Purpose: This scoping review aimed to identify the research trends for dysphagia among older Korean adults in long-term care facilities. Methods: A literature search was performed using Korean Studies Information Service System, Research Information Sharing Service, ScienceON, Cumulative Index to Nursing and Allied Health Literature, and PubMed. A total of 1,395 articles were identified, and 10 articles were selected for the final analysis. Two reviewers independently performed the study selection and extraction using pre-tested forms to confirm those for final inclusion. Results: Most of the studies were published between 2011 and 2014. The quasi-experimental design was most frequently applied. The Gugging Swallowing Screen was the most widely used assessment tool. All studies, including dysphagia intervention programs, involved oral and facial exercise programs. In addition, they all used swallowing-related outcome variables to assess the effectiveness of the interventions. Conclusion Additional studies on dysphagia among older Korean adults in long-term care facilities should be conducted, and various interventions and assessment tools should be developed and implemented. This study is anticipated to establish a fundamental foundation for further dysphagia-related research and help improve the quality of life of Korean older adults in long-term care.

Purpose: This scoping review aimed to identify the research trends for dysphagia among older Korean adults in long-term care facilities. Methods: A literature search was performed using Korean Studies Information Service System, Research Information Sharing Service, ScienceON, Cumulative Index to Nursing and Allied Health Literature, and PubMed. A total of 1,395 articles were identified, and 10 articles were selected for the final analysis. Two reviewers independently performed the study selection and extraction using pre-tested forms to confirm those for final inclusion. Results: Most of the studies were published between 2011 and 2014. The quasi-experimental design was most frequently applied. The Gugging Swallowing Screen was the most widely used assessment tool. All studies, including dysphagia intervention programs, involved oral and facial exercise programs. In addition, they all used swallowing-related outcome variables to assess the effectiveness of the interventions. Conclusion Additional studies on dysphagia among older Korean adults in long-term care facilities should be conducted, and various interventions and assessment tools should be developed and implemented. This study is anticipated to establish a fundamental foundation for further dysphagia-related research and help improve the quality of life of Korean older adults in long-term care.

Purpose: This scoping review aimed to identify the research trends for dysphagia among older Korean adults in long-term care facilities. Methods: A literature search was performed using Korean Studies Information Service System, Research Information Sharing Service, ScienceON, Cumulative Index to Nursing and Allied Health Literature, and PubMed. A total of 1,395 articles were identified, and 10 articles were selected for the final analysis. Two reviewers independently performed the study selection and extraction using pre-tested forms to confirm those for final inclusion. Results: Most of the studies were published between 2011 and 2014. The quasi-experimental design was most frequently applied. The Gugging Swallowing Screen was the most widely used assessment tool. All studies, including dysphagia intervention programs, involved oral and facial exercise programs. In addition, they all used swallowing-related outcome variables to assess the effectiveness of the interventions. Conclusion Additional studies on dysphagia among older Korean adults in long-term care facilities should be conducted, and various interventions and assessment tools should be developed and implemented. This study is anticipated to establish a fundamental foundation for further dysphagia-related research and help improve the quality of life of Korean older adults in long-term care.

Purpose: This scoping review aimed to identify the research trends for dysphagia among older Korean adults in long-term care facilities. Methods: A literature search was performed using Korean Studies Information Service System, Research Information Sharing Service, ScienceON, Cumulative Index to Nursing and Allied Health Literature, and PubMed. A total of 1,395 articles were identified, and 10 articles were selected for the final analysis. Two reviewers independently performed the study selection and extraction using pre-tested forms to confirm those for final inclusion. Results: Most of the studies were published between 2011 and 2014. The quasi-experimental design was most frequently applied. The Gugging Swallowing Screen was the most widely used assessment tool. All studies, including dysphagia intervention programs, involved oral and facial exercise programs. In addition, they all used swallowing-related outcome variables to assess the effectiveness of the interventions. Conclusion Additional studies on dysphagia among older Korean adults in long-term care facilities should be conducted, and various interventions and assessment tools should be developed and implemented. This study is anticipated to establish a fundamental foundation for further dysphagia-related research and help improve the quality of life of Korean older adults in long-term care.

OBJECTIVE: This study aimed to evaluate the hypotheses that administration routes [intra-arterial (IA) vs. intravenous (IV)] affect the early stage migration of transplanted human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in acute brain infarction. METHODS: Male Sprague-Dawley rats (n=40) were subjected to photothrombotic infarction. Three days after photothrombotic infarction, rats were randomly allocated to one of four experimental groups [IA group : n=12, IV group : n=12, superparamagnetic iron oxide (SPIO) group : n=8, control group : n=8]. All groups were subdivided into 1, 6, 24, and 48 hours groups according to time point of sacrifice. Magnetic resonance imaging (MRI) consisting of T2 weighted image (T2WI), T2* weighted image (T2*WI), susceptibility weighted image (SWI), and diffusion weighted image of rat brain were obtained prior to and at 1, 6, 24, and 48 hours post-implantation. After final MRI, rats were sacrificed and grafted cells were analyzed in brain and lung specimen using Prussian blue and immunohistochemical staining. RESULTS: Grafted cells appeared as dark signal intensity regions at the peri-lesional zone. In IA group, dark signals in peri-lesional zone were more prominent compared with IV group. SWI showed largest dark signal followed by T2*WI and T2WI in both IA and IV groups. On Prussian blue staining, IA administration showed substantially increased migration and a large number of transplanted hBM-MSCs in the target brain than IV administration. The Prussian blue-positive cells were not detected in SPIO and control groups. CONCLUSION: In a rat photothrombotic model of ischemic stroke, selective IA administration of human mesenchymal stem cells is more effective than IV administration. MRI and histological analyses revealed the time course of cell migration, and the numbers and distribution of hBM-MSCs delivered into the brain.
Animals ; Brain ; Brain Infarction ; Cell Movement ; Cerebral Infarction* ; Diffusion ; Humans* ; Infarction ; Infusions, Intravenous* ; Iron ; Lung ; Magnetic Resonance Imaging* ; Male ; Mesenchymal Stromal Cells* ; Rats* ; Rats, Sprague-Dawley ; Stroke ; Transplants

OBJECTIVE: To evaluate engraftment by visualizing the location of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) three-dimensionally in photothrombotic cerebral infarction (PTCI) models of rats. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) of an agarose block containing superparamagnetic iron oxide (SPIO)-labeled hBM-MSCs was performed using a 3.0-T MRI, T2-(T2WI), T2*-(T2*WI), and susceptibility-weighted images (SWI). PTCI was induced in 6 rats, and 2.5 x 10(5) SPIO-labeled hBM-MSCs were infused through the ipsilateral internal carotid artery (ICA group) or tail vein (IV group). MRI was performed on days 1, 3, 7, and 14 after stem cell injection. Dark signal regions were confirmed using histology. Three-dimensional MRI reconstruction was performed using the clinical workflow solution to evaluate the engraftment of hBM-MSCs. Volumetric analysis of the engraftment was also performed. RESULTS: The volumes of SPIO-labeled hBM-MSCs in the phantom MRI were 129.3, 68.4, and 25.9 microL using SWI, T2*WI, and T2WI, respectively. SPIO-labeled hBM-MSCs appeared on day 1 after injection, encircling the cerebral infarction from the ventral side. Dark signal regions matched iron positive cells and human origin (positive) cells. The volume of the engraftment was larger in the ICA group on days 1, 3, and 7, after stem cell injection (p < 0.05 on SWI). SWI was the most sensitive MRI pulse sequence (p < 0.05). The volume of infarction decreased until day 14. CONCLUSION: The engraftment of SPIO-labeled hBM-MSCs can be visualized and evaluated three-dimensionally in PTCI models of rats. The engraftment volume was larger in the ICA group than IV group on early stage within one week.
Animals ; Cerebral Infarction/pathology/*radiography ; Contrast Media ; Dextrans ; Humans ; Imaging, Three-Dimensional/methods ; Magnetic Resonance Imaging/*methods ; Magnetite Nanoparticles ; Male ; *Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/radiography ; Nanoparticles ; Neuroimaging/*methods ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Tomography, X-Ray Computed

OBJECTIVES: Closed reduction is generally recommended for acute nasal bone fractures, and rhinoplasty is considered in cases with an unsatisfactory outcome. However, concomitant rhinoplasty with fracture reduction might achieve better surgical outcomes. This study investigated the surgical techniques and outcomes in patients who underwent rhinoplasty and fracture reduction concomitantly, during the acute stage of nasal bone fracture. METHODS: Forty-five patients who underwent concomitant rhinoplasty and fracture reduction were enrolled. Nasal bone fractures were classified into three major types (type I, simple fracture; type II, fracture line that mimics nasal osteotomy; and type III, comminuted fracture) based on computed tomography images and preoperative facial images. Two independent otolaryngology-head and neck surgeons evaluated the surgical outcomes and telephone based survey were made to evaluate patients satisfaction. RESULTS: Among 45 patients, there were 39 males and 6 females. Type I was the commonest type of fracture with 18 patients (40%), while the most frequently used surgical technique for corrective surgery was dorsal augmentation with 44 patients (97.8%). The mean visual analogue scale satisfaction score of the surgeons and patients were 7.62 and 8, respectively, with no significant differences between fracture types. CONCLUSION: Concomitant rhinoplasty with fracture reduction can be performed for acute nasal bone fracture patients, and it might lead to better aesthetic outcomes.
Female ; Fractures, Bone ; Humans ; Male ; Nasal Bone* ; Neck ; Osteotomy ; Rhinoplasty ; Surgeons ; Telephone

BACKGROUND AND PURPOSE: Health-related quality of life (HRQoL) is a multidimensional concept that signifies a subjective evaluation of perceived health; hence, it has gained wide acceptance in geriatrics. However, its application has not been tested in patients with post-stroke cognitive impairment with no dementia (PSCIND). We investigated whether PSCIND interferes with HRQoL measured by EQ-5D, compared the findings to those of healthy people with normal cognition, and evaluated the influence of each cognitive domain on this score. METHODS: In total, 1,528 subjects were identified who had undergone neuropsychological assessment using the 60-min protocol of the Korean version of Vascular Cognitive Impairment Harmonization Standards, EQ-5D, and magnetic resonance imaging at the stroke prevention clinic. Fifty PSCIND patients were matched to 50 post-stroke dementia (PSD) patients and 50 normal age- (+/-3 years) and sex-matched controls. The effects of PSCIND, PSD, and control groups upon the EQ-5Dindex score were tested by generalized estimating equation modeling. RESULTS: Estimated means+/-standard errors of EQ-5Dindex scores were as follows: 0.94+/-0.06 (control group), 0.86+/-0.08 (PSCIND group), and 0.61+/-0.32 (PSD group); and the difference among the three groups was statistically significant (P<0.0001). Pairwise comparisons showed that EQ-5Dindex scores in the PSCIND group differed from those in the PSD and control groups (both P<0.01). No cognitive domain was specifically associated with EQ-5Dindex scores after adjusting for functional status. CONCLUSIONS: This study shows that PSCIND may interfere with the quality of life in stroke victims.
Cognition ; Dementia ; Geriatrics ; Humans ; Magnetic Resonance Imaging ; Quality of Life ; Stroke

In addition to cellular damage, ischemia-reperfusion (IR) injury induces substantial damage to the mitochondria and endoplasmic reticulum. In this study, we sought to determine whether impaired mitochondrial function owing to IR could be restored by transplanting mitochondria into the heart under ex vivo IR states. Additionally, we aimed to provide preliminary results to inform therapeutic options for ischemic heart disease (IHD). Healthy mitochondria isolated from autologous gluteus maximus muscle were transplanted into the hearts of Sprague–Dawley rats damaged by IR using the Langendorff system, and the heart rate and oxygen consumption capacity of the mitochondria were measured to confirm whether heart function was restored. In addition, relative expression levels were measured to identify the genes related to IR injury. Mitochondrial oxygen consumption capacity was found to be lower in the IR group than in the group that underwent mitochondrial transplantation after IR injury (p < 0.05), and the control group showed a tendency toward increased oxygen consumption capacity compared with the IR group. Among the genes related to fatty acid metabolism, Cpt1b (p < 0.05) and Fads1 (p < 0.01) showed significant expression in the following order: IR group, IR + transplantation group, and control group. These results suggest that mitochondrial transplantation protects the heart from IR damage and may be feasible as a therapeutic option for IHD.