Background: Skin diseases associated with Malassezia species include malassezia folliculitis, pityriasis versicolor, and seborrheic dermatitis. Although several treatment options are available for the treatment of pityriasis versicolor, there is a lack of research data on sulfur preparation, which is a time-honored therapeutic agent; furthermore, data comparing topical antifungal agent and sulfur preparation is not available. Objective: The purpose of this study was to compare the efficacy and usefulness of a mixture of diflucortone valerate 1 mg/g and isoconazole nitrate 10 mg/g ointment (Travocort) and sodium thiosulfate solution 25% for pityriasis versicolor. Methods: A retrospective review was performed with 185 patients diagnosed with pityriasis versicolor who presented to the Department of Dermatology, Daegu Catholic University Medical Center between August 2002 and December 2021. Results: Of the 185 patients, 82 used Travocort while 103 used sodium thiosulfate solution. The average duration of the treatment was 19.3 days for Travocort and 28.8 days for sodium thiosulfate solution (p=0.001). The success rate of the treatment after 2 weeks was 65.8% for Travocort and 56.3% for sodium thiosulfate solution. Side effects occurred in 12.1% and 4.8% of the patients in the Travocort and sodium thiosulfate solution group, respectively. Conclusion Travocort had a faster healing rate than sodium thiosulfate solution. However, topical antifungal agents can cause side effects like localized cutaneous reaction. Furthermore, the glucocorticoid portion in combination therapy may induce various side effects with long-term use. Therefore, considering the side effects of Travocort, sodium thiosulfate solution can be used as a safe alternative when long-term treatment is required.

OBJECTIVES: This study was performed to provide the basic data for establishing countermeasures for preventing injury by analyzing the incidence rates, the risk factors, the characteristics of the injury and the utilization of medical care for mild injury that lasted for two weeks. METHODS: We examined the injury survey data among the National Health and Nutrition Survey data. The definition of mild injury that lasted for two weeks was that the injury that caused pain at least once a day for two weeks or the injury for which the usual daily activity of the injured person was severely affected. We used statistical analysis methods such as chi-square test and multiple logistic regression analysis. RESULTS: The incidence rate of injury that lasted for two weeks was 4.7 per 1,000 persons. On the multiple logistic regression, the children and adolescents (OR=3.80, 95%CI=1.63-8.84) had higher rates of injuries than the adults, and the middle and high school (OR=0.51, 95%CI=0.31-0.85) and college(OR=0.34, 95%CI=0.17-0.68) students had lower rates of injuries than the elementary school students. The unemployed (OR=0.39, 95%CI=0.20-0.73) and others (OR=0.38, 95%CI=0.21-0.70) had lower rates of injuries than the blue collar workers. The major causes of injuries were found to be falling and slipping, and the most prevalent place of occurrence was near or at home. CONCLUSIONS: A prevention program needs to be developed and continuous education must be offered to the children, adolescents and blue collar workers.
Adolescent ; Adult ; Child ; Female ; Humans ; Incidence ; Korea/epidemiology ; Male ; Middle Aged ; *Nutrition Surveys ; Risk Factors ; Trauma Severity Indices ; Wounds and Injuries/classification/*epidemiology

In order to determine paternity by genetic testing, the Paternity Index (PI) and probability of paternity are calculated using likelihood ratio method. However, when it is necessary, additional testing can be performed to validate the genetic relationship. This research demonstrates autosomal short tandem repeat (STR) results of Jeju Island population in order to determine genetic relationship. Two notable cases showed that despite the acceptable PI value obtained from STR testing, average of 12 mismatches were found in total of 169 autosomal single nucleotide polymorphism typing. Such cases imply that cautious statistical approach is necessary when determining genetic relationship, especially within an isolated population group. Moreover, this would suggest that a further research and investigation are needed in order to understand the population structure of Korea.
Genetic Testing ; Humans ; Korea ; Microsatellite Repeats ; Oligonucleotide Array Sequence Analysis ; Paternity* ; Polymorphism, Single Nucleotide ; Population Groups

Purpose: This study aimed to investigate the oncofertility experiences of young women with breast cancer and elucidate their process of coping. Methods: Employing a grounded theory approach, in-depth interviews were conducted with 12 women aged 27~37 with breast cancer who experienced fertility challenges. Data analysis was conducted using the constant comparative method. Results: The core category identified was a journey to restore daily life with inevitable damage to fertility, and young women with breast cancer experienced three stages: the crisis stage, life restructuring stage, and daily life recovery stage. The causal conditions were chemotherapy and pregnancy planning. The contextual conditions were anxiety about embryo or oocyte cryopreservation, the need to make a decision quickly, and expectations for natural pregnancy. The central phenomenon of oncofertility in women with breast cancer was “choices for an uncertain future.” The action/interaction strategies included increasing immunity, weight control, having a strong mind, and finding knowledge related to breast cancer. The intervening conditions were support from health care providers and family support. The consequences were early onset of menopause and “desperate pregnancy.” Conclusion Nurses need to be interested in the decline in fertility of young women with breast cancer and play a role in understanding and actively helping them.

Purpose: This study aimed to investigate the oncofertility experiences of young women with breast cancer and elucidate their process of coping. Methods: Employing a grounded theory approach, in-depth interviews were conducted with 12 women aged 27~37 with breast cancer who experienced fertility challenges. Data analysis was conducted using the constant comparative method. Results: The core category identified was a journey to restore daily life with inevitable damage to fertility, and young women with breast cancer experienced three stages: the crisis stage, life restructuring stage, and daily life recovery stage. The causal conditions were chemotherapy and pregnancy planning. The contextual conditions were anxiety about embryo or oocyte cryopreservation, the need to make a decision quickly, and expectations for natural pregnancy. The central phenomenon of oncofertility in women with breast cancer was “choices for an uncertain future.” The action/interaction strategies included increasing immunity, weight control, having a strong mind, and finding knowledge related to breast cancer. The intervening conditions were support from health care providers and family support. The consequences were early onset of menopause and “desperate pregnancy.” Conclusion Nurses need to be interested in the decline in fertility of young women with breast cancer and play a role in understanding and actively helping them.

Purpose: This study aimed to investigate the oncofertility experiences of young women with breast cancer and elucidate their process of coping. Methods: Employing a grounded theory approach, in-depth interviews were conducted with 12 women aged 27~37 with breast cancer who experienced fertility challenges. Data analysis was conducted using the constant comparative method. Results: The core category identified was a journey to restore daily life with inevitable damage to fertility, and young women with breast cancer experienced three stages: the crisis stage, life restructuring stage, and daily life recovery stage. The causal conditions were chemotherapy and pregnancy planning. The contextual conditions were anxiety about embryo or oocyte cryopreservation, the need to make a decision quickly, and expectations for natural pregnancy. The central phenomenon of oncofertility in women with breast cancer was “choices for an uncertain future.” The action/interaction strategies included increasing immunity, weight control, having a strong mind, and finding knowledge related to breast cancer. The intervening conditions were support from health care providers and family support. The consequences were early onset of menopause and “desperate pregnancy.” Conclusion Nurses need to be interested in the decline in fertility of young women with breast cancer and play a role in understanding and actively helping them.

Background: Loss of companion animals can result in various psychological reactions, including complicated grief, depression, anxiety, and insomnia. However, research on the prevalence of patients requiring clinical intervention is limited. Moreover, research examining the relationship between childhood trauma and psychological symptoms after pet loss is lacking. Therefore, this study aimed to investigate the rates of clinically significant psychological distress after pet loss and the impact of childhood trauma on adults who have experienced pet loss. Methods: An online survey was conducted with non-clinical adult participants who had experienced the loss of a companion animal. Psychiatric characteristics were evaluated using standardized assessments, including the Inventory of Complicated Grief (ICG), the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), and the Insomnia Severity Index (ISI). Childhood trauma was evaluated using the Childhood Trauma Questionnaire (CTQ). Results: In a sample of 137 individuals who had experienced pet loss, the percentages of those who exceeded the cutoff points were 55% for the ICG, 52% for the PHQ-9, 40% for the GAD-7, and 32% for the ISI. The group that reported childhood trauma exhibited significantly higher scores on the ICG (t = 2.16, P = 0.032), PHQ-9 (t = 3.05, P = 0.003), GAD-7 (t = 2.61, P = 0.010), and ISI (t = 2.11, P = 0.037) than in the group without childhood trauma.For participants who experienced pet loss for less than one year, there was no significant difference in the ICG between the trauma and non-trauma groups, as both had extremely high scores. However, the trauma group had a significantly higher PHQ-9 (t = 2.58,P = 0.012) than the non-trauma group. In contrast, for participants who experienced pet loss for more than one year, the trauma group had a significantly higher ICG (t = 2.22, P = 0.03) than the non-trauma group, while there was no significant difference in the PHQ-9. Additionally, the emotional abuse scores on the CTQ were most significantly correlated with the ICG scores even after controlling for depressive symptoms. Conclusion People who experienced pet loss had significant psychological symptoms, ranging from 32% to 55%. Childhood trauma experiences affect complicated grief, depressive symptoms, anxiety symptoms, insomnia and prolonged grief disorder after pet loss. After pet loss, people with childhood trauma may require more psychological help than those without trauma.

Fecal incontinence (FI) undoubtedly reduces quality of life and adversely affects the social life of the affected individual. FI has a higher prevalence with age and has an equivalent prevalence to urinary incontinence in patients with genitourinary disease, but is often not confirmed in these cases. A thorough investigation is needed to diagnose FI, with the common etiology of this condition in mind, and several questionnaires can be used to identify symptoms. The physical examination contains digital rectal examination carries out to identify the patient’s condition. Ultrasound, colonoscopy, and rectum pressure test can be performed. Patients educated in diet-related issues, bowel movements, and defecation mechanism. Nonoperative options such as diet control and Kegel exercise should be performed at first. Surgical treatment of FI is considered when conservative management and oral medications produce no improvement. Surgical options include less invasive procedures like bulking agent injections, and more involved approaches from sacral nerve stimulation to invasive direct sphincter repair and artificial bowel sphincter insertion. Good outcomes in FI cases have also recently been reported for barrier devices.

Fecal incontinence (FI) undoubtedly reduces quality of life and adversely affects the social life of the affected individual. FI has a higher prevalence with age and has an equivalent prevalence to urinary incontinence in patients with genitourinary disease, but is often not confirmed in these cases. A thorough investigation is needed to diagnose FI, with the common etiology of this condition in mind, and several questionnaires can be used to identify symptoms. The physical examination contains digital rectal examination carries out to identify the patient’s condition. Ultrasound, colonoscopy, and rectum pressure test can be performed. Patients educated in diet-related issues, bowel movements, and defecation mechanism. Nonoperative options such as diet control and Kegel exercise should be performed at first. Surgical treatment of FI is considered when conservative management and oral medications produce no improvement. Surgical options include less invasive procedures like bulking agent injections, and more involved approaches from sacral nerve stimulation to invasive direct sphincter repair and artificial bowel sphincter insertion. Good outcomes in FI cases have also recently been reported for barrier devices.

OBJECTIVE: This study aimed to evaluate the hypotheses that administration routes [intra-arterial (IA) vs. intravenous (IV)] affect the early stage migration of transplanted human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in acute brain infarction. METHODS: Male Sprague-Dawley rats (n=40) were subjected to photothrombotic infarction. Three days after photothrombotic infarction, rats were randomly allocated to one of four experimental groups [IA group : n=12, IV group : n=12, superparamagnetic iron oxide (SPIO) group : n=8, control group : n=8]. All groups were subdivided into 1, 6, 24, and 48 hours groups according to time point of sacrifice. Magnetic resonance imaging (MRI) consisting of T2 weighted image (T2WI), T2* weighted image (T2*WI), susceptibility weighted image (SWI), and diffusion weighted image of rat brain were obtained prior to and at 1, 6, 24, and 48 hours post-implantation. After final MRI, rats were sacrificed and grafted cells were analyzed in brain and lung specimen using Prussian blue and immunohistochemical staining. RESULTS: Grafted cells appeared as dark signal intensity regions at the peri-lesional zone. In IA group, dark signals in peri-lesional zone were more prominent compared with IV group. SWI showed largest dark signal followed by T2*WI and T2WI in both IA and IV groups. On Prussian blue staining, IA administration showed substantially increased migration and a large number of transplanted hBM-MSCs in the target brain than IV administration. The Prussian blue-positive cells were not detected in SPIO and control groups. CONCLUSION: In a rat photothrombotic model of ischemic stroke, selective IA administration of human mesenchymal stem cells is more effective than IV administration. MRI and histological analyses revealed the time course of cell migration, and the numbers and distribution of hBM-MSCs delivered into the brain.
Animals ; Brain ; Brain Infarction ; Cell Movement ; Cerebral Infarction* ; Diffusion ; Humans* ; Infarction ; Infusions, Intravenous* ; Iron ; Lung ; Magnetic Resonance Imaging* ; Male ; Mesenchymal Stromal Cells* ; Rats* ; Rats, Sprague-Dawley ; Stroke ; Transplants