1.Association of microalbuminuria and von Willebrand factor with metabolic syndrome in hypertensive patients
Jing LIU ; Jing YANG ; Ningling SUN ; Jishun MA ; Dayi HU
Journal of Peking University(Health Sciences) 2003;0(06):-
Objective:To compare the difference of microalbuminuria (MAU) and von Willebrand factor (vWF) between essential hypertensives and hypertensive patients with metabolic syndrome (MS), and to explore the association of these factors with MS. Methods: According to the new definition of MS by International Diabetes Federation (IDF) for 2005, 133 consecutive essential hypertensives were divi-ded into two groups: hypertensive patients with metabolic syndrome (EH-MS group, n=97), and essential hypertensives (EH group, n=36). Biochemistry assay, plasma vWF, 24 hours urine albumin excretion (UAE) and morning urine albumin/creatinine ratio (ACR) were measured. The association of MAU and vWF with MS was analysed. Results: Waist circumference, body mass index, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), plasma vWF and UAE were increased(P0.05, respectively). Logistic regression showed HDL-C, TG, LDL-C,vWF and UAE were associated with the deve-lopment of MS in hypertensive patients (standardized coefficients: -0.825, 0.63, 0.339, 0.331, 0.371,P
2.The expression of TRAIL in psoriatic patients and healthy subjects
Jishun YANG ; Jianhua WU ; Quangang ZHU ; Jiyong LIU ; Jinhong HU
Chinese Pharmacological Bulletin 2003;0(10):-
Aim To explore the expression of TNF-related apoptosis-inducing ligand(TRAIL)between psoriatic patients and healthy subjects.Methods Immunohistochemical staining and Real-Time PCR methods were established to detect the expression of TRAIL.Results Immunohistochemical staining results indicated a significant difference of the expression of TRAIL between psoriatic patients and healthy subjects.Real-Time PCR results indicated that the quantities were 0.42?0.07,1.01?0.16 respectively of two type skins.Thus there were significant differences(P
3.The correlation analysis of LUTS and histological inflammation in patients with benign prostatic hyperplasia
Jishun SONG ; Lei YUAN ; Baizhi YANG ; Yixia LIU ; Aifa WANG
Chinese Journal of Primary Medicine and Pharmacy 2017;24(4):563-565,566
Objective To investigate the relationship between LUTS and degree,type of prostate histological inflammation in patients with benign prostatic hyperplasia (BPH).Methods From October 2013 to June 2016, 150 patients with BPH(62 -82 years old)were treated with selective TURP.After operation,the pathology examina-tion was practised.According to the international prostatitis histological classification standard,the patients were divid-ed into group A(without inflammation,18 cases),group B(inflammation around gland,45 cases),group C(gland inflammation,33 cases)and group D(mixed inflammation group,54 cases).There were no statistically significant differences among the 4 groups in age,course of disease,number of urinary retention and prostate volume(all P >0.05).The IPSS score before and 2 months after operation and the correlation between the IPSS and degree,type of histological inflammation were observed.Results In group A and C,the preoperative IPSS score and IPSS score at 2 months after surgery were (17.20 ±11.14)points,(8.45 ±5.14)points and (18.05 ±13.11)points,(9.85 ± 5.25)points respectively,there were no statistically significant differences between the two groups(t =0.485,1.294, all P >0.05).There were no statistically significant differences between group B[(22.55 ±11.85)points,(13.24 ± 6.46)points]and group D[(21.45 ±10.35)points,(12.36 ±6.04)points](t =0.824,1.436,all P >0.05).The group B had statistically significant differences compared with group A and group C (t =2.689,5.016,3.642,4.382, all P <0.05).The group D also had statistically significant differences compared with group A and group C (t =2.786,4.672,6.415,5.106,all P <0.05 ).There was positive correlation between the IPSS score before and 2 months after operation and the degree of inflammation in group B,D(B:r =0.698,0.795,D:r =0.546,0.485,all P <0.05),but there was no correlation in group C between them(r =0.182,0.170,all P >0.05 ).Conclusion There is a close correlation between LUTS and inflammation around gland in patients with BPH,and the LUTS can aggravate with the increased inflammation around gland and do not relate with the gland inflammation.
4.Clinical study of bladder gasification and stasis dispersion in BPH patients with histological prostatitis after TUEP about IPSS/Qol score
Jishun SONG ; Lei YUAN ; Baizhi YANG ; Yixia LIU ; Aifa WANG ; Zhiqiang WANG
Chinese Journal of Primary Medicine and Pharmacy 2016;23(20):3125-3129
Objective To evaluate the clinical efficacy of bladder gasification and stasis dispersion in BPH patients with histological prostatitis after TUEP about IPSS /Qol score.Methods 126 BPH patients with histological prostatitis after TURP were divided into group A,B and C of equal number,and received oral placebo,tamsulosin,and herbal decoction a week after operation,respectively,for a course of 4 weeks.IPSS and Qol score were evaluated. Results After 5 weeks,121 cases finished the follow -up,the unfinished were 2 cases in group A,2 cases in group B and 1 cases in group C.The differences of the IPSS total scores,irritative subscore,obstructive subscore,quality of life score in group C(7.16 ±3.37)points,(4.22 ±2.70)points,(2.94 ±2.06)points,(1.47 ±1.44)points were statis-tically significant than those in group A[(13.77 ±4.50)points,(7.48 ±3.50)points,(6.29 ±2.63)points,(2.83 ± 1.72)points]and group B [(12.77 ±5.24)points,(8.05 ±3.88)points,(4.72 ±3.24)points,(3.07 ± 1.67)points](t =2.692,3.544,3.296,2.698 and t =2.326,3.532,2.418,2.414;all P <0.05).There was only obstructive subscore in group B better than that in group A(t =2.572,P <0.05).Conclusion Bladder gasification and stasis dispersion is effective for the treatment of BPH patients with histological prostatitis after TUEP about IPSS and Qol score.The clinical effect is indeed and satisfactory.
5.Joint expansion of double fascia flaps for fall-ear mastoid reconstruction
Benshou ZHANG ; Jishun YANG ; Xiangbing SHUI ; Hui CHU ; Zhijiu XU ; Zihao LIN ; Yaozhong ZHAO
Chinese Journal of Medical Aesthetics and Cosmetology 2015;21(5):281-283
Objective To study the methods and clinical effects of joint expansion of double fascia flaps wrapping the Medpor to perform full-ear reconstruction on congenital microtia deformity.Methods 60 patients with congenital microtia deformity were selected.including 22 left ears and 38 right ears.Majority had loss of ear auricle or only partial earlobe.Phase Ⅰ procedures included:temporal-parietal branch was used for the vascular pedicle,and mastoid area behind the ear was moved and expanded for fascia flap.Phase Ⅱ included:the joint expansion of double fascia flap wrapped Medpor to do full-ear reconstruction.Results Flaps survived and no complications for all 60 patients.Reconstructed ears had lifelike appearance and clear anatomical structures.Auriculocephalic angulars positions and sizes were consistent with the healthy ears.None of them had exposed prosthesis and scar contraction.Three-dimensional shapes were good.Conclusions Joint expansion of double fascia flap wrapping Medpor could avoid the chest wall deformity and exposed prosthesis.The fine structure of the reconstructed ear is satisfactory.
6.Predictive value of neutrophil to lymphocyte ratio combined with BNP in elderly patients with heart failure complicated with pulmonary infection
Jie ZHANG ; Shengwu CHAO ; Jishun YANG
Journal of Pharmaceutical Practice and Service 2022;40(5):469-472
Objective To evaluate the predictive value of neutrophil to lymphocyte ratio(NLR) and B-type natriuretic peptide (BNP) in elderly patients with heart failure complicated with pulmonary infection. Methods 178 heart failure patients in our hospital from June 2018 to May 2020 were selected as the research objects, and they were divided into pulmonary infection group (n=92) and non-pulmonary infection group (n=86) according to whether they were complicated with pulmonary infection. The differences of NLR and BNP levels and other clinical indicators between the two groups were compared. Univariate and multivariate Cox regression were used to analyze the influence of NLR and BNP levels on heart failure complicated with pulmonary infection. The predictive value of NLR combined with BNP on heart failure complicated with pulmonary infection was analyzed by receiver operating characteristic (ROC) curve. Results Multivariate logistic regression analysis showed that NLR (OR=7.606, 95% CI: 3.123-18.526) and BNP (OR=4.264, 95% CI: 1.682-10.811) were independent risk factors of elderly heart failure complicated with pulmonary infection after adjusting for other related variables. Pearson correlation analysis showed that BNP level was positively correlated with NLR level (r=0.400, P<0.001). The area under ROC curve of NLR, BNP and NLR+BNP in predicting pulmonary infection in elderly patients with heart failure was 0.810, 0.756 and 0.838, respectively. Conclusion BNP and NLR are independent risk factors of elderly patients of heart failure with pulmonary infection .The combined detection of BNP and NLR has predictive value for those patients.
7.A Sampling Survey on the Distribution of Oncomelania Snails in Zhejiang Province
Liyong WEN ; Wei ZHENG ; Mingdong ZHU ; Dehua YAN ; Jishun YANG ; Lulu GAO ; Junhu CHEN ; Jianfeng ZHANG ; Liling YU ; Lijun LIN ; Haiquan TAO
Chinese Journal of Parasitology and Parasitic Diseases 1997;0(06):-
Objective To find out current distribution of Oncomelania snails and Schistosoma infection in snails in Zhejiang Province, so as to improve the project of schistosomiasis control. Methods Investigation spots were selected by stratified cluster sampling method, 100 villages of 34 counties were selected from 7 106 villages of 55 counties as survey spots. Synchronously systematic and environmental samplings were used for the survey. Snails were dissected to determine the infection status and spots with sham snails were set to assess the quality of the survey. Results The result showed that snails were found in 223 strips, 1 572 frames and 73 300 m 2 area in 32 villages of 21 counties. Snails were found in an area covering 72 640 m 2 in 29 villages of 18 counties in hilly region, which accounted for 99.1% of total snail habitats. The significantly larger area with snails was revealed in hilly region than that in water network region (t=3.04, P
8.Online moisture detection technology and its application prospect in drying of traditional Chinese medicine.
Xue-Cheng WANG ; Ya-Qi WANG ; Yuan-Hui LI ; Shi-Jun XU ; Feng SHAO ; Ying-Zi ZENG ; Zhen-Feng WU ; Ming YANG
China Journal of Chinese Materia Medica 2021;46(1):41-45
Drying is one of the most common unit operations in the production of traditional Chinese medicine. The drying process of traditional Chinese medicine materials is accompanied by the dynamic reduction of water content. As a key index to determine the end of the drying process, the moisture content of materials plays an important role in improving drying efficiency and saving energy. Recently, the drying process of traditional Chinese medicine is mostly monitored by offline detection, and there are few reports of online moisture detection applications. In this paper, the principle and current application of online inspection technology for the material drying process in different fields were introduced. The significance of online detection technology in drying of traditional Chinese medicine was also analyzed. Meanwhile, the application prospect of online detection technology in the field of drying of traditional Chinese medicine was predicted. In response to urgent transformation and upgrading of the traditional Chinese medicine manufacturing industry, the application of online moisture detection technology is expected to be a key breakthrough in the intelligent upgrading of traditional Chinese medicine drying technology and equipment.
Desiccation
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Drugs, Chinese Herbal
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Medicine, Chinese Traditional
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Quality Control
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Technology, Pharmaceutical