PURPOSE: This study was done to identify the factors involved in ageism in nurses.METHODS: The participants in this study were 178 general hospital nurses. Data were collected in March 2019 using self-report questionnaires, and were analyzed using descriptive statistics, independent t-test, Mann-Whitney U test, one-way ANOVA, Kruskal-Wallis test, and stepwise multiple linear regression.RESULTS: The total score for ageism was 39.75±5.44 out of a maximum of 72. Ageism had a statistically significant relationship with contact experience (r=-.47, p < .001), attitude (r=.40 p < .001), and aging anxiety (r=.35 p < .001). The determining factors affecting ageism were contact experience (β=-.45, p < .001), attitude(β=.20, p=.002), work place (β=.22, p < .001), marital status (β=.21, p < .001), geriatric nursing preference (β=.18, p=.006), geriatric education (β=.17, p=.006), and aging anxiety (β=.14, p=.041). The explanation power of these variables was 39%.CONCLUSION: The results suggest that contact experience with elders had the largest influence on ageism in nurses. Therefore, it is necessary to develop tailored education programs by hospital type to increase positive contact experience and promote understanding of older patients in acute care settings. Furthermore, the importance of the perception of ageism needs to be highlighted in nursing education and continuing education for nurses.
Ageism ; Aging ; Anxiety ; Education ; Education, Continuing ; Education, Nursing ; Geriatric Nursing ; Hospitals, General ; Humans ; Linear Models ; Marital Status ; Workplace

PURPOSE: The aim of this study was to identify the factors related to the social distance toward older adults in nursing college students.METHODS: The participants comprised 137 students in a nursing college. Data were collected using self-report questionnaires in March 2019. The measurement instruments included social distance scales, the Fact on Aging Quiz (FAQ I), a 20-item semantic differential scale (to assess attitudes), and the perceived elderly stigma scale. The data were analyzed using descriptive statistics, independent t-tests, one-way analysis of variance (ANOVA), Pearson's correlation coefficient, and a multiple regression analysis.RESULTS: The total score for social distance toward older adults was 3.98±0.54 out of a maximum of 5. Social distance had a statistically significant relationship with knowledge (r=.20, p=.022), attitudes toward older adults (r=−.31, p < .001), and elderly stigma (r=−.27 p=.008). The factors affecting social distance were education in geriatrics (β=.33, p=.004), grade (β=-.29, p=.014), attitudes (β=−.21, p=.018), academic major satisfaction (β=.19, p=.028), and knowledge (β=.15, p=.048); the explanatory power of the model was 34%.CONCLUSION: There is a need for departmental efforts that nursing students acquire correct knowledge about the life and health of the elderly with the aging process and develop positive attitudes toward older adults through various experiences in gerontological nursing practicum and community senior-college student link programs.

Purpose: This study aimed to identify the factors influencing COVID-19 vaccination intentions in nurses. Methods: The participants were 184 nurses in Korea. Data were collected using a Google Form online survey method in February, 2021, and analyzed using an independent t-test, one-way ANOVA, Pearson correlation, and multiple regression analysis with the SPSS/WIN 26.0 program. Results: COVID-19 vaccination intention in nurses was correlated significantly with vaccine hesitancy (r = .58, p < .001), risk perception of COVID-19 (r = .22, p = .003), perception of vaccination as a professional duty (r = .59, p < .001), and attitude towards workplace infection control policies (r = .20, p = .007). Vaccine hesitancy (β = .40, p < .001) and the perception of vaccination as a professional duty (β = .44, p < .001) significantly influenced COVID-19 vaccination intention. The model developed in this study explained 50% of the variation in COVID-19 vaccination intention. Conclusion Improving the perception of vaccination as a professional duty and lowering vaccine hesitancy may enhance nurses’ COVID-19 vaccination intention. Above all, it is necessary to provide programs to encourage voluntary recognition of vaccination as a professional duty and develop strategies to reduce hesitancy toward COVID-19 vaccinations.

Purpose: This study aimed to assess the factors influencing the political participation of nursing students who, as they become future leaders in the nursing field, will need to increase their participation in health policy decisions. Methods: Data were collected using web-based questionnaires answered by 157 nursing students between March 13 and 27, 2023. Those data were analyzed using t-test, a one-way ANOVA, Pearson’s correlation coefficient, and a multiple linear regression. Results: The average score of political participation was 2.77±0.70 out of 5 points. Political participation showed positive correlations between political efficacy (r=.48, p<.001) and nursing professionalism (r=.27, p<.001). Furthermore, sex (female) and political efficacy were identified as influencing factors on political participation among nursing students, which explained it with 24.0% power. Conclusion Providing timely nursing education is necessary for enhancing political efficacy, which could promote political participation among nursing students.

A 46-year-old man was found dead at the foot of a mountain, with a bloody knife aside of his neck. A horizontal throat cut wound with multiple vertebral incisions was observed, with damages of neck vessels and pharynx. There were also three stab wounds in the abdomen and a horizontal cut in the anterior side of left proximal arm. He had suffered from depression. Scene circumstances and autopsy findings pointed toward a suicidal etiology.
Abdomen ; Arm ; Autopsy ; Depression ; Foot ; Humans ; Middle Aged ; Neck ; Pharynx ; Suicide ; Wounds, Stab

Recent investigations on familial thoracic aortic aneurysm and dissection (TAAD) identified several genetic variants. Meanwhile, intracranial vasculopathy in familial TAAD has been scarcely reported. We report a case of a young man with Marfanoid habitus and familial TAAD carrying MFAP5, c.472C>T variant. He presented with recurrent thunderclap headache and multifocal intracranial vasculopathy, which is predominantly suggestive of reversible cerebral vasoconstriction syndrome. While the role of MFAP5 in vasculopathy requires clarification, we propose its haploinsufficiency may contribute to both TAAD and intracranial stenosis, highlighting a potential risk of cerebrovascular disease in familial TAAD.

PURPOSE: The purpose of this study was to investigate symptom frequency and symptom discomfort in liver, kidney and heart transplant recipients. METHODS: This descriptive, comparative study included 191 subjects (86 liver, 81 kidney, 24 heart: 135 male, 56 female). The symptom frequency and distress questionnaires were used to examine the symptom experience of the subjects. RESULTS: The most frequent and distressing symptom was fatigue. Increased hair, increased appetite, poor concentration and poor vision were frequently reported and poor vision, poor concentration, muscle weakness, and headache were causing high distress. Women reported a significantly higher level of symptom frequency and discomfort than men. Heart recipients reported a significantly higher level of symptom frequency and discomfort than renal or liver recipients. Significant (P<0.05) differences were found in symptom frequency and discomfort depending on transplant organs, numbers of immunosuppressants genders, age and types of drug and time after transplantation. Most of symptoms were related to the side effects of cyclosporine or corticosteroids. CONCLUSION: The results provide a basis for patient and family education and for symptom management. Further investigation of the symptom experience of the transplant patients is needed, especially in relation to quality of life.
Adrenal Cortex Hormones ; Appetite ; Cyclosporine ; Education ; Fatigue ; Female ; Hair ; Headache ; Heart ; Humans ; Immunosuppressive Agents ; Kidney ; Liver ; Male ; Muscle Weakness ; Quality of Life ; Surveys and Questionnaires ; Transplantation ; Transplants*

Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in parallel with worldwide epidemic of obesity. Reactive oxygen species (ROS) contributes to the development and progression of NAFLD. Peroxisomes play an important role in fatty acid oxidation and ROS homeostasis, and catalase is an antioxidant exclusively expressed in peroxisome. The present study examined the role of endogenous catalase in early stage of NAFLD. 8-week-old male catalase knock-out (CKO) and age-matched C57BL/6J wild type (WT) mice were fed either a normal diet (ND: 18% of total calories from fat) or a high fat diet (HFD: 60% of total calories from fat) for 2 weeks. CKO mice gained body weight faster than WT mice at early period of HFD feeding. Plasma triglyceride and ALT, fasting plasma insulin, as well as liver lipid accumulation, inflammation (F4/80 staining), and oxidative stress (8-oxo-dG staining and nitrotyrosine level) were significantly increased in CKO but not in WT mice at 2 weeks of HFD feeding. While phosphorylation of Akt (Ser473) and PGC1α mRNA expression were decreased in both CKO and WT mice at HFD feeding, GSK3β phosphorylation and Cox4-il mRNA expression in the liver were decreased only in CKO-HF mice. Taken together, the present data demonstrated that endogenous catalase exerted beneficial effects in protecting liver injury including lipid accumulation and inflammation through maintaining liver redox balance from the early stage of HFD-induced metabolic stress.
Animals ; Body Weight ; Catalase* ; Diet ; Diet, High-Fat ; Fasting ; Homeostasis ; Humans ; Inflammation ; Insulin ; Insulin Resistance ; Liver Diseases ; Liver* ; Male ; Mice* ; Non-alcoholic Fatty Liver Disease ; Obesity ; Oxidation-Reduction ; Oxidative Stress ; Peroxisomes ; Phosphorylation ; Plasma ; Reactive Oxygen Species ; RNA, Messenger ; Stress, Physiological ; Triglycerides

Clear cell hidradenoma (HA) is a rare tumor of sweat glands. Although this tumor is benign, local recurrence often occurs when the resection margin is insufficiently obtained. The common imaging finding of HA is a mixed solid and cystic mass with or without increased vascularity in the solid portion. Malignant transformation of the tumor is also recognized. Hidradenocarcinoma (HAC), which is a malignant counterpart of benign HA, can develop de novo or arise from benign HA. However, imaging findings of HAC are not well established because these tumors are rare and they are commonly excised without imaging study. We present two cases of benign HA and HAC arising from benign HA with characteristic ultrasonography and computed tomography imaging features.

PURPOSE: Vascular smooth muscle cell (VSMC) proliferation and extracellular matrix protein accumulation play important roles in chronic allograft vasculopathy. Mycophenolic acid (MPA) or rapamycin (RPM) was reported to inhibit VSMC proliferation in vitro and in vivo. However, effects of MPA or RPM on collagen synthesis of VSMCs, and the combined effects of MPA and RPM treatment on VSMC proliferation are not yet reported. METHODS: VSMCs isolated from the aorta of Sprague-Dawley rats were cultured with EMEM supplemented with 10% fetal bovine serum and insulin/ transferrin. Growth arrested and synchronized cells were pretreated with test drugs (alone or combination of various concentrations of MPA and RPM) 1 hour before the addition of 10 ng/ml PDGF. Cell proliferation was assessed by [H3]- thymidine incorporation, and collagen synthesis by [H3]- proline incorporation. RESULTS: PDGF increased cell proliferation and collagen synthesis by 3.4- and 2.1-fold, respectively, compared to control. MPA at above 100 nM or RPM at above 1 nM effectively inhibited PDGF-induced cell proliferation and collagen synthesis. The IC50 of MPA or RPM against PDGF-stimulated cell proliferation was between 100 nM and 1 micrometer or between 1 nM and 10 nM, respectively. The combination of MPA and RPM showed additive effects on PDGF-induced VSMC proliferation in a multiple regression analysis (R2=0.508, P<0.05). CONCLUSION: The present study demonstrated that MPA or RPM significantly inhibited PDGF-induced VSMC proliferation. These independent phenomena were well maintained as suggested by additive effects after combination treatment. PDGF-induced collagen synthesis was also effectively suppressed by the treatment of MPA or RPM.
Allografts ; Animals ; Aorta ; Cell Proliferation ; Collagen* ; Extracellular Matrix ; Inhibitory Concentration 50 ; Muscle, Smooth, Vascular* ; Mycophenolic Acid* ; Proline ; Rats* ; Rats, Sprague-Dawley ; Sirolimus* ; Thymidine ; Transferrin