Objective To compare FEV1 with BODE in evaluating COPD.Methods Forty-one stable COPD patients,23 males and 18 females,with mean age of 58.8 years,were evaluated for FEV1 and BODE scores,the number and duration of acute exacerbations of COPD(AECOPD),number of admissions and duration of hospitalization caused by AECOPD,and sputum culture.All data were statistically analyzed with SPSS 11.0 for Windows.Results There was a remarkable difference in disease severity between the group with FEV1≥1 L and BODE score

Objective To improve mental health of children in the rural area by intervention with moviewatching.Methods The participants were 438 students from Anhui province,including 273 students in grade 5 from two primary schools and 165 students in grade 2 from two middle schools.Subjects were randomly divided into two groups:an intervention group with movie-watching (n=188)and a control group(n=250).Results The inter-group difference between the pre-measurement and the post-measurement on depression and anxiety of the intervention groups and the control groups in grade 5 from two primary schools was not significant,while the intergroup difference between the pre-measurement and the post-measurement on value8(the intervention group (2669.52±2216.43),the control group(316.57±1410.83)),and the inter-group difference was significant(t_(values)=10.721,P=0.000).The inter-group difference between the pre-measurement and the post-depression, anxiety and values of the interntion groups and the control groups in grade 2from two middle schools was significant(t _(depression)=2.046,P=0.043;t _(state amxoetu)=3.507,P=0.001;t _(trait anxiety)=3.392,P=0.001;t _(values)=5.022,P=0.000)respectively).The intervention effect on mood of depression,anxiety and the values of intervention groups in grade 5 from two primary schools was not significant,while significant on values(F=91.62,P=0.000);while that of intervention groups in grade 2 from two =0.000 respectively).Conclusion Movie-watching intervention wag an effective way to improve middle school students' mental health and to develop correct values.Movie-watching should be an alternative way to improve met-al health of children in rural area for its operability.

Aim To investigate the antinociception, tolerance and withdrawal abstinence of δ/μ/κ opioid receptor triple agonist KUST201 ( DPI-125 ) in rats. Methods Male Sprague-Dawley rats were used to de-termine the time course of analgesic effects and ED50 effects of co-administration of naltrindole were assessed as well. In withdrawal experiments, KUST201 was ad-ministrated twice daily for 3 d with increasing doses each day. On the 4th day, the rats were given a single dose, challenged with naloxone 3 h later, and signs of abstinence were monitored. Results The ED50 values of KUST201 were 0. 34 mg·kg-1 in tail-pinch test and 0. 68 mg · kg-1 in hot-plate test. The antinociception actions of KUST201 started to decrease 1 h after ad-ministration, and disappeared after 2 h. In chronic tol-erance experiments, the antinociception actions started to decrease on d 3 , and completely disappeared on d 7 . Naltrindole could reduce the antinociceptive action of KUST201. In withdrawal experiments, abstinence scores increased significantly in the dose range between 2~8 times of tail-pinch ED50 . Conclusion Compared with previously reported δ/μ/κ triple agonist DPI-3290 , KUST201 exhibits similar antinociceptive effects in rats. The chronic tolerance to KUST201 actions de-velops less quickly, but the abstinence scores of KUST201 are slightly higher. The activation of δ-opi-oid receptor can synergistically enhance the antinoci-ception mediated by μ-receptor.

Objective To investigate the relationship between social network behaviors and personality.Methods Both questionnaires including self-reported Renren questionnaire and the simplified Chinese version of NEO five-factor inventory (NEO-FFI) were completed in university students (n =509).Results (1) Individuals with higher score of Extraversion used Renren applications more frequently,such as using Wall (2.26 ± 0.51,2.10±0.40,t=3.163,P=0.002),Status Update (2.58 ±0.71,2.33 ±0.62,t =3.268,P=0.001),Image (2.05±0.88,1.81 ±0.72,t=2.628,P=0.009),and Photo (2.17 ±0.49,1.96 ±0.33,t=4.409,P＜0.01).(2)Individuals with higher score of Openness of Experience were more likely to use Gift (2.01 ± 0.49,1.83 ± 0.59,t =2.870,P =0.005).(3) Individuals who were willing to use Blacklist (41.93 ± 4.41,43.07 ± 4.72,t =2.207,P =0.028) and who were willing to send private messages (42.23 ± 4.79,43.27 ± 4.55,t =2.476,P =0.014) have higher score of Agreeableness.(4) Individuals who checked messages more often had higher score of Conscientiousness (41.59 ± 6.33,40.72 ± 5.67,37.56 ± 8.33,F =7.170,P =0.001).(5) Individuals with higher score of Neuroticism were more likely to be dependent to Renren (2.91 ± 1.01,2.48 ± 1.02,t =3.815,P ＜0.01).Individuals who were more likely to express their emotions on SNS had higher score of Neuroticism (33.10 ± 6.78,32.19 ± 6.16,31.36 ± 5.77,F=3.594,P =0.010).Conclusion The data suggest that the usage of social networking sites are related to personality factors.Personality can be used to predict university students' social networking behaviors.

Objective To investigate the relationship between personality and social network profile-based information.Methods 438 college students were recruited,and Big five inventory NEO-FFI was applied to all subjects.The participants' Renren web profile information were recorded.Results ①Individuals with higher score of Extraversion had more friends (2.47 ± 0.29,2.34 ± 0.27,F =17.861,P =0.000),shared more (2.51 ± 0.56,2.32 ± 0.57,F =8.617,P =0.004),pasted more photographs (2.30 ± 0.51,2.14 ± 0.56,F =5.523,P =0.02).② There was a U shape correlation (t =2.258,P =0.024,t =2.115,P =0.035) between levels of neuroticism and numbers of blogs (0.66 ± 0.71) and photographs (1.92 ± 0.83).③There was no difference on numbers of friends (2.38 ± 0.31,2.39 ± 0.27,F =0.149,P =0.700) and e-gifts received (1.30 ± 0.52,1.26 ± 0.45,F =0.257,P=0.613) between participants of high and low levels of agreeableness.④ Individuals with higher scores in openness shared more with others(2.46 ± 0.57,2.29 ± 0.58,F =5.248,P =0.023).⑤ Individuals being more conscientious had more blogs(1.08 ±0.49,0.96 ±0.48,F=3.064,P=0.082).Conclusion There are significant differences about profile-based information among college students with different personality.

Objective:Through a study on knowledge, attitudes, and practice of tobacco control of medical staff in Gansu Province, the paper aims to analyze the issues of participation, community tobacco control leadership and other aspects that impact the creation of a smoke-free healthcare system in order to provide a basis for the formulation of policies to improve the health professional mechanism of tobacco control. Methods:The stratified cluster sampling method was adopted to select 34 companies, accounting for a total of 805 medical staff as the study population in all kinds of health institutions. A self-designed questionnaire was adopted to investigate their knowledge, attitudes, and practice via on-site self-administered surveys. Results:the medical staff lacks knowledge as to the depth and breadth of damage from the use of tobacco. Although their attitude towards tobacco control is positive, the comprehensive to-bacco control service capabilities are insufficient. Logistic regression analysis showed that tobacco control capabilities of medical staff is related to their attitude toward smoking and whether or not they discourage smoking or asking about smoking . Conclusion:The key to the creation of a smoke-free health system to lead the community in tobacco control is the targeted tobacco cessation knowledge and skills training of medical staff to reduce smoking rates among medical staff and enhance the awareness of administrative staff.

Objective To analyze the impact of electronic portal imagingdevice (EPID) position error on three-dimensional dose verification of volumetric modulated arc therapy (VMAT).Metbods Five Suremark SL-20 lead points were fixed on Elekta tray,and EPID images were collected in 0-360° rotation,one image per 5°.The position error relative to the accelerator was analyzed via Matlab.Then the images position error was corrected according to the analysis,and the 3D dose was reconstructed with the corrected images.The dose distributions of double arcs,clockwise arc(arc 1),and counterclockwise arc (arc 2) of 16 nasopharyngeal carcinoma patients' VMAT plan were evaluated by γ analysis,and the results of before and after position error correction were compared.Results Compared to 0° gantry angle,the error of source to the image distance (SID) was maximum (1.20 cm) when the gantry angle was 180°.On account of the SID change,the maximum error along the up-down (y) direction in the iso-center planar was 2.28 mm and the left-right (x) direction error was within ± O.5 mm.The 3D γ analyses of 16 nasopharyngeal carcinoma in VMAT plans were obviously increased after the position error along y was corrected.The double arcs,arc1 and arc 2 were increased by (4.12 ±1.67) ％ (t =-9.86,P＜ 0.05),(3.47±1.64) ％ (t=-8.46,P＜ 0.05) and (5.08±1.30) ％ (t=-15.63,P＜ 0.05) in 5％/3 mm standard,respectively.However,in 3％/3 mm standard,γ value of the double arcs,arc 1 and arc2 were increased by (7.63 ±2.24) ％ (t =-13.63,P＜ 0.05),(6.03 ±2.07) ％ (t =-11.66,P＜ 0.05),(9.17 ±2.23) ％ (t =-16.41,P＜ 0.05),respectively.Since the EPID position error along x was corrected after y,the 3D γ analysis of reconstruction dose indicated that the average of the 5％/3 mm and 3％/3 mm γ value were increased by 0.23％ and 0.24％,respectively.Conclusions EPID motion error along the gantry to table direction of the accelerator can't be ignored.When reconstruct dose based on EPID,a modification should be made for rebuilding more accurate patients' 3D dose distribution.

OBJECTIVETo explore the feasibility of the animal experimental cabin to copy the animal models with ATM/LP and low oxygen and high carbon dioxide environment.

METHODS60 SPF-class male SD rats were divided into two groups, 20 for normobaric hypoxia control experiments and the other 40 for hypobaric hypoxia control experiments. For each group, examine the pulmonary arterial pressure and carotid arterial pressure indicators of rats by using the multi-detector measurement of physiological, and observe the pulmonary vascular changes in the structure.

RESULTSThe ATM/LP and low oxygen and high carbon dioxide environment can promote the formation of pulmonary hypertension and accelerate changes in pulmonary vascular remodeling, promoting right ventricular hypertrophy.

CONCLUSIONClinical applications showed that the animal experimental cabin was observing and controlling accurately, safe, reliable, and the results was reproducible. It can successfully copy the regular low-pressure hypoxia and hypercapnia environment pulmonary hypertension model, in order to study the physiological mechanism of a variety of circulation and respiratory diseases caused by oxygen-poor and provide an experimental technology platform.

Animals ; Carbon Dioxide ; metabolism ; Disease Models, Animal ; Environment, Controlled ; Equipment Design ; Hypoxia ; Male ; Oxygen ; metabolism ; Rats ; Sleep Apnea Syndromes

Objective To understand the prevalence of senile dementia in the elderly aged ≥ 60 years in China between 2000 and 2015.Methods Publications between 2000 and 2015 were retrieved from China National Knowledge Infrastructure (CNKI),Wanfang Databases,Chinese Science and Technology Journal Databases (VIP) and PubMed.Observational studies on prevalence of senile dementia were included.Meta-analysis was carried out by using R software.Results A total of 25 papers were included in this study.The total number of participants investigated was 76 980,with 4 295 dementia cases identified.The prevalence of senile dementia in the elderly was 5.15％ (95％CI:4.21％-6.09％);Subgroup analysis showed that the women had a higher prevalence (6.08％) than the men (4.10％);and the prevalence was significant increased with age (The senile dementia prevalence was 1.01％ in age groups 60-64 years,but 23.60％ in age group ≥85 years).The prevalence of Alzheimer's disease (3.56％) was higher than that of cerebral vascular dementia (1.11％).The senile dementia prevalence in the illiterate was 8.74％,higher than 3.17％ in the literate.The prevalence of senile dementia in the unmarried was 6.83％,higher than that in the married (3.95％).Conclusion The prevalence of senile dementia was high in the population aged ≥60 years in China.Age,sex,education level and marital status might influence the prevalence of senile dementia.

This paper developed an experimental animal cabin with ATM/LP and low oxygen and high carbon dioxide. It is based on the unitized design of modern transmission technology, industrial measurement modules and configuration software. The cabin successfully simulated an enclosed environment of low oxygen and high carbon dioxide at constant pressure, automatically measured and controlled the concentrations of oxygen and carbon dioxide as well as temperature and humidity in the cabin for the first time. The system provided a technology platform for the equipment supporting clinical COPD study. The result is accurate, stable and reliable and can realize automatic measurement and control of cross. The clinical applications show that the cabin with accurate measurement and control is practical and reliable.
Animal Use Alternatives ; instrumentation ; Animals ; Biosensing Techniques ; instrumentation ; Carbon Dioxide ; analysis ; metabolism ; Environment, Controlled ; Equipment Design ; Hypoxia ; Oxygen ; analysis ; Sleep Apnea Syndromes