Objective To evaluate the effect of oxytocin on Tp-e and QTc interval during caesarean section under spinal anesthesia in healthy puerperas. Methods Forty ASA Ⅰ puerperas were selected and allocated to receive oxytocin intravenous bolus group (group-IB) or oxytocin continuous infusion group (group-CI) with 20 puerperas in each by random digits table. An intravenous bolus of 5% glucose 5 ml and 5 U oxytocin was administered after delivery a 55-60 s period. A continuous infusion of 5% glucose 5 ml and 5U oxytocin was administered after delivery a 10 min period. Measured the QTc interval,Tp-e interval,mean arterial pressure (MAP) and beart rate ( HR ) pre-operatively, then 1,3 and 5 ain after spinal anesthesia, and at least 1,3,5 and 10 min after oxytocin injection. Results In group-IB:HR was fast 1 min after oxytocin injection compared with pre-operatively [(89 ± 13) beats/min vs. (73 ± 12) beats/min] ,MAP was decreased [(69 ± 12 ) mm Hg ( 1 mm Hg= 0. 133 kPa ) vs. ( 82 ± 13 ) mm Hg] and QTc interval was prolonged [(426 ±21 ) ms vs. (405 ± 18 ) ms] (P ＜ 0.01 ); but Tp-e interval was prolonged 1,3,5 min after oxytocin injection compared with pre-operatively (P ＜ 0.01 or ＜ 0.05 ). Conclusions Single large dose of oxytocin intravenous bolus (5 U) can prolong QTc interval and Tp-e interval in healthy puerperas, and Tp-e interval can exact predict the occurrence of ventricular arrhythmias. The risk-benefit balance of oxytocin bolus during caesarean delivery should be discussed with women with a history of long QT syndrome.

Objective To investigate the predictive effect of multiple serological indicators on the occurrence of heart failure(HF)after percutaneous coronary intervention(PCI)in elderly pa-tients with acute myocardial infarction(AMI).Methods A retrospective study was conducted on 276 elderly AMI patients.Based on whether HF occurred within 6 months,they were divided into HF group(n=65)and non-HF group(n=211).Multivariate Logistic regression was used to screen the influencing factors of AMI complicated with HF.The receiver operating characteristic(ROC)curve was applied to evaluate the efficacy of serological indicators in predicting HF.Results Age,uric acid,fibrinogen,high-sensitivity C-reactive protein(hs-CRP),systemic immune-inflammation index(SII)and level of interleukin-6(IL-6)in the HF group were significantly higher than those in the non-HF group,while the left ventricular ejection fraction and the proportion of TIMI grade 3 blood flow in the HF group were significantly lower(P＜0.05).Multivariate Logistic regression analysis showed that age(OR=1.401,95％CI,1.103 to 1.937),hs-CRP(OR=1.428,95％CI,1.108 to 1.839),SII(OR=1.645,95％CI,1.262 to 2.145),uric acid(OR=1.376,95％CI,1.123 to 1.685)and TIMI grade 3 blood flow(OR=0.502,95％CI,0.335 to 0.752)were independent influencing factors for HF after PCI in AMI patients.The ROC curve demonstrated that the area under the curve(AUC)of hs-CRP,SII and uric acid for predicting HF after PCI in AMI patients were 0.694(95％CI,0.619 to 0.768),0.854(95％CI,0.796 to 0.912)and 0.716(95％CI,0.646 to 0.786),respectively,with sensitivities of 75.38％,81.54％and 66.15％,and specificities of 57.32％,74.88％and 73.93％.Conclusion SII has the highest predictive value for HF after PCI in elderly AMI patients,which is helpful for assisting clinical management of high-risk HF populations.

Objective To investigate the predictive effect of multiple serological indicators on the occurrence of heart failure(HF)after percutaneous coronary intervention(PCI)in elderly pa-tients with acute myocardial infarction(AMI).Methods A retrospective study was conducted on 276 elderly AMI patients.Based on whether HF occurred within 6 months,they were divided into HF group(n=65)and non-HF group(n=211).Multivariate Logistic regression was used to screen the influencing factors of AMI complicated with HF.The receiver operating characteristic(ROC)curve was applied to evaluate the efficacy of serological indicators in predicting HF.Results Age,uric acid,fibrinogen,high-sensitivity C-reactive protein(hs-CRP),systemic immune-inflammation index(SII)and level of interleukin-6(IL-6)in the HF group were significantly higher than those in the non-HF group,while the left ventricular ejection fraction and the proportion of TIMI grade 3 blood flow in the HF group were significantly lower(P＜0.05).Multivariate Logistic regression analysis showed that age(OR=1.401,95％CI,1.103 to 1.937),hs-CRP(OR=1.428,95％CI,1.108 to 1.839),SII(OR=1.645,95％CI,1.262 to 2.145),uric acid(OR=1.376,95％CI,1.123 to 1.685)and TIMI grade 3 blood flow(OR=0.502,95％CI,0.335 to 0.752)were independent influencing factors for HF after PCI in AMI patients.The ROC curve demonstrated that the area under the curve(AUC)of hs-CRP,SII and uric acid for predicting HF after PCI in AMI patients were 0.694(95％CI,0.619 to 0.768),0.854(95％CI,0.796 to 0.912)and 0.716(95％CI,0.646 to 0.786),respectively,with sensitivities of 75.38％,81.54％and 66.15％,and specificities of 57.32％,74.88％and 73.93％.Conclusion SII has the highest predictive value for HF after PCI in elderly AMI patients,which is helpful for assisting clinical management of high-risk HF populations.

Traumatic supraorbital fissure syndrome (TSOFS) is a symptom complex caused by nerve entrapment in the supraorbital fissure after skull base trauma. If the compressed cranial nerve in the supraorbital fissure is not decompressed surgically, ptosis, diplopia and eye movement disorder may exist for a long time and seriously affect the patients′ quality of life. Since its overall incidence is not high, it is not familiarized with the majority of neurosurgeons and some TSOFS may be complicated with skull base vascular injury. If the supraorbital fissure surgery is performed without treatment of vascular injury, it may cause massive hemorrhage, and disability and even life-threatening in severe cases. At present, there is no consensus or guideline on the diagnosis and treatment of TSOFS that can be referred to both domestically and internationally. To improve the understanding of TSOFS among clinical physicians and establish standardized diagnosis and treatment plans, the Skull Base Trauma Group of the Neurorepair Professional Committee of the Chinese Medical Doctor Association, Neurotrauma Group of the Neurosurgery Branch of the Chinese Medical Association, Neurotrauma Group of the Traumatology Branch of the Chinese Medical Association, and Editorial Committee of Chinese Journal of Trauma organized relevant experts to formulate Chinese expert consensus on the diagnosis and treatment of traumatic supraorbital fissure syndrome ( version 2024) based on evidence of evidence-based medicine and clinical experience of diagnosis and treatment. This consensus puts forward 12 recommendations on the diagnosis, classification, treatment, efficacy evaluation and follow-up of TSOFS, aiming to provide references for neurosurgeons from hospitals of all levels to standardize the diagnosis and treatment of TSOFS.