Objective To study the clinical value of serum SCC,CYFRA21-1,NSE and CEA for patients with nasopharyngeal carcinoma (NPC) and squamous cell carcinoma of head and neck (NHSCC). Methods From Aug 2004 to Sep 2007, the serum levels of SCC, CYFRA21-1, NSE and CEA were detected in 79 NPC and 51 HNSCC before and after radiotherapy. The clinical related factors were analyzed. Results Before treatment, the positive rates of serum SCC, CYFRA21-1, NSE and CEA for patients with NPC were 10.53 %, 46.75 %, 17.5 % and 2.04 %, respectively. The sensitivity of combined detection was 78.95 %. The positive rates for patients with HNSCC were 22 %, 19.75 %, 11.11% and 0, respectively. The sensitivity of combined detection was 36.17 %. The level of SCC was related to staging in HNSCC group. CYFRA21-1 was related to the rote of treatment response in NPC group. Conclusion The sensitivity of combined detection of tumor markers were significantly increased. CYFRA21-1 associated with NPC and SCC with HNSCC were noted in this study.

As the main drug in colorectal cancer chemotherapy,oxaliplatin is gradually infiltrated into other malignancies therapy.But oxaliplatin-induced peripheral neuropathy limits its clinical application.The mechanisms of oxaliplatin neurotoxicity are not yet clear.Recent researches show that the acute neurotoxicity of oxaliplatin is mediated through changes in Na + transient conductances.And the function of the mitogen-activated protein kinases in chronic neuropathy has already been demonstrated in vitro.Furthermore,numerous indicators can be used to predict oxaliplatin-induced peripheral neuropathy,which bring the hope for improving the continuity of chemotherapy and realizing personalized medicine therapy.

Objective: To explore the protective effects of zinc on learning and memory of mice suffering from acute repeated hypoxia. Method: 36 mice were divided into three groups randomly: normal control, saline+hypoxia (NS) group, zinc+hypoxia (Zinc) group. Model of acute repeated hypoxic mice was duplicated and the anoxia endurance was recorded. The step-through test and step-down test were used to evaluate the ability of learning and memory. Results: 1.Compared with saline+hypoxia group, the anoxia endurance was significantly increased in zinc+hypoxia group (P

In order to meet the requirements of logistic supply in peacetime and wartime, General Health Department developed Managerial and Maintenance System of Army Medical Equipments, which is the important subject of 10th 5-year Army Medical Research. This system is based upon Basic Medical Equipments Distribution Standard, Army Medical Equipments Management System, joint support system and three-level maintenance network. An efficient platform for whole-survival-circle medical equipments monitoring is developed using computer information technology. This system can greatly advance the informatized, normative management of medical equipments, and thus is of avail in military and economic aspects.

Objective To observe and study the influence state of ulinastatin for multi system function state of patients with acute abdomen during the the perioperative period.Methods 60 patients with acute abdomen treated with operation in our hospital during the time of October 2015 to July 2016 were selected as the research object, and they were randomly divided into control group ( conventional perioperative treatment group ) 30 cases and observation group(conventional treatment and ulinastatin group)30 cases,then the liver function,renal function,gastrointestinal function and immune function related indexes of two groups before the operation and at second,fifth and seventh day after the operation were detected and compared.Results The liver function,renal function,gastrointestinal function and immune function related indexes of two groups before the operation were compared ,,while the liver function,renal function,gastrointestinal function and immune function related indexes of observation group at second,fifth and seventh day after the operation were all significantly better than those of control group(P<0.05),those detection results of two groups after the operation all had significant differences.Conclusion The ulinastatin can effectively protect multi system function state of patients with acute abdomen during the the perioperative period,so its application value in these surgical patients is higher.

Objective To observe the inflammatory state and residual renal function (RRF) of the patients with maintenance hemodialysis treated through Shenkangling. Methods Sixty patients with maintenance hemodialysis were randomly divided into two groups, the observation group (30 cases) and the control group (30 cases). They were treated through hemodialysis and hemodiafiltration. The patients in the observation group were treated with Shenkangling 8 tablets/time, 3 times/day. RRF and urine volume after six months were evalued. Serum high-sensitivity C reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), and leukocyte mediated IL-6 (IL-6) before and after treatment were detected. Results There were no statistical differences in RRF and urine volume between the two groups before treatment (P>0.05). After six months, RRF and urine volume in the two groups were significantly reduced (P<0.05), and those of the observation group were significantly higher than those of the control group (P<0.05). There was no statistical significance in serum hs-CRP, TNF-α and IL-6 between the two groups before treatment (P>0.05). After treatment, the serum levels of hs-CRP, TNF-α, IL-6 significantly decreased in the observation group, and lower than those of the control group (P<0.05). Conclusion Shenkangling can protect the residual renal function of hemodialysis patients, and reduce the inflammatory reaction.

Objective To determine the effect of exogenous wild-type p53(WT-p53) on the growth of hepatocellular carcinoma (HCC) cell lines possessing different p53 functional status.Methods With recombinant adenoviral vector expressing WT-p53(Ad-p53),p53 gene was transfected into HCC cell lines:Bel-7402,QGY-7701, and PLC/PRF/5.The cytotoxicities of Ad-p53 to these cell lines were measured by MTT assay,cell growth properties and cell cycle pattern were assessed by flow cytometry.Results The OD of PLC/PRF/5, Bel-7402,and QGY-7701 cells transfected with Ad-p53 of 40,200,and 800 MOI were 0.02?0.00 vs 0.98?0.16(P0.05),compared with control groups respectively. Analysis of flow cytometry showed higher G2/M? lower S and apoptosis ratio in PLC/PRF/5 cells,while higher G0/G1 ratio and lower S ratio in Bel-7402 cells. ConclusionReplication-deficient adenoviral vector expressing WT-p53 may be useful for gene therapy in HCC regardless the status of endogenous p53.

The effects of superoxide dismutase (SOD) on mitochondrial function after hypoxic and reoxygenated perfusions in isolated rat hearts were observed. Significant decreases in respiration control ratio (RCR) and ADP/O ratio (P/O) as well as activities of succinic dehydrogenase (SDH) and cytochrome oxidase (CCO) were found alter 40 minutes' hypoxia and 20 minutes' reoxygenated perfusion. Adding SOD to the perfusion fluid during the reperfusion period could restore the decreased mitochondfial function, which was shown by increased RCR and P/O as well as activities of SDH and CCO.

Objective: To develop Attributional Style Questionnaire for Adolescents (ASQA) and explore the correlation between attributional style and mental health in adolescents. Method: ASQA was drawn up through referring to Peterson's method. 534 students were measured by ASQA, SSDA, SAS and MMOCI. Results: The goodness of fit indices of three-factor model in ASQA as follows: x2/df = 511.69/188, GFI = 0.91, AGFI = 0.89, NNFI = 0.91, CFI = 0.92, IFI = 0.92. Cronbach's α coefficient was 0.82. Spearman - Brown split - half reliability was 0.84. Stable and global variables entered the equations of depression, anxiety, obaession and compulsion in multiple linear regression analysis. Conclusion:ASQA had good reliability and construct validity. Adolescents were in low level of mental health when they attributed negative events to stable and global causes.

Objective To observe the effect of the combined therapy on headache after craniotomy.Methods 30 patients complained severe headache after craniotomy were divided into the treatment group (n=15, received the combined therapy mainly including nerve block) and control group (n=15, received professional medicine). The visual analogue scale (VAS), admission days after surgery, and medical fees of the patients in two groups were compared.Results The VAS scores of the patients in the treatment group decreased significantly after treatment ( P<0.01), the admission days after surgery significantly shortened ( P<0.01), and the fees of examination, medicine, and ward bed significantly decreased compared with the control group.Conclusion The combined therapy mainly including nerve block is effective on headache after craniotomy.