1.Protective Effect of Renal Function from Damage Due to ESWL by Nifedipine Controlled-release Tablet
Huixin SONG ; Jixu GAO ; Tonger ZHU
Journal of Chinese Physician 2001;0(02):-
Objective To study the protective effect of nifedipine controlled release tablet on renal function from damage due to extracorporeal shock wave lithotripsy(ESWL).Methods 93 cases of renal stone underwent extracoporeal shock wave lithotripsy(ESWL) were randomly divided into 2 groups,the adalat gits group (n=56)and the control group(n=37).In the former group ,adalat gits was given 30mg once a day for 3 days before ESWL and 1 days after ESWL, but in the control group did not take any drug.Urinary albumin, immunoglobulin-G, ? 2-microglobulin and Thmm-Horsfall protein were assayed to evaluate the renal function.Results In the control group,ALB, lgG and ? 2-MG showed a significant increased(P0 05).Conclusions Adalat gits could protect the renal function from damage due to ESWL.
2.ldentification of Viola yedoensis Makino and Viola inconspicua by FT-l R
Yuxin HE ; Zhirong SUN ; Jixu QU ; Lili CHENG ; Nannan ZHU
Journal of China Pharmaceutical University 2018;49(3):310-316
The different extracts and of Viola yedoensis Makino and Viola inconspicua were analyzed and identi-fied by Fourier transform infrared spectroscopy (FT-IR). One-dimensional infrared spectrum showed that the extracts of Viola yedoensis Makino and Viola inconspicua contained the aromatics,volatile substances and glyco-sides,with not significant differences from each other. However,different extraction sites of the two medicinal materials in second derivation spectrum were obviously different,especially the number of automatic peaks and peak intensity in the range of 970 800 cm-1. Viola yedoensis Makino displayed 5 automatic peaks,6 automatic peaks and 6 automatic peaks,while Viola inconspicua displayed 7 automatic peaks,4 peaks,4 peaks in the second derivation spectrum of petroleum ether extraction site,chloroform extraction site and the ethyl acetate extraction site. In addition,the peak position of the strongest peak in the second derivative of the ethyl acetate extraction site was 1 467 cm-1,while the strongest peak of the Viola inconspicua was at 1 384 cm-1,so the two medicinal mate-rials can be distinguished by the strongest peak position of ethyl acetate extraction site in second derivation spec-trum. Studies demonstrated that one-dimensional infrared spectroscopy combined with the second-order derivative analysis could achieve the accurate identification between Viola yedoensis Makino and Viola inconspicua. This research provides new ideas and new methods for the identification of Viola and other adulterants.
3.Recent advance in epoxyeicosatrienoic acids in intracerebral hemorrhage
Hongmin WEI ; Jixu YU ; Zhenchuan LIU ; Yushuang WANG ; Huimin ZHU ; Fengyuan CHE
Chinese Journal of Neuromedicine 2020;19(1):93-97
Epoxyeicosatrienoic acids (EETs) are mainly from intracellular arachidonic acids catalyzed by cytochrome P450 cyctooxygenase and degraded to lower active dihydroxyeicosapentaenoic acids by soluble epoxide hydrolase.In recent years,EETs have been found to be a new target for prevention and treatment of various nervous system diseases,such as anti-inflammatory reaction,anti-atherosclerosis,anti-cell apoptosis and angiogenesis.Intracerebral hemorrhage is a kind of serious acute cerebrovascular disease.Cerebral hemorrhage is a kind of acute cerebrovascular disease;secondary injury is one of the important mechanisms of cerebral hemorrhage;the present studies have confirmed that EETs have protective role in brain tissues after cerebral hemorrhage,thus,become new hotspot in the research of cerebral hemorrhage.This review focuses on the role and mechanism of EETs in intracerebral hemorrhage,hoping to provide some references for exploration of new research directions and therapeutic targets in the treatment ofintracerebral hemorrhage.
4.Recent advance in protective mechanism of regulatory T cells in secondary injury of intracerebral hemorrhage
Huimin ZHU ; Jixu YU ; Nian WANG ; Lijuan WANG ; Fengyuan CHE
Chinese Journal of Neuromedicine 2019;18(5):501-506
Intracerebral hemorrhage (ICH) is a serious acute cerebrovascular disease,and secondary injury is one of the important mechanisms of injury after ICH.Studies have confirmed that regulatory T cells (Tregs) play important protective roles after ICH by modulating microglial phenotype and inhibiting inflammation,and other pathways.This article reviews the protective mechanism of Tregs in the secondary injury,in order to provide a new therapeutic target for ICH.
5.Epidemiological characteristics and influencing factors of 245 COVID⁃19 cases in Shaanxi Province in 2020
Zecheng LI ; Jixu ZHU ; Lin ZHANG ; Jiuping WANG ; Zhangqian CHEN
Shanghai Journal of Preventive Medicine 2022;34(7):655-659
ObjectiveTo determine the epidemiological characteristics of COVID-19 in Shaanxi Province. MethodsEpidemiological analysis was conducted on the confirmed cases of COVID-19 (n=245) from January 23rd, 2020 through February 21st, 2020 based on the official data announced by Shaanxi Province. The effects of local population migration, prevention and control measures on the epidemic were explored. ResultsAs of February 21st, 2020, a total of 245 COVID-19 cases had been notified in Shaanxi Province, with a cumulative incidence rate of 0.63 per 100 000, of which imported cases accounted for 47.34%. The high incidence was observed between January 31st and February 5th. Xi’an had the largest number of COVID-19 cases, followed by Ankang, Hanzhong and Xianyang, totally accounting for 81.20% of the cases in the province. In terms of social factors, daily morbidity was positively correlated with Baidu migration scale index 14 days before. On January 25th, the provincial health emergency response was launched, and on January 31st, it was further upgraded for quarantine. On February 20th, the provincial prevention and control system was implemented by classified areas. There were no emerging local cases after February 21st and no confirmed cases for 28th consecutive days as of March 19th. Local cases and close contacts were cleared to zero on March 27th. ConclusionThe COVID-19 epidemic in Shaanxi Province is mainly concentrated in Guanzhong area and southern Shaanxi, with a widespread pattern in all cities. The prevention and control measures have effectively contained the epidemic, with a declining incidence. However, quarantine of suspected cases and close contacts remains crucial for routine prevention and control strategy.