PURPOSE: To compare the efficacy and safety of a 3-day regimen of extended-release ciprofloxacin (ciprofloxacin ER), 500mg qd, with trimethoprim-sulfamethoxazole (TMP/SMX), 800mg/160mg bid, for the empirical treatment of acute uncomplicated cystitis in Korean women. MATERIALS AND METHODS: A randomized, single-blind treatment trial of 75 women with acute uncomplicated cystitis was conducted. The women were prescribed ciprofloxacin ER, 500mg qd, or TMP/SMX, 800mg/160 mg, bid for 3 days. The patients were assessed in terms of the clinical and microbiological outcome and safety 7 days after treatment. RESULTS: Sixty-five women were eligible for the analyses (32 ciprofloxacin ER and 33 TMP/SMX). The most prevalent causative organism was Escherichia coli (76.9%), followed by Proteus (6.2%) and coagulase-negative Staphylococcus (6.2%). The rates of in vitro susceptibility to ciprofloxacin and TMP/SMX were 86.2 (56/65) and 73.4% (48/65), respectively. The clinical cure rates with ciprofloxacin ER and TMP/SMX were 87.5 and 78.8%, respectively. Microbiological cures at 7 days were observed in 25 of the 32 (78.1%) with ciprofloxacin ER and 18 of the 33 (54.5%) with TMP/SMX. The mean interval to improvement in the clinical symptoms after ciprofloxacin and TMP/SMX medications were 1.93+/-0.55 and 2.92+/-0.48 days, respectively. Adverse events with ciprofloxacin and TMP/SMX occurred in 28.1 and 15.5%, respectively, but both treatments were well tolerated. CONCLUSIONS: Although some organisms were resistant (13.8%) to ciprofloxacin, ciprofloxacin ER was superior to TMP/SMX in terms of the clinical and microbiological cure rates and the mean interval to improvement in the clinical symptoms. The high prevalence of resistance and low microbiological cure rates for TMP/SMX suggest that this drug does not provide an adequate initial therapy, while once-daily ciprofloxacin ER was safe and effective in the empirical treatment of symptomatic uncomplicated cystitis.
Ciprofloxacin* ; Cystitis* ; Escherichia coli ; Female ; Humans ; Prevalence ; Proteus ; Staphylococcus ; Trimethoprim-Sulfamethoxazole Combination

Background: Skin diseases associated with Malassezia species include malassezia folliculitis, pityriasis versicolor, and seborrheic dermatitis. Although several treatment options are available for the treatment of pityriasis versicolor, there is a lack of research data on sulfur preparation, which is a time-honored therapeutic agent; furthermore, data comparing topical antifungal agent and sulfur preparation is not available. Objective: The purpose of this study was to compare the efficacy and usefulness of a mixture of diflucortone valerate 1 mg/g and isoconazole nitrate 10 mg/g ointment (Travocort) and sodium thiosulfate solution 25% for pityriasis versicolor. Methods: A retrospective review was performed with 185 patients diagnosed with pityriasis versicolor who presented to the Department of Dermatology, Daegu Catholic University Medical Center between August 2002 and December 2021. Results: Of the 185 patients, 82 used Travocort while 103 used sodium thiosulfate solution. The average duration of the treatment was 19.3 days for Travocort and 28.8 days for sodium thiosulfate solution (p=0.001). The success rate of the treatment after 2 weeks was 65.8% for Travocort and 56.3% for sodium thiosulfate solution. Side effects occurred in 12.1% and 4.8% of the patients in the Travocort and sodium thiosulfate solution group, respectively. Conclusion Travocort had a faster healing rate than sodium thiosulfate solution. However, topical antifungal agents can cause side effects like localized cutaneous reaction. Furthermore, the glucocorticoid portion in combination therapy may induce various side effects with long-term use. Therefore, considering the side effects of Travocort, sodium thiosulfate solution can be used as a safe alternative when long-term treatment is required.

Purpose: This scoping review aimed to identify the research trends for dysphagia among older Korean adults in long-term care facilities. Methods: A literature search was performed using Korean Studies Information Service System, Research Information Sharing Service, ScienceON, Cumulative Index to Nursing and Allied Health Literature, and PubMed. A total of 1,395 articles were identified, and 10 articles were selected for the final analysis. Two reviewers independently performed the study selection and extraction using pre-tested forms to confirm those for final inclusion. Results: Most of the studies were published between 2011 and 2014. The quasi-experimental design was most frequently applied. The Gugging Swallowing Screen was the most widely used assessment tool. All studies, including dysphagia intervention programs, involved oral and facial exercise programs. In addition, they all used swallowing-related outcome variables to assess the effectiveness of the interventions. Conclusion Additional studies on dysphagia among older Korean adults in long-term care facilities should be conducted, and various interventions and assessment tools should be developed and implemented. This study is anticipated to establish a fundamental foundation for further dysphagia-related research and help improve the quality of life of Korean older adults in long-term care.

Purpose: This scoping review aimed to identify the research trends for dysphagia among older Korean adults in long-term care facilities. Methods: A literature search was performed using Korean Studies Information Service System, Research Information Sharing Service, ScienceON, Cumulative Index to Nursing and Allied Health Literature, and PubMed. A total of 1,395 articles were identified, and 10 articles were selected for the final analysis. Two reviewers independently performed the study selection and extraction using pre-tested forms to confirm those for final inclusion. Results: Most of the studies were published between 2011 and 2014. The quasi-experimental design was most frequently applied. The Gugging Swallowing Screen was the most widely used assessment tool. All studies, including dysphagia intervention programs, involved oral and facial exercise programs. In addition, they all used swallowing-related outcome variables to assess the effectiveness of the interventions. Conclusion Additional studies on dysphagia among older Korean adults in long-term care facilities should be conducted, and various interventions and assessment tools should be developed and implemented. This study is anticipated to establish a fundamental foundation for further dysphagia-related research and help improve the quality of life of Korean older adults in long-term care.

Purpose: This scoping review aimed to identify the research trends for dysphagia among older Korean adults in long-term care facilities. Methods: A literature search was performed using Korean Studies Information Service System, Research Information Sharing Service, ScienceON, Cumulative Index to Nursing and Allied Health Literature, and PubMed. A total of 1,395 articles were identified, and 10 articles were selected for the final analysis. Two reviewers independently performed the study selection and extraction using pre-tested forms to confirm those for final inclusion. Results: Most of the studies were published between 2011 and 2014. The quasi-experimental design was most frequently applied. The Gugging Swallowing Screen was the most widely used assessment tool. All studies, including dysphagia intervention programs, involved oral and facial exercise programs. In addition, they all used swallowing-related outcome variables to assess the effectiveness of the interventions. Conclusion Additional studies on dysphagia among older Korean adults in long-term care facilities should be conducted, and various interventions and assessment tools should be developed and implemented. This study is anticipated to establish a fundamental foundation for further dysphagia-related research and help improve the quality of life of Korean older adults in long-term care.

Purpose: This scoping review aimed to identify the research trends for dysphagia among older Korean adults in long-term care facilities. Methods: A literature search was performed using Korean Studies Information Service System, Research Information Sharing Service, ScienceON, Cumulative Index to Nursing and Allied Health Literature, and PubMed. A total of 1,395 articles were identified, and 10 articles were selected for the final analysis. Two reviewers independently performed the study selection and extraction using pre-tested forms to confirm those for final inclusion. Results: Most of the studies were published between 2011 and 2014. The quasi-experimental design was most frequently applied. The Gugging Swallowing Screen was the most widely used assessment tool. All studies, including dysphagia intervention programs, involved oral and facial exercise programs. In addition, they all used swallowing-related outcome variables to assess the effectiveness of the interventions. Conclusion Additional studies on dysphagia among older Korean adults in long-term care facilities should be conducted, and various interventions and assessment tools should be developed and implemented. This study is anticipated to establish a fundamental foundation for further dysphagia-related research and help improve the quality of life of Korean older adults in long-term care.

OBJECTIVE: To evaluate engraftment by visualizing the location of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) three-dimensionally in photothrombotic cerebral infarction (PTCI) models of rats. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) of an agarose block containing superparamagnetic iron oxide (SPIO)-labeled hBM-MSCs was performed using a 3.0-T MRI, T2-(T2WI), T2*-(T2*WI), and susceptibility-weighted images (SWI). PTCI was induced in 6 rats, and 2.5 x 10(5) SPIO-labeled hBM-MSCs were infused through the ipsilateral internal carotid artery (ICA group) or tail vein (IV group). MRI was performed on days 1, 3, 7, and 14 after stem cell injection. Dark signal regions were confirmed using histology. Three-dimensional MRI reconstruction was performed using the clinical workflow solution to evaluate the engraftment of hBM-MSCs. Volumetric analysis of the engraftment was also performed. RESULTS: The volumes of SPIO-labeled hBM-MSCs in the phantom MRI were 129.3, 68.4, and 25.9 microL using SWI, T2*WI, and T2WI, respectively. SPIO-labeled hBM-MSCs appeared on day 1 after injection, encircling the cerebral infarction from the ventral side. Dark signal regions matched iron positive cells and human origin (positive) cells. The volume of the engraftment was larger in the ICA group on days 1, 3, and 7, after stem cell injection (p < 0.05 on SWI). SWI was the most sensitive MRI pulse sequence (p < 0.05). The volume of infarction decreased until day 14. CONCLUSION: The engraftment of SPIO-labeled hBM-MSCs can be visualized and evaluated three-dimensionally in PTCI models of rats. The engraftment volume was larger in the ICA group than IV group on early stage within one week.
Animals ; Cerebral Infarction/pathology/*radiography ; Contrast Media ; Dextrans ; Humans ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/*methods ; Magnetite Nanoparticles ; Male ; *Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/radiography ; Nanoparticles ; Neuroimaging/*methods ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Tomography, X-Ray Computed

PURPOSE: We evaluated the effect of tamsulosin for the short-term treatment of urinary stones. MATERIALS AND METHODS: Two hundred forty-seven patients who were diagnosed with urinary stones were enrolled in this prospective, randomized multicenter study. The treatment and extracorporeal shock wave lithotripsy (ESWL) group (Group 1, n=115) was given diclofenac sodium 100 mg plus tamsulosin 0.2 mg for 1 week. The control and SWL group (Group 2, n=92) was given diclofenac sodium for 1 week. The treatment and no SWL group (Group 3, n=19) was treated the same as Group 1. The control and no SWL group (Group 4, n=21) was given diclofenac sodium only. Patients in Groups 3 and 4 did not want to take SWL treatment. The size of the stone, expulsion rate according to stone location and ESWL machines, changes in pain score, and distance of stone migration when expulsion of the stone failed were compared among the groups. RESULTS: There were no differences in the 4 groups in sex or stone size. The stone expulsion rate of lower ureter stones in group 1 (59.6%) was significantly higher than in group 2 (30.8%) (p=0.01). The distance of stone migration in group 3 was longer than that in group 4 (5.63+/-5.48 cm compared with 0.33+/-0.68 cm; p=0.002). Although the difference was not significant in the SWL groups, the distance of stone migration in group 1 was longer than that in group 2 (7.08+/-6.9 cm compared with 5.46+/-7.4 cm; p>0.05). There were no significant differences in changes on the pain scale among the groups. CONCLUSIONS: These results suggest that adjunctive medical therapy for 1 week with tamsulosin after SWL increases the stone expulsion rate of lower ureteral stones and increases the distance of stone migration in case of failure of stone expulsion.
Diclofenac ; Humans ; Lithotripsy ; Prospective Studies ; Shock ; Sulfonamides ; Ureter ; Urinary Calculi

OBJECTIVE: This study aimed to evaluate the hypotheses that administration routes [intra-arterial (IA) vs. intravenous (IV)] affect the early stage migration of transplanted human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in acute brain infarction. METHODS: Male Sprague-Dawley rats (n=40) were subjected to photothrombotic infarction. Three days after photothrombotic infarction, rats were randomly allocated to one of four experimental groups [IA group : n=12, IV group : n=12, superparamagnetic iron oxide (SPIO) group : n=8, control group : n=8]. All groups were subdivided into 1, 6, 24, and 48 hours groups according to time point of sacrifice. Magnetic resonance imaging (MRI) consisting of T2 weighted image (T2WI), T2* weighted image (T2*WI), susceptibility weighted image (SWI), and diffusion weighted image of rat brain were obtained prior to and at 1, 6, 24, and 48 hours post-implantation. After final MRI, rats were sacrificed and grafted cells were analyzed in brain and lung specimen using Prussian blue and immunohistochemical staining. RESULTS: Grafted cells appeared as dark signal intensity regions at the peri-lesional zone. In IA group, dark signals in peri-lesional zone were more prominent compared with IV group. SWI showed largest dark signal followed by T2*WI and T2WI in both IA and IV groups. On Prussian blue staining, IA administration showed substantially increased migration and a large number of transplanted hBM-MSCs in the target brain than IV administration. The Prussian blue-positive cells were not detected in SPIO and control groups. CONCLUSION: In a rat photothrombotic model of ischemic stroke, selective IA administration of human mesenchymal stem cells is more effective than IV administration. MRI and histological analyses revealed the time course of cell migration, and the numbers and distribution of hBM-MSCs delivered into the brain.
Animals ; Brain ; Brain Infarction ; Cell Movement ; Cerebral Infarction* ; Diffusion ; Humans* ; Infarction ; Infusions, Intravenous* ; Iron ; Lung ; Magnetic Resonance Imaging* ; Male ; Mesenchymal Stromal Cells* ; Rats* ; Rats, Sprague-Dawley ; Stroke ; Transplants

We experienced a case of carcinoma ex pleomorphic adenoma arising in the submandibular gland of a 47-year-old male patient. The patient underwent submandibular gland ressection and supraomohyoid neck dissection. Histologic examination revealed that the malignant component of carcinoma ex pleomorphic adenoma was adenosquamous carcinoma. The patient refused postoperative radiation therapy and tumor recurred at the neck and lung about 18 month later. Modified radical neck dissection was carried out, and additional postoperative radiotherapy and palliative chemotherapy were initiated. To the best of our knowledge, this is the first case of carcinoma ex pleomorphic adenoma, of which the malignant component is adenosquamous carcinoma in the submandibular gland. Therefore the authors report this rare case with a literature review.
Adenoma, Pleomorphic* ; Carcinoma, Adenosquamous* ; Drug Therapy ; Humans ; Lung ; Male ; Middle Aged ; Neck ; Neck Dissection ; Radiotherapy ; Submandibular Gland*