OBJECTIVE:To observe the short-term curative effect of treating malignant tumor with compound glycyrrhizin injection plus chemotherapy and the effect of the combined therapy on liver function.METHODS:A total of62patients with malignant tumor were randomly divided into two groups:the treatment group was assigned to receive compound glycyrrhizin injection(60ml)combined with chemotherapy,and control group receive single conventional chemotherapy,the short-term curative effect and the impact on liver function between groups were compared.RESULTS:The total effective rates were51.6%and32.8%,respectively for the treatment group and the control group(P

Objective To observe change of T regulatory cells (Tregs) and its relation with in-jury severity and sepsis following severe muhiple injury. Methods A total of 60 patients were em-ployed in the study and divided into severe group (30 patients) and critical group (30 patients) based on ISS scores and into sepsis group (22 patients) and non-sepsis group (38 patients) based on complication of sepsis. The proportion of Tregs in peripheral blood in different groups was detected by flow cytometry at days 1,3,5 and 8 after injury. Results The proportion of Tregs was significantly increased at day 5 postinjury, with statistical difference compared with that at day 3 postinjury (P < 0.01). The proportion of Tregs remained increasing at day 8 pestinjury (P < 0.05). At day 8 postinjury, the proportion of Tregs in critical group was significantly higher than that in severe group (P < 0.01). At the same time, the proportion of Tregs in sepsis group was significantly higher than that in non-sepsis group (P < 0.05). Spearman correlation analysis showed a positive correlation of Tregs proportion with ISS score (rs =0.654, P < 0.01). Conclusions Tregs play an important role in suppression of T cell-mediated im-munity after severe injury. The variation of Tregs can help evaluate prognosis and predict the risk of com-plicating sepsis in patients with severe multiple injury.

Objective:To observe the efficacy of Xiaochaihu Decoction combined with Tongqiao-Huoxue Decoction in the treatment of cardiac neurosis with syndrome of blood stasis and the effect on serum levels of inflammatory cytokines. Methods:A total of 84 patients with cardiac neurosis, who were admitted to Zhongtieshanqiao Group Hospital, were randomly devided intoto the observation group (42 cases) and the control group (42 cases) withthe random number table method. The control group received Betalog and Glutamine tablet. The observation group took Xiaochaihu Decoction combined with Tongqiao-Huoxue Decoction orally on the basis of the control group. Both groups were treated for 4 weeks. Hamilton depression scale (HAMD) was used to evaluate the degree of depression, Hamilton anxiety scale (HAMA) was used to evaluate the degree of anxiety, and hypersensitive c-reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-α were measured by ELISA, and the clinical efficacy was evaluated. Results:The total effective rate of the observation group was 95.24% (40/42) andthe control group was 75.61% (31/41). The difference between the two groups was statistically significant ( χ2=4.973, P=0.026). After the treatment, scores of HAMD and HAMA of the observation group were signifcantly lower than that of the control group ( t values were 6.579, 8.941, respectively, all Ps<0.01), and scores of impatience, headache, insomnia, forgetfulness, and chest and rib pain were significantly lower than those of the control group ( t values were 7.888, 8.777, 8.836, 9.964, respectively, all Ps<0.01). After the treatment, serum levels of hs-CRP and TNF-α in the observation group were significantly lower than that of the control group ( t values were 5.847, 8.453, respectively, all Ps<0.01). Conclusions:Xiaochaihu Decoction combined with Tongqiao-Huoxue Decoction can relieve the clinical symptoms of cardiac neurosis, and down-regulate serum levels of hs-CRP and TNF-α.

Objective:To investigate the therapeutic effect of comprehensive geriatric assessment(CGA) in elderly patients with chronic heart failure(CHF) complicated with sarcopenia, and to provide a theoretical reference for clinical application.Methods:This study was a prospective randomized controlled study. 110 elderly CHF patients with myopenia admitted to the Third People's Hospital of Hefei from January 2019 to February 2022 were selected. Using the random number table method, 56 cases were divided into an observation group and 54 cases into a control group. Before treatment, the control group of patients underwent a selective single assessment based on the hospital's requirements and the patient's actual situation, including a fall risk assessment, nutritional risk screening checklist assessment, and routine medication to improve cardiac function and prognosis; Before treatment, the patients in the observation group were assessed with CGA, including the assessment of physical function, mental and psychological status, multiple drug management, pain, Sleep disorder, and social environment. According to the assessment results, individual diagnosis and treatment plans were formulated, implemented, and dynamically adjusted. The two groups were treated for 12 weeks. The general information, treatment compliance, B-type brain natriuretic peptide (BNP) level, left ventricular Ejection fraction (LVEF), 6 min walking distance (6MWD), arm strength of upper limbs and 6 m walking speed, clinical efficacy and prognosis of the two groups were compared before and after treatment. The measurement data is represented by xˉ± s, group t-tests are used for inter group comparison, and paired t-tests are used for intra group comparison before and after treatment; Counting data is represented as an example (%), and inter group comparisons are made using χ 2 test, non parametric rank sum test was used for inter group comparison of hierarchical data. Results:There was no statistically significant difference in gender, age, course of CHF, smoking, alcohol consumption, number of comorbidities, cardiac function grading, and treatment compliance between the two groups of patients (all P>0.05), indicating comparability. Before treatment, there was no statistically significant difference in plasma BNP, LVEF, 6MWD, upper limb grip strength, and 6-meter walking speed between the two groups of patients (all P>0.05); After treatment, the BNP of both groups of patients was lower than before treatment and the observation group was lower than the control group. LVEF, 6MWD, upper limb grip strength, and 6-meter walking speed were all higher than before treatment and the observation group was higher than the control group [(343.45±34.95) ng/L vs (387.09±46.96) ng/L, (49.61±7.11)% vs (42.94±5.72)%, (348.92±37.73) m vs (297.74±43.48) m, (22.64±3.82) kg vs (19.48±3.88) kg, (0.97±0.10) m/s vs (0.83±0.12) m/s], The differences were statistically significant ( t-values were 5.51, -5.40, -6.60, -4.31, -6.60, all P<0.001). After 12 weeks of treatment, there was no statistically significant difference in clinical efficacy between the two groups of patients ( P=0.216), but the overall poor prognosis rate in the follow-up observation group was lower than that in the control group [7.14%(4/56) vs 22.22% (12/54)], and the difference was statistically significant (χ 2=5.03, P=0.025). Conclusions:Developing, implementing, and dynamically adjusting the individualized treatment plan involving CGA can improve the prognosis of elderly CHF patients with sarcopenia, help improve cardiac function, increase grip strength and somatic function, and reduce the risk of major adverse cardiovascular events ,all-cause mortality in elderly patients with CHF combined with sarcopeni and has certain clinical application value.

OBJECTIVE: To study the expression of VEGF in sinonasal squamous cell carcinoma and its correlations with microvessel density (MVD), microlymphatic vessel density (MLVD). METHOD: The expression of VEGF, MVD and MLVD in 41 cases of sinonasal squamous cell carcinoma were detected by immunohistochemical technique. RESULT: In the sinonasal squamous cell carcinoma, the positive rate of VEGF was 82.9% (34/41). The over expression of VEGF was related with tumor invasion, histological grading and lymphatic metastasis (P < 0.05). The MVD of cases with positive VEGF expression was significantly higher than those without VEGF expression (P < 0.05), but was not statistical difference in MLVD (P > 0.05). CONCLUSION VEGF may participate in the metastasis of sinonasal squamous cell carcinoma through promoting vascularization in the tumors, but not promoting MLVD.
Carcinoma, Squamous Cell ; blood supply ; metabolism ; pathology ; Female ; Humans ; Male ; Microvessels ; Nasal Cavity ; Neovascularization, Pathologic ; Nose Neoplasms ; blood supply ; metabolism ; pathology ; Paranasal Sinus Neoplasms ; blood supply ; metabolism ; pathology ; Vascular Endothelial Growth Factor A ; metabolism