Objective:To compare hard tissue morphology by cephalometric measurements between extraction and non extraction orthodontic treatment in borderline cases. Methods: The samples consisted of 33 cases selected as borderline cases by 5 orthodontic specialists. They were divided into 21 extraction cases (including 13 four first premolar extraction cases and 8 second premolar extraction cases) and 12 nonextraction cases by checking patients’ treatment records. Conventional cephalometric analysis was made to compare hard tissue structures before and after orthodontic treatment and the same comparison was made between two different extraction patterns. Results: No statistical difference was found on pretreatment hard tissue morphology between extraction and non extraction groups divided from borderline cases. The SNB angle of the four first premolars extraction group was smaller than that of the four second premolars extraction group by (4.0?1.3)?( P

40? or 40?)comprised 10 cases and the hypodivergent group (MP-SN

AIM: To investigate the antitumor and immunological activities of the polysaccharides obtained from rabdosia rubescens (RRP). METHODS: In vitro and in vivo tumor inhibitory experiments as well as MTT method were used. RESULTS: With increasing concentration, the RRP exerted direct cytotoxicity effect in vitro on the cell growth of EAC mice,and its inhibitory rate in vivo against sarcoma 180 reached 35% ( P

Objective To study the friction between brackets and archwires and the influential factors. Methods To test the friction of six combinations of canine bracket and stainless steel archwire, and to calculate the critical contact angles for each combination. Results The friction maintains stability with slight changes when the contact angle is smaller than the critical contact angle. The friction increases linearly when the contact angle is larger than the critical contact angle. The friction of different combinations of bracket-archwire are different and the critical contact angles are also different. Conclusion The critical contact angle influences the friction between bracket and archwire significantly. The critical contact angle is relevant to both the structure of the bracket and the size of the archwire.

Objective:To investigate the effects of periacetabular osteotomy (PAO) combined with hip arthroscopy in treating adult developmental dysplasia of the hip (DDH).Methods:A total of sixty-one patients with DDH who received PAO surgery were enrolled in the present retrospective study. Of all patients, forty of them were treated by PAO combined with open arthrotomy from December 2015 to June 2018 as arthrotomy group. There were three males and 37 females in this group. Twenty-one DDH patients, including 2 males and 19 females, were treated by PAO combined with hip arthroscopy from July 2018 to June 2019 as arthroscopy group. The average ages were 31.08±11.24 and 33.25±11.70 years, respectively. Radiological parameters before and after surgery were compared between two groups. Modified Harris hip score (mHHS), nonarthritic hip score (NAHS), hip outcome score activity of daily living scale (HOS-ADL) at 6 months and 12 months postoperatively were compared between two groups.Results:The preoperative LCE (lateral center edge) angle, ACE (anterior center edge) angle, T?nnis angle, extrusion index in each group were 8.53°±9.09° vs. 9.15°±10.86°, 13.69°±12.43° vs. 7.18°±15.74°, 20.12°±6.24° vs. 22.13°±8.86° and 38.97%±7.55% vs. 37.64%±10.01% respectively. There was no statistical difference between two groups. Cam deformity (α angle >50°) existed in 17 patients (81%, 17/21) in arthroscopy group and in 31 patients (78%, 31/40) in arthrotomy group without significant difference between two groups (χ 2=0.096, P=0.756). At 12 months follow-up, all radiological parameters were improved from those before surgery. The LCE angle, ACE angle, T?nnis angle, extrusion index were 34.29°±5.07° vs. 32.76°±9.48°, 32.87°±4.23° vs. 30.26°±5.39°, -1.82°±5.88° vs. 2.16°±7.89° and 16.81%±4.53% vs. 18.20%±9.16% between groups without significant difference. The preoperative mHHS, NAHS, HOS-ADL in two groups were 60.38±12.19, 50.90±8.54, 72.23±11.86 and 60.00±13.53, 52.55±7.92, 72.70±12.18 respectively. At 12 months, there was no statistical difference in mHHS between the two groups (87.90±4.34 vs. 86.50±5.11, t=1.135, P=0.261). The NAHS and HOS-ADL in arthroscopy group were higher than those in arthrotomy group at 12 months follow-up (88.71±4.49 vs. 82.17±5.23, t=6.066, P<0.001; 90.33±2.71 vs. 87.12±3.33, t=3.800, P<0.001). Conclusion:During PAO in treating DDH, better short-term clinical results could be achieved when it combined with hip arthroscopy.

AIM: To study the pathological change in mouse organs immunitied by inactivated SARS-CoV vaccine. METHODS: Inactivated SARS-CoV vaccine was injected into BALB/c and C57BL/6 mice. Anti-SARS antibody was analyzed by ELISA. After 8 weeks, the immunitied mice were killed and those organs were analyzed by pathological methods. RESULTS: Anti-SARS antibody in mice was positive after 8 days. Only minimal injury was observed in a few lungs and livers, but the other organs were not. CONCLUSIONS: Inactivated SARS-CoV vaccine induced mice to create antibody, whereas they did not cause severe injury. This result will be valuable for vaccine into clinical research. [

OBJECTIVETo propose a new three-dimensional method or grading scale in the evaluation of the secondary alveolar bone grafting, thus modifying the Bergland grading scale.

METHODSA total of 40 patients (26 male, 14 female) with unilateral cleft lip and palate (UCLP), who underwent secondary alveolar bone grafting at least 3 months ago, were enrolled. Regional cone-beam CT (CBCT) scans were taken to evaluate the height and thickness of the postoperative bone bridges. A new three-dimensional grafting scale was established, including four grades respectively in alveolar height and thickness.

RESULTSAccording to the new three-dimensional scale in this study, 15 grafted sites were rated grade T-I or T-II in the alveolar thickness among 18 sites of grade H-I in height, and 10 among 15 of grade H-II in height. Therefore, 25 grafted sites were considered as clinical success in the alveolar thickness (grade T-I or T-II) among 33 sites with clinical success in alveolar height (grade H-I and H-II). There were 24% of 33 sites with clinical success in height, which were considered as clinical failure in the alveolar thickness.

CONCLUSIONSIt is necessary to establish a new three-dimensional method or grading scale for evaluating the secondary alveolar bone grafting. The three-dimensional scale can take comprehensive view of the bone-grafted alveolar clefts and thus modify the Bergland grading scale.

Alveolar Bone Grafting ; Alveolar Process ; diagnostic imaging ; surgery ; Cleft Lip ; diagnostic imaging ; surgery ; Cleft Palate ; diagnostic imaging ; surgery ; Cone-Beam Computed Tomography ; Female ; Humans ; Male ; Postoperative Period

Objective:To analyze the effect of patellar tilt angle on postoperative outcomes after total knee arthroplasty (TKA) without patella resurfacing.Methods:A total of 143 patients with end-stage knee osteoarthritis who underwent TKA without patellar replacement in the First Affiliated Hospital of Nanjing Medical University from October 2020 to October 2021 were retrospectively analyzed. There were 32 males and 111 females, aged 68.44±6.79 years (range, 52-86 years). Patients were divided into three groups according to the postoperative patellar tilt angle: tilt angle<5° was the mild tilt group (97 cases), 5°≤tilt angle<10° was the moderate tilt group (31 cases), and tilt angle≥10° was the severe tilt group (15 cases). All patients were followed up in the outpatient clinic at 3, 6 and 12 months after surgery, and knee visual analogue score (VAS), Hospital for Special Surgery (HSS) score and patella Feller score were observed and recorded to compare the postoperative knee pain and function of patients in different patella tilt groups.Results:All patients were followed up for 1.16±0.23 years (range, 1.0-2.0 years). There was no significant difference in baseline data between the groups. There were significant differences in the intra-group comparison of the VAS score before and after surgery among the three groups ( F=51.12, P<0.001; F=36.90, P<0.001; F=15.76, P<0.001). The VAS scores at 3, 6 and 12 months after operation were significantly lower than those before operation ( P<0.05). The knee VAS of the severe group was higher than that of the mild and moderate groups at 3, 6 and 12 months after surgery, and the difference was statistically significant ( P<0.05). There were statistically significant differences in knee HSS scores before and after surgery among the three groups ( F=81.12, P<0.001; F=36.05, P<0.001; F=32.93, P<0.001). The knee HSS scores at 3, 6 and 12 months after surgery were higher than those before surgery, and the difference was statistically significant ( P<0.05). The knee HSS scores of the severe tilt group at 3, 6 and 12 months after surgery were lower than those of the mild and moderate groups, and the difference was statistically significant ( P<0.05). There were statistically significant differences in the intra-group comparison of the patella Feller score before and after surgery among the three groups ( F=88.81, P<0.001; F=49.59, P<0.001; F=37.40, P<0.001). The patellar Feller score at 3, 6 and 12 months after surgery was higher than that before surgery, and the difference was statistically significant ( P<0.05). The patellar Feller score of the severe group at 3, 6 and 12 months after surgery was lower than that of the mild and moderate groups, and the difference was statistically significant ( P<0.05). Conclusion:Patellar tilt angle after TKA without patellar resurfacing will increase knee pain and limit joint function.

Inflammatory bowel disease (IBD) is an intestinal immune-dysfunctional disease worldwide whose prevalence increasing in Asia including China. It is a chronic disease of the gastrointestinal tract with unknown cause. Exosomes are small vesicles in various body fluids. They have diameters of 40-120 nm, and one of their functions is long-distance transfer of various substances. In this study, we investigated the contents of salivary exosomes in patients with IBD and in healthy controls to explore a new biomarker in patients with IBD. In this study, whole saliva was obtained from patients with IBD (ulcerative colitis (UC), n = 37; Crohn's disease (CD), n = 11) and apparently healthy individuals (HC, n = 10). Salivary exosomes were extracted from samples, and the proteins within the exosomes were identified by liquid chromatograph-mass spectrometer (LC-MS/MS). The results showed that more than 2000 proteins were detected in salivary exosomes from patients with IBD. Through gene ontology analysis, we found that proteasome subunit alpha type 7 (PSMA7) showed especially marked differences between patients with IBD and the healthy controls, in that its expression level was much higher in the CD and UC groups. This exosomal protein is related to proteasome activity and inflammatory responses. So we conclude that in this research, salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with IBD. It can be a very promising biomarker to release the patients from the pain of colonoscopy.
Animals ; Biomarkers ; metabolism ; Female ; Humans ; Inflammatory Bowel Diseases ; metabolism ; Male ; Proteasome Endopeptidase Complex ; metabolism ; Salivary Proteins and Peptides ; metabolism