1.Changes of ventricular relaxation, contractility and compliance and their effects on cardiac pump function during the development of chronic high output heart failure
Chinese Journal of Pathophysiology 1986;0(04):-
Changes of ventricular relaxation, contractility and compliance and their effects on cardiac pump function during the development of chronic high output heart failure were studied in the animal model produced by establishment of combined aorto-caval fistula (ACF) and unilateral renal artery stenosis (RAS) in rats.In the present study, all the rats with ACF+RAS showed the characteristics of high output hear failure of varying degree, the cardiac index rised significantly even at rest, while pump function reserving force (CORF) decreased to different extent.The resu(?)lts show that with the aggravation of cardiac pump function deterioration, ventricular relaxation and contractility decreased progressively, the ventricular diastolic compliance rised significantly. With stepwise regression analysis, the changes of ventricular relaxation, comtractility and compliance have different effects on cardiac pump function at different stage of heart failure.
2.Analysis of anxiety influencing factors of computer department students in vocation selecting period
Zhene CHEN ; Jisheng TANG ; Tianliang ZHANG
Chinese Journal of Behavioral Medicine and Brain Science 2008;17(3):263-265
Objective To explore the anxiety influencing factors of students of computer department in vocation selecting period.Methods A total of 363 students of computer department in periods of vocational selection were assessed with 16PF, SCL-90, Coping Style Questionnaire,and Vocational Selection Anxiety Questionnaire for University Graduate. Results The anxiety score of students of computer department in vocation selecting period were much higher statisticaly than the Chinese youth norm(t=6.631,P=0.000).The results of multivariable stepwise regression showed that the major factors affecting the anxiety score of the students were anxiousness (stb=0.24928,t=4.72,P<0.000),press of employment compete(stb=0.22126,t=4.54,P<0.000),apprehension(stb=0.18320,t=3.36, P=0.001),vigilance (stb=0.15002,t=3.16, P=0.002), family-incompleteness (stb=0.09474,t=2.17, P=0.031)et al. Conclusion The anxiety score were affected by many factors. Unhealthy personality such as high vigilance and high anxiousness are the internal factors of the vocation selecting anxiety, press of employment compete is only the inducing factor. Family-incompleteness has adverse effect on response ability of the students.
3.Effect of morphine dependence on nucleic metabolism in hippocampal neurons in mice
Yinguo ZHANG ; Jisheng LI ; Jie WEI
Chinese Journal of Behavioral Medicine and Brain Science 2001;10(2):87-88
Objective To study the molecular mechanism about injurious effect of morphine dependence on the construction and function of hippocampal neurons. Method Mice were given (sc) increasing doses of morphine to form morphine-dependence model ,and the DNA and RNA changes stained with acridine orange (AO) fluorescence probe technique were investigated in hippocampal neurons of morphine-dependence group,naloxone-precipitated withdrawal group in morphine-dependence mice and control group. Results Compared with control group , the staining changes of DNA,RNA decreased obviously in hippocampal neurons of both morphine-dependence group and naloxone- precipitated withdrawal group in morphine-dependence mice,especially the later. Conclusion Both morphine-dependence and naloxone-precipitated withdrawal in morphine-dependence mice injured nucleic acid metabolism in hippocampal neurons ,especially the later.Those changes may be some reasons of decreased brain function ,especially in learning and memory deficits.
4.Effect of ulinastatin for multi system function state of patients with acute abdomen during the the perioperative period
Jisheng ZHANG ; Lifu WANG ; Xiaorong YE
Chinese Journal of Biochemical Pharmaceutics 2017;37(2):226-228
Objective To observe and study the influence state of ulinastatin for multi system function state of patients with acute abdomen during the the perioperative period.Methods 60 patients with acute abdomen treated with operation in our hospital during the time of October 2015 to July 2016 were selected as the research object, and they were randomly divided into control group ( conventional perioperative treatment group ) 30 cases and observation group(conventional treatment and ulinastatin group)30 cases,then the liver function,renal function,gastrointestinal function and immune function related indexes of two groups before the operation and at second,fifth and seventh day after the operation were detected and compared.Results The liver function,renal function,gastrointestinal function and immune function related indexes of two groups before the operation were compared ,,while the liver function,renal function,gastrointestinal function and immune function related indexes of observation group at second,fifth and seventh day after the operation were all significantly better than those of control group(P<0.05),those detection results of two groups after the operation all had significant differences.Conclusion The ulinastatin can effectively protect multi system function state of patients with acute abdomen during the the perioperative period,so its application value in these surgical patients is higher.
5.Myocardial reperfusion evaluated by myocardial blush grade after thrombolysis in acute myocardial infarction
Ankang LU ; Weifeng SHEN ; Jisheng ZHANG
Chinese Journal of Interventional Cardiology 1993;0(03):-
Objective Myocardial blush grade (MBG) as a new angiographic parameter was used to describe the effectiveness of myocardial reperfusion in patients treated with thrombolysis for acute myocardial infarction (AMI) Methods Eighty nine patients received a small dose alteplase 50mg within 12 hours of acute infarction Coronary angiography was performed at 90 min after the initiation of thrombolytic therapy to evaluate infarct related artery (IRA) patency and myocardial reperfusion Cardiac events during a 6 month period were recorded Results There were 87 6% and 12 4% patients with and without successful clinical recanalization after thrombolysis respectively Coronary angiography showed that 82 6% patients with TIMI flow 2 or 3, 88 8% patients with MBG 2 or 3, and 40 4% patients with TIMI flow 3 and MBG 3 Mortality at follow up was 10 1% Multivariate analysis showed that the MBG and Killip grade at admission were major significant predictors of 6 month mortality Conclusion The primary objective of reperfusion therapies is not only restoration of blood flow in the epicardial coronary artery, but also complete reperfusion of the infarcted myocardium
6.Effect of Shenkangling on Inflammatory State and Residual Renal Function in Patients with ;Maintenance Hemodialysis
Zhi ZHANG ; Hongjuan LIANG ; Jisheng WANG
Chinese Journal of Information on Traditional Chinese Medicine 2017;24(2):36-39
Objective To observe the inflammatory state and residual renal function (RRF) of the patients with maintenance hemodialysis treated through Shenkangling. Methods Sixty patients with maintenance hemodialysis were randomly divided into two groups, the observation group (30 cases) and the control group (30 cases). They were treated through hemodialysis and hemodiafiltration. The patients in the observation group were treated with Shenkangling 8 tablets/time, 3 times/day. RRF and urine volume after six months were evalued. Serum high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), and leukocyte mediated IL-6 (IL-6) before and after treatment were detected. Results There were no statistical differences in RRF and urine volume between the two groups before treatment (P>0.05). After six months, RRF and urine volume in the two groups were significantly reduced (P<0.05), and those of the observation group were significantly higher than those of the control group (P<0.05). There was no statistical significance in serum hs-CRP, TNF-α and IL-6 between the two groups before treatment (P>0.05). After treatment, the serum levels of hs-CRP, TNF-α, IL-6 significantly decreased in the observation group, and lower than those of the control group (P<0.05). Conclusion Shenkangling can protect the residual renal function of hemodialysis patients, and reduce the inflammatory reaction.
7.Nerve cells injury in hippocampal region after focal cerebral ischemia-reperfusion for rats with diabetes
Xin DING ; Jisheng ZHANG ; Wei LAN
Chinese Journal of Practical Internal Medicine 2001;0(07):-
Objective To understand the effect of diabetes on the nerve cells injury in hippocampal region by observing the nerve cells changes in this region of ischemia after focal cerebral ischemia reperfusion for rats with diabetes.Methods Sixty healthy male Wister rats were randomly divided into four groups:the control group,sham operation group,normal cerebral ischemia-reperfusion(NIR)group,and diabetic cerebral ischemia-reperfusion(DIR)group.The model of local cerebral ischemia and reperfusion was established by the thread-embolism and cerclage of rats with STZ-induced diabetes.Hematoxylin-eosin(HE)-stained neurons in hippocampal CA1 region were observed by selecting 8 un-overlapped fields under light microscope(?400);the total number of the normal pyramidal neurons with whole cellular organ structure were counted within 100 ?m length in CA1 region.The numbers of positive neurons were presented as mean with standard errors(?s).Significant differences between groups were analyzed by t-test.Results Neuronal loss or apoptotic cells were not found in the control group or sham operation group after observing under light microscope.There were neuronal losses in both NIR and DIR groups,neuronal loss of DIR group being more serious than that of NIR group(P
8.Design and application of Managerial and Maintenance System of Army Medical Equipments
Jisheng WANG ; Chunlei JI ; Aiping ZHANG
Chinese Medical Equipment Journal 2004;0(07):-
In order to meet the requirements of logistic supply in peacetime and wartime, General Health Department developed Managerial and Maintenance System of Army Medical Equipments, which is the important subject of 10th 5-year Army Medical Research. This system is based upon Basic Medical Equipments Distribution Standard, Army Medical Equipments Management System, joint support system and three-level maintenance network. An efficient platform for whole-survival-circle medical equipments monitoring is developed using computer information technology. This system can greatly advance the informatized, normative management of medical equipments, and thus is of avail in military and economic aspects.
9.Effect of Qinqinye on Hyperuricemia Uric Acid Metabolism and Related Enzymes Activity
Fengxian MENG ; Shiju LIU ; Jisheng ZHANG
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(04):-
0.05). Positive medicine group, Qingqinye high dosage group, Qingqinye low dosage group and Qingqinye middle dosage group reduced blood ADA activity and better than model group (P
10.Repairment Effect of Qingqinye on Joint Immune Pathological Injury in Hyperuricemia Model Rats
Fengxian MENG ; Guixiang HAO ; Jisheng ZHANG
Chinese Journal of Information on Traditional Chinese Medicine 2006;0(06):-
0.05). But according to the data, IL-8 in Qingqinye low dosage group was lower than model group, positive medicine group, Qingqinye high dosage group and Qingqinye middle dosage group. TNF-? in Qingqinye group was lower than model group and positive medicine group, especially in Qingqinye middle dosage group. Pathological section with articular cavity and surrounding tissues were better in positive medicine group and Qingqinye group. Conclusion Qingqinye has a certain effect for repairing joint immune pathological injury in hyperuricemia model rats.