The hospital water environment serves as a reservoir for Gram-negative multidrug-resistant organisms. Drains, sinks, drink dispensers, toilets, and shower equipment were identified as sources of the outbreak. Plumbing systems with variable nutrient and microbial loads promote bacterial colonization and biofilm formation. Plumbing traps (P-traps) in sinks are the primary source of sink-related outbreaks. Pathogens are introduced into P-traps through handwashing and disposal of waste or nutrients. Some pathogens can survive and develop biofilms in P-traps. When nutrients are introduced, the biofilm can extend upwards, reaching the sink strainer. During faucet operation, aerosols and drain contents are dispersed into the surrounding environment. Guidelines for handwash basin design generally recommend that large basins contain splashes and taps that are not aligned directly over the drains to minimize aerosol generation. Ensuring that basins are not used for the disposal of patient-related waste or nutrients and prohibiting the storage of clean patient material near the sink is important. Daily cleaning and disinfection of sink surfaces with bleach (sodium hypochlorite) are essential. Additionally, self-disinfecting traps that use heat, vibration, or ultraviolet radiation have been reported to reduce microbial burden and prevent further biofilm formation. Eradicating sink and drain contamination is often difficult and outbreaks can recur. Even after the replacement of the sink, the sink component had only temporary effects, suggesting a persistent reservoir in the retained sink fit. Further research is needed to develop continuous and effective disinfection methods for sinks and drains.

The hospital water environment serves as a reservoir for Gram-negative multidrug-resistant organisms. Drains, sinks, drink dispensers, toilets, and shower equipment were identified as sources of the outbreak. Plumbing systems with variable nutrient and microbial loads promote bacterial colonization and biofilm formation. Plumbing traps (P-traps) in sinks are the primary source of sink-related outbreaks. Pathogens are introduced into P-traps through handwashing and disposal of waste or nutrients. Some pathogens can survive and develop biofilms in P-traps. When nutrients are introduced, the biofilm can extend upwards, reaching the sink strainer. During faucet operation, aerosols and drain contents are dispersed into the surrounding environment. Guidelines for handwash basin design generally recommend that large basins contain splashes and taps that are not aligned directly over the drains to minimize aerosol generation. Ensuring that basins are not used for the disposal of patient-related waste or nutrients and prohibiting the storage of clean patient material near the sink is important. Daily cleaning and disinfection of sink surfaces with bleach (sodium hypochlorite) are essential. Additionally, self-disinfecting traps that use heat, vibration, or ultraviolet radiation have been reported to reduce microbial burden and prevent further biofilm formation. Eradicating sink and drain contamination is often difficult and outbreaks can recur. Even after the replacement of the sink, the sink component had only temporary effects, suggesting a persistent reservoir in the retained sink fit. Further research is needed to develop continuous and effective disinfection methods for sinks and drains.

The hospital water environment serves as a reservoir for Gram-negative multidrug-resistant organisms. Drains, sinks, drink dispensers, toilets, and shower equipment were identified as sources of the outbreak. Plumbing systems with variable nutrient and microbial loads promote bacterial colonization and biofilm formation. Plumbing traps (P-traps) in sinks are the primary source of sink-related outbreaks. Pathogens are introduced into P-traps through handwashing and disposal of waste or nutrients. Some pathogens can survive and develop biofilms in P-traps. When nutrients are introduced, the biofilm can extend upwards, reaching the sink strainer. During faucet operation, aerosols and drain contents are dispersed into the surrounding environment. Guidelines for handwash basin design generally recommend that large basins contain splashes and taps that are not aligned directly over the drains to minimize aerosol generation. Ensuring that basins are not used for the disposal of patient-related waste or nutrients and prohibiting the storage of clean patient material near the sink is important. Daily cleaning and disinfection of sink surfaces with bleach (sodium hypochlorite) are essential. Additionally, self-disinfecting traps that use heat, vibration, or ultraviolet radiation have been reported to reduce microbial burden and prevent further biofilm formation. Eradicating sink and drain contamination is often difficult and outbreaks can recur. Even after the replacement of the sink, the sink component had only temporary effects, suggesting a persistent reservoir in the retained sink fit. Further research is needed to develop continuous and effective disinfection methods for sinks and drains.

The hospital water environment serves as a reservoir for Gram-negative multidrug-resistant organisms. Drains, sinks, drink dispensers, toilets, and shower equipment were identified as sources of the outbreak. Plumbing systems with variable nutrient and microbial loads promote bacterial colonization and biofilm formation. Plumbing traps (P-traps) in sinks are the primary source of sink-related outbreaks. Pathogens are introduced into P-traps through handwashing and disposal of waste or nutrients. Some pathogens can survive and develop biofilms in P-traps. When nutrients are introduced, the biofilm can extend upwards, reaching the sink strainer. During faucet operation, aerosols and drain contents are dispersed into the surrounding environment. Guidelines for handwash basin design generally recommend that large basins contain splashes and taps that are not aligned directly over the drains to minimize aerosol generation. Ensuring that basins are not used for the disposal of patient-related waste or nutrients and prohibiting the storage of clean patient material near the sink is important. Daily cleaning and disinfection of sink surfaces with bleach (sodium hypochlorite) are essential. Additionally, self-disinfecting traps that use heat, vibration, or ultraviolet radiation have been reported to reduce microbial burden and prevent further biofilm formation. Eradicating sink and drain contamination is often difficult and outbreaks can recur. Even after the replacement of the sink, the sink component had only temporary effects, suggesting a persistent reservoir in the retained sink fit. Further research is needed to develop continuous and effective disinfection methods for sinks and drains.

BACKGROUND: Anesthesia induction with desflurane is troublesome because of the frequent sympathetic hyperactivity during desflurane administration. We thought that a low concentration of desflurane combined with a target-controlled infusion (TCI) of remifentanil would eliminate the desflurane-related complications and provide hemodynamic stability during desflurane induction. An up-and-down study was planned to find the target effect-site concentration of remifentanil to block the hemodynamic response to endotracheal intubation, the highest level of stimulus, during anesthesia induction with administering desflurane at 1 MAC. METHODS: Remifentanil TCI was initiated before desflurane administration. When the preset target was achieved, spontaneous inhalation of desflurane 1 MAC was performed until the patients became unconscious. Laryngoscopic tracheal intubation was facilitated with rocuronium injection. The starting concentration of remifentanil and the test space were 5 and 1 ng/ml, respectively. The criteria for up-and-down was a 20% increase of the mean arterial pressure or heart rate after intubation. The median effective concentration (EC50) of remifentanil was calculated from 6 independent pairs. The complications related with remifentanil and desflurane were assessed during the study. RESULTS: We studied 20 patients using 2-5 ng/ml of the effect-site concentrations of remifentanil. The EC50 of remifentanil was 3.7 ng/ml. Loss of consciousness was achieved at 125 +/- 22 s after desflurane inhalation and this was irrespective of the combined remifentanil concentrations. Any remifentanil-related complication was not observed. Transient cough was seen in one patient who received 2 ng/ml of remifentanil. CONCLUSIONS: We demonstrated that uncomplicated induction with desflurane was possible by the use of target-controlled remifentanil. The EC50 of remifentanil to block the hemodynamic response to tracheal intubation was 3.7 ng/ml during inhalational induction with 1 MAC desflurane.
Androstanols ; Anesthesia ; Arterial Pressure ; Cough ; Heart Rate ; Hemodynamics ; Humans ; Inhalation ; Intubation ; Intubation, Intratracheal ; Isoflurane ; Isoxazoles ; Piperidines ; Unconscious (Psychology) ; Unconsciousness