1.Reconstruction of the anterior cruciate ligament by allogeneic tendon graft:clinical curative effect and immune rejection
Zesong TU ; Lixue LIANG ; Jisi XING
Chinese Journal of Tissue Engineering Research 2016;20(15):2190-2196
BACKGROUND:Problems can occur at the donor site where the autologous tendon graft is taken. Alogenic tissue has become an important graft option for the reconstruction of the anterior cruciate ligament.
OBJECTIVE: To study the clinical curative effect and immune rejection of arthroscopic reconstruction of the anterior cruciate ligament by alogeneic tendon graft.
METHODS:The 120 included patients with anterior cruciate ligament injury were randomized into autologous tendon graft and alogeneic tendon graft groups, respectively, with 60 patients in each group. The autologous semitendinosus-gracilis graft at the affected side or the alogeneic anterior cruciate ligament was implanted into the knee joint in autologous tendon graft group or alogeneic tendon graft group, respectively. Lachman test results, Lysholm and Larson scores of joint function, and postoperative immune rejection were observed and assessed during 2-year folow-up.
RESULTS AND CONCLUSION: Lysholm and Larson scores in autologous tendon graft and alogeneic tendon graft groups were significantly increased after the reconstruction compared with before the reconstruction; however, there was no difference in the scores between both two groups at 2 years after the reconstruction (P > 0.05). At the end of the folow-up, the normal function of the knee joint was restored, and no lag and flexion constraint of the knee joint were observed. No significant differences were observed in Lachman test results between both groups (P> 0.05). Compared with the autologous tendon graft group, immune rejection rates were higher in the alogeneic tendon graft group; however, no significant differences were observed between both groups (P > 0.05). In summary, the alogeneic tendon graft may be a candidate for the reconstruction of the anterior cruciate ligament due to its similar clinical curative effect to the autologous tendon graft and low immune rejection rates.
2.The effect of Shujinxi external granule on knee joints function recovery after meniscus suture
Jisi XING ; Lei HOU ; Zongquan FENG ; Yonggen ZOU
International Journal of Traditional Chinese Medicine 2012;34(6):496-498
ObjectiveTo investigate the affection of Shujinxi external granule on the knee joints function after meniscus suture.Methods60 patients who undertook meniscus suture were randomly recruited into two groups,30 cases in each group.The control group accepted conventional rehabilitation training,while the treatment group received Shujinxi external granule on the basis of the conventional rehabilitation training.Both groups were treated for two weeks for a therapeutic course,and statistics analysis was made after 3~4therapeutic courses.ResultsThe average postoperative knee activity after 8 weeks and 12 weeks was [ (114.1 ±18.6)° and [(129.6±10.3)° ],in thetreatment group,comparing to [(89.7±t2.5 )° and (112.7±16.6)° ]in the control group,the difference was statistically significant (P<0.05).the IKDC score and the Lysholm score of treatment group after 12 weeks was [(84.76±5.21) and (92.54±3.22)],while the control group was [(79.63±4.67) and (85.61±4.92)],the difference was significant (P<0.05).ConclusionShujinxi external granule can promote the recovery of knee joints function after the operation of meniscus suture.
3.Arthroscopic double Endobutton plate internal fixation for acute acromioclavicular joint dislocation
Lilian ZHAO ; Mingfeng LU ; Ting XU ; Jisi XING ; Lilei HE
Chinese Journal of Trauma 2019;35(1):71-78
Objective To investigate the clinical efficacy of arthroscopic double Endobutton plate internal fixation in the treatment of acute acromioclavicular joint dislocation.Methods A retrospective case series study was performed to analyze the clinical data of 32 patients with Rockwood type Ⅲ or Ⅴ acute acromioclavicular joint dislocation admitted to Foshan Hospital of TCM from May 2015 to February 2018.There were 26 males and six females,aged 22-56 years [(37.7 ± 1.6)years].There were 22 patients with Rockwood type Ⅲ and 10 patients with type Ⅴ.The duration from injury to operation was 2-5 days.All patients were treated with arthroscopic double Endobutton plate internal fixation for coracoclavicular ligament reconstruction.The operation time,hospitalization time,and postoperative shoulder joint braking time were recorded.The shoulder joint function was evaluated by the Constant-Murley score (CMS),visual analogue scale (VAS),American shoulder and elbow surgeons (ASES) score,University of California Los Angeles (UCLA) score and simple shoulder test (SST) before operation and at the last follow-up.Meanwhile,complications such as infection,loosening and joint dislocation were recorded.Results All patients were followed up for 8-48 months [(27.8 ± 11.6) months].The operation time was 48-93 minutes [(65.0 ± 24.6) minutes],the hospitalization time was 3.2-10 days [(6.5 ± 2.6)days],and the postoperative braking time was 21-35.3 days [(28.2 ± 7.1)days].All patients had a grade A healing of surgical incision.The VAS was decreased from preoperative (5.7 ±2.5)points to (1.2 ±0.8)points at the last follow-up (P <0.01);CMS wasvincreased from preoperative (29.3 ± 3.4) points to (93.2 ± 2.1) points at the last follow-up (P <0.05);ASES score was increased from preoperative (28.9 ± 10.1) points to (95.7 ± 5.6) points at the last follow-up (P < 0.05);UCLA score was improved from preoperative (11.6 ± 2.8) points to (34.2 ±1.5)points at the last follow-up (P <0.05);SST score was improved from preoperative (3.5 ±1.2)points to (9.7± 1.4)points at the last follow-up (P < 0.O1).The incidence of intraoperative and postoperative complications was 16% (5/32).In two patients,the surgery was changed to U shape fixation circulating the coracoid base due to the coracoidbone tunnel cutting out.One patient was found to have insufficient reduction and received the acromioclavicular joint operation.One patient had reduction loss due to the clavicle button collapsing,and one patient had excessive reduction.Conclusions For Rockwood type Ⅲ or Ⅴ acute acromioclavicular dislocation patients,arthroscopic double Endobutton plates for coracoclavicular ligament reconstruction has the advantages of less intraoperative trauma,quick recovery and satisfactory clinical result.However,the incidence of intraoperative and postoperative complications is relatively high,and indications should be strictly controlled.