrospective cohort study of 156 patients with chronic hepatitis C virus (HCV) infection who received combination treatment of PEG-IFN plus RBV. Blood samples from these patients were analyzed to identify the IL28B SNPs at rs12979860, rs12980275, rs8099917, and rs8103142. Association analyses were performed to evaluate the relationships between each IL28B SNP and SVRs. RESULTS: Seventy six patients with HCV genotype 1 and 80 with genotype non-1 were enrolled. The frequencies of rs12979860 CC and CT genotypes were 90.4% and 9.6%, respectively; those of rs12980275 AA and AG genotypes were 87.2% and 12.8%, respectively; those of rs8099917 TT and TG genotypes were 92.3% and 7.7%, respectively; and those of rs8103142 TT and CT genotypes were 90.4% and 9.6%, respectively. Among the patients with HCV genotype 1, the SVR rates were 69.7% and 80.0% for rs12979860 CC and CT, respectively (P=0.71). Among the HCV genotype non-1 patients, SVR rates were 88.0% and 100% for rs12979860 CC and CT (P=1.00), respectively. CONCLUSIONS: Genotypes of the IL28B SNP that are known to be favorable were present in most of the Korean patients with chronic hepatitis C in this study. Moreover, the IL28B SNP did not influence the SVR rate in either the HCV genotype 1 or non-1 patients. Therefore, IL28B SNP analysis might be not useful for the initial assessment, prediction of treatment outcomes, or treatment decision-making of Korean chronic hepatitis C patients.
Adult
;
Alleles
;
Antiviral Agents/*therapeutic use
;
Asian Continental Ancestry Group/*genetics
;
Cohort Studies
;
Drug Therapy, Combination
;
Female
;
Gene Frequency
;
Genotype
;
Hepatitis C, Chronic/drug therapy/*genetics
;
Humans
;
Interferon-alpha/therapeutic use
;
Interleukins/*genetics
;
Linkage Disequilibrium
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Male
;
Middle Aged
;
Polyethylene Glycols/therapeutic use
;
*Polymorphism, Single Nucleotide
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Recombinant Proteins/therapeutic use
;
Republic of Korea
;
Retrospective Studies
;
Ribavirin/therapeutic use
7.Severity of hyperechoic pancreas on ultrasonography as a risk factor for glycemic progression
Jiyun OH ; Hyun Jeong PARK ; Eun Sun LEE ; Sung Bin PARK ; Byung Ihn CHOI ; Soohyun AHN
Ultrasonography 2021;40(4):499-511
Purpose:
The aim of this study was to evaluate the association between the severity of hyperechoic pancreas (HP) on ultrasonography (US) and glycemic progression.
Methods:
In total, 1,386 participants who underwent abdominal US as part of health examinations between December 2008 and May 2014 were included in this retrospective study. We classified pancreatic echogenicity on a 4-point scale, and compared it using two distinct criteria: fatty pancreas (FP) 1 criterion (normal vs. ≥mild HP) and FP2 criterion (normal/mild HP vs. ≥moderate HP). According to the presence of nonalcoholic fatty liver disease (NAFLD), participants were subdivided into four groups: non-NAFLD and non-HP, isolated NAFLD, isolated HP, and HP with NAFLD. Glycemic progression was defined as progression from normoglycemia to prediabetes or diabetes or progression from prediabetes to diabetes.
Results:
During the follow-up (median, 5.9 years), 262 of the 1,386 participants developed glycemic progression. Using FP2, the probability of glycemic progression across the four subgroups showed cumulative aggravation for NAFLD and HP (all P<0.05). Isolated HP showed a higher probability of glycemic progression than isolated NAFLD according to FP2 (P<0.001). The highest probability of glycemic progression was observed in patients with both NAFLD and HP (P<0.001). The hazard ratio for glycemic progression increased with the severity of HP.
Conclusion
Increasing severity of HP on US was found to be significantly correlated with glycemic progression. Moreover, isolated HP of moderate or greater severity predicted glycemic progression independent of NAFLD.
8.Subcategorization of intermediate suspicion thyroid nodules based on suspicious ultrasonographic findings
Haejung KIM ; Jung Hee SHIN ; Ka Eun KIM ; Myoung Kyoung KIM ; Jiyun OH ; Soo Yeon HAHN
Ultrasonography 2023;42(2):307-313
Purpose:
This study compared the malignancy risk of intermediate suspicion thyroid nodules according to the presence of suspicious ultrasonographic (US) findings.
Methods:
From January 2014 to December 2014, 299 consecutive intermediate suspicion thyroid nodules in 281 patients (mean age, 50.6±12.5 years) with final diagnoses were included in this study. Two radiologists retrospectively reviewed the US findings and subcategorized the intermediate suspicion category into nodules without suspicious findings and nodules with suspicious findings, including punctate echogenic foci, nonparallel orientation, or irregular margins. The malignancy rates were compared between the two subcategory groups.
Results:
Of the 299 intermediate suspicion thyroid nodules, 230 (76.9%) were subcategorized as nodules without suspicious findings and 69 (23.1%) as nodules with suspicious findings. The total malignancy rate was 33.4% (100/299) and the malignancy rate of nodules with suspicious findings was significantly higher than that of nodules without suspicious findings (47.8% vs. 29.1%, P=0.004). In nodules with suspicious findings, the most common suspicious finding was punctate echogenic foci (48/82, 58.5%) followed by nonparallel orientation (22/82, 26.8%) and irregular margins (12/82, 14.6%). Thirteen nodules had two suspicious findings simultaneously. A linearly increasing trend in the malignancy rate was observed according to the number of suspicious US findings (P for trend=0.001).
Conclusion
Intermediate suspicion thyroid nodules with suspicious findings showed a higher malignancy rate than those without suspicious findings. Further management guidelines for nodules with suspicious findings should differ from guidelines for nodules without suspicious findings, even in the same US category.