ROS-mediated oxidative stress involved in a variety of cellular signal transduction, FOXO3a transcription factor is an intersection in regulating a variety of cellular oxidative stress. FoxO3a has been extensively studied in regulating oxidative stress because of its rather complex and pivotal regulation of cell proliferation, cell cycle arrest, ROS scavenging and apoptosis. This review will elucidate the FOXO3a’s regulatory mechanisms and describe the target genes involved. It will also provide the clinical significance and strategies to target FOXO3a to regulate oxidative stress.

Objective:The relationship between the effect of early metabolism in 18F-FDG PET/CT and conventional CT based on the RE-CIST standard to evaluate the best objective response after chemotherapy in patients with non-small cell lung cancer (NSCLC). Meth-ods:We studied 40 patients with unresectable locally advanced or advanced NSCLC that were confirmed pathologically. The patients were 35 years old to 78 years old and included 31 males and 9 females. Three patients have unresectable stageⅢA, 8 patients have stageⅢB, 29 patients have stageⅣ, 12 patients have squamous cell carcinoma, and 28 patients have adenocarcinoma. The PET/CT for the effect of chemotherapy was evaluated in NSCLC according to the SUV standard (SUVmax reduction>30%of primary lung can-cer after one cycle of chemotherapy), and the CT for the effect of chemotherapy was evaluated on the basis of NSCLC according to the RECIST standard. The objectives of the study are as follows:compare the differences and consistency between 18F-FDG PET/CT metabol-ic response after the first cycle of chemotherapy and the RECIST best objective response after the first or second cycle of chemothera-py with the paired chi-square test and kappa test;calculate the 18F-FDG PET/CT to predict the best objective response of two cycles of chemotherapy according to RECIST on the basis of NSCLC in terms of sensitivity, specificity, accuracy, positive predictive value, and neg-ative predictive value;compare the differences in SUVmax reduction between the metabolic remission group and metabolic no relief group with the two-sample t-test. All statistical methods were 0.05 for the inspection level, and P<0.05 was considered statistically sig-nificant difference (SPSS19.0). Results:Differences were found between the first cycle of chemotherapy for the RECIST best objective response and 18F-FDG PET/CT metabolic response (χ2=5.063, P=0.021), and the results had bad consistency (Kappa=0.240, P=0.085). No differences were observed between the second cycle of chemotherapy for the RECIST best objective response and 18F-FDG PET/CT metabolic response (χ2=2.083, P=0.146);the results had good consistency (Kappa=0.413, P=0.006). The sensitivity, specificity, accura-cy, positive predictive value, and negative predictive value were 82%, 61%, 70%, 61%, and 82%, respectively. The differences in SUV-max reduction between the metabolic remission group and metabolic no relief group with the two-sample t-test were statistically sig-nificant (P<0.001). Conclusion: 18F-FDG PET/CT may predict the best objective response to chemotherapy for NSCLC patients. Com-pared with conventional CT, 18F-FDG PET/CT can be an early and accurate way to evaluate the chemotherapy effect in NSCLC.

Objective To systemic evaluate postoperative pulmonary function between segmentectomy and lobectomy in patients with early stage non-small cell lung cancer.Methods Computer searched was performed up to September 2016 at the Cochrane Library,PubMed,EMBASE,CBM,CNKI,VIP and Wanfang database,collected postoperative pulmonary function between segmentectomy and lobectomy in Patients with early stage Non-Small Cell Lung Cancer.Study selection,data collection and critical assessment of the included studies were performed according to the recommendations of the Cochrane Collaboration.Results Eight studies included 308 segmentectomy and 386 lobectomy were identified for inclusion.FVC％ (MD =9.91,95％ CI:3.53-16.30,P =0.002),postoperation / preoperation FVC％ (MD =6.74,95％ CI:5.52-7.79,P ＜0.05),FEV1％ (MD =13.25,95％ CI:10.25-16.26,P ＜ 0.05),postoperation / preoperation FEV1％ (MD =7.18,95 ％ CI:5.88-8.48,P ＜ 0.05) showed significant difference.Conclusion Pulmonary function index was superior to lobectomy after segmentectomy in patients with early stage lung cancer,and segmentectomy resection was more beneficial to preserve lung function.

Objective To study the effects of maternal gestational diabetes mellitus (GDM) on neonatal cardiac development.Method From January to December in 2016,full-term neonates of GDM mothers admitted to the neonatal department of our hospital were retrospectively included as the GDM group,and full-term neonates with non-GDM mothers during the same period as the control group.Their birth weight,length,placenta weight,birth weight/placenta weight ratio,echocardiographic cardiac measurements within the first week,and the incidence of congenital heart disease were compared between the two groups.Multivariate linear regression analysis was used to analyse the possible factors causing neonatal ventricular septal hypertrophy in GDM group.Result A total of 104 cases in the GDM group and 107 cases in the control group were included.Significant differences existed in birth weight,length and placental weight between the two groups (P ＜ 0.05).No significant differences in gender,gestational age and birth weight/placental weight ratio between the two groups (P ＞ 0.05).The width of the aorta and main pulmonary artery,the size of the left atrium,the left ventricle and the right ventricle,and the thickness of the ventricular septum in the GDM group were greater than the control group,the differences were statistically significant (P ＜ 0.05).The ventricular septal thickness of the GDM group was greater than the control group [≥3500g:(3.6±0.5) mmvs.(3.3±0.3) mm,＜3500g:(3.5±1.0) mmvs.(3.1 ± 0.4) mm],the difference was statistically significant (P ＜ 0.05).The incidence of congenital heart disease was 4.8％ (5/104) in the GDM group and 0％ in the control group.The difference between the two groups was statistically significant (P ＜ 0.05).Multivariate linear regression analysis showed that the interventricular septal thickness of the GDM group was positively correlated with the levels of HbA1c,HbA1 c,insulin of their mothers during pregnancy and birth weight of the newborn (P ＜ 0.05).Conclusion GDM mother may pose adverse effects on neonatal myocardial development.Further research is needed on its mechanism and how to monitor the incidence.

Objective:To observe the application effect of caregiver coaching program in primary caregivers of patients with colorectal neoplasms.Methods:A total of 114 primary caregivers of patients with colorectal neoplasms who were hospitalized and treated in Beijing Friendship Hospital, Capital Medical University from January 2018 to January 2019 were selected as the research objects by the convenient sampling method. The routine intervention group was given routine discharge guidance before discharge. The coaching program group implemented the caregiver coaching program on the basis of routine intervention, that was, after training, the caregivers with nursing experience acted as caregiver coaches to mentor the caregivers and provided professional care knowledge and skills as well as psychological support. Interventions in two groups both lasted for 12 weeks. The Chinese version of Family Caregiver Task Inventory (FCTI) and Caregiver Burden Inventory (CBI) were used to assess and compare the care capacity and care burden of caregivers between two groups at discharge and after 12 weeks of intervention.Results:After 12 weeks of intervention, the five-dimensional scores of adapting to the caregiver's role ability, adapting and providing assistance for patients ability, adjusting self and patient's emotional ability, coordinating other care resources and adjusting the conflicts between self-life and care activities ability in the coaching program group were all lower than those at discharge and the routine intervention group, and the differences were statistically significant ( P<0.01) . After 12 weeks of intervention, there was no statistically significant difference in scores of the five dimensions of time dependence, developmental limitation, body, sociability and emotionality in the routine intervention group compared with those at discharge ( P>0.05) . However, scores of these five dimensions of the coaching program group were lower than those at discharge and they were all lower than those of the routine intervention group. The differences were statistically significant ( P<0.01) . Conclusions:The caregiver coaching program can improve the care ability of primary caregivers of patients with colorectal neoplasms and reduce their care burden. It is an intervention method with better application prospects.

Objective:To explore effects of different timing of extubation on catheter-related lower urinary tract symptoms and urinary control recovery after extubation in patients with indwelling catheter after general anesthesia.Methods:Using the stratified random selection method, a total of 198 patients who underwent indwelling catheter after general anesthesia in Beijing Friendship Hospital affiliated to Capital Medical University were selected from January 2018 to July 2019. Using the random number table method, they were randomly divided into the observation group (101 cases) and the control group (97 cases) . In both groups, the extubation method was established by evidence-based nursing demonstration and the water sac test results of the material and model of urinary duct in the hospital. In the control group, the timing of extubation was to remove the catheter when the bladder was empty and the patient had no urination intention, and then assist urination when the urination intention appeared. In the observation group, the time of extubation was when the bladder was in a full state and the patient had the intention to urinate, the urinary duct was naturally discharged with urine by abdominal pressure. The lower urinary tract symptoms associated with urinary tube and the recovery of urinary control after extubation were compared between the two groups.Results:The success rate of urination in the observation group was higher than that of the control group, the core lower urinary tract symptom score and incidences of frequency of urination, urgency and acute urinary retention were lower than those of the control group, and the differences were statistically significant ( P<0.05) . The maximum bladder pressure measurement volume and residual urine volume in the observation group were lower than those in the control group, and the urine control rate and maximum urine flow rate at 72 h after extubation were higher than those in the control group, and the differences were statistically significant ( P<0.05) . Conclusions:Extubation in patients with bladder filling and urination after general anesthesia can reduce the incidence and severity of lower urinary tract symptoms associated with the catheter, which help patients recover bladder function and improve urinary control ability.

Objective:To investigate the effect of different timing of urinary catheter removal on postoperative recovery of elderly patients undergoing transurethral resection of prostate (TURP) .Methods:A total of 159 elderly patients undergoing TURP from Beijing Friendship Hospital Affiliated to Capital Medical University from March 2021 to June 2022 were selected as research objects by convenience sampling method, and were divided into the urinary catheter removal within 48 h after surgery group ( n=47), urinary catheter removal within 48 to 72 h after surgery group, urinary catheter removal>72 h after surgery group. The degree of dysuria after catheter removal, incidence of urinary tract infection, secondary catheter insertion rate and postoperative hospital stay were compared among the three groups. Results:The proportion of patients with moderate or above dysuria of the urinary catheter removal within 48 to 72 h after surgery group was lower than those of the urinary catheter removal within 48 h after surgery group and the urinary catheter removal>72 h after surgery group, and the differences were statistically significant ( P<0.05). The incidence of urinary tract infection of the urinary catheter removal within 48 h after surgery group and the urinary catheter removal within 48 to 72 h after surgery group were lower than that of the urinary catheter removal>72 h after surgery group, and the differences were statistically significant ( P<0.05). The rate of secondary catheterization of the urinary catheter removal within 48 to 72 h after surgery group and the urinary catheter removal>72 h after surgery group were lower than that of the urinary catheter removal within 48 h after surgery group, and the differences were statistically significant ( P<0.05). The postoperative hospital stay of the curinary catheter removal within 48 to 72 h after surgery group was shorter than those of the urinary catheter removal within 48 h after surgery group and the urinary catheter removal>72 h after surgery group, and the differences were statistically significant ( P<0.05) . Conclusions:Removing urinary catheter within 48 to 72 h after surgery can effectively reduce the degree of urination difficulty in elderly patients undergoing TURP, the incidence of urinary tract infection and the rate of secondary catheterization, and shorten the postoperative hospital stay.